메뉴 건너뛰기




Volumn 21, Issue 10, 2016, Pages 1342-1350

A genome-wide association study of kynurenic acid in cerebrospinal fluid: Implications for psychosis and cognitive impairment in bipolar disorder

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; INTERLEUKIN 1BETA; KYNURENIC ACID; SORTING NEXIN;

EID: 84949843575     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2015.186     Document Type: Article
Times cited : (71)

References (49)
  • 1
    • 0035798252 scopus 로고    scopus 로고
    • Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
    • Erhardt S, Blennow K, Nordin C, Skogh E, Lindstrom LH, Engberg G. Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia. Neurosci Lett 2001; 313: 96-98.
    • (2001) Neurosci Lett , vol.313 , pp. 96-98
    • Erhardt, S.1    Blennow, K.2    Nordin, C.3    Skogh, E.4    Lindstrom, L.H.5    Engberg, G.6
  • 4
    • 84857632874 scopus 로고    scopus 로고
    • Subchronic elevation of brain kynurenic acid augments amphetamine-induced locomotor response in mice
    • Olsson SK, Larsson MK, Erhardt S. Subchronic elevation of brain kynurenic acid augments amphetamine-induced locomotor response in mice. J Neural Transm 2012; 119: 155-163.
    • (2012) J Neural Transm , vol.119 , pp. 155-163
    • Olsson, S.K.1    Larsson, M.K.2    Erhardt, S.3
  • 5
    • 84860159640 scopus 로고    scopus 로고
    • Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia
    • Linderholm KR, Skogh E, Olsson SK, Dahl ML, Holtze M, Engberg G et al. Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia. Schizophr Bull 2012; 38: 426-432.
    • (2012) Schizophr Bull , vol.38 , pp. 426-432
    • Linderholm, K.R.1    Skogh, E.2    Olsson, S.K.3    Dahl, M.L.4    Holtze, M.5    Engberg, G.6
  • 6
    • 79960312085 scopus 로고    scopus 로고
    • Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophe-notypes
    • Wonodi I, Stine OC, Sathyasaikumar KV, Roberts RC, Mitchell BD, Hong LE et al. Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophe-notypes. Arch Gen Psychiatry 2011; 68: 665-674.
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 665-674
    • Wonodi, I.1    Stine, O.C.2    Sathyasaikumar, K.V.3    Roberts, R.C.4    Mitchell, B.D.5    Hong, L.E.6
  • 7
    • 84894560873 scopus 로고    scopus 로고
    • The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression
    • Lavebratt C, Olsson S, Backlund L, Frisen L, Sellgren C, Priebe L et al. The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression. Mol Psychiatry 2014; 19: 334-341.
    • (2014) Mol Psychiatry , vol.19 , pp. 334-341
    • Lavebratt, C.1    Olsson, S.2    Backlund, L.3    Frisen, L.4    Sellgren, C.5    Priebe, L.6
  • 8
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in the mammalian brain: When physiology meets pathology
    • Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ. Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 2012; 13: 465-477.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3    Wu, H.Q.4
  • 11
    • 0028323167 scopus 로고
    • Sub-anesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses
    • Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD et al. Sub-anesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 1994; 51: 199-214.
    • (1994) Arch Gen Psychiatry , vol.51 , pp. 199-214
    • Krystal, J.H.1    Karper, L.P.2    Seibyl, J.P.3    Freeman, G.K.4    Delaney, R.5    Bremner, J.D.6
  • 13
    • 0004485680 scopus 로고    scopus 로고
    • Prevalence and description of psychotic features in bipolar mania
    • Dunayevich E, Keck PE Jr. Prevalence and description of psychotic features in bipolar mania. Curr Psychiatry Rep 2000; 2: 286-290.
    • (2000) Curr Psychiatry Rep , vol.2 , pp. 286-290
    • Dunayevich, E.1    Keck, P.E.2
  • 14
    • 84868092047 scopus 로고    scopus 로고
    • Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar i disorder
    • Olsson SK, Sellgren C, Engberg G, Landen M, Erhardt S. Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar I disorder. Bipolar Disord 2012; 14: 719-726.
