Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression

Biomaterials

Volumn 78, Issue , 2016, Pages 50-61

  Estrada, Marta F ^a,b   Rebelo, Sofia P ^a,b   Davies, Emma J ^c,d   Pinto, Marta T ^e   Pereira, Hugo ^a,f   Santo, Vítor E ^a,b   Smalley, Matthew J ^c   Barry, Simon T ^d   Gualda, Emilio J ^f   Alves, Paula M ^a,b   Anderson, Elizabeth ^g   Brito, Catarina ^a,b  

^a INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d ASTRAZENECA   (United Kingdom)

^e UNIVERSITY OF PORTO   (Portugal)

^f INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^g BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

Author keywords

3D; Alginate microencapsulation; Co culture; Stirred tank bioreactors; Tumour microenvironment; Tumour progression

Indexed keywords

AGGREGATES; ALGINATE; CELL CULTURE; CELLS; CYTOLOGY; DISEASES; DRUG THERAPY; FIBROBLASTS; MICROENCAPSULATION; SCAFFOLDS (BIOLOGY);

CO-CULTURES; COLLECTIVE CELL MIGRATIONS; LONG TERM MONITORING; MCF-7 BREAST CANCER CELLS; MICROENVIRONMENTS; PRO-INFLAMMATORY CYTOKINES; STIRRED TANK BIOREACTORS; TUMOUR PROGRESSION;

TUMORS;

COCULTURE; DISEASE COURSE; DRUG RESISTANCE; HUMAN; MCF-7 CELL LINE; TUMOR MICROENVIRONMENT;

COCULTURE TECHNIQUES; DISEASE PROGRESSION; DRUG RESISTANCE, NEOPLASM; HUMANS; MCF-7 CELLS; TUMOR MICROENVIRONMENT;

EID: 84949946054     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.11.030     Document Type: Article

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