Netrin-1 regulates the inflammatory response of neutrophils and macrophages, and suppresses ischemic acute kidney injury by inhibiting COX-2-mediated PGE2 production

Kidney International

Volumn 83, Issue 6, 2013, Pages 1087-1098

  Ranganathan, Punithavathi V ^a   Jayakumar, Calpurnia ^a   Mohamed, Riyaz ^a   Dong, Zheng ^a   Ramesh, Ganesan ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Cyclooxygenase; Inflammation; Netrin 1; PGE2

Indexed keywords

CHEMOKINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 17; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; NETRIN 1; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; THROMBOXANE;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; IN VITRO STUDY; IN VIVO STUDY; INJURY SEVERITY; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY PERFUSION; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; RENAL PROTECTION; REPERFUSION INJURY; WILD TYPE;

EID: 84882240012     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.423     Document Type: Article

References (42)

1. Kinsey GR, Li L, Okusa MD. Inflammation in acute kidney injury. Nephron Exp Nephrol 2008; 109: e102-e107.
2. Li L, Huang L, Sung SS et al. NKT cell activation mediates neutrophil IFN-{gamma} production and renal ischemia-reperfusion injury. J Immunol 2007; 178: 5899-5911.
3. Day YJ, Huang L, Ye H et al. Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: the role of CD4\+ T cells and IFN-gamma. J Immunol 2006; 176: 3108-3114.
4. Burne MJ, Daniels F, El Ghandour A et al. Identification of the CD4(\+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 2001; 108: 1283-1290.
5. Rabb H, Mendiola CC, Saba SR et al. Antibodies to ICAM-1 protect kidneys in severe ischemic reperfusion injury. Biochem Biophys Res Commun 1995; 211: 67-73.
6. Bonventre JV, Zuk A. Ischemic acute renal failure: an inflammatory disease? Kidney Int 2004; 66: 480-485.
7. Leemans JC, Stokman G, Claessen N et al. Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005; 115: 2894-2903.
8. Jo SK, Sung SA, Cho WY et al. Macrophages contribute to the initiation of ischaemic acute renal failure in rats. Nephrol Dial Transplant 2006; 21: 1231-1239.
9. Tadagavadi RK, Wang W, Ramesh G. Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. J Immunol 2010; 185: 3750-3758.
10. Wang W, Reeves WB, Ramesh G. Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney. Am J Physiol Renal Physiol 2008; 294: F739-F747.
11. Grenz A, Dalton JH, Bauerle JD et al. Partial netrin-1 deficiency aggravates acute kidney injury. PLoS one 2011; 6: e14812.
12. Jayakumar C, Mohamed R, Ranganathan PV et al. Intracellular kinases mediate increased translation and secretion of netrin-1 from renal tubular epithelial cells. PLoS one 2011; 6: e26776.
13. Ly NP, Komatsuzaki K, Fraser IP et al. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci USA 2005; 102: 14729-14734.
14. Rosenberger P, Schwab JM, Mirakaj V et al. Hypoxia-inducible factordependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat Immunol 2009; 10: 195-202.
15. Mirakaj V, Thix CA, Laucher S et al. Netrin-1 dampens pulmonary inflammation during acute lung injury. Am J Respir Crit Care Med 2010; 181: 815-824.
16. Mirakaj V, Gatidou D, Pö tzsch C et al. Netrin-1 signaling dampens inflammatory peritonitis. J Immunol 2011; 186: 549-555.
17. Samuelsson B. Arachidonic acid metabolism: role in inflammation. Z Rheumatol 1991; 50(Suppl 1): 3-6.
18. Seibert K, Masferrer JL. Role of inducible cyclooxygenase (COX-2) in inflammation. Receptor 1994; 4: 17-23.
19. Gilroy DW, Colville-Nash PR. New insights into the role of COX 2 in inflammation. J Mol Med 2000; 78: 121-129.
