Ibudilast, a phosphodiesterase inhibitor with anti-inflammatory activity, protects against ischemic brain injury in rats

Brain Research

Volumn 1431, Issue , 2012, Pages 97-106

  Lee, Joo Yong ^a   Cho, Eunsil ^a   Ko, Young Eun ^a   Kim, Inki ^a   Lee, Kyung Jin ^a   Kwon, Sun U ^a   Kang, Dong Wha ^a   Kim, Jong S ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Anti inflammation; Infarction; Ischemic stroke; Neuroprotection; Phosphodiesterase inhibitor

Indexed keywords

IBUDILAST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BRAIN ATROPHY; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; ISCHEMIC BRAIN INJURY; MIDDLE CEREBRAL ARTERY OCCLUSION; MORTALITY; NERVE CELL NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REPERFUSION; TRANSIENT ISCHEMIC ATTACK; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BRAIN EDEMA; BRAIN INFARCTION; CELL DEATH; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION REGULATION; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NERVE TISSUE PROTEINS; NEUROLOGIC EXAMINATION; NEURONS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 84855700419     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.11.007     Document Type: Article

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