Gemcitabine and mitomycin induced autophagy regulates cancer stem cell pool in urothelial carcinoma cells

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1863, Issue 2, 2016, Pages 347-359

  Ojha, Rani ^a   Jha, V ^a   Singh, S K ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Apoptosis; Autophagy; Cancer stem cells; Chemotherapy; Glycolysis; Urothelial carcinoma

Indexed keywords

BECLIN 1; BREAST CANCER RESISTANCE PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; GEMCITABINE; MITOMYCIN; MULTIDRUG RESISTANCE PROTEIN 1; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; ANTINEOPLASTIC AGENT; ATG7 PROTEIN, HUMAN; DEOXYCYTIDINE; UBIQUITIN PROTEIN LIGASE;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL CULTURE; CANCER STEM CELL; CARCINOMA CELL; CELL DEATH; CELL PROLIFERATION; CELL SURFACE; CELL SURVIVAL; CELL VIABILITY; CONFOCAL MICROSCOPE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICROSCOPY; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; PHENOTYPE; PRIORITY JOURNAL; TRANSITIONAL CELL CARCINOMA; WESTERN BLOTTING; ADULT; AGED; ANALOGS AND DERIVATIVES; BLADDER TUMOR; DRUG EFFECTS; DRUG RESISTANCE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL CULTURE; YOUNG ADULT;

ADULT; AGED; ANTINEOPLASTIC AGENTS; AUTOPHAGY; BLOTTING, WESTERN; CARCINOMA, TRANSITIONAL CELL; DEOXYCYTIDINE; DRUG RESISTANCE, NEOPLASM; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOLYSIS; HUMANS; MALE; MIDDLE AGED; MITOMYCIN; NEOPLASTIC STEM CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELLS, CULTURED; UBIQUITIN-ACTIVATING ENZYMES; URINARY BLADDER NEOPLASMS; YOUNG ADULT;

EID: 84949845105     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2015.12.002     Document Type: Article

References (39)

