Future suicide attempt and responses to serotonergic challenge

Neuropsychopharmacology

Volumn 35, Issue 5, 2010, Pages 1063-1072

  Keilp, John G ^a,b   Oquendo, Maria A ^a,b   Stanley, Barbara H ^a,b   Burke, Ainsley K ^a,b   Cooper, Thomas B ^a,b   Malone, Kevin M ^a,b   Mann, J John ^a,b  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

Challenge test; Cortisol; Depression; Prolactin; Serotonin; Suicide

Indexed keywords

FENFLURAMINE; HYDROCORTISONE; NORFENFLURAMINE; PLACEBO; PROLACTIN;

ADULT; AGE DISTRIBUTION; ANXIETY; ARTICLE; BEHAVIOR; CLINICAL ARTICLE; CLINICAL TRIAL; CONFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DIZZINESS; DRUG BLOOD LEVEL; DRUG EFFECT; FATIGUE; FEMALE; FINGER; FOLLOW UP; FUTUROLOGY; HORMONE RESPONSE; HUMAN; HYDROCORTISONE BLOOD LEVEL; MALE; MOOD; NAUSEA; PREDICTION; PRIORITY JOURNAL; PROFILE OF MOOD STATES; PROLACTIN BLOOD LEVEL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; RISK FACTOR; SCORING SYSTEM; SEROTONINERGIC SYSTEM; SUICIDAL IDEATION; SUICIDE ATTEMPT;

ADULT; AFFECT; AGE FACTORS; AREA UNDER CURVE; DEPRESSIVE DISORDER; FATIGUE; FEMALE; FENFLURAMINE; FOLLOW-UP STUDIES; HUMANS; HYDROCORTISONE; LOGISTIC MODELS; MALE; MIDDLE AGED; MOTOR ACTIVITY; PROLACTIN; PSYCHIATRIC STATUS RATING SCALES; SEROTONIN AGENTS; SUICIDE, ATTEMPTED; TIME FACTORS;

EID: 77949513180     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2008.28     Document Type: Article

References (50)

