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Volumn 28, Issue 5, 2016, Pages 317-326

PIK3CA Mutation, Aspirin Use after Diagnosis and Survival of Colorectal Cancer. A Systematic Review and Meta-analysis of Epidemiological Studies

Author keywords

Adjuvant trials; Aspirin; Colorectal cancer; Overall survival; PIK3CA; Post diagnosis use

Indexed keywords

ACETYLSALICYLIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN, HUMAN;

EID: 84950112625     PISSN: 09366555     EISSN: 14332981     Source Type: Journal    
DOI: 10.1016/j.clon.2015.11.008     Document Type: Article
Times cited : (53)

References (53)
  • 1
    • 78650215449 scopus 로고    scopus 로고
    • Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomized trials
    • Rothwell P.M., Wilson M., Elvin C.E., et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomized trials. Lancet 2010, 376(9754):1741-1750.
    • (2010) Lancet , vol.376 , Issue.9754 , pp. 1741-1750
    • Rothwell, P.M.1    Wilson, M.2    Elvin, C.E.3
  • 2
    • 84863399038 scopus 로고    scopus 로고
    • Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
    • Rothwell P.M., Wilson M., Price J.F., et al. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet 2012, 379:1591-1601.
    • (2012) Lancet , vol.379 , pp. 1591-1601
    • Rothwell, P.M.1    Wilson, M.2    Price, J.F.3
  • 3
    • 78650825618 scopus 로고    scopus 로고
    • Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
    • Rothwell P.M., Fowkes F.G., Belch J.F., et al. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 2011, 377(9759):31-41.
    • (2011) Lancet , vol.377 , Issue.9759 , pp. 31-41
    • Rothwell, P.M.1    Fowkes, F.G.2    Belch, J.F.3
  • 4
    • 84867817838 scopus 로고    scopus 로고
    • Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival
    • Liao X., Lochhead P., Nishihara R., et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 2012, 25(367):1596-1606.
    • (2012) N Engl J Med , vol.25 , Issue.367 , pp. 1596-1606
    • Liao, X.1    Lochhead, P.2    Nishihara, R.3
  • 5
    • 84991268841 scopus 로고    scopus 로고
    • PIK3CA mutation, aspirin use and mortality in patients with metastatic colorectal cancer participating in early-phase clinical trials
    • Chae Y.K., Kunwha K., David S.H., et al. PIK3CA mutation, aspirin use and mortality in patients with metastatic colorectal cancer participating in early-phase clinical trials. Cancer Res 2013, 73(Suppl. 1, abstract 164).
    • (2013) Cancer Res , vol.73
    • Chae, Y.K.1    Kunwha, K.2    David, S.H.3
  • 6
    • 84892843686 scopus 로고    scopus 로고
    • Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer
    • Domingo E., Church D.N., Sieber O., et al. Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer. J Clin Oncol 2013, 31:4297-4305.
    • (2013) J Clin Oncol , vol.31 , pp. 4297-4305
    • Domingo, E.1    Church, D.N.2    Sieber, O.3
  • 7
    • 84925446564 scopus 로고    scopus 로고
    • Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation
    • Kothari N., Kim R., Jorissen R.N., et al. Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation. Acta Oncol 2015, 54(4):487-492.
    • (2015) Acta Oncol , vol.54 , Issue.4 , pp. 487-492
    • Kothari, N.1    Kim, R.2    Jorissen, R.N.3
  • 8
    • 84897978063 scopus 로고    scopus 로고
    • Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer
    • Reimers M.S., Bastiaannet E., Langley R.E., et al. Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer. JAMA Intern Med 2014, 174(5):732-739.
    • (2014) JAMA Intern Med , vol.174 , Issue.5 , pp. 732-739
    • Reimers, M.S.1    Bastiaannet, E.2    Langley, R.E.3
  • 9
    • 84871485133 scopus 로고    scopus 로고
    • The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination
    • Labelle M., Hynes R.O. The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov 2012, 2:1091-1099.
    • (2012) Cancer Discov , vol.2 , pp. 1091-1099
    • Labelle, M.1    Hynes, R.O.2
  • 10
    • 11144230059 scopus 로고    scopus 로고
    • Platelets and fibrin(ogen) increase metastatic potential by implementing natural killer cell-mediated elimination of tumor cells
    • Palumbo J.S., Talmage K.E., Massari J.V., et al. Platelets and fibrin(ogen) increase metastatic potential by implementing natural killer cell-mediated elimination of tumor cells. Blood 2005, 105:178-185.
