메뉴 건너뛰기




Volumn 5, Issue NOV, 2015, Pages

Current challenges in glioblastoma: Intratumour heterogeneity, residual disease, and models to predict disease recurrence

Author keywords

Bayesian models; GBM; Intratumor heterogeneity; Neural networks; Residual disease

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN;

EID: 84949761583     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2015.00251     Document Type: Review
Times cited : (82)

References (77)
  • 1
    • 84863562673 scopus 로고    scopus 로고
    • Glioblastoma survival in the United States before and during the temozolomide era
    • Johnson DR, O'Neill BP. Glioblastoma survival in the United States before and during the temozolomide era. J Neurooncol (2012) 107:359-64. doi: 10.1007/s11060-011-0749-4.
    • (2012) J Neurooncol , vol.107 , pp. 359-364
    • Johnson, D.R.1    O'Neill, B.P.2
  • 2
    • 79955765689 scopus 로고    scopus 로고
    • Next-generation sequencing applied to molecular diagnostics
    • Natrajan R, Reis-Filho JS. Next-generation sequencing applied to molecular diagnostics. Expert Rev Mol Diagn (2011) 11:425-44. doi:10.1586/erm.11.18.
    • (2011) Expert Rev Mol Diagn , vol.11 , pp. 425-444
    • Natrajan, R.1    Reis-Filho, J.S.2
  • 3
    • 79551557586 scopus 로고    scopus 로고
    • Incorporation of biomarker assessment in novel clinical trial designs: personalizing brain tumor treatments
    • Galanis E, Wu W, Sarkaria J, Chang SM, Colman H, Sargent D, et al. Incorporation of biomarker assessment in novel clinical trial designs: personalizing brain tumor treatments. Curr Oncol Rep (2011) 13:42-9. doi:10.1007/s11912-010-0144-x.
    • (2011) Curr Oncol Rep , vol.13 , pp. 42-49
    • Galanis, E.1    Wu, W.2    Sarkaria, J.3    Chang, S.M.4    Colman, H.5    Sargent, D.6
  • 4
    • 78650018623 scopus 로고    scopus 로고
    • The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and IDH1 mutations
    • von Deimling A, Korshunov A, Hartmann C. The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and IDH1 mutations. Brain Pathol (2011) 21:74-87. doi:10.1111/j.1750-3639.2010.00454.x.
    • (2011) Brain Pathol , vol.21 , pp. 74-87
    • von Deimling, A.1    Korshunov, A.2    Hartmann, C.3
  • 7
    • 44449147948 scopus 로고    scopus 로고
    • Role of mismatch repair and MGMT in response to anticancer therapies
    • Casorelli I, Russo MT, Bignami M. Role of mismatch repair and MGMT in response to anticancer therapies. Anticancer Agents Med Chem (2008) 8:368-80. doi:10.2174/187152008784220276.
    • (2008) Anticancer Agents Med Chem , vol.8 , pp. 368-380
    • Casorelli, I.1    Russo, M.T.2    Bignami, M.3
  • 8
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Network CGAR. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature (2008) 455:1061-8. doi:10.1038/nature07385.
    • (2008) Nature , vol.455 , pp. 1061-1068
    • Network, C.G.A.R.1
  • 9
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell (2010) 17:98-110. doi:10.1016/j.ccr.2009.12.020.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 11
    • 0032850203 scopus 로고    scopus 로고
    • Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area-specific CGH on microdissected tumor cells
    • Jung V, Romeike BF, Henn W, Feiden W, Moringlane JR, Zang KD, et al. Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area-specific CGH on microdissected tumor cells. J Neuropathol Exp Neurol (1999) 58:993-9. doi:10.1097/00005072-199909000-00009.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 993-999
    • Jung, V.1    Romeike, B.F.2    Henn, W.3    Feiden, W.4    Moringlane, J.R.5    Zang, K.D.6
  • 12
    • 84893372082 scopus 로고    scopus 로고
    • Glioblastoma multiforme: a look inside its heterogeneous nature
    • Inda MM, Bonavia R, Seoane J. Glioblastoma multiforme: a look inside its heterogeneous nature. Cancers (Basel) (2014) 6:226-39. doi:10.3390/cancers6010226.