    • (2012) Bipolar Disord , vol.14 , pp. 719-726
    • Olsson, S.K.1    Sellgren, C.2    Engberg, G.3    Landen, M.4    Erhardt, S.5
  • 15
    • 84858445314 scopus 로고    scopus 로고
    • Acute elevations of brain kynurenic acid impair cognitive flexibility: Normalization by the alpha7 positive modulator galantamine
    • Alexander KS, Wu HQ, Schwarcz R, Bruno JP. Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine. Psychopharmacology 2012; 220: 627-637.
    • (2012) Psychopharmacology , vol.220 , pp. 627-637
    • Alexander, K.S.1    Wu, H.Q.2    Schwarcz, R.3    Bruno, J.P.4
  • 17
    • 77954856199 scopus 로고    scopus 로고
    • The International Society for Bipolar Disorders-Battery for Assessment of Neuro-cognition (ISBD-BANC)
    • Yatham LN, Torres IJ, Malhi GS, Frangou S, Glahn DC, Bearden CE et al. The International Society for Bipolar Disorders-Battery for Assessment of Neuro-cognition (ISBD-BANC). Bipolar Disord 2010; 12: 351-363.
    • (2010) Bipolar Disord , vol.12 , pp. 351-363
    • Yatham, L.N.1    Torres, I.J.2    Malhi, G.S.3    Frangou, S.4    Glahn, D.C.5    Bearden, C.E.6
  • 18
    • 77956254099 scopus 로고    scopus 로고
    • Neurocognitive markers of psychosis in bipolar disorder: A meta-analytic study
    • Bora E, Yucel M, Pantelis C. Neurocognitive markers of psychosis in bipolar disorder: a meta-analytic study. J Affect Disord 2010; 127: 1-9.
    • (2010) J Affect Disord , vol.127 , pp. 1-9
    • Bora, E.1    Yucel, M.2    Pantelis, C.3
  • 20
    • 58149464318 scopus 로고    scopus 로고
    • Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: A population-based study
    • Lichtenstein P, Yip BH, Bjork C, Pawitan Y, Cannon TD, Sullivan PF et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009; 373: 234-239.
    • (2009) Lancet , vol.373 , pp. 234-239
    • Lichtenstein, P.1    Yip, B.H.2    Bjork, C.3    Pawitan, Y.4    Cannon, T.D.5    Sullivan, P.F.6
  • 21
    • 84883465830 scopus 로고    scopus 로고
    • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
    • Cross-Disorder Group of the Psychiatric Genomics C, Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013; 45: 984-994.
    • (2013) Nat Genet , vol.45 , pp. 984-994
    • Lee, S.H.1    Ripke, S.2    Neale, B.M.3    Faraone, S.V.4    Purcell, S.M.5
  • 22
    • 0038823525 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatry: Etymology and strategic intentions
    • Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636-645.
    • (2003) Am J Psychiatry , vol.160 , pp. 636-645
    • Gottesman, I.I.1    Gould, T.D.2
  • 23
    • 21244432332 scopus 로고    scopus 로고
    • Test review: Delis-Kaplan executive function system
    • Homack S, Lee D, Riccio CA. Test review: Delis-Kaplan executive function system. J Clin Exp Neuropsychol 2005; 27: 599-609.
    • (2005) J Clin Exp Neuropsychol , vol.27 , pp. 599-609
    • Homack, S.1    Lee, D.2    Riccio, C.A.3
  • 24
    • 84866358306 scopus 로고    scopus 로고
    • Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder
    • Bergen SE, O'Dushlaine CT, Ripke S, Lee PH, Ruderfer DM, Akterin S et al. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Mol Psychiatry 2012; 17: 880-886.
    • (2012) Mol Psychiatry , vol.17 , pp. 880-886
    • Bergen, S.E.1    O'Dushlaine, C.T.2    Ripke, S.3    Lee, P.H.4    Ruderfer, D.M.5    Akterin, S.6
  • 25
    • 80055015161 scopus 로고    scopus 로고
    • Temporal dynamics and genetic control of transcription in the human prefrontal cortex
    • Colantuoni C, Lipska BK, Ye T, Hyde TM, Tao R, Leek JT et al. Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Nature 2011; 478: 519-523.