    • (2005) Blood , vol.105 , pp. 178-185
    • Palumbo, J.S.1    Talmage, K.E.2    Massari, J.V.3
  • 11
    • 77951708287 scopus 로고    scopus 로고
    • Deadly allies: the fatal interplay between platelets and metastasizing cancer cells
    • Erpenbeck L., Schon M.P. Deadly allies: the fatal interplay between platelets and metastasizing cancer cells. Blood 2010, 115:3227-3236.
    • (2010) Blood , vol.115 , pp. 3227-3236
    • Erpenbeck, L.1    Schon, M.P.2
  • 12
    • 79251478398 scopus 로고    scopus 로고
    • Contribution of platelets to tumor metastasis
    • Gay L.J., Felding-Habermann B. Contribution of platelets to tumor metastasis. Nat Rev Cancer 2011, 11:123-134.
    • (2011) Nat Rev Cancer , vol.11 , pp. 123-134
    • Gay, L.J.1    Felding-Habermann, B.2
  • 13
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144(5):646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 14
    • 84903769474 scopus 로고    scopus 로고
    • Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)
    • Aleksandrova K., Jenab M., Bueno-de-Mesquita H.B., et al. Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). Eur J Epidemiol 2014, 29:261-275.
    • (2014) Eur J Epidemiol , vol.29 , pp. 261-275
    • Aleksandrova, K.1    Jenab, M.2    Bueno-de-Mesquita, H.B.3
  • 15
    • 47249136072 scopus 로고    scopus 로고
    • C-reactive protein and colorectal cancer risk: a systematic review of prospective studies
    • Tsilidis K.K., Branchini C., Guallar E., et al. C-reactive protein and colorectal cancer risk: a systematic review of prospective studies. Int J cancer 2008, 123(5):1133-1140.
    • (2008) Int J cancer , vol.123 , Issue.5 , pp. 1133-1140
    • Tsilidis, K.K.1    Branchini, C.2    Guallar, E.3
  • 16
    • 76849095665 scopus 로고    scopus 로고
    • The role of COX-2 in intestinal inflammation and colorectal cancer
    • Wang D., Dubois R.N. The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene 2010, 29(6):781-788.
    • (2010) Oncogene , vol.29 , Issue.6 , pp. 781-788
    • Wang, D.1    Dubois, R.N.2
  • 17
    • 0027993458 scopus 로고
    • Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
    • Eberhart C.E., Coffey R.J., Radhika A., et al. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1994, 107(4):1183-1188.
    • (1994) Gastroenterology , vol.107 , Issue.4 , pp. 1183-1188
    • Eberhart, C.E.1    Coffey, R.J.2    Radhika, A.3
  • 18
    • 58149340659 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer
    • Ogino S., Kirkner G.J., Nosho K., et al. Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. Clin Cancer Res 2008, 14(24):8221-8227.
    • (2008) Clin Cancer Res , vol.14 , Issue.24 , pp. 8221-8227
    • Ogino, S.1    Kirkner, G.J.2    Nosho, K.3
  • 19
    • 84919888555 scopus 로고    scopus 로고
    • Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis
    • Vogel L.K., Saebo M., Hoyer H., et al. Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis. Plos One 2014, 9(8):1-8.
    • (2014) Plos One , vol.9 , Issue.8 , pp. 1-8
    • Vogel, L.K.1    Saebo, M.2    Hoyer, H.3
  • 20
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y., Wang Z., Bardelli A., et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004, 304(5670):554.
    • (2004) Science , vol.304 , Issue.5670 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3
  • 21
    • 78449241791 scopus 로고    scopus 로고
    • PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac
    • Kaur J., Sanyal S.N. PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac. Tumour Biol 2010, 31(6):623-631.
    • (2010) Tumour Biol , vol.31 , Issue.6 , pp. 623-631
    • Kaur, J.1    Sanyal, S.N.2
  • 22
    • 73549085622 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer
    • Uddin S., Ahmed M., Hussain A., et al. Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer. Int J Cancer 2010, 126(2):382-394.