    • (2014) Cancers (Basel) , vol.6 , pp. 226-239
    • Inda, M.M.1    Bonavia, R.2    Seoane, J.3
  • 13
    • 84867744264 scopus 로고    scopus 로고
    • Evolution of the cancer genome
    • Yates LR, Campbell PJ. Evolution of the cancer genome. Nat Rev Genet (2012) 13:795-806. doi:10.1038/nrg3317.
    • (2012) Nat Rev Genet , vol.13 , pp. 795-806
    • Yates, L.R.1    Campbell, P.J.2
  • 15
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumour heterogeneity: a looking glass for cancer?
    • Marusyk A, Almendro V, Polyak K. Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer (2012) 12:323-34. doi:10.1038/nrc3261.
    • (2012) Nat Rev Cancer , vol.12 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 16
    • 84862757952 scopus 로고    scopus 로고
    • Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
    • Gillies RJ, Verduzco D, Gatenby RA. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer (2012) 12:487-93. doi:10.1038/nrc3298.
    • (2012) Nat Rev Cancer , vol.12 , pp. 487-493
    • Gillies, R.J.1    Verduzco, D.2    Gatenby, R.A.3
  • 17
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M, Maley CC. Clonal evolution in cancer. Nature (2012) 481:306-13. doi:10.1038/nature10762.
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 18
    • 84923608597 scopus 로고    scopus 로고
    • Molecular heterogeneity in glioblastoma: potential clinical implications
    • Parker NR, Khong P, Parkinson JF, Howell VM, Wheeler HR. Molecular heterogeneity in glioblastoma: potential clinical implications. Front Oncol (2015) 5:55. doi:10.3389/fonc.2015.00055.
    • (2015) Front Oncol , vol.5 , pp. 55
    • Parker, N.R.1    Khong, P.2    Parkinson, J.F.3    Howell, V.M.4    Wheeler, H.R.5
  • 19
    • 84920660635 scopus 로고    scopus 로고
    • Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone
    • Piccirillo SG, Spiteri I, Sottoriva A, Touloumis A, Ber S, Price SJ, et al. Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone. Cancer Res (2015) 75:194-202. doi:10.1158/0008-5472.CAN-13-3131.
    • (2015) Cancer Res , vol.75 , pp. 194-202
    • Piccirillo, S.G.1    Spiteri, I.2    Sottoriva, A.3    Touloumis, A.4    Ber, S.5    Price, S.J.6
  • 20
    • 84882713028 scopus 로고    scopus 로고
    • Glioblastoma-initiating cells: relationship with neural stem cells and the micro-environment
    • Goffart N, Kroonen J, Rogister B. Glioblastoma-initiating cells: relationship with neural stem cells and the micro-environment. Cancers (Basel) (2013) 5:1049-71. doi:10.3390/cancers5031049.
    • (2013) Cancers (Basel) , vol.5 , pp. 1049-1071
    • Goffart, N.1    Kroonen, J.2    Rogister, B.3
  • 21
    • 84902668801 scopus 로고    scopus 로고
    • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
    • Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science (2014) 344:1396-401. doi:10.1126/science.1254257.
    • (2014) Science , vol.344 , pp. 1396-1401
    • Patel, A.P.1    Tirosh, I.2    Trombetta, J.J.3    Shalek, A.K.4    Gillespie, S.M.5    Wakimoto, H.6
  • 22
    • 84857397985 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
    • Szerlip NJ, Pedraza A, Chakravarty D, Azim M, McGuire J, Fang Y, et al. Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc Natl Acad Sci U S A (2012) 109:3041-6. doi:10.1073/pnas.1114033109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3041-3046
    • Szerlip, N.J.1    Pedraza, A.2    Chakravarty, D.3    Azim, M.4    McGuire, J.5    Fang, Y.6
  • 23
    • 83455176258 scopus 로고    scopus 로고
    • Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
    • Snuderl M, Fazlollahi L, Le LP, Nitta M, Zhelyazkova BH, Davidson CJ, et al. Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Cancer Cell (2011) 20:810-7. doi:10.1016/j.ccr.2011.11.005.
