메뉴 건너뛰기




Volumn 31, Issue 1, 2016, Pages 34-50

Pulsatility of hypothalamo-pituitary hormones: A challenge in quantification

Author keywords

[No Author keywords available]

Indexed keywords

HYPOPHYSIS HORMONE;

EID: 84949939577     PISSN: 15489213     EISSN: 15489221     Source Type: Journal    
DOI: 10.1152/physiol.00027.2015     Document Type: Review
Times cited : (32)

References (74)
  • 1
    • 0034058843 scopus 로고    scopus 로고
    • A mathematical modelquantifying GnRH-induced LH secretion from gonadotropes
    • Blum JJ, Reed MC, Janovick JA, Conn PM. A mathematical model quantifying GnRH-induced LH secretion from gonadotropes. Am J Physiol Endocrinol Metab 278: E263-E272, 2000
    • (2000) Am Jphysiol Endocrinol Metab , vol.278 , pp. E263-E272
    • Blum, J.J.1    Reed, M.C.2    Janovick, J.A.3    Conn, P.M.4
  • 3
    • 84860839843 scopus 로고    scopus 로고
    • Pathophysiology of hypercortisolism in depression:Pituitary and adrenal responses to low glucocorticoidfeedback
    • Carroll BJ, Iranmanesh A, Keenan DM, Cassidy F, Wilson WH, Veldhuis JD. Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback. Acta Psychiatr Scand 125: 478-491, 2012
    • (2012) Acta Psychiatr Scand , vol.125 , pp. 478-491
    • Carroll, B.J.1    Iranmanesh, A.2    Keenan, D.M.3    Cassidy, F.4    Wilson, W.H.5    Veldhuis, J.D.6
  • 4
    • 55449095322 scopus 로고    scopus 로고
    • Probabilistic recoveryof pulsatile structure: Detecting brain signaling by itsdownstream effects
    • Chattopadhyay S, Keenan DM, Veldhuis JD. Probabilistic recovery of pulsatile structure: detecting brain signaling by its downstream effects. Quart Appl Math 66: 401-421, 2008
    • (2008) Quart Appl Math , vol.66 , pp. 401-421
    • Chattopadhyay, S.1    Keenan, D.M.2    Veldhuis, J.D.3
  • 5
    • 0020727948 scopus 로고
    • Cycle detection: A technique forestimating the frequency and amplitude of episodic fluctuationsin blood hormone and substrate concentrations
    • Clifton DK, Steiner RA. Cycle detection: a technique for estimating the frequency and amplitude of episodic fluctuations in blood hormone and substrate concentrations. Endocrinology 112: 1057-1064, 1983
    • (1983) Endocrinology , vol.112 , pp. 1057-1064
    • Clifton, D.K.1    Steiner, R.A.2
  • 8
    • 0032239547 scopus 로고    scopus 로고
    • Pathophysiology of the neuroregulationof growth hormone secretion in experimental animalsand the human
    • Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 19: 717-797, 1998
    • (1998) Endocr Rev , vol.19 , pp. 717-797
    • Giustina, A.1    Veldhuis, J.D.2
  • 9
    • 77956889087 scopus 로고
    • Reversible jump Markov chain Monte Carlo computationand Bayesian model determination
    • Green PJ. Reversible jump Markov chain Monte Carlo computation and Bayesian model determination. Biometrika 82: 711-732, 1995
    • (1995) Biometrika , vol.82 , pp. 711-732
    • Green, P.J.1
  • 13
    • 1542427875 scopus 로고    scopus 로고
    • A signal extraction approach tomodeling hormone time series with pulses and a changingbaseline
    • Guo W, Wang Y, Brown MB. A signal extraction approach to modeling hormone time series with pulses and a changing baseline. J Am Stat Assn 94: 746-756, 1999
    • (1999) J am Stat Assn , vol.94 , pp. 746-756
    • Guo, W.1    Wang, Y.2    Brown, M.B.3
  • 14
    • 84864003110 scopus 로고    scopus 로고
    • Model choice using reversible jumpMarkov chain Monte Carlo
    • Hastie D, Green PJ. Model choice using reversible jump Markov chain Monte Carlo. Statistica Neerlandica 66: 309-338, 2011
    • (2011) Statistica Neerlandica , vol.66 , pp. 309-338
    • Hastie, D.1    Green, P.J.2
  • 15
    • 0016609358 scopus 로고