    • (2010) Int J Cancer , vol.126 , Issue.2 , pp. 382-394
    • Uddin, S.1    Ahmed, M.2    Hussain, A.3
  • 23
    • 0034676333 scopus 로고    scopus 로고
    • IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells
    • Di Popolo A., Memoli A., Apicella A., et al. IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells. Oncogene 2000, 19(48):5517-5524.
    • (2000) Oncogene , vol.19 , Issue.48 , pp. 5517-5524
    • Di Popolo, A.1    Memoli, A.2    Apicella, A.3
  • 24
    • 0034685429 scopus 로고    scopus 로고
    • Meta-analysis of observational studies in epidemiology. A proposal for reporting
    • Stroup D.F., Berlin J.A., Morton S.C. Meta-analysis of observational studies in epidemiology. A proposal for reporting. JAMA 2000, 283:2008-2012.
    • (2000) JAMA , vol.283 , pp. 2008-2012
    • Stroup, D.F.1    Berlin, J.A.2    Morton, S.C.3
  • 25
    • 84925548115 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement
    • Moher D., Liberati A., Tetzlaff J., et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement. J Clin Epidemiol 2009, 62:1006-1012.
    • (2009) J Clin Epidemiol , vol.62 , pp. 1006-1012
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3
  • 26
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • DerSimonian R., Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986, 7(3):177-188.
    • (1986) Control Clin Trials , vol.7 , Issue.3 , pp. 177-188
    • DerSimonian, R.1    Laird, N.2
  • 27
    • 79961238388 scopus 로고    scopus 로고
    • Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials
    • 22 Jul
    • Sterne J.A., Sutton A.J., Ioannidis J.P., et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. Br Med J 22 Jul, 2011, 343:d4002.
    • (2011) Br Med J , vol.343 , pp. d4002
    • Sterne, J.A.1    Sutton, A.J.2    Ioannidis, J.P.3
  • 28
    • 84922532328 scopus 로고    scopus 로고
    • Estimates of benefits and harms of prophylactic use of aspirin in the general population
    • Cuzick J., Thorat M.A., Bosetti C., et al. Estimates of benefits and harms of prophylactic use of aspirin in the general population. Ann Oncol 2015, 26(1):47-57.
    • (2015) Ann Oncol , vol.26 , Issue.1 , pp. 47-57
    • Cuzick, J.1    Thorat, M.A.2    Bosetti, C.3
  • 29
    • 33947545402 scopus 로고    scopus 로고
    • The use of aspirin for primary prevention of colorectal cancer. A systematic review prepared for the US Preventive Services Task Force
    • Dubè C., Rostom A., Lewin G., US Preventive Services Task Force, et al. The use of aspirin for primary prevention of colorectal cancer. A systematic review prepared for the US Preventive Services Task Force. Ann Intern Med 2007, 146(5):365-375.
    • (2007) Ann Intern Med , vol.146 , Issue.5 , pp. 365-375
    • Dubè, C.1    Rostom, A.2    Lewin, G.3    US Preventive Services Task, Force4
  • 30
    • 84860467522 scopus 로고    scopus 로고
    • Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomized trials
    • Algra A.M., Rothwell P.M. Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomized trials. Lancet Oncol 2012, 13:518-527.
    • (2012) Lancet Oncol , vol.13 , pp. 518-527
    • Algra, A.M.1    Rothwell, P.M.2
  • 31
    • 84861722871 scopus 로고    scopus 로고
    • Aspirin and cancer risk: a quantitative review to 2011
    • Bosetti C., Rosato V., Gallus S., Cuzick J., La Vecchia C. Aspirin and cancer risk: a quantitative review to 2011. Ann Oncol 2012, 23(6):1403-1415.
    • (2012) Ann Oncol , vol.23 , Issue.6 , pp. 1403-1415
    • Bosetti, C.1    Rosato, V.2    Gallus, S.3    Cuzick, J.4    La Vecchia, C.5
  • 33
    • 80053994835 scopus 로고    scopus 로고
    • Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?
    • Langley R.E., Burdett S., Tierney J.F., et al. Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy?. Br J Cancer 2011, 105(8):1107-1113.