1. Aardal-Eriksson E, Karlberg BE, Holm AC (1998). Salivary cortisolFan alternative to serum cortisol determinations in dynamic function tests. Clin Chem Lab Med 36: 215-222.
2. Barratt ES (1985). Impulsiveness defined within a system model of personality. In: Spielberger CD, Butcher JN (eds). Advances in Personality Assessment, Vol.5, Earlbaum: New York. pp 113-132.
3. Barratt ES (1994). Impulsivity and aggression. In: Monahan J, Steadman HJ (eds). Violence and Mental Disorder: Developments in Risk Assessment. University of Chicago Press: Chicago. pp 61-80.
4. Beck AT, Beck R, Kovacs M (1975). Classification of suicidal behaviors: I. Quantifying intent and medical lethality. Am J Psychiatry 132: 285-287.
5. Beck AT, Kovacs M, Weissman A (1979). Assessment of suicidal intention: the Scale for Suicide Ideation. J Consult Clin Psychol 47: 343-352.
6. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961). An inventory for measuring depression. Arch Gen Psychiatry 4: 561-571.
7. Beck AT, Weissman A, Lester D, Trexler L (1974). The measurement of pessimism: the hopelessness scale. J Consult Clin Psychol 42: 861-865.
8. Bhagwagar Z, Hafizi S, Cowen PJ (2002a). Acute citalopram administration produces correlated increases in plasma and salivary cortisol. Psychopharmacology (Berlin) 163: 118-120.
9. Bhagwagar Z, Whale R, Cowen PJ (2002b). State and trait abnormalities in serotonin function in major depression. Br J Psychiatry 180: 24-28.
10. Brodsky BS, Oquendo M, Ellis SP, Haas GL, Malone KM, Mann JJ (2001). The relationship of childhood abuse to impulsivity and suicidal behavior in adults with major depression. Am J Psychiatry 158: 1871-1877.
11. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF (1979). Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res 1: 131-139.
12. Buss AR, Durkee A (1961). An inventory for assessing different kinds of hostility. J Consult Psychol 21: 343-349.
13. Cleare AJ, Murray RM, O'Keane V (1996). Reduced prolactin and cortisol responses to D-fenfluramine in depressed compared to healthy matched control subjects. Neuropsychopharmacology 14: 349-354.
14. Coccaro EF, Siever LJ, Klar HM, Maurer G, Cochrane K, Cooper TB et al (1989). Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry 46: 587-599.
15. Correa H, Duval F, Mokrani M, Bailey P, Tremeau F, Staner L et al (2000). Prolactin response to D-fenfluramine and suicidal behavior in depressed patients. Psychiatry Res 93: 189-199.
16. Dulchin MC, Oquendo MA, Malone KM, Ellis SP, Li S, Mann JJ (2001). Prolactin response to DL-fenfluramine challenge before and after treatment with paroxetine. Neuropsychopharmacology 25: 395-401.
17. Duval F, Mokrani MC, Correa H, Bailey P, Valdebenito M, Monreal J et al (2001). Lack of effect of HPA axis hyperactivity on hormonal responses to D-fenfluramine in major depressed patients: implications for pathogenesis of suicidal behaviour. Psychoneuro-endocrinology 26: 521-537.
18. First MB, Spitzer RL, Gibbon M, Williams JBW (1997). Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Non-patient Edition. New York State Psychiatric Institute: New York, NY.
19. First MB, Spitzer RL, Gibbon M, Williams JBW, Loma B (1996). Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II), Version 2.0. Biometric Research Department, New York State Psychiatric Institute: New York.
20. Flory JD, Mann JJ, Manuck SB, Muldoon MF (1998). Recovery from major depression is not associated with normalization of serotonergic function. Biol Psychiatry 43: 320-326.
21. Flory JD, Manuck SB, Perel JM, Muldoon MF (2004). A comparison of D, L-fenfluramine and citalopram challenges in healthy adults. Psychopharmacology 174: 376-380.
22. Grunebaum MF, Galfalvy HC, Oquendo MA, Burke AK, Mann JJ (2004). Melancholia and the probability and lethality of suicide attempts. Br J Psychiatry 184: 534-535.
23. Grunebaum MF, Keilp J, Li S, Ellis SP, Burke AK, Oquendo MA et al (2005). Symptom components of standard depression scales and past suicidal behavior. J Affect Disord 87: 73-82.
24. Hamilton M (1960). A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56-62.
25. Heim C, Nemeroff CB (2001). The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry 49: 1023-1039.
26. Jokinen J, Carlborg A, Martensson B, Forslund K, Nordstrom AL, Nordstrom P (2007). DST non-suppression predicts suicide after attempted suicide. Psychiatry Res 150: 297-303.
27. Kegeles LS, Malone KM, Slifstein M, Ellis SP, Xanthopoulos E, Keilp JG et al (2003). Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders. Am J Psychiatry 160: 76-82.
28. Malone KM, Corbitt EM, Li S, Mann JJ (1996). Prolactin response to fenfluramine and suicide attempt lethality in major depression. Br J Psychiatry 168: 324-329.
29. Mann JJ (2003). Neurobiology of suicidal behaviour. Nat Rev Neurosci 4: 819-828.
30. Mann JJ, Currier D (2007). A review of prospective studies of biologic predictors of suicidal behavior in mood disorders. Arch Suicide Res 11: 3-16.
31. Mann JJ, Waternaux C, Haas GL, Malone KM (1999). Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiatry 156: 181-189.
32. Manuck SB, Flory JD, McCaffery JM, Matthews KA, Mann JJ, Muldoon MF (1998). Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology 19: 287-299.
33. Manuck SB, Flory JD, Muldoon MF, Ferrell RE (2002). Central nervous system serotonergic responsivity and aggressive disposition in men. Physiol Behav 77: 705-709.
34. McNair DM, Lorr M, Droppleman LF (1981). Manual for the Profile of Mood States. Educational and Industrial Testing Service: San Diego.
35. New AS, Trestman RF, Mitropoulou V, Goodman M, Koenigsberg HH, Silverman J et al (2004). Low prolactin response to fenfluramine in impulsive aggression. J Psychiatr Res 38: 223-230.
36. Newman ME, Shapira B, Lerer B (1998). Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review. Int J Neuropsycho-pharmcol 1: 49-69.
37. Oquendo MA, Echavarria G, Galfalvy HC, Grunebaum MF, Burke A, Barrera A et al (2003a). Lower cortisol levels in depressed patients with comorbid post-traumatic stress disorder. Neuropsychopharmacology 28: 591-598.
38. Oquendo MA, Friend JM, Halberstam B, Brodsky BS, Burke AK, Gruenbaum MF et al (2003b). Association of comorbid posttraumatic stress disorder and major depression with greater risk for suicidal behavior. Am J Psychiatry 160: 580-582.
39. Oquendo MA, Halberstam B, Mann JJ (2003c). Risk factors for suicidal behavior: the utility and limitations of research instruments. In: First M (ed). Standardized Evaluation in Clinical Practice, Review of Psychiatry, Vol.22, American Psychiatric Publishing: Washington, DC. pp 103-130.
40. Oquendo MA, Placidi GP, Malone KM, Campbell C, Keilp J, Brodsky B et al (2003d). Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Arch Gen Psychiatry 60: 14-22.
41. Perlis RH, Beasley Jr CM, Wines Jr JD, Tamura RN, Cusin C, Shear D et al (2007). Treatment-associated suicidal ideation and adverse effects in an open, multicenter trial of fluoxetine for major depressive episodes. Psychother Psychosom 76: 40-46.
42. Pfennig A, Kunzel HE, Kern N, Ising M, Majer M, Fuchs B et al (2005). Hypothalamus-pituitary-adrenal system regulation and suicidal behavior in depression. Biol Psychiatry 57: 336-342.
43. Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration vs time-dependent change. Neuropsychoendocrinology 28: 916-931.
44. Reitan RM, Wolfson D (1985). The Halstead-Reitan Neuropsycho-logical Test Battery. Neuropsychology Press: Tucson, Arizona.
45. Soloff PH, Kelly TM, Strotmeyer SJ, Malone KM, Mann JJ (2003). Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. Psychiatry Res 119: 11-24.
46. Spitzer RL, Williams JBW, Gibbon M, First MB (1990). Instruction Manual for the Structured Clinical Interview for the DSM-IV (SCID-P). American Psychiatric Press: Washington, DC.
47. Spreen O, Strauss E (1998). A Compendium of Neuropsychological Tests. Oxford University Press: New York.
48. Taylor MJ, Freemantle N, Geddes JR, Bhagwagar Z (2006). Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis. Arch Gen Psychiatry 63: 1217-1223.
49. Yehuda R (2001). Biology of posttraumatic stress disorder. J Clin Psychiatry 62: 41-46.
50. Yehuda R, LeDoux J (2007). Response variation following trauma: a translational neuroscience approach to understanding PTSD. Neuron 56: 19-32.