1. Witjes J.A., Compérat E., Cowan N.C., De Santis M., Gakis G., Lebret T., Ribal M.J., Vander Heijden A.G., Sherif A. EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines. Eur. Urol. 2014, 65:778-792.
2. Knowles M.A., Hurst C.D. Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity. Nat. Rev. Cancer 2015, 15:25-41.
3. Apolo A.B., Grossman H.B., Bajorin D., Steinberg G., Kamat A.M. Practical use of perioperative chemotherapy for muscle-invasive bladder cancer: summary of session at the Society of Urologic Oncology annual meeting. Urol. Oncol. 2012, 30:772-780.
4. Choueiri T.K., Raghavan D. Chemotherapy for muscle-invasive bladder cancer treated with definitive radiotherapy: persisting uncertainties. Nat. Clin. Pract. Oncol. 2008, 5:444-454.
5. Kurtova A.V., Xiao J., Mo Q., Pazhanisamy S., Krasnow R., Lerner S.P., Chen F., Roh T.T., Lay E., Ho P.L., et al. Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. Nature 2015, 8:209-213.
6. Zhang Y., Wang Z., Yu J., Jz S., Wang C., Wh F., Zw C., Yang J. Cancer stem-like cells contribute to cisplatin resistance and progression in bladder cancer. Cancer Lett. 2012, 1:70-77.
7. Tirino V., Desiderio V., Paino F., De Rosa A., Papaccio F., La Noce M., Laino L., De Francesco F., Papaccio G. Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization. FASEB J. 2013, 27:13-24.
8. Visvader J.E., Lindeman G.J. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat. Rev. Cancer 2008, 8:755-768.
9. Ojha R., Jha V., Singh S.K., Bhattacharyya S. Autophagy inhibition suppresses the tumorigenic potential of cancer stem cell enriched side population in bladder cancer. Biochim. Biophys. Acta 1842, 2014:2073-2086.
10. Zhang H., Baehrecke E.H. Eaten alive: novel insights into autophagy from multicellular model systems. Trends Cell Biol. 2015, 25:376-387.
11. Rabinowitz J.D., White E. Autophagy and metabolism. Science 2010, 3:1344-1348.
12. Lock R., Roy S., Kenific C.M., Su J.S., Salas E., Ronen S.M., Debnath J. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol. Biol. Cell 2011, 15:165-178.
13. McCoy M.K., Kaganovich A., Rudenko I.N., Ding J., Cookson M.R. Hexokinase activity is required for recruitment of parkin to depolarized mitochondria. Hum. Mol. Genet. 2014, 1:145-156.
14. Cheong H., Lu C., Lindsten T., Thompson C.B. Therapeutic targets in cancer cell metabolism and autophagy. Nat. Biotechnol. 2012, 30:671-678.
15. DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008, 7:11-20.
16. Liu P.P., Liao J., Tang Z.J., Wu W.J., Yang J., Zeng Z.L., et al. Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway. Cell Death Differ. 2014, 21:124-135.
17. Eble J.N., Sauter G., Epstein J., Sesterhenn I.A. WHO Classification of Tumors of the Urinary System and Male Genital Organs 2004, IARC Press, Lyon, France.
18. Hepburn A.C., Veeratterapillay R., Williamson S.C., El-Sherif A., Sahay N., Thomas H.D., Mantilla A., Pickard R.S., Robson C.N., Heer R. Side population in human non-muscle invasive bladder cancer enriches for cancer stem cells that are maintained by MAPK signalling. PLoS ONE 2012, 7.
19. Liu P.P., Liao J., Tang Z.J., Wu W.J., Yang J., Zeng Z.L., Hu Y., Wang P., Ju H.Q., Xu R.H., et al. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis. 2013, 4.
20. Cao L., Zhou Y., Zhai B., Liao J., Xu W., Zhang R., Li J., Zhang Y., Chen L., Qian H., et al. Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. BMC Gastroenterol. 2011, 11:1-11.
21. Ogasawara M.A., Zhang H. Redox regulation and its emerging roles in stem cells and stem-like cancer cells. Antioxid. Redox Signal. 2009, 11:1107-1122.
22. Richard V., Nair M.G., Santhosh Kumar T.R., Pillai M.R. Side population cells as prototype of chemoresistant, tumor-initiating cells. Biomed. Res. Int. 2013, 2013:517237.
23. Ojha R., Bhattacharyya S., Singh S.K. Autophagy in cancer stem cells: a potential link between chemoresistance, recurrence, and metastasis. BioResearch Open Access. 2015, 4:97-108.
24. Hama A., Codogno P., Mehrpour M. Cancer stem cells and autophagy: facts and perspectives. J. Cancer Stem Cell Res. 2014, 2.
25. Justus C.R., Sanderlin E.J., Yang L.V. Molecular connections between cancer cell metabolism and the tumor microenvironment. Int. J. Mol. Sci. 2015, 16:11055-11086.
26. Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
27. Elmore S. Apoptosis: a review of programmed cell death. Toxicol. Pathol. 2007, 35:495-516.
28. Amaravadi R.K. Autophagy-induced tumor dormancy in ovarian cancer. J. Clin. Invest. 2008, 118:3837-3840.
29. Chen S., Rehman S.K., Zhang W., Wen A., Yao L., Zhang J. Autophagy is a therapeutic target in anticancer drug resistance. Biochim. Biophys. Acta 1806, 2010:220-229.
30. Cheung-Ong K., Giaever G., Nislow C. DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology. Chem. Biol. 2013, 23:648-659.
31. Hall M.C., Chang S.S., Dalbagni G., Pruthi R.S., Seigne J.D., Skinner E.C., Wolf J.S., Schellhammer P.F. Guideline for the management of nonmuscle invasive bladder cancer (stages Ta, T1, and Tis): 2007 update. J. Urol. 2007, 178:2314-2330.
32. Ishaq M., Khan M.A., Sharma K., Sharma G., Dutta R.K., Majumdar S. Gambogic acid induced oxidative stress dependent caspase activation regulates both apoptosis and autophagy by targeting various key molecules (NF-kappa B, Beclin-1, p62 and NBR1) in human bladder cancer cells. Biochim. Biophys. Acta 1840, 2014:3374-3384.
33. Ning Z.F., Huang Y.J., Lin T.X., Zhou Y.X., Jiang C., Xu K.W., Huang H., Yin X.B., Huang J. Subpopulations of stem-like cells in side population cells from the human bladder transitional cell cancer cell line T24. J. Int. Med. Res. 2009, 37:621-630.
34. Auffinger B., Tobias A.L., Han Y., Lee G., Guo D., Dey M., Lesniak M.S., Ahmed A.U. Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy. Cell Death Differ. 2014, 21:1119-1131.
35. Ojha R., Singh S.K., Bhattacharyya S., Dhanda R.S., Rakha A., Mandal A.K., Jha V. Inhibition of grade dependent autophagy in urothelial carcinoma increases cell death under nutritional limiting condition and potentiates the cytotoxicity of chemotherapeutic agent. J. Urol. 2014, 191:1889-1898.
36. Amaravadi R.K., Lippincott-Schwartz J., Yin X.M., Weiss W.A., Takebe N., Timmer W., DiPaola R.S., Lotze M.T., White E. Principles and current strategies for targeting autophagy for cancer treatment. Clin. Cancer Res. 2011, 15:654-666.
37. Modok S., Mellor H.R., Callaghan R. Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer. Curr. Opin. Pharmacol. 2006, 6:350-354.
38. Folmes C.D., Dzeja P.P., Nelson T.J., Terzic A. Metabolic plasticity in stem cell homeostasis and differentiation. Cell Stem Cell 2012, 11:596-606.
39. Chen C.T., Shih Y.R., Kuo T.K., Lee O.K., Wei Y.H. Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells. Stem Cells 2008, 26:960-968.