A Curcumin-loaded liquid crystal precursor mucoadhesive system for the treatment of vaginal candidiasis

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 4815-4824

  Salmazi, Rafael ^a   Calixto, Giovana ^a   Bernegossi, Jéssica ^a   Aparecido Dos, Matheus ^a   Ramos, Santos ^a   Bauab, Taís Maria ^a   Chorilli, Marlus ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Candida albicans; Liquid crystalline systems; Mucoadhesive polymers; Nanostructured drug delivery systems; Vaginal administration

Indexed keywords

ACETYL ALCOHOL; CHEMICAL COMPOUND; CHITOSAN; CURCUMIN; MACROGOL; OLEIC ACID; POLOXAMER; POLYOXPROPYLENE; UNCLASSIFIED DRUG; DRUG CARRIER;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SCREENING; DRUG STRUCTURE; FLOW KINETICS; IN VITRO STUDY; LIQUID CRYSTAL PRECURSOR MUCOADHESIVE SYSTEM; MICROSCOPY; MUCOADHESION; NONHUMAN; PIG; VAGINA CANDIDIASIS; BIOLOGICAL MODEL; CHEMISTRY; FEMALE; HUMAN; LIQUID CRYSTAL; METABOLISM; MUCUS;

CANDIDIASIS, VULVOVAGINAL; CURCUMIN; DRUG CARRIERS; FEMALE; HUMANS; LIQUID CRYSTALS; MODELS, BIOLOGICAL; MUCUS;

EID: 84950289094     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S82385     Document Type: Article

References (39)

