Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agents

Journal of Ethnopharmacology

Volumn 178, Issue , 2016, Pages 222-228

  Costa, Gustavo ^a,b   Ferreira, João Pinto ^a,b   Vitorino, Carla ^a,b   Pina, Maria Eugénia ^c   Sousa, João José ^a,b   Figueiredo, Isabel Vitória ^a,d   Batista, Maria Teresa ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Anti inflammatoryin vivo studies; Cymbopogon citratus; Drug release; Lemongrass; Topicalapplication

Indexed keywords

ANTIINFLAMMATORY AGENT; CARLINOSIDE; CASSIAOCCIDENTALIN B; CYMBOPOGON CITRATUS EXTRACT; FLAVONOID; ISOORIENTIN; KURILESIN A; LUTEOLIN 7 GLUCOSIDE; LUTEOLIN 7 O NEOHESPERIDOSIDE; POLYPHENOL DERIVATIVE; TANNIN DERIVATIVE; TOPICAL AGENT; UNCLASSIFIED DRUG; WATER OIL CREAM; PLANT EXTRACT; POLYPHENOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARRAGEENAN-INDUCED PAW EDEMA; CONTROLLED STUDY; CYMBOPOGON CITRATUS; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; NONHUMAN; PH; PLANT LEAF; RAT; TOPICAL TREATMENT; TREATMENT OUTCOME; ANIMAL; CHEMISTRY; CYMBOPOGON; EDEMA; INFLAMMATION; MALE; MEDICINAL PLANT; PROCEDURES; TRADITIONAL MEDICINE; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CYMBOPOGON; EDEMA; FLAVONOIDS; INFLAMMATION; MALE; MEDICINE, TRADITIONAL; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; POLYPHENOLS; RATS; RATS, WISTAR; TANNINS;

EID: 84951202476     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.12.016     Document Type: Article

References (24)

