Cortisol levels and suicidal behavior: A meta-analysis

Psychoneuroendocrinology

Volumn 63, Issue , 2016, Pages 370-379

  O'Connor, Daryl B ^a   Ferguson, Eamonn ^b   Green, Jessica A ^a   O'Carroll, Ronan E ^c   O'Connor, Rory C ^d  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c UNIVERSITY OF STIRLING   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Allostatic load; Chronic stress; Cortisol; Suicide

Indexed keywords

HYDROCORTISONE;

AGE; CAUSE OF DEATH; CHRONIC STRESS; DISEASE ASSOCIATION; GENDER; HIGH RISK PATIENT; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; PATHOGENESIS; POPULATION EXPOSURE; PRIORITY JOURNAL; REVIEW; SUICIDE ATTEMPT; ADULT; FEMALE; MALE; META ANALYSIS; METABOLISM; PSYCHOLOGY; SELF-INJURIOUS BEHAVIOR; STATISTICS AND NUMERICAL DATA; SUICIDAL IDEATION; YOUNG ADULT;

ADULT; FEMALE; HUMANS; HYDROCORTISONE; MALE; SELF-INJURIOUS BEHAVIOR; SUICIDAL IDEATION; SUICIDE, ATTEMPTED; YOUNG ADULT;

EID: 84949921767     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2015.10.011     Document Type: Review

References (68)