1. da Silva PB, Ramos MA, Bonifácio BV, et al. Nanotechnological strategies for vaginal administration of drugs – a review. J Biomed Nanotechnol. 2014;10(9):2218–2243.
2. Dou N, Li W, Zhou E, Wang C, Xiao Z, Zhou H. Risk factors for candida infection of the genital tract in the tropics. Afr Health Sci. 2015; 14(4):835–839.
3. Tsai PW, Chen YT, Hsu PC, Lan CY. Study of Candida albicans and its interactions with the host: a mini review. Bio Medicine. 2013; 3(1):51–64.
4. Machado-de-Sena RM, Corrêa L, Kato IT, et al. Photodynamic therapy has antifungal effect and reduces inflammatory signals in Candida albicans-induced murine vaginitis. Photodiagn Photodyn Ther. 2014; 11(3):275–282.
5. Dovigo LN, Pavarina AC, Ribeiro AP, et al. Investigation of the photodynamic effects of curcumin against Candida albicans. Photochem Photobiol. 2011;87(4):895–903.
6. Anand P, Nair HB, Sung B, et al. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol. 2010;79(3):330–338.
7. Dovigo LN, Pavarina AC, Carmello JC, Machado AL, Brunetti IL, Bagnato VS. Susceptibility of clinical isolates of Candida to photodynamic effects of curcumin. Lasers Surg Med. 2011;43(9):927–934.
8. Martins CV, Da Silva DL, Neres AT, et al. Curcumin as a promising antifungal of clinical interest. J Antimicrob Chemother. 2009; 63(2):337–339.
9. Nguyen TNG, Tran PHL, Van Vo T, Van Tran T, Tran TTD. Dissolution enhancement of curcumin by solid dispersion with polyethylene glycol 6000 and hydroxypropyl methylcellulose. In: 5th International Conference on Biomedical Engineering in Vietnam. Cham, Switzerland: Springer International Publishing; 2015:298–301.
10. Gosenca M, Bešter-Rogač M, Gašperlin M. Lecithin based lamellar liquid crystals as a physiologically acceptable dermal delivery system for ascorbyl palmitate. Eur J Pharm Sci. 2013;50(1):114–122.
11. Calixto G, Bernegossi J, Fonseca-Santos B, Chorilli M. Nanotechnology-based drug delivery systems for treatment of oral cancer: a review. Int J Nanomedicine. 2014;9:3719.
12. Bonifácio BV, da Silva PB, dos Santos Ramos MA, Negri KM, Bauab TM, Chorilli M. Nanotechnology-based drug delivery systems and herbal medicines: a review. Int J Nanomedicine. 2014;9:1–15.
13. Oliveira MB, do Prado AH, Bernegossi J, et al. Topical application of retinyl palmitate-loaded nanotechnology-based drug delivery systems for the treatment of skin aging. Biomed Res Int. 2014; 2014:632570.
14. Bruschi ML, de Freitas O, Lara EH, Panzeri H, Gremião MP, Jones DS. Precursor system of liquid crystalline phase containing propolis microparticles for the treatment of periodontal disease: development and characterization. Drug Dev Ind Pharm. 2008;34(3):267–278.
15. Carvalho FC, Campos ML, Peccinini RG, Gremião MP. Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy. Eur J Pharm Biopharm. 2013;84(1):219–227.
16. Hyde ST. Identification of lyotropic liquid crystalline mesophases. In: Holmberg K, editor. Handbook of Applied Surface and Colloid Chemistry. West Sussex, England: Wiley; 2002:299–332.
17. Rossetti FC, Fantini MC, Carollo AR, Tedesco AC, Bentley MV. Analysis of liquid crystalline nanoparticles by small angle X-ray diffraction: evaluation of drug and pharmaceutical additives influence on the internal structure. J Pharm Sci. 2011;100(7):2849–2857.
18. Gonçalez ML, Corrêa MA, Chorilli M. Skin delivery of kojic acid-loaded nanotechnology-based drug delivery systems for the treatment of skin aging. Biomed Res Int. 2013;2013:271276.
19. Carvalho FC, Sarmento VH, Chiavacci LA, Barbi MS, Gremião MP. Development and in vitro evaluation of surfactant systems for controlled release of zidovudine. J Pharm Sci. 2010;99(5):2367–2374.
20. Smart JD, Riley RG, Tsibouklis J, et al. The retention of 14 C-labelled poly (acrylic acids) on gastric and oesophageal mucosa: an in vitro study. Eur J Pharm Sci. 2003;20(1):83–90.
21. Carvalho FC, Calixto G, Hatakeyama IN, Luz GM, Gremião MP, Chorilli M. Rheological, mechanical, and bioadhesive behavior of hydrogels to optimize skin delivery systems. Drug Dev Ind Pharm. 2013;39(11):1750–1757.
22. Johal HS, Garg T, Rath G, Goyal AK. Advanced topical drug delivery system for the management of vaginal candidiasis. Drug Deliv. 2014:1–14.
23. Dumortier G, Grossiord JL, Agnely F, Chaumeil JC. A Review of poloxamer 407 pharmaceutical and pharmacological characteristics. Pharm Res. 2006;23(12):2709–2728.
24. Carvalho FC, Bruschi ML, Evangelista RC, Gremião MP. Mucoadhesive drug delivery systems. Brazilian J Pharm Sci. 2010;46(1):1–17.
25. Canella KMNC, Garcia RB. Characterization of chitosn by gel permeation chromatography – influence of preparation method and solvent [Caracterização de quitosana por cromatografia de permeação em gel – influência do método de preparação e do solvent]. Quim Nova. 2001;24(1):13–17. Portugese.
26. Owen DH, Katz DF. A vaginal fluid simulant. Contraception. 1999;59(2):91–95.
27. Vermani K, Garg S, Zaneveld LJ. Assemblies for in vitro measurement of bioadhesive strength and retention characteristics in simulated vaginal environment. Drug Dev Ind Pharm. 2002;28(9):1133–1146.
28. Cevher E, Şensoy D, Zloh M, Mülazımoğlu L. Preparation and characterisation of natamycin: γ-cyclodextrin inclusion complex and its evaluation in vaginal mucoadhesive formulations. J Pharm Sci. 2008; 97(10):4319–4335.
29. Calixto G, Yoshii AC, Rocha e Silva H, Stringhetti Ferreira Cury B, Chorilli M. Polyacrylic acid polymers hydrogels intended to topical drug delivery: preparation and characterization. Pharm Dev Technol. 2015;20(4):490–496.
30. de Freitas Araújo MG, Pacífico M, Vilegas W, et al. Evaluation of Syngonanthus nitens (Bong.) Ruhl. extract as antifungal and in treatment of vulvovaginal candidiasis. Med Mycol. 2013;51(7):673–682.
31. Duarte MC, Figueira GM, Sartoratto A, Rehder VL, Delarmelina C. Anti-Candida activity of Brazilian medicinal plants. J Ethnopharmacol. 2005;97(2):305–311.
32. Oliveira MB, Calixto G, Graminha M, Cerecetto H, González M, Chorilli M. Development, characterization, and in vitro biological performance of fluconazole-loaded microemulsions for the topical treatment of cutaneous leishmaniasis. Biomed Res Int. 2015;2015:396894.
33. Prestes PS, Chorilli M, Chiavacci LA, Scarpa MV, Leonardi GR. Physicochemical characterization and rheological behavior evaluation of the liquid crystalline mesophases developed with different silicones. J Dispers Sci Technol. 2009;31(1):117–123.
34. Carvalho FC, Barbi MS, Sarmento VH, Chiavacci LA, Netto FM, Gremião MP. Surfactant systems for nasal zidovudine delivery: structural, rheological and mucoadhesive properties. J Pharm Pharmacol. 2010;62(4):430–439.
35. Takeuchi H, Thongborisute J, Matsui Y, Sugihara H, Yamamoto H, Kawashima Y. Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems. Adv Drug Deliv Rev. 2005;57(11):1583–1594.
36. Chang JY, Oh YK, Choi HG, Kim YB, Kim CK. Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions. Int J Pharm. 2002;241(1):155–163.
37. Niazy EM. Influence of oleic acid and other permeation promoters on transdermal delivery of dihydroergotamine through rabbit skin. Int J Pharm. 1991;67(1):97–100.
38. Martindale RG, Shikora SA, Nishikawa R, Siepler JK. The metabolic response to stress and alterations in nutrient metabolism. In: ShikoraSA, Martindale RG, Steven D, editors. Nutritional Considerations in the Intensive Care Unit – Science, Rationale and Practice. Dubuque, IA: Kendall/Hunt; 2002:11–20.
39. Souza C, Watanabe E, Borgheti-Cardoso LN, Fantini MC, Lara MG. Mucoadhesive system formed by liquid crystals for buccal administration of poly(hexamethylene biguanide) hydrochloride. J Pharm Sci. 2014:1–10.