    • Partial pharmacodynamicmodel for the circadian-episodic secretion of cortisolin man
    • Jusko WJ, Slaunwhite WR Jr., Aceto T Jr. Partial pharmacodynamic model for the circadian-episodic secretion of cortisol in man. J Clin Endocrinol Metab 40: 278-289, 1975
    • (1975) J Clin Endocrinol Metab , vol.40 , pp. 278-289
    • Jusko, W.J.1    Slaunwhite, W.R.2    Aceto, T.3
  • 17
    • 63849183968 scopus 로고    scopus 로고
    • Quantifyingnonlinear interactions within the hypothalamo-pituitary-adrenalaxis in the conscious horse
    • Keenan DM, Alexander S, Irvine C, Veldhuis JD. Quantifying nonlinear interactions within the hypothalamo-pituitary-adrenal axis in the conscious horse. Endocrinology 150: 1941-1951, 2009
    • (2009) Endocrinology , vol.150 , pp. 1941-1951
    • Keenan, D.M.1    Alexander, S.2    Irvine, C.3    Veldhuis, J.D.4
  • 18
    • 84864504467 scopus 로고    scopus 로고
    • Logistic model of glucose-regulated C-peptide secretion:Hysteresis-pathway disruption in impaired fasting glycemia
    • Keenan DM, Basu R, Liu Y, Basu A, Bock G, Veldhuis JD. Logistic model of glucose-regulated C-peptide secretion: hysteresis-pathway disruption in impaired fasting glycemia. Am J Physiol Endocrinol Metab 303: E397-E409, 2012
    • (2012) Am J Physiol Endocrinol Metab , vol.303 , pp. E397-E409
    • Keenan, D.M.1    Basu, R.2    Liu, Y.3    Basu, A.4    Bock, G.5    Veldhuis, J.D.6
  • 19
    • 82355165077 scopus 로고    scopus 로고
    • Noninvasive analyticalestimation of endogenous gonadotropin-releasing hormone(GnRH) drive: Analysis using graded competitive GnRH-receptorantagonism and a calibrating pulse of exogenousGnRH
    • Keenan DM, Clarke IJ, Veldhuis JD. Noninvasive analytical estimation of endogenous gonadotropin-releasing hormone (GnRH) drive: analysis using graded competitive GnRH-receptor antagonism and a calibrating pulse of exogenous GnRH. Endocrinology 152: 4882-4893, 2011
    • (2011) Endocrinology , vol.152 , pp. 4882-4893
    • Keenan, D.M.1    Clarke, I.J.2    Veldhuis, J.D.3
  • 20
    • 0142084685 scopus 로고    scopus 로고
    • Control of LH secretoryburstfrequency and interpulse-interval regularity in women
    • Keenan DM, Evans WS, Veldhuis JD. Control of LH secretoryburst frequency and interpulse-interval regularity in women. Am J Physiol Endocrinol Metab 285: E938-E948, 2003
    • (2003) Am J Physiol Endocrinol Metab , vol.285 , pp. E938-E948
    • Keenan, D.M.1    Evans, W.S.2    Veldhuis, J.D.3
  • 21
    • 0035957418 scopus 로고    scopus 로고
    • Interactive construct of feedbackcontrol in the stress-responsive hypothalamo-pituitary-adrenalaxis
    • Keenan DM, Licinio J, Veldhuis JD. Interactive construct of feedback control in the stress-responsive hypothalamo-pituitary-adrenal axis. Proc Natl Acad Sci USA 98: 4028-4033, 2001
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4028-4033
    • Keenan, D.M.1    Licinio, J.2    Veldhuis, J.D.3
  • 22
    • 0042388450 scopus 로고    scopus 로고
    • Physiologicalcontrol of pituitary hormone secretory-burst mass, frequency andwaveform: A statistical formulation and analysis
    • Keenan DM, Roelfsema F, Biermasz N, Veldhuis JD. Physiological control of pituitary hormone secretory-burst mass, frequency and waveform: a statistical formulation and analysis. AmJ Physiol Regul Integr Comp Physiol 285: R664-R673, 2003
    • (2003) Amj Physiol Regulintegr Comp Physiol , vol.285 , pp. R664-R673
    • Keenan, D.M.1    Roelfsema, F.2    Biermasz, N.3    Veldhuis, J.D.4
  • 24
    • 4544221501 scopus 로고    scopus 로고
    • Veldhuis (2004) JD. EndogenousACTH concentration-dependent drive of pulsatilecortisol secretion in the human