    • (2011) Br J Cancer , vol.105 , Issue.8 , pp. 1107-1113
    • Langley, R.E.1    Burdett, S.2    Tierney, J.F.3
  • 34
    • 84871623952 scopus 로고    scopus 로고
    • Potential biomarker for aspirin use in colorectal cancer therapy
    • Langley R.E., Rothwell P.M. Potential biomarker for aspirin use in colorectal cancer therapy. Nat Rev Clin Oncol 2013, 10(1):8-10.
    • (2013) Nat Rev Clin Oncol , vol.10 , Issue.1 , pp. 8-10
    • Langley, R.E.1    Rothwell, P.M.2
  • 35
    • 84894598403 scopus 로고    scopus 로고
    • The Aspirin Foundation Scientific Conference: the history, the present state and the future of aspirin prophylaxis
    • Smith T., Elwood P., Keating C., et al. The Aspirin Foundation Scientific Conference: the history, the present state and the future of aspirin prophylaxis. Ecancermedicalscience 2014, 8:388.
    • (2014) Ecancermedicalscience , vol.8 , pp. 388
    • Smith, T.1    Elwood, P.2    Keating, C.3
  • 36
    • 0030851487 scopus 로고    scopus 로고
    • Suppression of human colorectal mucosal prostaglandins: determining the lowest effective aspirin dose
    • Ruffin M.T.I.V., Krishnan K., Rock C.L., et al. Suppression of human colorectal mucosal prostaglandins: determining the lowest effective aspirin dose. J Natl Cancer Inst 1997, 89:1152-1160.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1152-1160
    • Ruffin, M.T.I.V.1    Krishnan, K.2    Rock, C.L.3
  • 37
    • 0036227319 scopus 로고    scopus 로고
    • A dose-finding study of aspirin for chemoprevention utilizing rectal mucosal prostaglandin E(2) levels as a biomarker
    • Sample D., Wargovich M., Fisher S.M., et al. A dose-finding study of aspirin for chemoprevention utilizing rectal mucosal prostaglandin E(2) levels as a biomarker. Cancer Epidemiol Biomarkers Prev 2002, 11:275-279.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 275-279
    • Sample, D.1    Wargovich, M.2    Fisher, S.M.3
  • 39
    • 84873704094 scopus 로고    scopus 로고
    • Colon cancer molecular subtypes identified by expression profiling and associated to stroma, mucinous type and different clinical behavior
    • Perez V.B., Romera L.A., Hernandez P.S., et al. Colon cancer molecular subtypes identified by expression profiling and associated to stroma, mucinous type and different clinical behavior. BMC Cancer 2012, 12:260.
    • (2012) BMC Cancer , vol.12 , pp. 260
    • Perez, V.B.1    Romera, L.A.2    Hernandez, P.S.3
  • 40
    • 84859865072 scopus 로고    scopus 로고
    • Prognostic role of PIK3CA mutation in colorectal cancer: cohort study and literature review
    • Lia X., Morikawa T., Lochhead P., et al. Prognostic role of PIK3CA mutation in colorectal cancer: cohort study and literature review. Clin Cancer Res 2012, 18(8):2257-2268.
    • (2012) Clin Cancer Res , vol.18 , Issue.8 , pp. 2257-2268
    • Lia, X.1    Morikawa, T.2    Lochhead, P.3
  • 41
    • 84860589077 scopus 로고    scopus 로고
    • Assessment of colorectal cancer molecularfeatures along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
    • Yamauchi M., Morikawa T., Kuchiba A., et al. Assessment of colorectal cancer molecularfeatures along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 2012, 61:847-854.
    • (2012) Gut , vol.61 , pp. 847-854
    • Yamauchi, M.1    Morikawa, T.2    Kuchiba, A.3
  • 42
    • 84879001702 scopus 로고    scopus 로고
    • PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival
    • Rosty C., Young J.P., Walsh M.D., et al. PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival. Plos One 2013, 8(6):1-9.
    • (2013) Plos One , vol.8 , Issue.6 , pp. 1-9
    • Rosty, C.1    Young, J.P.2    Walsh, M.D.3
  • 43
    • 84875804295 scopus 로고    scopus 로고
    • Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012
    • Ferlay J., Steliarova-Foucher E., Lortet-Tieulent J., et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 2013, 49(6):1374-1403.