1. Ayuso-Gutiérrez J., Cabranes J. Pituitary-adrenal disinhibition and suicide attempts in depressed patients. Biol. Psychiatry 1987, 22:1409-1412.
2. Brown R., Mason B., Stoll P., Brizer D. Adrenocortical function and suicidal behavior in depressive disorders. Psychiatry Res. 1986, 17:317-323.
3. Brunner J., Stalla G.K., Stalla J., Uhr M., Grabner A., Wetter T.C., Bronisch T. Decreased corticotropin-releasing hormone (CRH) concentrations in the cerebrospinal fluid of eucortisolemic suicide attempters. J. Psychiatric Res. 2001, 35:1-9.
4. Brunner J., Keck M.E., Landgraf R., Uhr M., Namendorf C., Bronisch T. Vasopressin in CSF and plasma in depressed suicide attempters: preliminary results. Eur. Neuropsychopharmacol. 2002, 12:489-494.
5. Burke H.M., Davis M.C., Otte C., Mohr D.C. Depression and cortisol responses to psychological stress: a meta-analysis. Psychoneuroendocrinology 2005, 30:846-856.
6. Carroll B., Martin F., Davies B. Resistance to suppression by dexamethasone of plasma 11-OHCS levels in severe depressive illness. BMJ 1968, 3:285.
7. Chatzittofis A., Nordström P., Hellström C., Arver S., Asberg M., Jokinen J. CSF 5-HIAA, cortisol and DHEAS levels in suicide attempters. Eur. Neuropsychopharmacol. 2013, 23:1280-1287.
8. Coryell W., Schlesser M.A. Suicide and the dexamethasone suppression test in unipolar depression. Am. J. Psychiatry 1981, 138:1120-1121.
9. Coryell W., Schlesser M.A. The dexamethasone suppression test and suicide prediction. Am. J. Psychiatry 2001, 158:748-753.
10. Coryell W., Young E., Carroll B. Hyperactivity of the hypothalamic-pituitary-adrenal axis and mortality in major depressive disorder. Psychiatry Res. 2006, 142:99-104.
11. Ehnvall A., Sjogren M., Zachrisson O.C., Agren H. HPA axis activation determined by the CRH challenge test in patients with few versus multiple episodes of treatment-refractory depression. Eur. Arch. Psychiatry Clin. Neurosci. 2004, 254:349-355.
12. Ferrari E., Arcaini A., Goranti R., Pelanconi L., Cravello L., Fioravanti M., Solerte S.B., Magri F. Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia. Exp. Gerontol. 2000, 35:1239-1250.
13. Fries E., Hesse J., Hellhammer J., Hellhammer D.H. A new view of hypocortisolism. Psychoneuroendocrinology 2005, 30:1010-1016.
14. Gartland N., O'Connor D.B., Lawton R., Bristow M. Exploring day-to-day dynamics of daily stressor appraisals, physical symptoms and the cortisol awakening response. Psychoneuroendocrinology 2014, 50:130-138.
15. Giletta M., Calhoun C.D., Hastings P.D., Rudolph K.D., Nock M.K., Prinstein M.J. Multi-level risk factors for suicide ideation among at-risk adolescent females: the role of hypothalamic-pituitary-adrenal axis responses to stress. J. Abnorm. Child Psychol. 2015, 43:807-820.
16. Gmitrowicz A., Kołodziej-Maciejewska H. Dysfunction of the hypothalamic-pituitary-adrenal axis in adolescents after a suicide attempt. Psychiatr. Pol. 2002, 35:803-818.
17. Hawton K., van Heeringen K. Suicide. Lancet 2009, 373:1372-1381.
18. Hawton K., Saunders K.E.A., O'Connor R.C. Self-harm and suicide in adolescents. Lancet 2012, 379:2373-2382.
19. Hwang A., Peng L., Wen Y., Tsai Y., Chang L., Chiou S., Chen L. Predicting all-cause and cause specific mortality by static and dynamic measurements of allostatic load: a 10-year population-based cohort study in Taiwan. J. Am. Med. Dir. Assoc. 2014, 15:490-496.
20. Inder W.J., Donald R.A., Prickett T.C., Frampton C.M., Sullivan P.F., Mulder R.T., Joyce P.R. Arginine vasopressin is associated with hypercortisolemia and suicide attempts in depression. Biol. Psychiatry 1997, 42:744-747.
21. Jokinen J., Nordstrom P. HPA axis hyperactivity as suicide predictor in elderly mood disorder inpatients. Psychoneuroendocrinology 2008, 33:1387-1393.
22. Jokinen J., Nordstrom P. HPA axis hyperactivity and attempted suicide in young adult mood disorder inpatients. J. Affect. Disord. 2009, 116:117-120.
23. Jokinen J., Nordstrom A.L., Nordstrom P. CSF 5-HIAA and DST non-suppression-orthogonal biologic risk factors for suicide in male mood disorder inpatients. Psychiatry Res. 2009, 165:96-102.