    • Keenan DM, Roelfsema F, Veldhuis (2004) JD. Endogenous ACTH concentration-dependent drive of pulsatile cortisol secretion in the human. Am J Physiol Endocrinol Metab 287: E652-E661, 2004
    • (2004) Am J Physiolendocrinol Metab , vol.287 , pp. E652-E661
    • Keenan, D.M.1    Roelfsema, F.2
  • 26
    • 0034911713 scopus 로고    scopus 로고
    • A stochasticbiomathematical model of the male reproductivehormone system
    • Keenan DM, Sun W, Veldhuis JD. A stochastic biomathematical model of the male reproductive hormone system. SIAM J Appl Math 61: 934-965, 2000
    • (2000) SIAM J Appl Math , vol.61 , pp. 934-965
    • Keenan, D.M.1    Sun, W.2    Veldhuis, J.D.3
  • 28
    • 0030759141 scopus 로고    scopus 로고
    • A stochastic model ofadmixed basal and pulsatile hormone secretionas modulated by a deterministic oscillator
    • Keenan DM, Veldhuis JD. A stochastic model of admixed basal and pulsatile hormone secretion as modulated by a deterministic oscillator. Am J Physiol Regul Integr Comp Physiol 273: R1182-R1192, 1997
    • (1997) Am Jphysiol Regul Integr Comp Physiol , vol.273 , pp. R1182-R1192
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 29
    • 0031876840 scopus 로고    scopus 로고
    • A biomathematical modelof time-delayed feedback in the human male hypothalamic-pituitary-Leydig cell axis
    • Keenan DM, Veldhuis JD. A biomathematical model of time-delayed feedback in the human male hypothalamic- pituitary-Leydig cell axis. AmJ Physiol Endocrinol Metab 275: E157-E176, 1998
    • (1998) Amj Physiol Endocrinolmetab , vol.275 , pp. E157-E176
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 30
    • 0034119848 scopus 로고    scopus 로고
    • Explicating hypergonadotropismin postmenopausal women: A statisticalmodel
    • Keenan DM, Veldhuis JD. Explicating hypergonadotropism in postmenopausal women: a statistical model. Am J Physiol Regul Integr Comp Physiol 278: R1247-R1257, 2000
    • (2000) Am J Physiol Regul Integr Compphysiol , vol.278 , pp. R1247-R1257
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 31
    • 0035665125 scopus 로고    scopus 로고
    • Disruptions in the hypothalamicluteinizing-hormone pulsing mechanismin aging men
    • Keenan DM, Veldhuis JD. Disruptions in the hypothalamic luteinizing-hormone pulsing mechanism in aging men. Am J Physiol Regul Integr Comp Physiol 281: R1917-R1924, 2001
    • (2001) Am J Physiol Regul Integrcomp Physiol , vol.281 , pp. R1917-R1924
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 32
    • 0034968016 scopus 로고    scopus 로고
    • Hypothesis testing ofthe aging male gonadal axis via a biomathematicalconstruct
    • Keenan DM, Veldhuis JD. Hypothesis testing of the aging male gonadal axis via a biomathematical construct. Am J Physiol Regul Integr Comp Physiol 280: R1755-R1771, 2001
    • (2001) Am J Physiol Regul Integr Compphysiol , vol.280 , pp. R1755-R1771
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 33
    • 0142116132 scopus 로고    scopus 로고
    • Cortisol feedback stategoverns adrenocorticotropin secretory-burstshape, frequency, and mass in a dual-waveformconstruct: Time of day-dependent regulation
    • Keenan DM, Veldhuis JD. Cortisol feedback state governs adrenocorticotropin secretory-burst shape, frequency, and mass in a dual-waveform construct: time of day-dependent regulation. Am J Physiol Regul Integr Comp Physiol 285: R950-R961, 2003
    • (2003) Amj Physiol Regul Integr Comp Physiol , vol.285 , pp. R950-R961
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 34
    • 0942298219 scopus 로고    scopus 로고
    • Divergent gonadotropin-gonadal dose-responsive coupling in healthyyoung and aging men