    • (2011) Cancer Cell , vol.20 , pp. 810-817
    • Snuderl, M.1    Fazlollahi, L.2    Le, L.P.3    Nitta, M.4    Zhelyazkova, B.H.5    Davidson, C.J.6
  • 24
    • 84859940323 scopus 로고    scopus 로고
    • Characterizing mutational heterogeneity in a glioblastoma patient with double recurrence
    • Nickel GC, Barnholtz-Sloan J, Gould MP, McMahon S, Cohen A, Adams MD, et al. Characterizing mutational heterogeneity in a glioblastoma patient with double recurrence. PLoS One (2012) 7:e35262. doi:10.1371/journal.pone.0035262.
    • (2012) PLoS One , vol.7
    • Nickel, G.C.1    Barnholtz-Sloan, J.2    Gould, M.P.3    McMahon, S.4    Cohen, A.5    Adams, M.D.6
  • 25
    • 77955562856 scopus 로고    scopus 로고
    • Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes
    • Li M, Schönberg A, Schaefer M, Schroeder R, Nasidze I, Stoneking M. Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes. Am J Hum Genet (2010) 87:237-49. doi:10.1016/j.ajhg.2010.07.014.
    • (2010) Am J Hum Genet , vol.87 , pp. 237-249
    • Li, M.1    Schönberg, A.2    Schaefer, M.3    Schroeder, R.4    Nasidze, I.5    Stoneking, M.6
  • 26
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ, Puzio-Kuter AM. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science (2010) 330:1340-4. doi:10.1126/science.1193494.
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 27
    • 84892373020 scopus 로고    scopus 로고
    • Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma
    • Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, et al. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science (2014) 343:189-93. doi:10.1126/science.1239947.
    • (2014) Science , vol.343 , pp. 189-193
    • Johnson, B.E.1    Mazor, T.2    Hong, C.3    Barnes, M.4    Aihara, K.5    McLean, C.Y.6
  • 28
    • 84923911546 scopus 로고    scopus 로고
    • Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution
    • Kim H, Zheng S, Amini SS, Virk SM, Mikkelsen T, Brat DJ, et al. Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution. Genome Res (2015) 25:316-27. doi:10.1101/gr.180612.114.
    • (2015) Genome Res , vol.25 , pp. 316-327
    • Kim, H.1    Zheng, S.2    Amini, S.S.3    Virk, S.M.4    Mikkelsen, T.5    Brat, D.J.6
  • 29
    • 70350683354 scopus 로고    scopus 로고
    • The subependymal zone neurogenic niche: a beating heart in the centre of the brain
    • Kazanis I. The subependymal zone neurogenic niche: a beating heart in the centre of the brain. Brain (2009) 132:2909-21. doi:10.1093/brain/awp237.
    • (2009) Brain , vol.132 , pp. 2909-2921
    • Kazanis, I.1
  • 30
    • 77950432267 scopus 로고    scopus 로고
    • CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors
    • Patru C, Romao L, Varlet P, Coulombel L, Raponi E, Cadusseau J, et al. CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors. BMC Cancer (2010) 10:66. doi:10.1186/1471-2407-10-66.
    • (2010) BMC Cancer , vol.10 , pp. 66
    • Patru, C.1    Romao, L.2    Varlet, P.3    Coulombel, L.4    Raponi, E.5    Cadusseau, J.6
  • 32
    • 0019152630 scopus 로고
    • Neocognitron: a self organizing neural network model for a mechanism of pattern recognition unaffected by shift in position
    • Fukushima K. Neocognitron: a self organizing neural network model for a mechanism of pattern recognition unaffected by shift in position. Biol Cybern (1980) 36:193-202. doi:10.1007/BF00344251.
    • (1980) Biol Cybern , vol.36 , pp. 193-202
    • Fukushima, K.1
  • 33
    • 84055179397 scopus 로고    scopus 로고
    • Application of neural networks in diagnosing cancer disease using demographic data
    • Ganesan N, Venkatesh K, Rama MA, Malathi Palani A. Application of neural networks in diagnosing cancer disease using demographic data. Int J Comput Appl (2010) 1(26):76-85. doi:10.5120/476-783.