24. Jokinen J., Ouda J., Nordstrom P. Noradrenergic function and HPA axis dysregulation in suicidal behaviour. Psychoneuroendocrinology 2010, 35:1536-1542.
25. Jollant F., Lawrence N.L., Olie E., Guillaume S., Courtet P. The suicidal mind and brain: a review of neuropsychological and neuroimaging studies. World J. Biol. Psychiatry 2011, 12:319-339.
26. Kamali M., Saunders E.F.H., Prossin A.R., Brucksch C.B., Harrington G.J., Langenecker S., McInnis M.G. Associations between suicide attempts and elevated bedtime salivary cortisol levels in bipolar disorder. J. Affect. Disord. 2012, 136:350-358.
27. Karlović D., Serretti A., Vrkić N., Martinac M., Marčinko D. Serum concentrations of CRP, IL-6, TNF-α and cortisol in major depressive disorder with melancholic or atypical features. Psychiatry Res. 2012, 198:74-80.
28. Keilp J.G., Oquendo M.A., Stanley B.H., Burke A.K., Cooper T.B., Malone K.M., Mann J.J. Future suicide attempt and responses to serotonergic challenge. Neuropsychopharmacology 2010, 35:1063-1072.
29. Kim B., Kang E.-S., Fava M., Mischoulon D., Soskin D., Yu B.-H., Jeon H.J. Follicle-stimulating hormone (FSH), current suicidal ideation and attempt in female patients with major depressive disorder. Psychiatry Res. 2013, 210:951-956.
30. Lindqvist D., Isaksson A., Träskman-Bendz L., Brundin L. Salivary cortisol and suicidal behavior-a follow-up study. Psychoneuroendocrinology 2008, 33:1061-1068.
31. Lindqvist D., Traskman-Bendz L., Vang F. Suicidal Intent and the HPA-axis characteristics of suicide attempters with major depressive disorder and adjustment disorder. Arch. Suicide Res. 2008, 12:197-207.
32. Mann J.J. The serotonergic system in mood disorders and suicidal behaviour. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2013, 368:20120537.
33. Mann J.J., Currier D. A review of prospective studies of biologic predictors of suicidal behavior in mood disorders. Arch. Suicide Res. 2007, 11:3-16.
34. Mann J.J., Waternaux C., Haas G.L., Malone K.M. Toward a clinical model of suicidal behavior in psychiatric patients. Am. J. Psychiatry 1999, 156:181-189.
35. Marcinko D., Martinac M., Karlović D., Filipcić I., Loncar C., Pivac N., Jakovljević M. Are there differences in serum cholesterol and cortisol concentrations between violent and non-violent schizophrenic male suicide attempters?. Coll. Antropol. 2005, 29:153-157.
36. Markianos M., Tripodianakis J., Istikoglou C., Rouvali O., Christopoulos M., Papageorgopoulos P., Seretis A. Suicide attempt by jumping: a study of gonadal axis hormones in male suicide attempters versus men who fell by accident. Psychiatry Res. 2009, 170:82-85.
37. McEwen B.S. Protective and damaging effects of stress mediators. NEJM 1998, 338:171-179.
38. McEwen B.S. Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology 2000, 22:108-124.
39. McGirr A., Diaconu G., Berlim M.T., Pruessner J.C., Sable R., Cabot S., Turecki G. Dysregulation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis and executive function in individuals at risk for suicide. J. Psychiatry Neurosci. 2010, 35:399-408.
40. McGirr A., Diaconu G., Berlim M.T., Turecki G. Personal and family history of suicidal behavior is associated with lower peripheral cortisol in depressed outpatients. J. Affect. Disord. 2011, 131:368-373.
41. Miller G.E., Chen E., Zhou E.S. If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol. Bull. 2007, 133:25-45.
42. Nock M.K., Borges G., Bromet E.J., Alonso J., Angermeyer M., Beautrais A., Bruffaerts R., TatChiu W., de Girolamo G., Gluzman S., de Graaf R., Gureje O., Haro J.M., Huang Y., Karam E., Kessler R.C., Lepine J.P., Levinson D., Medina-Mora M.E., Ono Y., Posada-Villa J., Williams D. Cross-national prevalence and risk factors for suicidal ideation, plans and attempts. Br. J. Psychiatry 2008, 192:98-105.
43. Norman W.H., Brown W., Miller I.W., Keitner G.I., Overholser J. The dexamethasone suppression test and completed suicide. Acta Psychiatr. Scand. 1990, 81:120-125.
44. O'Connor R.C. Towards an integrated motivational-volitional of suicidal behaviour. International Handbook of Suicide Prevention: Research, Policy and Practice 2011, 181-191. Wiley Blackwell. R. O'Connor, S. Platt, J. Gordon (Eds.).
