Community-Based Adherence Clubs for the Management of Stable Antiretroviral Therapy Patients in Cape Town, South Africa: A Cohort Study

Journal of Acquired Immune Deficiency Syndromes

Volumn 71, Issue 1, 2016, Pages e16-e23

  Grimsrud, Anna ^a   Lesosky, Maia ^a   Kalombo, Cathy ^b   Bekker, Linda Gail ^a   Myer, Landon ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b WESTERN CAPE DEPARTMENT OF AGRICULTURE   (South Africa)

Author keywords

adherence club; ART delivery; community based care; decentralization; loss to follow up; models of care; task shifting

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIRETROVIRUS AGENT;

ADOLESCENT; ADULT; ANTIVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; FEMALE; FOLLOW UP; HEALTH CENTER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SOUTH AFRICA; VIRUS LOAD; YOUNG ADULT; COMMUNITY CARE; HEALTH CARE DELIVERY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV INFECTIONS; MEDICATION COMPLIANCE; MIDDLE AGED; ORGANIZATION AND MANAGEMENT; PROPORTIONAL HAZARDS MODEL; STATISTICS AND NUMERICAL DATA; SYSTEM ANALYSIS;

ADOLESCENT; ADULT; ANTI-RETROVIRAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; COMMUNITY HEALTH SERVICES; DELIVERY OF HEALTH CARE; FEMALE; HIV INFECTIONS; HUMANS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; OPERATIONS RESEARCH; PROPORTIONAL HAZARDS MODELS; SOUTH AFRICA; VIRAL LOAD; YOUNG ADULT;

EID: 84951568399     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000000863     Document Type: Article

References (33)