    • (2010) Int J Comput Appl , vol.1 , Issue.26 , pp. 76-85
    • Ganesan, N.1    Venkatesh, K.2    Rama, M.A.3    Malathi Palani, A.4
  • 35
    • 33745805403 scopus 로고    scopus 로고
    • A fast learning algorithm for deep belief nets
    • Hinton GE, Osindero S, Teh Y-W. A fast learning algorithm for deep belief nets. Neural Comput (2006) 18:1527-54. doi:10.1162/neco.2006.18.7.1527.
    • (2006) Neural Comput , vol.18 , pp. 1527-1554
    • Hinton, G.E.1    Osindero, S.2    Teh, Y.-W.3
  • 37
    • 84930630277 scopus 로고    scopus 로고
    • Deep learning
    • LeCun Y, Bengio Y, Hinton G. Deep learning. Nature (2015) 521:436-44. doi:10.1038/nature14539.
    • (2015) Nature , vol.521 , pp. 436-444
    • LeCun, Y.1    Bengio, Y.2    Hinton, G.3
  • 39
    • 84972539015 scopus 로고
    • Neural networks: a review from a statistical perspective
    • Cheng B, Titterington DM. Neural networks: a review from a statistical perspective. Stat Sci (1994) 9:2-30. doi:10.1214/ss/1177010638.
    • (1994) Stat Sci , vol.9 , pp. 2-30
    • Cheng, B.1    Titterington, D.M.2
  • 40
    • 0026925678 scopus 로고
    • A comparison of neural network and fuzzy clustering-techniques in segmenting magnetic-resonance images of the brain
    • Hall LO, Bensaid AM, Clarke LP, Velthuizen RP, Silbiger MS, Bezdek JC. A comparison of neural network and fuzzy clustering-techniques in segmenting magnetic-resonance images of the brain. IEEE Trans Neural Netw (1992) 3:672-82. doi:10.1109/72.159057.
    • (1992) IEEE Trans Neural Netw , vol.3 , pp. 672-682
    • Hall, L.O.1    Bensaid, A.M.2    Clarke, L.P.3    Velthuizen, R.P.4    Silbiger, M.S.5    Bezdek, J.C.6
  • 41
    • 1142299677 scopus 로고    scopus 로고
    • Prediction of respiratory tumour motion for real-time image-guided radiotherapy
    • Sharp GC, Jiang SB, Shimizu S, Shirato H. Prediction of respiratory tumour motion for real-time image-guided radiotherapy. Phys Med Biol (2004) 49:425-40. doi:10.1088/0031-9155/49/3/006.
    • (2004) Phys Med Biol , vol.49 , pp. 425-440
    • Sharp, G.C.1    Jiang, S.B.2    Shimizu, S.3    Shirato, H.4
  • 43
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE, Davidson NE, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med (2005) 353:1673-84. doi:10.1056/NEJMoa052122.
    • (2005) N Engl J Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3    Suman, V.J.4    Geyer, C.E.5    Davidson, N.E.6
  • 44
    • 33846852882 scopus 로고    scopus 로고
    • PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors
    • MellinghoffIK, Cloughesy TF, Mischel PS. PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors. Clin Cancer Res (2007) 13:378-81. doi:10.1158/1078-0432.CCR-06-1992.
    • (2007) Clin Cancer Res , vol.13 , pp. 378-381
    • Mellinghoff, I.K.1    Cloughesy, T.F.2    Mischel, P.S.3
  • 45
    • 0842288337 scopus 로고    scopus 로고
    • Inferring cellular networks using probabilistic graphical models
    • Friedman N. Inferring cellular networks using probabilistic graphical models. Science (2004) 303:799-805. doi:10.1126/science.1094068.
    • (2004) Science , vol.303 , pp. 799-805
    • Friedman, N.1
  • 46
    • 34249761849 scopus 로고
    • Learning Bayesian networks-the combination of knowledge and statistical-data
    • Heckerman D, Geiger D, Chickering DM. Learning Bayesian networks-the combination of knowledge and statistical-data. Mach Learn (1995) 20:197-243. doi:10.1023/A:1022623210503.