20. FitzGerald GA. COX-2 and beyond: approaches to prostaglandin inhibition in human disease. Nat Rev Drug Discov 2003; 2: 879-890.
21. Knight S, Johns EJ. Effect of COX inhibitors and NO on renal hemodynamics following ischemia-reperfusion injury in normotensive and hypertensive rats. Am J Physiol 2005; 289: F1072-F1077.
22. Do"egowska B, B"ogowski W, Domań ski L. Dynamics of thromboxane level changes during early phase of allograft reperfusion. Clin Transplant 2009; 23: 716-722.
23. Garvin PJ, Niehoff ML, Robinson SM et al. Evaluation of the thromboxane A2 synthetase inhibitor OKY-046 in a warm ischemia-reperfusion rat model. Transplantation 1996; 61: 1429-1434.
24. Hamilton TA, Rigsbee JE, Scott WA et al. Gamma-Interferon enhances the secretion of arachidonic acid metabolites from murine peritoneal macrophages stimulated with phorbol diesters. J Immunol 1985; 134: 2631-2636.
25. Shi H, Yokoyama A, Kohno N et al. Effect of thromboxane A2 inhibitors on allergic pulmonary inflammation in mice. Eur Respir J 1998; 11: 624-629.
26. Yao C, Sakata D, Esaki Y et al. Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med 2009; 15: 633-640.
27. Li L, Huang L, Vergis AL et al. IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemiareperfusion injury. J Clin Invest 2010; 120: 331-342.
28. Li L, Huang L, Sung SS et al. The chemokine receptors CCR2 and CX3CR1 mediate monocyte//macrophage trafficking in kidney ischemiareperfusion injury. Kidney Int 2008; 74: 1526-1537.
29. Li L, Okusa MD. Macrophages, dendritic cells, and kidney ischemiareperfusion injury. Sem Nephrol 2010; 30: 268-277.
30. Lemos HP, Grespan R, Vieira SM et al. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNg production. PNAS 2009; 106: 5954-5959.
31. Villanueva S, Céspedes C, González AA et al. Effect of ischemic acute renal damage on the expression of COX-2 and oxidative stress-related elements in rat kidney. Am J Physiol 2007; 292: F1364-F1371.
32. Schneider R, Meusel M, Renker S et al. Low-dose indomethacin after ischemic acute kidney injury prevents downregulation of Oat1/3 and improves renal outcome. Am J Physio 2009; 297: F1614-F1621.
33. Feitoza CQ, Goncalves GM, Semedo P et al. Inhibition of COX 1 and 2 prior to renal ischemia/reperfusion injury decreases the development of fibrosis. Mol Med 2008; 14: 724-730.
34. Matsuyama M, Yoshimura R, Hase T et al. Study of cyclooxygenase-2 in renal ischemia-reperfusion injury. Transplan Proceed 2005; 37: 370-372.
35. Profita M, Sala A, Bonanno A et al. Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products. Am J Physiol Lung Cell Mol Physiol 2010; 298: L261-L269.
36. Aso H, Ito S, Mori A et al. Prostaglandin E2 enhances interleukin-8 production via EP4 receptor in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol 2012; 302: L266-L273.
37. Simon LS. Role and regulation of cyclooxygenase-2 during inflammation. Am J Med 1999; 106: 37S-42S.
38. Lukiw WJ, Ottlecz A, Lambrou G et al. Coordinate activation of HIF-1 and NF-kB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia. Invest Ophthalmol Vis Sci 2003; 44: 4163-4170.
39. Jung YJ, Isaacs JS, Lee S et al. IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 2003; 17: 2115-2117.
40. Oliver K, Taylor C, Cummins E. Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylases. Arthritis Res Ther 2009; 11: 215.
41. Wang W, Brian RW, Ramesh G. Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney. Am J Physiol Renal Physiol 2008; 294: F739-F747.
42. Ramesh G, Reeves WB. p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice. Am J Physiol Renal Physiol 2005; 289: F166-F174.