    • (2013) Eur J Cancer , vol.49 , Issue.6 , pp. 1374-1403
    • Ferlay, J.1    Steliarova-Foucher, E.2    Lortet-Tieulent, J.3
  • 44
    • 84906228912 scopus 로고    scopus 로고
    • Refining the chemotherapy approach for older patients with colon cancer
    • McCleary N.J., Dotan E., Browner I. Refining the chemotherapy approach for older patients with colon cancer. J Clin Oncol 2014, 32(24):2570-2580.
    • (2014) J Clin Oncol , vol.32 , Issue.24 , pp. 2570-2580
    • McCleary, N.J.1    Dotan, E.2    Browner, I.3
  • 45
    • 84860250352 scopus 로고    scopus 로고
    • Use of aspirin postdiagnosis improves survival for colon cancer patients
    • Bastiaannet E., Sampieri K., Dekkers O.M., et al. Use of aspirin postdiagnosis improves survival for colon cancer patients. Br J Cancer 2012, 106:1564-1570.
    • (2012) Br J Cancer , vol.106 , pp. 1564-1570
    • Bastiaannet, E.1    Sampieri, K.2    Dekkers, O.M.3
  • 46
    • 2542615200 scopus 로고    scopus 로고
    • Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    • Andre T., Boni C., Mounedji-Boudiaf L., et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004, 350:2343-2351.
    • (2004) N Engl J Med , vol.350 , pp. 2343-2351
    • Andre, T.1    Boni, C.2    Mounedji-Boudiaf, L.3
  • 47
    • 28844482345 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age, and differentiation
    • Jessup J.M., Stewart A., Greene F.L., et al. Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age, and differentiation. JAMA 2005, 294:2703-2711.
    • (2005) JAMA , vol.294 , pp. 2703-2711
    • Jessup, J.M.1    Stewart, A.2    Greene, F.L.3
  • 48
    • 0035846320 scopus 로고    scopus 로고
    • A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients
    • Sargent D.J., Goldberg R.M., Jacobson S.D., et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 2001, 345:1091-1097.
    • (2001) N Engl J Med , vol.345 , pp. 1091-1097
    • Sargent, D.J.1    Goldberg, R.M.2    Jacobson, S.D.3
  • 49
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
    • de Roock W., Claes B., Bernasconi D., et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010, 11(8):753-762.
    • (2010) Lancet Oncol , vol.11 , Issue.8 , pp. 753-762
    • de Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 50
    • 84881543270 scopus 로고    scopus 로고
    • Promising biomarkers for predicting the outcomes of patients with KRAS wild-type metastatic colorectal cancer treated with anti-epidermal growth factor receptor monoclonal antibodies: a systematic review with meta-analysis
    • Yang Z.-Y., Wu X.-Y., Huang Y.-F., et al. Promising biomarkers for predicting the outcomes of patients with KRAS wild-type metastatic colorectal cancer treated with anti-epidermal growth factor receptor monoclonal antibodies: a systematic review with meta-analysis. Int J Cancer 2013, 133(8):1914-1925.
    • (2013) Int J Cancer , vol.133 , Issue.8 , pp. 1914-1925
    • Yang, Z.-Y.1    Wu, X.-Y.2    Huang, Y.-F.3
  • 51
    • 83355163988 scopus 로고    scopus 로고
    • ASCOLT Trial Investigators. The utility of aspirin in Dukes C and high risk Dukes B colorectal cancer - the ASCOLT study: study protocol for a randomized controlled trial
    • Ali R., Toh H.C., Chia W.K. ASCOLT Trial Investigators. The utility of aspirin in Dukes C and high risk Dukes B colorectal cancer - the ASCOLT study: study protocol for a randomized controlled trial. Trials 2011, 12:261.
    • (2011) Trials , vol.12 , pp. 261
    • Ali, R.1    Toh, H.C.2    Chia, W.K.3
  • 52
    • 84961906769 scopus 로고    scopus 로고
    • http://www.addaspirintrial.org/.
  • 53
    • 84877143409 scopus 로고    scopus 로고
    • Aspirin as a treatment for cancer
    • Phillips I., Langley R., Gilbert D., et al. Aspirin as a treatment for cancer. Clin Oncol 2013, 25(6):333-335.
    • (2013) Clin Oncol , vol.25 , Issue.6 , pp. 333-335
    • Phillips, I.1    Langley, R.2    Gilbert, D.3


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