    • (1995) Mach Learn , vol.20 , pp. 197-243
    • Heckerman, D.1    Geiger, D.2    Chickering, D.M.3
  • 47
    • 0842309206 scopus 로고    scopus 로고
    • Inferring gene networks from time series microarray data using dynamic Bayesian networks
    • Kim SY, Imoto S, Miyano S. Inferring gene networks from time series microarray data using dynamic Bayesian networks. Brief Bioinform (2003) 4:228-35. doi:10.1093/bib/4.3.228.
    • (2003) Brief Bioinform , vol.4 , pp. 228-235
    • Kim, S.Y.1    Imoto, S.2    Miyano, S.3
  • 48
    • 77952479257 scopus 로고    scopus 로고
    • How can systems pathology help us personalize cancer therapy?
    • Faratian D, Langdon SP, Harrison DJ. How can systems pathology help us personalize cancer therapy? Discov Med (2009) 8:81-6.
    • (2009) Discov Med , vol.8 , pp. 81-86
    • Faratian, D.1    Langdon, S.P.2    Harrison, D.J.3
  • 49
    • 39749086288 scopus 로고    scopus 로고
    • Integrative mathematical oncology
    • Anderson AR, Quaranta V. Integrative mathematical oncology. Nat Rev Cancer (2008) 8:227-34. doi:10.1038/nrc2329.
    • (2008) Nat Rev Cancer , vol.8 , pp. 227-234
    • Anderson, A.R.1    Quaranta, V.2
  • 50
    • 45449126571 scopus 로고    scopus 로고
    • Mathematical models of cancer stem cells
    • Michor F. Mathematical models of cancer stem cells. J Clin Oncol (2008) 26:2854-61. doi:10.1200/JCO.2007.15.2421.
    • (2008) J Clin Oncol , vol.26 , pp. 2854-2861
    • Michor, F.1
  • 51
    • 84907482235 scopus 로고    scopus 로고
    • Dynamics of leukemia stem-like cell extinction in acute promyelocytic leukemia
    • Werner B, Gallagher RE, Paietta EM, Litzow MR, Tallman MS, Wiernik PH, et al. Dynamics of leukemia stem-like cell extinction in acute promyelocytic leukemia. Cancer Res (2014) 74:5386-96. doi:10.1158/0008-5472.CAN-14-1210.
    • (2014) Cancer Res , vol.74 , pp. 5386-5396
    • Werner, B.1    Gallagher, R.E.2    Paietta, E.M.3    Litzow, M.R.4    Tallman, M.S.5    Wiernik, P.H.6
  • 52
    • 75149132546 scopus 로고    scopus 로고
    • Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity
    • Sottoriva A, VerhoeffJJ, Borovski T, McWeeney SK, Naumov L, Medema JP, et al. Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity. Cancer Res (2010) 70:46-56. doi:10.1158/0008-5472.CAN-09-3663.
    • (2010) Cancer Res , vol.70 , pp. 46-56
    • Sottoriva, A.1    Verhoeff, J.J.2    Borovski, T.3    McWeeney, S.K.4    Naumov, L.5    Medema, J.P.6
  • 53
    • 67349111353 scopus 로고    scopus 로고
    • Migration rules: tumours are conglomerates of self-metastases
    • Enderling H, Hlatky L, Hahnfeldt P. Migration rules: tumours are conglomerates of self-metastases. Br J Cancer (2009) 100:1917-25. doi:10.1038/sj.bjc.6605071.
    • (2009) Br J Cancer , vol.100 , pp. 1917-1925
    • Enderling, H.1    Hlatky, L.2    Hahnfeldt, P.3
  • 55
    • 84881483492 scopus 로고    scopus 로고
    • Evolutionary dynamics of cancer in response to targeted combination therapy
    • Bozic I, Reiter JG, Allen B, Antal T, Chatterjee K, Shah P, et al. Evolutionary dynamics of cancer in response to targeted combination therapy. Elife (2013) 2:e00747. doi:10.7554/eLife.00747.
    • (2013) Elife , vol.2
    • Bozic, I.1    Reiter, J.G.2    Allen, B.3    Antal, T.4    Chatterjee, K.5    Shah, P.6
  • 57
    • 84949746882 scopus 로고    scopus 로고
    • Prediction of glioma using genetic optimized neural network
    • Karpagam S, Gowri S. Prediction of glioma using genetic optimized neural network. J Comput Sci (2013) 9(11):1543-55. doi:10.3844/jcssp.2013.1543.1555.