    • Keenan DM, Veldhuis JD. Divergent gonadotropin- gonadal dose-responsive coupling in healthy young and aging men. Am J Physiol Regul Integr Comp Physiol 286: R381-R389, 2004
    • (2004) Am J Physiol Regul Integrcomp Physiol , vol.286 , pp. R381-R389
    • Keenan, D.M.1    Veldhuis, J.D.2
  • 36
    • 22444450185 scopus 로고    scopus 로고
    • Composite model of time-varying appearanceand disappearance of neurohormone pulse signalsin blood
    • Keenan DM, Veldhuis JD, Chattopadhyay C. Composite model of time-varying appearance and disappearance of neurohormone pulse signals in blood. J Theor Biol 236: 242-255, 2005
    • (2005) J Theor Biol , vol.236 , pp. 242-255
    • Keenan, D.M.1    Veldhuis, J.D.2    Chattopadhyay, C.3
  • 37
    • 0032415120 scopus 로고    scopus 로고
    • Joint recoveryof pulsatile and basal hormone secretion by stochasticnonlinear random-effects analysis
    • Keenan DM, Veldhuis JD, Yang R. Joint recovery of pulsatile and basal hormone secretion by stochastic nonlinear random-effects analysis. Am J Physiol Regul Integr Comp Physiol 275: R1939-R1949, 1998
    • (1998) Am Jphysiol Regul Integr Comp Physiol , vol.275 , pp. R1939-R1949
    • Keenan, D.M.1    Veldhuis, J.D.2    Yang, R.3
  • 38
    • 84865577964 scopus 로고    scopus 로고
    • Modeling the nonlinear time dynamics of multidimensionalhormonal systems
    • Keenan DM, Wang X, Pincus SM, Veldhuis JD. Modeling the nonlinear time dynamics of multidimensional hormonal systems. J Time Series Anal 33: 779-796, 2012
    • (2012) J Time Seriesanal , vol.33 , pp. 779-796
    • Keenan, D.M.1    Wang, X.2    Pincus, S.M.3    Veldhuis, J.D.4
  • 39
    • 0026022520 scopus 로고
    • A model for the identificationof hormone pulses
    • Kushler RH, Brown MB. A model for the identification of hormone pulses. Stat Med 10: 329-340, 1991
    • (1991) Stat Med , vol.10 , pp. 329-340
    • Kushler, R.H.1    Brown, M.B.2
  • 41
    • 12344289256 scopus 로고    scopus 로고
    • Analysis of bidirectional pattern synchronyof concentration-secretion pairs: Implementationin the human testicular and adrenalaxis
    • Liu PY, Pincus SM, Keenan DM, Roelfsema F, Veldhuis JD. Analysis of bidirectional pattern synchrony of concentration-secretion pairs: implementation in the human testicular and adrenal axis. Am J Physiol Regul Integr Comp Physiol 288: R440-R446, 2005
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.288 , pp. R440-R446
    • Liu, P.Y.1    Pincus, S.M.2    Keenan, D.M.3    Roelfsema, F.4    Veldhuis, J.D.5
  • 43
    • 0028797289 scopus 로고
    • A comparisonof methods that characterize pulses in a timeseries
    • Mauger DT, Brown MB, Kushler RH. A comparison of methods that characterize pulses in a time series. Stat Med 14: 311-325, 1995
    • (1995) Stat Med , vol.14 , pp. 311-325
    • Mauger, D.T.1    Brown, M.B.2    Kushler, R.H.3
  • 44
    • 0020197525 scopus 로고
    • Algorithms for thestudy of episodic hormone secretion
    • Merriam GR, Wachter KW. Algorithms for the study of episodic hormone secretion. Am J Physiol Endocrinol Metab 243: E310-E318, 1982
    • (1982) Am Jphysiol Endocrinol Metab , vol.243 , pp. E310-E318
    • Merriam, G.R.1    Wachter, K.W.2
  • 45
    • 0007354202 scopus 로고
    • Pulse detection inhormone data: Simplified efficient algorithm
    • Munson PJ, Rodbard D. (1989) Pulse detection in hormone data: simplified efficient algorithm. Proc Stat Comp Sect Am Stat Assn 1989: 295-300, 1989
    • (1989) Proc Stat Comp Sect am Stat Assn , vol.1989 , pp. 295-300
    • Munson, P.J.1    Rodbard, D.2
  • 46
    • 0022529247 scopus 로고
    • Detectionand characterization of peaks and estimationof instantaneous secretory rate for episodic pulsatilehormone secretion