    • (2011) Nature , vol.478 , pp. 519-523
    • Colantuoni, C.1    Lipska, B.K.2    Ye, T.3    Hyde, T.M.4    Tao, R.5    Leek, J.T.6
  • 26
  • 27
    • 77955813487 scopus 로고    scopus 로고
    • Serum inflammatory proteins and frontal lobe dysfunction in patients with cardiovascular risk factors
    • Hoshi T, Yamagami H, Furukado S, Miwa K, Tanaka M, Sakaguchi M et al. Serum inflammatory proteins and frontal lobe dysfunction in patients with cardiovascular risk factors. Eur J Neurol 2010; 17: 1134-1140.
    • (2010) Eur J Neurol , vol.17 , pp. 1134-1140
    • Hoshi, T.1    Yamagami, H.2    Furukado, S.3    Miwa, K.4    Tanaka, M.5    Sakaguchi, M.6
  • 28
    • 0036096937 scopus 로고    scopus 로고
    • Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid
    • Erhardt S, Engberg G. Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid. Acta Physiol Scand 2002; 175: 45-53.
    • (2002) Acta Physiol Scand , vol.175 , pp. 45-53
    • Erhardt, S.1    Engberg, G.2
  • 29
    • 84907887015 scopus 로고    scopus 로고
    • Statistical mediation analysis with a multicategorical independent variable
    • Hayes AF, Preacher KJ. Statistical mediation analysis with a multicategorical independent variable. Br J Math Stat Psychol 2013; 67: 451-470.
    • (2013) Br J Math Stat Psychol , vol.67 , pp. 451-470
    • Hayes, A.F.1    Preacher, K.J.2
  • 30
    • 79952256739 scopus 로고    scopus 로고
    • The architecture of gene regulatory variation across multiple human tissues: The MuTHER study
    • Nica AC, Parts L, Glass D, Nisbet J, Barrett A, Sekowska M et al. The architecture of gene regulatory variation across multiple human tissues: the MuTHER study. PLoS Genet 2011; 7: e1002003.
    • (2011) PLoS Genet , vol.7 , pp. e1002003
    • Nica, A.C.1    Parts, L.2    Glass, D.3    Nisbet, J.4    Barrett, A.5    Sekowska, M.6
  • 31
    • 84874368349 scopus 로고    scopus 로고
    • Activating RNAs associate with Mediator to enhance chromatin architecture and transcription
    • Lai F, Orom UA, Cesaroni M, Beringer M, Taatjes DJ, Blobel GA et al. Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature 2013; 494: 497-501.
    • (2013) Nature , vol.494 , pp. 497-501
    • Lai, F.1    Orom, U.A.2    Cesaroni, M.3    Beringer, M.4    Taatjes, D.J.5    Blobel, G.A.6
  • 32
    • 84055185227 scopus 로고    scopus 로고
    • Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: Structures, functions and roles in disease
    • Teasdale RD, Collins BM. Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease. Biochem J 2012; 441: 39-59.
    • (2012) Biochem J , vol.441 , pp. 39-59
    • Teasdale, R.D.1    Collins, B.M.2
  • 33
    • 84861570317 scopus 로고    scopus 로고
    • An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish
    • Xu L, Yin W, Xia J, Peng M, Li S, Lin S et al. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Hepatology 2012; 55: 1985-1993.
    • (2012) Hepatology , vol.55 , pp. 1985-1993
    • Xu, L.1    Yin, W.2    Xia, J.3    Peng, M.4    Li, S.5    Lin, S.6
  • 35
    • 84857166396 scopus 로고    scopus 로고
    • A new path to IL-1beta production controlled by caspase-8
    • Dupaul-Chicoine J, Saleh M. A new path to IL-1beta production controlled by caspase-8. Nat Immunol 2012; 13: 211-212.
    • (2012) Nat Immunol , vol.13 , pp. 211-212
    • Dupaul-Chicoine, J.1    Saleh, M.2
  • 36
    • 84908670910 scopus 로고    scopus 로고
    • IL-1beta increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells
    • Urata Y, Koga K, Hirota Y, Akiyama I, Izumi G, Takamura M et al. IL-1beta increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells. Am J Reprod Immunol 2014; 72: 496-503.
    • (2014) Am J Reprod Immunol , vol.72 , pp. 496-503
    • Urata, Y.1    Koga, K.2    Hirota, Y.3    Akiyama, I.4    Izumi, G.5    Takamura, M.6
  • 37
    • 33644963618 scopus 로고    scopus 로고
    • Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder
    • Miller CL, Llenos IC, Dulay JR, Weis S. Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res 2006; 1073-1074: 25-37.