    • (2013) J Comput Sci , vol.9 , Issue.11 , pp. 1543-1555
    • Karpagam, S.1    Gowri, S.2
  • 58
    • 84896483986 scopus 로고    scopus 로고
    • Automated detection and extraction of brain tumor from MRI images
    • Tirpude N, Welekar R. Automated detection and extraction of brain tumor from MRI images. Int J Comput Appl (2013) 77:26-30. doi:10.5120/13383-1007.
    • (2013) Int J Comput Appl , vol.77 , pp. 26-30
    • Tirpude, N.1    Welekar, R.2
  • 59
    • 84918495305 scopus 로고    scopus 로고
    • Effects of anti-angiogenesis on glioblastoma growth and migration: model to clinical predictions
    • Scribner E, Saut O, Province P, Bag A, Colin T, Fathallah-Shaykh HM. Effects of anti-angiogenesis on glioblastoma growth and migration: model to clinical predictions. PLoS One (2014) 9:e115018. doi:10.1371/journal.pone.0115018.
    • (2014) PLoS One , vol.9
    • Scribner, E.1    Saut, O.2    Province, P.3    Bag, A.4    Colin, T.5    Fathallah-Shaykh, H.M.6
  • 60
    • 84927171082 scopus 로고    scopus 로고
    • A multilayer grow-or-go model for GBM: effects of invasive cells and anti-angiogenesis on growth
    • Saut O, Lagaert JB, Colin T, Fathallah-Shaykh HM. A multilayer grow-or-go model for GBM: effects of invasive cells and anti-angiogenesis on growth. Bull Math Biol (2014) 76:2306-33. doi:10.1007/s11538-014-0007-y.
    • (2014) Bull Math Biol , vol.76 , pp. 2306-2333
    • Saut, O.1    Lagaert, J.B.2    Colin, T.3    Fathallah-Shaykh, H.M.4
  • 61
    • 70849116358 scopus 로고    scopus 로고
    • Profiling critical cancer gene mutations in clinical tumor samples
    • MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, et al. Profiling critical cancer gene mutations in clinical tumor samples. PLoS One (2009) 4:e7887. doi:10.1371/annotation/613c7509-e4c9-42ac-82fb-fc504400d9e0.
    • (2009) PLoS One , vol.4
    • MacConaill, L.E.1    Campbell, C.D.2    Kehoe, S.M.3    Bass, A.J.4    Hatton, C.5    Niu, L.6
  • 62
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • Khambata-Ford S, Garrett CR, Meropol NJ, Basik M, Harbison CT, Wu S, et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol (2007) 25:3230-7. doi:10.1200/JCO.2006.10.5437.
    • (2007) J Clin Oncol , vol.25 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3    Basik, M.4    Harbison, C.T.5    Wu, S.6
  • 63
    • 84865542459 scopus 로고    scopus 로고
    • Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240
    • Fenton TR, Nathanson D, Ponte de Albuquerque C, Kuga D, Iwanami A, Dang J, et al. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A (2012) 109:14164-9. doi:10.1073/pnas.1211962109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 14164-14169
    • Fenton, T.R.1    Nathanson, D.2    Ponte de Albuquerque, C.3    Kuga, D.4    Iwanami, A.5    Dang, J.6
  • 64
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med (2004) 350:2129-39. doi:10.1056/NEJMoa040938.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 65
    • 84877579861 scopus 로고    scopus 로고
    • Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
    • Murtaza M, Dawson SJ, Tsui DW, Gale D, Forshew T, Piskorz AM, et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature (2013) 497:108-12. doi:10.1038/nature12065.
    • (2013) Nature , vol.497 , pp. 108-112
    • Murtaza, M.1    Dawson, S.J.2    Tsui, D.W.3    Gale, D.4    Forshew, T.5    Piskorz, A.M.6
  • 66
    • 84872020299 scopus 로고    scopus 로고
    • Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing
    • Chan KC, Jiang P, Zheng YW, Liao GJ, Sun H, Wong J, et al. Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing. Clin Chem (2013) 59:211-24. doi:10.1373/clinchem.2012.196014.