    • Oerter KE, Guardabasso V, Rodbard D. Detection and characterization of peaks and estimation of instantaneous secretory rate for episodic pulsatile hormone secretion. Computers Biomed Res 19: 170-191, 1986
    • (1986) Computers Biomedres , vol.19 , pp. 170-191
    • Oerter, K.E.1    Guardabasso, V.2    Rodbard, D.3
  • 47
    • 0023785961 scopus 로고
    • Deconvolution of episodichormone data: An analysis of the role ofseason on the onset of puberty in cows
    • O’Sullivan F, O’Sullivan J. Deconvolution of episodic hormone data: an analysis of the role of season on the onset of puberty in cows. Biometrics 44: 339-353, 1988
    • (1988) Biometrics , vol.44 , pp. 339-353
    • O’Sullivan, F.1    O’Sullivan, J.2
  • 48
    • 0030450771 scopus 로고    scopus 로고
    • Older males secreteluteinizing hormone and testosterone moreirregularly, and jointly more asynchronously, thanyounger males: Dual novel facets
    • Pincus SM, Mulligan T, Iranmanesh A, Gheorghiu S, Godschalk M, Veldhuis JD. Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males: dual novel facets. Proc Natl Acad Sci USA 93: 14100-14105, 1996
    • (1996) Proc Natl Acadsci USA , vol.93 , pp. 14100-14105
    • Pincus, S.M.1    Mulligan, T.2    Iranmanesh, A.3    Gheorghiu, S.4    Godschalk, M.5    Veldhuis, J.D.6
  • 49
    • 0021858047 scopus 로고
    • Central modulation ofimmunoreactive arginine vasopressin and oxytocinsecretion into the hypophysial-portal circulation bycorticotropin-releasing factor
    • Plotsky P, Bruhn TO, Otto S. Central modulation of immunoreactive arginine vasopressin and oxytocin secretion into the hypophysial-portal circulation by corticotropin-releasing factor. Endocrinology 116: 1669-1671, 1985
    • (1985) Endocrinology , vol.116 , pp. 1669-1671
    • Plotsky, P.1    Bruhn, T.O.2    Otto, S.3
  • 51
    • 83155168499 scopus 로고    scopus 로고
    • EndogenousACTH concentration-cortisol secretion doseanalysis unmasks decreased ACTH potency inCushing’s disease with restoration after successfulpituitary adenomectomy
    • Roelfsema F, Keenan DM, Veldhuis JD. Endogenous ACTH concentration-cortisol secretion dose analysis unmasks decreased ACTH potency in Cushing’s disease with restoration after successful pituitary adenomectomy. J Clin Endocrinol Metab 96: 3768-3774, 2011
    • (2011) J Clin Endocrinolmetab , vol.96 , pp. 3768-3774
    • Roelfsema, F.1    Keenan, D.M.2    Veldhuis, J.D.3
  • 52
    • 84867570043 scopus 로고    scopus 로고
    • Diminishedadrenal sensitivity and adrenocorticotropinefficacy in obese premenopausal women
    • Roelfsema F, Keenan DM, Veldhuis JD. Diminished adrenal sensitivity and adrenocorticotropin efficacy in obese premenopausal women. J Clin Endocrinol Metab 167: 633-642, 2012
    • (2012) J Clinendocrinol Metab , vol.167 , pp. 633-642
    • Roelfsema, F.1    Keenan, D.M.2    Veldhuis, J.D.3
  • 53
    • 0015868425 scopus 로고
    • Episodic luteinizing hormonein man: Pulse analysis, clinical interpretation,physiological mechanisms
    • Santen RJ, Bardin CW. Episodic luteinizing hormone in man: pulse analysis, clinical interpretation, physiological mechanisms. J Clin Invest 52: 2617-2628, 1973
    • (1973) J Clin Invest , vol.52 , pp. 2617-2628
    • Santen, R.J.1    Bardin, C.W.2
  • 54
    • 0023954666 scopus 로고
    • Contemporary aspects ofdiscrete peak detection algorithms. I. The paradigmof the luteinizing hormone pulse signal inmen
    • Urban RJ, Evans WS, Rogol AD, Kaiser DL, Johnson ML, Veldhuis JD. Contemporary aspects of discrete peak detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men. Endocr Rev 9: 3-37, 1988
    • (1988) Endocr Rev , vol.9 , pp. 3-37
