Indomethacin preconditioning induces ischemic tolerance by modifying zinc availability in the brain

Neurobiology of Disease

Volumn 81, Issue , 2015, Pages 186-195

  Lee, Joo Yong ^a,b   Oh, Shin Bi ^a   Hwang, Jung Jin ^a   Suh, Nayoung ^a   Jo, Dong Gyu ^c   Kim, Jong S ^b   Koh, Jae Young ^b  

^a Asan Medical Center   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

Chemical preconditioning; Neuroprotection; Non steroidal anti inflammatory drug; Stroke; Zinc homeostasis; Zinc transporter

Indexed keywords

CHELATING AGENT; HEAT SHOCK PROTEIN 70; INDOMETACIN; METALLOTHIONEIN I; METALLOTHIONEIN II; N,N,N',N' TETRA(2 PICOLYL)ETHYLENEDIAMINE; PROTEIN MTF 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC; ZINC TRANSPORTER; ZINC TRANSPORTER 1; ZINC TRANSPORTER 3; ZINC TRANSPORTER 4; ZINC TRANSPORTER 5; ZINC TRANSPORTER 6; CARRIER PROTEIN; ETHYLENEDIAMINE DERIVATIVE; HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; METALLOTHIONEIN; N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE; NONSTEROID ANTIINFLAMMATORY AGENT; ZINC-BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL LEVEL; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; IN VIVO STUDY; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PHYSICAL TOLERANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ZINC CELL LEVEL; ZINC HOMEOSTASIS; ANIMAL; BRAIN; CELL DEATH; DISEASE MODEL; DRUG ADMINISTRATION; DRUG EFFECTS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT; TIME FACTOR;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRAIN; CARRIER PROTEINS; CELL DEATH; CHELATING AGENTS; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; ETHYLENEDIAMINES; HSP70 HEAT-SHOCK PROTEINS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INDOMETHACIN; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; METALLOTHIONEIN; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; ZINC;

EID: 84950325610     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.12.019     Document Type: Article

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