    • (2013) Clin Chem , vol.59 , pp. 211-224
    • Chan, K.C.1    Jiang, P.2    Zheng, Y.W.3    Liao, G.J.4    Sun, H.5    Wong, J.6
  • 67
    • 84870312106 scopus 로고    scopus 로고
    • Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing
    • Leary RJ, Sausen M, Kinde I, Papadopoulos N, Carpten JD, Craig D, et al. Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Sci Transl Med (2012) 4:162ra154. doi:10.1126/scitranslmed.3004742.
    • (2012) Sci Transl Med , vol.4
    • Leary, R.J.1    Sausen, M.2    Kinde, I.3    Papadopoulos, N.4    Carpten, J.D.5    Craig, D.6
  • 68
    • 84896371874 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in early-and late-stage human malignancies
    • Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, et al. Detection of circulating tumor DNA in early-and late-stage human malignancies. Sci Transl Med (2014) 6:224ra24. doi:10.1126/scitranslmed.3007094.
    • (2014) Sci Transl Med , vol.6
    • Bettegowda, C.1    Sausen, M.2    Leary, R.J.3    Kinde, I.4    Wang, Y.5    Agrawal, N.6
  • 69
    • 84908406981 scopus 로고    scopus 로고
    • Brain tumor cells in circulation are enriched for mesenchymal gene expression
    • Sullivan JP, Nahed BV, Madden MW, Oliveira SM, Springer S, Bhere D, et al. Brain tumor cells in circulation are enriched for mesenchymal gene expression. Cancer Discov (2014) 4:1299-309. doi:10.1158/2159-8290.CD-14-0471.
    • (2014) Cancer Discov , vol.4 , pp. 1299-1309
    • Sullivan, J.P.1    Nahed, B.V.2    Madden, M.W.3    Oliveira, S.M.4    Springer, S.5    Bhere, D.6
  • 71
    • 84899512130 scopus 로고    scopus 로고
    • Detection of brain tumor cells in the peripheral blood by a telomerase promoter-based assay
    • MacArthur KM, Kao GD, Chandrasekaran S, Alonso-Basanta M, Chapman C, Lustig RA, et al. Detection of brain tumor cells in the peripheral blood by a telomerase promoter-based assay. Cancer Res (2014) 74:2152-9. doi:10.1158/0008-5472.CAN-13-0813.
    • (2014) Cancer Res , vol.74 , pp. 2152-2159
    • MacArthur, K.M.1    Kao, G.D.2    Chandrasekaran, S.3    Alonso-Basanta, M.4    Chapman, C.5    Lustig, R.A.6
  • 73
    • 20344378933 scopus 로고    scopus 로고
    • Why are systemic glioblastoma metastases rare? Systemic and cerebral growth of mouse glioblastoma
    • Mourad PD, Farrell L, Stamps LD, Chicoine MR, Silbergeld DL. Why are systemic glioblastoma metastases rare? Systemic and cerebral growth of mouse glioblastoma. Surg Neurol (2005) 63:511-9. doi:10.1016/j.surneu.2004.08.062 discussion 519.
    • (2005) Surg Neurol , vol.63 , pp. 511-519
    • Mourad, P.D.1    Farrell, L.2    Stamps, L.D.3    Chicoine, M.R.4    Silbergeld, D.L.5
  • 75
    • 84927176534 scopus 로고    scopus 로고
    • Neuro-oncology a step towards clinical blood biomarkers of glioblastoma
    • Preusser M. Neuro-oncology a step towards clinical blood biomarkers of glioblastoma. Nat Rev Neurol (2014) 10:681-2. doi:10.1038/nrneurol.2014.208.
    • (2014) Nat Rev Neurol , vol.10 , pp. 681-682
    • Preusser, M.1
  • 76
    • 33847343860 scopus 로고    scopus 로고
    • Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patients
    • Khwaja FW, Reed MS, Olson JJ, Schmotzer BJ, Gillespie GY, Guha A, et al. Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patients. J Proteome Res (2007) 6:559-70. doi:10.1021/pr060240z.
    • (2007) J Proteome Res , vol.6 , pp. 559-570
    • Khwaja, F.W.1    Reed, M.S.2    Olson, J.J.3    Schmotzer, B.J.4    Gillespie, G.Y.5    Guha, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.