Tripartite control of dynamic ACTH-cortisol dose responsiveness by age, body mass index, and gender in 111 healthy adults

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 9, 2011, Pages 2874-2881

  Veldhuis, Johannes D ^a   Iranmanesh, Ali ^b   Roelfsema, Ferdinand ^c   Aoun, Paul ^a   Takahashi, Paul ^a   Miles, John M ^a   Keenan, Daniel M ^d  

^a MAYO CLINIC   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; HYDROCORTISONE;

ADRENAL FUNCTION; ADULT; AGE; AGED; ARTICLE; BODY MASS; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; DOSE RESPONSE; DOWN REGULATION; FEMALE; HEALTH STATUS; HORMONAL REGULATION; HORMONE SENSITIVITY; HUMAN; HYDROCORTISONE BLOOD LEVEL; MALE; MOLECULAR DYNAMICS; NORMAL HUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

ADOLESCENT; ADRENOCORTICOTROPIC HORMONE; ADULT; AGE FACTORS; AGED; BODY MASS INDEX; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MIDDLE AGED; PITUITARY-ADRENAL SYSTEM; SEX FACTORS;

EID: 80052543497     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-0084     Document Type: Article

References (38)

1. Dempsher D.P., Gann D.S., Phair R.D. 1984 A mechanistic model of ACTH-stimulated cortisol secretion.AmJ Physiol 246:R587-R596 (Pubitemid 14137808)
2. Giustina A., Veldhuis J.D. 1998 Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 19:717-797 (Pubitemid 128506521)
3. Jusko W.J., Slaunwhite Jr W.R., Aceto Jr T. 1975 Partial pharmacodynamic model for the circadian-episodic secretion of cortisol in man. J Clin Endocrinol Metab 40:278-289
4. Veldhuis J.D., Keenan D.M., Pincus S.M. 2008 Motivations and methods for analyzing pulsatile hormone secretion. Endocr Rev 29:823-864
5. Keenan D.M., Licinio J., Veldhuis J.D. 2001 A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis. Proc Natl Acad Sci USA 98:4028-4033 (Pubitemid 32249892)
6. Keenan D.M., Alexander S.L., Irvine C.H., Clarke I., Scott C., Turner A., Tilbrook A.J., Canny B.J., Veldhuis J.D. 2004 Reconstruction of in vivo time-evolving neuroendocrine dose-response properties unveils admixed deterministic and stochastic elements. Proc Natl Acad Sci USA 101:6740-6745 (Pubitemid 38586044)
7. Keenan D.M., Veldhuis J.D. 2003 Mathematical modeling of receptormediated interlinked systems. Encyclopedia of hormones. San Diego: Academic Press; 286-294
8. Schulster D., Rafferty B., Williams B. 1984 Corticotropin-induced desensitization: Steroidogenic and cyclic AMP responses in superfused adrenocortical cells. Mol Cell Endocrinol 36:43-51 (Pubitemid 14122920)
9. Keenan D.M., Roelfsema F., Veldhuis J.D. 2010 Dose-response downregulation within the span of single interpulse intervals.AmJ Physiol Regul Integr Comp Physiol 299:R11-R18
10. Keenan D.M., Iranmanesh A., Veldhuis J.D. 2011 Analytical construct of reversible desensitization of pituitary-testicular signaling: Illustrative application in aging.AmJ Physiol Regul IntegrCompPhysiol 300:R349-R360
11. Swords F.M., Baig A., Malchoff D.M., Malchoff C.D., Thorner M.O., King P.J., Hunyady L., Clark A.J. 2002 Impaired desensitization of a mutant adrenocorticotropin receptor associated with apparent constitutive activity. Mol Endocrinol 16:2746-2753 (Pubitemid 36020655)
12. Veldhuis J.D., Iranmanesh A., Naftolowitz D., Tatham N., Cassidy F., Carroll B.J. 2001 Corticotropin secretory dynamics in humans under low glucocorticoid feedback. J Clin Endocrinol Metab 86:5554-5563 (Pubitemid 33070288)
13. Veldhuis J.D., Iranmanesh A., Johnson M.L., Lizarralde G. 1990 Twenty- four hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts. J Clin Endocrinol Metab 71:1616-1623 (Pubitemid 120032784)
14. Roelfsema F., Van den Berg G., Frölich M., Veldhuis J.D., Van Eijk A., Buurman M.M., Etman B.H. 1993 Sex-dependent alteration in cortisol response to endogenous adrenocorticotropin. J Clin Endocrinol Metab 77:234-240 (Pubitemid 23206809)
15. Van den Berg G., Pincus S.M., Veldhuis J.D., Frölich M., Roelfsema F. 1997 Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing's disease. Eur J Endocrinol 136: 394-400 (Pubitemid 27207145)
16. Liu P.Y., Keenan D.M., Kok P., Padmanabhan V., O'Byrne K.T., Veldhuis J.D. 2009 Sensitivity and specificity of pulse detection using a new deconvolution method. Am J Physiol Endocrinol Metab 297: E538-E544
17. Lamberts S.W., Bons E.G., Zuiderwijk-van der Roest J.M. 1987 Studies on the mechanism of corticotrophin-mediated desensitization of corticosterone secretion by rat adrenocortical cells. Mol Cell Endocrinol 52:243-249 (Pubitemid 17106984)