    • (2006) Brain Res , vol.1073-1074 , pp. 25-37
    • Miller, C.L.1    Llenos, I.C.2    Dulay, J.R.3    Weis, S.4
  • 38
    • 71049173312 scopus 로고    scopus 로고
    • The role of dopamine in bipolar disorder
    • Cousins DA, Butts K, Young AH. The role of dopamine in bipolar disorder. Bipolar Disord 2009; 11: 787-806.
    • (2009) Bipolar Disord , vol.11 , pp. 787-806
    • Cousins, D.A.1    Butts, K.2    Young, A.H.3
  • 39
    • 0035005620 scopus 로고    scopus 로고
    • Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons
    • Erhardt S, Oberg H, Mathe JM, Engberg G. Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons. Amino Acids 2001; 20: 353-362.
    • (2001) Amino Acids , vol.20 , pp. 353-362
    • Erhardt, S.1    Oberg, H.2    Mathe, J.M.3    Engberg, G.4
  • 41
    • 43649083084 scopus 로고    scopus 로고
    • Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives
    • Arts B, Jabben N, Krabbendam L, van Os J. Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol Med 2008; 38: 771-785.
    • (2008) Psychol Med , vol.38 , pp. 771-785
    • Arts, B.1    Jabben, N.2    Krabbendam, L.3    Van Os, J.4
  • 42
    • 84862596433 scopus 로고    scopus 로고
    • Treating impaired cognition in schizophrenia
    • Ibrahim HM, Tamminga CA. Treating impaired cognition in schizophrenia. Curr Pharm Biotechnol 2012; 13: 1587-1594.
    • (2012) Curr Pharm Biotechnol , vol.13 , pp. 1587-1594
    • Ibrahim, H.M.1    Tamminga, C.A.2
  • 43
    • 51249083462 scopus 로고    scopus 로고
    • Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia
    • Labrie V, Lipina T, Roder JC. Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia. Psycho-pharmacology 2008; 200: 217-230.
    • (2008) Psycho-pharmacology , vol.200 , pp. 217-230
    • Labrie, V.1    Lipina, T.2    Roder, J.C.3
  • 44
    • 79957791056 scopus 로고    scopus 로고
    • Blockade of glycine transporter 1 by SSR-504734 promotes cognitive flexibility in glycine/NMDA receptor-dependent manner
    • Nikiforuk A, Kos T, Rafa D, Behl B, Bespalov A, Popik P. Blockade of glycine transporter 1 by SSR-504734 promotes cognitive flexibility in glycine/NMDA receptor-dependent manner. Neuropharmacology 2011; 61: 262-267.
    • (2011) Neuropharmacology , vol.61 , pp. 262-267
    • Nikiforuk, A.1    Kos, T.2    Rafa, D.3    Behl, B.4    Bespalov, A.5    Popik, P.6
  • 45
    • 84872168596 scopus 로고    scopus 로고
    • Microglia: Scapegoat, saboteur, or something else?
    • Aguzzi A, Barres BA, Bennett ML. Microglia: scapegoat, saboteur, or something else? Science 2013; 339: 156-161.
    • (2013) Science , vol.339 , pp. 156-161
    • Aguzzi, A.1    Barres, B.A.2    Bennett, M.L.3
  • 46
    • 84897103161 scopus 로고    scopus 로고
    • Mechanisms of astrocyte development and their contributions to neurodevelopmental disorders
    • Sloan SA, Barres BA. Mechanisms of astrocyte development and their contributions to neurodevelopmental disorders. Curr Opin Neurobiol 2014; 27: 75-81.
    • (2014) Curr Opin Neurobiol , vol.27 , pp. 75-81
    • Sloan, S.A.1    Barres, B.A.2
  • 48
    • 77950354954 scopus 로고    scopus 로고
    • Fetal hemoglobin in sickle cell anemia: Genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster
    • Solovieff N, Milton JN, Hartley SW, Sherva R, Sebastiani P, Dworkis DA et al. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. Blood 2010; 115: 1815-1822.
    • (2010) Blood , vol.115 , pp. 1815-1822
    • Solovieff, N.1    Milton, J.N.2    Hartley, S.W.3    Sherva, R.4    Sebastiani, P.5    Dworkis, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.