1. A.A. Adeneye, and E.O. Agbaje Hypoglycemic and hypolipidemic effects of fresh leaf aqueous extract of Cymbopogon citratus Stapf. in rats J. Ethnopharmacol. 112 2007 440 444
2. J. Campos, G. Schmeda-Hirschmann, E. Leiva, L. Guzmán, R. Orrego, P. Fernández, M. González, C. Radojkovic, F. a Zuñiga, L. Lamperti, E. Pastene, and C. Aguayo Lemongrass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein Food Chem. 151 2014 175 181
3. E.-J. Chang, J.K. Kundu, L. Liu, J.-W. Shin, and Y.-J. Surh Ultraviolet B radiation activates NF-κB and induces iNOS expression in HR-1 hairless mouse skin: role of IκB kinase-β Mol. Carcinog. 50 2011 310 317
4. G. Costa, S. González-Manzano, A. González-Paramás, I.V. Figueiredo, C. Santos-Buelga, and M.T. Batista Flavan hetero-dimers in the Cymbopogon citratus infusion tannin fraction and their contribution to the antioxidant activity Food Funct. 6 2015 932 937
5. G. Costa, F. Nunes, C. Vitorino, M.T. Batista, and I. Vitória Validation of a RP-HPLC method for quantitation of phenolic compounds in three different extracts from Cymbopogon citratus Res. J. Med. Plant 9 2015 331 339
6. S. Das, H.-S. Lin, P.C. Ho, and K.-Y. Ng The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol Pharm. Res. 25 2008 2593 2600
7. FDA, 2013. Guidance for Industry Bioanalytical Method Validation.
8. A. Figueirinha, M.T. Cruz, V. Francisco, M.C. Lopes, and M.T. Batista Anti-inflammatory activity of Cymbopogon citratus leaf infusion in lipopolysaccharide-stimulated dendritic cells: contribution of the polyphenols J. Med. Food 13 2010 681 690
9. A. Figueirinha, A. Paranhos, J.J. Pérez-Alonso, C. Santos-Buelga, and M.T. Batista Cymbopogon citratus leaves: Characterization of flavonoids by HPLC-PDA-ESI/MS/MS and an approach to their potential as a source of bioactive polyphenols Food Chem. 110 2008 718 728
10. V. Francisco, G. Costa, A. Figueirinha, C. Marques, P. Pereira, B. Miguel Neves, M. Celeste Lopes, C. García-Rodríguez, M. Teresa Cruz, and M. Teresa Batista Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-κB pathway inhibition: contribution of chlorogenic acid J. Ethnopharmacol. 148 2013 126 134
11. V. Francisco, A. Figueirinha, G. Costa, J. Liberal, M.C. Lopes, C. García-Rodríguez, C.F.G.C. Geraldes, M.T. Cruz, and M.T. Batista Chemical characterization and anti-inflammatory activity of luteolin glycosides isolated from lemongrass J. Funct. Foods 10 2014 436 443
12. V. Francisco, A. Figueirinha, B.M. Neves, C. García-Rodríguez, M.C. Lopes, M.T. Cruz, and M.T. Batista Cymbopogon citratus as source of new and safe anti-inflammatory drugs: bio-guided assay using lipopolysaccharide-stimulated macrophages J. Ethnopharmacol. 133 2011 818 827
13. R. Garcia, J. Pinto Ferreira, G. Costa, T. Santos, F. Branco, M. Caramona, R. Carvalho, A. Dinis, M. Batista, M. Castel-Branco, and I. Figueiredo Evaluation of anti-inflammatory and analgesic activities of Cymbopogon citratus in vivo-polyphenols contribution Res. J. Med. Plant 9 2015 1 13
14. Y. Green, and D. Green Wy 23205, a new non-steroidal anti-inflammatory agent Br. J. Pharmacol. 1971 638 639
15. J.K. Kundu, E. Chang, H. Fujii, B. Sun, and Y. Surh Oligonol inhibits UVB-induced COX-2 expression in HR-1 hairless mouse skin - AP-1 and C/EBP as potential upstream targets Photochem. Photobiol. 84 2008 399 406
16. R. Orrego, E. Leiva, and J. Cheel Inhibitory effect of three C-glycosylflavonoids from Cymbopogon citratus (Lemongrass) on human low density lipoprotein oxidation Molecules 14 2009 3906 3913
17. PubChem BioAssay Database, 2015. PubChem BioAssay Database. Natl. Cent. Biotechnol. Inf. URL (https://pubchem.ncbi.nlm.nih.gov/) (accessed 01.04.15)
18. C.L. Roriz, L. Barros, A.M. Carvalho, C. Santos-Buelga, and I.C.F.R. Ferreira Pterospartum tridentatum, Gomphrena globosa and Cymbopogon citratus: a phytochemical study focused on antioxidant compounds Food Res. Int. 62 2014 684 693
19. T. Senyiʇit, I. Tekmen, U. Sönmez, P. Santi, and O. Ozer Deoxycholate hydrogels of betamethasone-17-valerate intended for topical use: In vitro and in vivo evaluation Int. J. Pharm. 403 2011 123 129
20. G. Shah, R. Shri, V. Panchal, N. Sharma, B. Singh, and a S. Mann Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemongrass) J. Adv. Pharm. Technol. Res. 2 2011 3 8
21. T. Singh, and S.K. Katiyar Green tea polyphenol, (-)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting β-catenin signaling Toxicol. Appl. Pharmacol. 273 2013 418 424
22. C. Vitorino, L. Alves, F.E. Antunes, J.J. Sousa, and A.A.C.C. Pais Design of a dual nanostructured lipid carrier formulation based on physicochemical, rheological, and mechanical properties J. Nanoparticle Res. 15 2013 1 14
23. C. Vitorino, J.J. Sousa, and A.A.C.C. Pais A rapid reversed-phase HPLC method for the simultaneous analysis of olanzapine and simvastatin in dual nanostructured lipid carriers Anal. Methods 5 2013 5058 5064
24. M. Yaar, and B.A. Gilchrest Photoageing: mechanism, prevention and therapy Br. J. Dermatol. 157 2007 874 887