18. Lebrethon M.C., Naville D., Begeot M., Saez J.M. 1994 Regulation of corticotropin receptor number and messenger RNA in cultured human adrenocortical cells by corticotropin and angiotensin II. J Clin Invest 93:1828-1833 (Pubitemid 24116426)
19. Rani C.S., Keri G., Ramachandran J. 1983 Studies on corticotropininduced desensitization of normal rat adrenocortical cells. Endocrinology 112:315-320
20. Keenan D.M., Roelfsema F., Carroll B.J., Iranmanesh A., Veldhuis J.D. 2009 Sex defines the age dependence of endogenous ACTH-cortisol dose responsiveness. Am J Physiol Regul Integr Comp 297:R515-R523
21. Oelkers W., Boelke T., Bähr V. 1988 Dose-response relationships between plasma adrenocorticotropin (ACTH), cortisol, aldosterone, and 18-hydroxycorticosterone after injection of ACTH-(1-39) or human corticotropin-releasing hormone in man. J Clin Endocrinol Metab 66:181-186 (Pubitemid 18027749)
22. Thomas M.A., Rebar R.W., LaBarbera A.R., Pennington E.J., Liu J.H. 1991 Dose-response effects of exogenous pulsatile human corticotropin- releasing hormone on adrenocorticotropin, cortisol, and gonadotropin concentrations in agonadal women. J Clin Endocrinol Metab 72:1249-1254 (Pubitemid 21921836)
23. Tuchelt H., Dekker K., Bahr V., Oelkers W. 2000 Dose-response relationship between plasma ACTH and serum cortisol in the insulinhypoglycaemia test in 25 healthy subjects and 109 patients with pituitary disease. Clin Endocrinol (Oxf) 53:301-307
24. Orth D.N., Jackson R.V., DeCherney G.S., DeBold C.R., Alexander A.N., Island D.P., Rivier J., Rivier C., Spiess J., Vale W. 1983 Effect of synthetic ovine corticotropin-releasing factor. Dose response of plasma adrenocorticotropin and cortisol. J Clin Invest 71:587-595 (Pubitemid 13160805)
25. Hensen J., Hader O., Bähr V., Oelkers W. 1988 Effects of incremental infusions of arginine vasopressin on adrenocorticotropin and cortisol secretion in man. J Clin Endocrinol Metab 66:668-671
26. Peterson R.E. 1959 The miscible pool and turnover rate of adrenocortical steroids in man. Recent Prog Horm Res 15:231-274
27. Esteban N.V., Loughlin T., Yergey A.L., Zawadzki J.K., Booth J.D., Winterer J.C., Loriaux D.L. 1991 Daily cortisol production rate in man determined by stable isotope dilution/mass spectrometry. J Clin Endocrinol Metab 72:39-45 (Pubitemid 21921653)
28. Bright G.M. 1995 Corticosteroid-binding globulin influences kinetic parameters of plasma cortisol transport and clearance. J Clin Endocrinol Metab 80:770-775
29. Kraan G.P., Dullaart R.P., Pratt J.J., Wolthers B.G., De Bruin R. 1997 Kinetics of intravenously dosed cortisol in four men. Consequences for calculation of the plasma cortisol production rate. J Steroid Biochem Mol Biol 63:139-146 (Pubitemid 28018146)
30. Parker Jr C.R., Slayden S.M., Azziz R., Crabbe S.L., Hines G.A., Boots L.R., Bae S. 2000 Effects of aging on adrenal function in the human: Responsiveness and sensitivity of adrenal androgens and cortisol to adrenocorticotropin in premenopausal and postmenopausal women. J Clin Endocrinol Metab 85:48 -54
31. Greenspan S.L., Rowe J.W., Maitland L.A., McAloon-Dyke M., ElahiD. 1993 The pituitary-adrenal glucocorticoid response is altered by gender and disease. J Gerontol 48:M72-M77 (Pubitemid 23143637)
32. Otte C., Hart S., Neylan T.C., Marmar C.R., Yaffe K., Mohr D.C. 2005 A meta-analysis of cortisol response to challenge in human aging: Importance of gender. Psychoneuroendocrinology 30:80-91 (Pubitemid 39195047)
33. Karaca Z., Lale A., Tanriverdi F., Kula M., Unluhizarci K., Kelestimur F. 2010 The comparison of the low and standard dose ACTH and glucagon stimulation tests in the evaluation of hypothalamo-pituitary- adrenal axis in healthy adults. Pituitary 14:134-140
34. Kino T., Chrousos G.P. 2011 Circadian CLOCK-mediated regulation of target-tissue sensitivity to glucocorticoids: Implications for cardiometabolic diseases. Endocr Dev 20:116-126
35. Polderman K.H., Gooren L.J., Van der Veen E.A. 1994 Testosterone administration increases adrenal response to adrenocorticotrophin. Clin Endocrinol (Oxf) 40:595-601 (Pubitemid 24194662)
36. Miller G.E., Chen E., Fok A.K., Walker H., Lim A., Nicholls E.F., Cole S., Kobor M.S. 2009 Lowearly-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proc Natl Acad Sci USA 106:14716-14721
37. Revsin Y., Van Wijk D., Saravia F.E., Oitzl M.S., De Nicola A.F., De Kloet E.R. 2008 Adrenal hypersensitivity precedes chronic hypercorticism in streptozotocin-induced diabetes mice. Endocrinology 149:3531-3539 (Pubitemid 351919603)
38. Kempná P., Körner M., Waser B., Hofer G., Nuoffer J.M., Reubi J.C., Flück C.E. 2010 Neuropeptide Y modulates steroid production of human adrenal H295R cells through Y1 receptors. Mol Cell Endocrinol 314:101-109