1. UNAIDS. Fast-track: Ending the AIDS Epidemic by 2030. Geneva, Switzerland: UNAIDS; 2014.
2. World Health Organization. Retention in HIV Programmes Defining the Challenges and Identifying Solutions: Meeting Report, 13-15 September 2011. Geneva, Switzerland: WHO; 2012.
3. Fox MP, Rosen S. Retention of adult patients on antiretroviral therapy in low-And middle-income countries: systematic review and meta-Analysis 2008-2013. J Acquir Immune Defic Syndr. 2015;69:98-108.
4. Wandeler G, Keiser O, Pfeiffer K, et al. Outcomes of antiretroviral treatment programs in rural Southern Africa. J Acquir Immune Defic Syndr. 2012;59:e9-16.
5. Meloni ST, Chang C, Chaplin B, et al. Time-dependent predictors of loss to follow-up in a large HIV treatment cohort in Nigeria. Open Forum Infect Dis. 2014;1:1-11.
6. World Health Organization. Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a Public Health Approach. Geneva, Switzerland: World Health Organization; 2015. Available at: http://apps.who.int/iris/bitstream/10665/186275/1/9789241509565-eng.pdf.
7. Kredo T, Adeniyi FB, Bateganya M, et al. Task shifting from doctors to non-doctors for initiation and maintenance of antiretroviral therapy. Cochrane Database Syst Rev. 2014;7:CD007331.
8. Suthar AB, Rutherford GW, Horvath T, et al. Improving antiretroviral therapy scale-up and effectiveness through service integration and decentralization. AIDS. 2014;28:S175-S185.
9. World Health Organization. March 2014 Supplement to the 2013 Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection. Recommendations for a Public Health Approach. Geneva, Switzerland: WHO; 2014.
10. Decroo T, Koole O, Remartinez D, et al. Four-year retention and risk factors for attrition among members of community ART groups in Tete, Mozambique. Trop Med Int Health. 2014;19:514-521.
11. Luque-Fernandez MA, Van Cutsem G, Goemaere E, et al. Effectiveness of patient adherence groups as a model of care for stable patients on antiretroviral therapy in Khayelitsha, Cape Town, South Africa. PLoS One. 2013;8:e56088.
12. Brennan AT, Long L, Maskew M, et al. Outcomes of stable HIV-positive patients down-referred from a doctor-managed antiretroviral therapy clinic to a nurse-managed primary health clinic for monitoring and treatment. AIDS. 2011;25:2027-2036.
13. Bekker L-G, Myer L, Orrell C, et al. Rapid scale-up of a communitybased HIV treatment service: programme performance over 3 consecutive years in Guguletu, South Africa. South Afr Med J. 2006;96:315-320.
14. Grimsrud A, Kaplan R, Bekker LG, et al. Outcomes of a nurse-managed service for stable HIV-positive patients in a large South African public sector antiretroviral therapy programme. Trop Med Int Health. 2014;19: 1029-1039.
15. Nglazi MD, Lawn SD, Kaplan R, et al. Changes in programmatic outcomes during 7 years of scale-up at a community-based antiretroviral treatment service in South Africa. J Acquir Immune Defic Syndr. 2011;56:e1-8.
16. Wilkinson LS. ART adherence clubs: a long-term retention strategy for clinically stable patients receiving antiretroviral therapy. S Afr J HIV Med. 2013;14:48-50.
17. Grimsrud A, Sharp J, Kalombo C, et al. Implementation of community-based adherence clubs for stable ART patients. J Int AIDS Soc. 2015;18:19984.
18. Grimsrud AT, Cornell M, Egger M, et al. Impact of definitions of loss to follow-up (LTFU) in antiretroviral therapy program evaluation: variation in the definition can have an appreciable impact on estimated proportions of LTFU. J Clin Epidemiol. 2013;66:1006-1013.
19. Cole SR, Hernan MA. Constructing inverse probability weights for marginal structural models. Am J Epidemiol. 2008;168:656-664.
20. Rosenbaum PR, Rubin DB. The central role of the propensity score in observational studies for causal effects. Biometrika. 1983;70:41-55.
21. Kredo T, Ford N, Adeniyi FB, et al. Decentralising HIV treatment in lower-And middle-income countries. Cochrane Database Syst Rev. 2013; 6:CD009987.
22. Shisana O, Rehle T, Simbayi L, et al. South African National HIV Prevalence, Incidence and Behaviour Survey, 2012. Cape Town, South Africa: HSRC Press; 2014.
23. Cornell M, Schomaker M, Garone DB, et al. Gender differences in survival among adult patients starting antiretroviral therapy in South Africa: a multicentre cohort study. PLoS Med. 2012;9:e1001304.
24. Cornell M, Grimsrud A, Fairall L, et al. Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007. AIDS. 2010;24:2263-2270.
25. Grimsrud A, Balkan S, Casas EC, et al. Outcomes of antiretroviral therapy over a 10-year period of expansion: a multicohort analysis of African and Asian HIV programs. J Acquir Immune Defic Syndr. 2014; 67:e55-e66.
26. Koole O, Tsui S, Wabwire-Mangen F, et al. Retention and risk factors for attrition among adults in antiretroviral treatment programmes in Tanzania, Uganda and Zambia. Trop Med Int Health. 2014;19:1397-1410.
27. Bekker LG, Slack C, Lee S, et al. Ethical issues in adolescent HIV research in resource-limited countries. J Acquir Immune Defic Syndr. 2014;65(suppl 1):S24-S28.
28. Katz IT, Dietrich J, Tshabalala G, et al. Understanding treatment refusal among adults presenting for HIV-testing in Soweto, South Africa: a qualitative study. AIDS Behav. 2014;19:704-714.
29. Geng EH, Nash D, Kambugu A, et al. Retention in care among HIVinfected patients in resource-limited settings: emerging insights and new directions. Curr HIV/AIDS Rep. 2010;7:234-244.
30. Johnson L, Estill J, Keiser O, et al. Do increasing rates of loss to followup in antiretroviral therapy programs imply deteriorating patient retention? Am J Epidemiol. 2014;180:1208-1212.
31. Grimsrud A, Patten G, Sharp J, et al. Extending dispensing intervals for stable patients on ART. J Acquir Immune Defic Syndr. 2014;66:e58-60.
32. Alamo ST, Colebunders R, Ouma J, et al. Return to normal life after AIDS as a reason for lost to follow-up in a community-based antiretroviral treatment program. J Acquir Immune Defic Syndr. 2012; 60:e36-e45.
33. Ford N, Mills EJ. Simplified ART delivery models are needed for the next phase of scale up. PLoS Med. 2011;8:e1001060.