45. O'Connor R.C., Nock M. The psychology of suicidal behaviour. Lancet Psychiatry 2014, 1:73-85.
46. O'Connor D.B., Hendrickx H., Dadd T., Talbot D., Mayes A., Elliman T., Willis T., Dye L. Cortisol awakening rise in middle-aged women in relation to chronic psychological stress. Psychoneuroendocrinology 2009, 34:1486-1494.
47. Ostroff R., Giller E., Bonese K. Neuroendocrine risk factors of suicidal behavior. Am. J. Psychiatry 1982, 139:1323-1325.
48. Pitchot W., Hansenne M., Gonzalez Moreno A., Ansseau M. The dexamethasone suppression test in violent suicide attempters with major depression. Biol. Psychiatry 1995, 37:273-274.
49. Pitchot W., Hansenne M., Pinto E., Reggers J., Fuchs S., Ansseau M. 5-Hydroxytryptamine 1A receptors, major depression, and suicidal behavior. Biol. Psychiatry 2005, 58:854-858.
50. Płocka-Lewandowska M., Araszkiewicz A., Rybakowski J.K. Dexamethasone suppression test and suicide attempts in schizophrenic patients. Eur. Psychiatry 2011, 16:428-431.
51. Pompili M., Serafini G., Innamorati M., Moller-Leimkuhler A.M., Giupponi G., Girardi P., Lester D. The hypothalamic-pituitary-adrenal axis and serotonin abnormalities: a selective overview for the implications of suicide prevention. Eur. Arch. Psychiatry Clin. Neurosci. 2010, 260:583-600.
52. Roberts B.W., Kuneel N.R., Shiner R., Caspi A., Goldberg L.E. The power of personality. Perspect. Psychol. Sci. 2007, 2:313-345.
53. Roy A. Hypothalamic-pituitary-adrenal axis function and suicidal behavior in depression. Biol. Psychiatry 1992, 32:812-816.
54. Saiz P., Bobes J., Gonzalez M. Searching for a predictive peripherical biological model in parasuicidal behavior. Eur. Psychiatry 1997, 12:75-81.
55. Sapolsky R.M., Romero L.M., Munck A.U. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 2000, 21:55-89.
56. Secunda S.K., Cross C.K., Koslow S., Katz M.M., Kocsis J., Maas J.W., Landis H. Biochemistry and suicidal behavior in depressed patients. Biol. Psychiatry 1986, 21:756-767.
57. Traskman L., Tybring G., Asberg M., Bertilsson L., Lantto O., Schalling D. Cortisol in the CSF of depressed and suicidal patients. Arch. Gen. Psychiatry 1980, 37:761-767.
58. Tripodianakis J., Markianos M., Sarantidis D., Leotsakou C. Neurochemical variables in subjects with adjustment disorder after suicide attempts. Eur. Psychiatry 2000, 15:190-195.
59. Turecki G., Ernst C., Jollant F., Labonte B., Mechawar N. The neurodevelopmental origins of suicidal behavior. Trends Neurosci. 2012, 35:14-23.
60. van Heeringen K., Mann J.J. The neurobiology of suicide. Lancet Psychiatry 2014, 1:63-72.
61. van Heeringen K., Audenaert K., Van de Wiele L., Verstraete A. Cortisol in violent suicidal behavior: association with personality and monoaminergic activity. J. Affect. Disord. 2000, 60:181-189.
62. van Heeringen C., Bijttebier S., Godfrin K. Suicidal brains: a review of functional and structural brain studies in association with suicidal behaviour. Neurosci. Biobehav. Rev. 2011, 35:688-698.
63. van Honk J., Shutter D.J., Hermans E.J., Putman P. Low cortisol levels and the balance between punishment sensitivity and reward dependency. Neuroreport 2003, 14:1993-1996.
64. van Orden K.A., Witte T.K., Cukrowicz K.C., Braithwaite S.R., Selby E.A., Joiner T.E. The interpersonal theory of suicide. Psychol. Rev. 2010, 117:575-600.
65. Westrin A., Ekman R., Träskman-Bendz L. Alterations of corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) plasma levels in mood disorder patients with a recent suicide attempt. Eur. Neuropsychopharmacology 1999, 9:205-211.
66. World Health Organization, 2014. Preventing suicide: a global imperative. Geneva, Switzerland.
67. Yehuda R., Kahana B., Binder-Brynes K., Southwick S.M., Mason J.W., Giller E.L. Low urinary cortisol excretion in Holocaust survivors with posttraumatic stress disorder. Am. J. Psychiatry 1995, 152:982-986.
68. Yehuda R., Golier J.A., Kaufman S. Circadian rhythm of salivary cortisol in Holocaust survivors with and without PTSD. Am. J. Psychiatry 2005, 162:998-1000.