    • Urban, R.J.1    Evans, W.S.2    Rogol, A.D.3    Kaiser, D.L.4    Johnson, M.L.5    Veldhuis, J.D.6
  • 55
    • 0018522817 scopus 로고
    • Method for characterization of24-hour temporal variation of blood components
    • Van Cauter E. Method for characterization of 24-hour temporal variation of blood components. Am J Physiol Endocrinol Metab Gastrointest Physiol 237: E255-E264, 1979
    • (1979) Am J Physiol Endocrinol Metab Gastrointestphysiol , vol.237 , pp. E255-E264
    • Van Cauter, E.1
  • 57
    • 0022447036 scopus 로고
    • Cluster analysis: A simple,versatile, and robust algorithm for endocrinepulse detection
    • Veldhuis JD, Johnson ML. Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am J Physiol Endocrinol Metab 250: E486-E493, 1986
    • (1986) Am J Physiol Endocrinol Metab , vol.250 , pp. E486-E493
    • Veldhuis, J.D.1    Johnson, M.L.2
  • 58
    • 84873442778 scopus 로고    scopus 로고
    • Model-based evaluationof growth hormone secretion
    • Veldhuis JD, Keenan DM. Model-based evaluation of growth hormone secretion. Methods Enzymol 514: 231-248, 2012
    • (2012) Methods Enzymol , vol.514 , pp. 231-248
    • Veldhuis, J.D.1    Keenan, D.M.2
  • 59
    • 57349179195 scopus 로고    scopus 로고
    • Estradiol supplementation in postmenopausalwomen attenuates suppression of pulsatilegrowth hormone secretion by recombinant humaninsulin-like growth factor type I
    • Veldhuis JD, Keenan DM, Bailey JN, Adeniji A, Miles JM, Paulo R, Cosma M, Soares-Welch C. Estradiol supplementation in postmenopausal women attenuates suppression of pulsatile growth hormone secretion by recombinant human insulin-like growth factor type I. J Clin Endocrinol Metab 93: 4471-4478, 2008
    • (2008) J Clin Endocrinolmetab , vol.93 , pp. 4471-4478
    • Veldhuis, J.D.1    Keenan, D.M.2    Bailey, J.N.3    Adeniji, A.4    Miles, J.M.5    Paulo, R.6    Cosma, M.7    Soares-Welch, C.8
  • 60
    • 34548447981 scopus 로고    scopus 로고
    • Estimationof the size and shape of GH secretory bursts inhealthy women using a physiological estradiolclamp and variable-waveform deconvolutionmodel
    • Veldhuis JD, Keenan DM, Bowers CY. Estimation of the size and shape of GH secretory bursts in healthy women using a physiological estradiol clamp and variable-waveform deconvolution model. Am J Physiol Regul Integr Comp Physiol 293: R1013-R1021, 2007
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293 , pp. R1013-R1021
    • Veldhuis, J.D.1    Keenan, D.M.2    Bowers, C.Y.3
  • 61
    • 27644486761 scopus 로고    scopus 로고
    • Testosterone supplementation inhealthy older men drives GH and IGF-I secretionwithout potentiating peptidyl secretagogue efficacy
    • Veldhuis JD, Keenan DM, Mielke K, Miles JM, Bowers CY. Testosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacy. Eur J Endocrinol 153: 577-586, 2005
    • (2005) Eur J Endocrinol , vol.153 , pp. 577-586
    • Veldhuis, J.D.1    Keenan, D.M.2    Mielke, K.3    Miles, J.M.4    Bowers, C.Y.5
  • 62
    • 57349192792 scopus 로고    scopus 로고
    • Motivationsand methods for analyzing pulsatile hormone secretion
    • Veldhuis JD, Keenan DM, Pincus SM. Motivations and methods for analyzing pulsatile hormone secretion. Endocr Rev 29: 823-864, 2008
    • (2008) Endocr Rev , vol.29 , pp. 823-864
    • Veldhuis, J.D.1    Keenan, D.M.2    Pincus, S.M.3
  • 63
    • 77955506123 scopus 로고    scopus 로고
    • Regulationof complex pulsatile and rhythmic neuroendocrinesystems: The male gonadal axis as a prototype
    • Veldhuis JD, Keenan DM, Pincus SM. Regulation of complex pulsatile and rhythmic neuroendocrine systems: the male gonadal axis as a prototype. Prog Brain Res 181: 79-110, 2010
