Development and validation of a new dynamic computer-controlled model of the human stomach and small intestine

Biotechnology and Bioengineering

Volumn 113, Issue 6, 2016, Pages 1325-1335

  Guerra, Aurélie ^a   Denis, Sylvain ^a   le Goff, Olivier ^a   Sicardi, Vincent ^a   François, Olivier ^b   Yao, Anne Françoise ^a   Garrait, Ghislain ^a   Manzi, Aimé Pacifique ^a   Beyssac, Eric ^a   Alric, Monique ^a   Blanquet Diot, Stéphanie ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b Protolab   (France)

Author keywords

Bioaccessibility; Dynamic gastrointestinal model; ESIN; Immediate and sustained release forms; In vitro in vivo correlation (IVIVC); Pharmaceutical behavior

Indexed keywords

DESIGN; DIGESTIVE SYSTEM; PHYSIOLOGICAL MODELS; PHYSIOLOGY;

BIOACCESSIBILITY; ESIN; GASTROINTESTINAL MODEL; IN-VITRO; SUSTAINED RELEASE;

DRUG PRODUCTS;

PARACETAMOL; THEOPHYLLINE; BIOMIMETIC MATERIAL;

ADULT; ARTICLE; COMPUTER MODEL; DIGESTION; DRUG DOSAGE FORM; DRUG SOLUBILITY; GASTROINTESTINAL ABSORPTION; HUMAN; HUMAN EXPERIMENT; INTESTINAL SECRETION; INTESTINE TRANSIT TIME; MEAL; NORMAL HUMAN; SMALL INTESTINE; STOMACH; STOMACH EMPTYING; STOMACH PH; SUSTAINED RELEASE FORMULATION; TABLET FORMULATION; TABLET MATRIX; VALIDATION STUDY; BIOLOGICAL MODEL; COMPUTER SIMULATION; DEVICE FAILURE ANALYSIS; EQUIPMENT DESIGN; EVALUATION STUDY; GASTROINTESTINAL MOTILITY; PHYSIOLOGY;

BIOMIMETIC MATERIALS; COMPUTER SIMULATION; DIGESTION; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; GASTROINTESTINAL MOTILITY; HUMANS; INTESTINE, SMALL; MODELS, BIOLOGICAL; STOMACH;

EID: 84949843919     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25890     Document Type: Article

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