Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps

Chemistry and Biology

Volumn 22, Issue 12, 2015, Pages 1633-1642

  Huang, Sheng ^a   Elsayed, Somayah Sameer ^b   Lv, Meinan ^a   Tabudravu, Jioji ^b   Rateb, Mostafa E ^b,d   Gyampoh, Roland ^c   Kyeremeh, Kwaku ^c   Ebel, Rainer ^b   Jaspars, Marcel ^b   Deng, Zixin ^a   Yu, Yi ^a   Deng, Hai ^b  

^a WUHAN UNIVERSITY   (China)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c UNIVERSITY OF GHANA   (Ghana)

^d Beni Suef University   (Egypt)

Author keywords

biosynthesis; carbazole alkaloids; neocarazostatin A; P450 enzyme; prenyltransferase; reconstitution

Indexed keywords

ALKALOID DERIVATIVE; CARBAZOLE DERIVATIVE; CYTOCHROME P450; DIMETHYLALLYLTRANSFERASE; NEOCARAZOSTATIN A; OXYGENASE; PHYTOENE SYNTHASE; SCAVENGER; UNCLASSIFIED DRUG; CARBAZOLE;

ARTICLE; BIOSYNTHESIS; BIOTRANSFORMATION; CATALYSIS; ENZYME ASSAY; ENZYME MECHANISM; GENE CLUSTER; GENE INACTIVATION; HYDROXYLATION; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; TANDEM MASS SPECTROMETRY;

BIOSYNTHETIC PATHWAYS; CARBAZOLES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; ESCHERICHIA COLI; HYDROXYLATION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PRENYLATION; TANDEM MASS SPECTROMETRY;

EID: 84950301578     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2015.10.012     Document Type: Article

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