Estradiol supplementation in postmenopausal women attenuates suppression of pulsatile growth hormone secretion by recombinant human insulin-like growth factor type I

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 11, 2008, Pages 4471-4478

  Veldhuis, Johannes D ^a   Keenan, Daniel M ^b   Bailey, Joy N ^a   Adeniji, Adenborduin ^a   Miles, John M ^a   Paulo, Remberto ^a   Cosma, Mihaela ^a   Soares Welch, Cacia ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; GROWTH HORMONE; PLACEBO; RECOMBINANT SOMATOMEDIN C;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ELECTROCARDIOGRAPHY; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL;

EID: 57349179195     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-1493     Document Type: Article

References (38)

1. Veldhuis JD, Roemmich JN, Richmond EJ, Bowers CY 2006 Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition. Endocr Rev 27:101-140
2. Greenwood FC, Landon J, Stamp TC 1966 The plasma sugar, free fatty acid, cortisol, and growth hormone response to insulin. I. In control subjects. J Clin Invest 45:429-436
3. Arvat E, Ceda G, Ramunni J, Lanfranco F, Aimaretti G, Gianotti L, Broglio F, Ghigo E 1998 The IGF-I response to very low rhGH doses is preserved in human ageing. Clin Endocrinol (Oxf) 49:757-763
4. Weltman A, Weltman JY, Hartman ML, Abbott RD, Rogol AD, Evans WS, Veldhuis JD 1994 Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: effects of gender. J Clin Endocrinol Metab 78:543-548
5. Dawson-Hughes B, Stern D, Goldman J, Reichlin S 1986 Regulation of growth hormone and somatomedin-C secretion in postmenopausal women: effect of physiological estrogen replacement. J Clin Endocrinol Metab 63:424-432
6. Mauras N, Rogol AD, Veldhuis JD 1990 Increased hGH production rate after low-dose estrogen therapy in prepubertal girls with Turner's syndrome. Pediatr Res 28:626-630
7. Shah N, Evans WS, Veldhuis JD 1999 Actions of estrogen on the pulsatile, nyctohemeral, and entropic modes of growth hormone secretion. Am J Physiol 276:R1351-R1358
8. Veldhuis JD, Evans WS, Bowers CY 2003 Estradiol supplementation enhances submaximal feedforward drive of growth hormone (GH) secretion by recombinant human GH-releasing hormone-1,44-amide in a putatively somatostatin-withdrawn milieu. J Clin Endocrinol Metab 88:5484-5489
9. Veldhuis JD, Anderson SM, Patrie JT, Bowers CY 2004 Estradiol supplementation in postmenopausal women doubles rebound-like release of growth hormone (GH) triggered by sequential infusion and withdrawal of somatostatin: evidence that estrogen facilitates endogenous GH-releasing hormone drive. J Clin Endocrinol Metab 89:121-127
10. Anderson SM, Shah N, Evans WS, Patrie JT, Bowers CY, Veldhuis JD 2001 Short-term estradiol supplementation augments growth hormone (GH) secretory responsiveness to dose-varying GH-releasing peptide infusions in healthy postmenopausal women. J Clin Endocrinol Metab 86:551-560
11. Veldhuis JD, Keenan DM, Iranmanesh A, Mielke K, Miles JM, Bowers CY 2006 Estradiol potentiates ghrelin-stimulated pulsatile GH secretion in postmenopausal women. J Clin Endocrinol Metab 91:3559-3565
12. Bray MJ, Vick TM, Shah N, Anderson SM, Rice LW, Iranmanesh A, Evans WS, Veldhuis JD 2001 Short-term estradiol replacement in postmenopausal women selectively mutes somatostatin's dose-dependent inhibition of fasting growth hormone secretion. J Clin Endocrinol Metab 86:3143-3149
13. Anderson SM, Wideman L, Patrie JT, Weltman A, Bowers CY, Veldhuis JD 2001 Estradiol supplementation selectively relieves GH's autonegative feedback on GH-releasing peptide-2-stimulated GH secretion. J Clin Endocrinol Metab 86:5904-5911
14. Simard J, Hubert JF, Hosseinzadeh T, Labrie F 1986 Stimulation of growth hormone release and synthesis by estrogens in rat anterior pituitary cells in culture. Endocrinology 119:2004-2011
15. Leung KC, Doyle N, Ballesteros M, Sjogren K, Watts CK, Low TH, Leong GM, Ross RJ, Ho KK 2003 Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Proc Natl Acad Sci USA 100:1016-1021
16. Kimura N, Tomizawa S, Arai KN, Kimura N 1998 Chronic treatment with estrogen up-regulates expression of sst2 messenger ribonucleic acid (mRNA) but down-regulates expression of sst5 mRNA in rat pituitaries. Endocrinology 139:1573-1580
17. Bennett PA, Levy A, Carmignac DF, Robinson IC, Lightman SL 1996 Differential regulation of the growth hormone receptor gene: effects of dexamethasone and estradiol. Endocrinol 137:3891-3896