    • (2010) Prog Brain Res , vol.181 , pp. 79-110
    • Veldhuis, J.D.1    Keenan, D.M.2    Pincus, S.M.3
  • 64
    • 83455242982 scopus 로고    scopus 로고
    • Older men exhibit reduced efficacy of andheightened potency downregulation by intravenouspulses of recombinant human LH: A study in92 healthy men
    • Veldhuis JD, Liu PY, Keenan DM, Takahashi PY. Older men exhibit reduced efficacy of and heightened potency downregulation by intravenous pulses of recombinant human LH: a study in 92 healthy men. Am J Physiol Endocrinol Metab 302: E117-E122, 2012
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , pp. E117-E122
    • Veldhuis, J.D.1    Liu, P.Y.2    Keenan, D.M.3    Takahashi, P.Y.4
  • 65
    • 0023448602 scopus 로고
    • The pituitarygland secretes in bursts: Appraising the natureof glandular secretory impulses bysimultaneous multiple-parameter deconvolutionof plasma hormone concentrations
    • Veldhuis JD, Carlson ML, Johnson ML. The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84: 7686-7690, 1987
    • (1987) Proc Natlacad Sci USA , vol.84 , pp. 7686-7690
    • Veldhuis, J.D.1    Carlson, M.L.2    Johnson, M.L.3
  • 66
    • 33645517241 scopus 로고    scopus 로고
    • Somatotropic and gonadotropic axeslinkages in infancy, childhood, and the pubertyadulttransition
    • Veldhuis JD, Roemmich JN, Richmond EJ, Bowers CY. Somatotropic and gonadotropic axes linkages in infancy, childhood, and the pubertyadult transition. Endocr Rev 27: 101-140, 2006
    • (2006) Endocr Rev , vol.27 , pp. 101-140
    • Veldhuis, J.D.1    Roemmich, J.N.2    Richmond, E.J.3    Bowers, C.Y.4
  • 67
    • 70349918145 scopus 로고    scopus 로고
    • Basal, pulsatile, entropic(Patterned), and spiky (staccato-like) propertiesof ACTH secretion: Impact of age, gender,and body mass index
    • Veldhuis JD, Roelfsema F, Iranmanesh A, Carroll BJ, Keenan DM, Pincus SM. Basal, pulsatile, entropic (patterned), and spiky (staccato-like) properties of ACTH secretion: impact of age, gender, and body mass index. J Clin Endocrinol Metab 94: 4045-4052, 2009
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4045-4052
    • Veldhuis, J.D.1    Roelfsema, F.2    Iranmanesh, A.3    Carroll, B.J.4    Keenan, D.M.5    Pincus, S.M.6
  • 68
    • 78650887936 scopus 로고    scopus 로고
    • Gender, age, body mass index, and IGF-I individuallyand jointly determine distinct GH dynamics:Analyses in one hundred healthy adults
    • Veldhuis JD, Roelfsema F, Keenan DM, Pincus S. Gender, age, body mass index, and IGF-I individually and jointly determine distinct GH dynamics: analyses in one hundred healthy adults. J Clin Endocrinol Metab 96: 115-121, 2011
    • (2011) J Clinendocrinol Metab , vol.96 , pp. 115-121
    • Veldhuis, J.D.1    Roelfsema, F.2    Keenan, D.M.3    Pincus, S.4
  • 71
    • 15244358530 scopus 로고    scopus 로고
    • Amathematical model for LH release in responseto continuous and pulsatile exposure of gonadotrophsto GnRH
    • Washington TM, Blum JJ, Reed MC, Conn PM. A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH. Theor Biol Med Model 1: 9-26, 2004
    • (2004) Theor Biol Med Model , vol.1 , pp. 9-26
    • Washington, T.M.1    Blum, J.J.2    Reed, M.C.3    Conn, P.M.4
  • 74
    • 33645051440 scopus 로고    scopus 로고
    • Detecting pulsatile hormonesecretions using nonlinear mixed effectspartial spline models
    • Yang YC, Liu A, Wang Y. Detecting pulsatile hormone secretions using nonlinear mixed effects partial spline models. Biometrics 62: 230-238, 2006
    • (2006) Biometrics , vol.62 , pp. 230-238
    • Yang, Y.C.1    Liu, A.2    Wang, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.