18. Slama A, Videau C, Kordon C, Epelbaum J 1992 Estradiol regulation of somatostatin receptors in the arcuate nucleus of the female rat. Neuroendocrinol 56:240-245
19. Keenan DM, Roelfsema F, Biermasz N, Veldhuis JD 2003 Physiological control of pituitary hormone secretory-burst mass, frequency and waveform: a statistical formulation and analysis. Am J Physiol 285:R664-R673
20. Faria ACS, Veldhuis JD, Thorner MO, Vance ML 1989 Half-time of endogenous growth hormone (GH) disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin. J Clin Endocrinol Metab 68:535-541
21. Akaike H 1974 A new look at the statistical model identification. IEEE Trans Autom Control 19:716-723
22. Veldhuis JD, Straume M, Iranmanesh A, Mulligan T, Jaffe CA, Barkan A, Johnson ML, Pincus SM 2001 Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans. Am J Physiol 280:R721-R729
23. Zar JH 1996 Biostatistical analysis. 3rd ed. Upper Saddle River, NJ: Prentice Hall
24. Taylor AE, Whitney H, Hall JE, Martin K, Crowley Jr WF 1995 Midcycle levels of sex steroids are sufficient to recreate the follicle-stimulating hormone but not the luteinizing hormone midcycle surge: evidence for the contribution of other ovarian factors to the surge in normal women. J Clin Endocrinol Metab 80:1541-1547
25. Simon JA, Bustillo M, Thorneycroft IH, Cohen SW, Buster JE 1987 Variability of midcycle estradiol positive feedback: evidence for unique pituitary responses in individual women. J Clin Endocrinol Metab 64:789-793
26. Fritz MA, McLachlan RI, Cohen NL, Dahl KD, Bremner WJ, Soules MR 1992 Onset and characteristics of the midcycle surge in bioactive and immunoactive luteinizing hormone secretion in normal women: influence of physiological variations in periovulatory ovarian steroid hormone secretion. J Clin Endocrinol Metab 75:489-493
27. Luque RM, Gahete MD, Valentine RJ, Kineman RD 2006 Examination of the direct effects of metabolic factors on somatotrope function in a non-human primate model, Papio anubis. J Mol Endocrinol 37:25-38
28. Ghigo E, Gianotti L, Arvat E, Ramunni J, Valetto MR, Broglio F, Rolla M, Cavagnini F, Muller EE 1999 Effects of recombinant human insulin-like growth factor I administration on growth hormone (GH) secretion, both spontaneous and stimulated by GH-releasing hormone or hexarelin, a peptidyl GH secretagogue, in humans. J Clin Endocrinol Metab 84:285-290
29. Veldhuis JD, Anderson SM, Kok P, Iranmanesh A, Frystyk J, Orskov H, Keenan DM 2004 Estradiol supplementation modulates growth hormone (GH) secretory-burst waveform and recombinant human insulin-like growth factor-I-enforced suppression of endogenously driven GH release in postmenopausal women. J Clin Endocrinol Metab 89:1312-1318
30. Veldhuis JD, Anderson SM, Iranmanesh A, Bowers CY 2005 Testosterone blunts feedback inhibition of GH secretion by experimentally elevated IGF-I concentrations. J Clin Endocrinol Metab 90:1613-1617
31. Gianotti L, Maccario M, Lanfranco F, Ramunni J, Di Vito L, Grottoli S, Mueller EE, Ghigo E, Arvat E 2000 Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab 85:3604-3608
32. Nass R, Pezzoli SS, Chapman IM, Patrie J, Hintz RL, Hartman ML, Thorner MO 2002 IGF-I does not affect the net increase in GH release in response to arginine. Am J Physiol Endocrinol Metab 283:E702-E710
33. Farhy LS, Bowers CY, Veldhuis JD 2007 Model-projected mechanistic bases for sex differences in growth-hormone regulation in humans. Am J Physiol Regul Integr Comp Physiol 292:R1577-R1593
34. Luque RM, Kineman RD 2007 Gender-dependent role of endogenous somatostatin in regulating growth hormone (GH)-axis function in mice. Endocrinology 148:5998-6006
35. Chapman IM, Hartman ML, Pezzoli SS, Harrell Jr FE, Hintz RL, Alberti KG, Thorner MO 1997 Effect of aging on the sensitivity of growth hormone secretion to insulin-like growth factor-I negative feedback. J Clin Endocrinol Metab 82:2996-3004
36. Veldhuis JD, Weltman JY, Weltman AL, Iranmanesh A, Muller EE, Bowers CY 2004 Age and secretagogue type jointly determine dynamic growth hormone responses to exogenous insulin-like growth factor-negative feedback in healthy men. J Clin Endocrinol Metab 89:5542-5548
37. Chen JW, Hojlund K, Beck-Nielsen H, Sandahl CJ, Orskov H, Frystyk J 2005 Free rather than total circulating insulin-like growth factor-I determines the feedback on growth hormone release in normal subjects. J Clin Endocrinol Metab 90:366-371
38. Veldhuis JD, Frystyk J, Iranmanesh A, Orskov H 2005 Testosterone and estradiol regulate free IGF-I, IGFBP-I and dimeric IGF-I/IGFBP-I concentrations. J Clin Endocrinol Metab 90:2941-2947