메뉴 건너뛰기




Volumn 159, Issue 4, 2015, Pages 547-553

The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test

Author keywords

Acetylcholine; Acetylcholinesterase; Alzheimer disease; Donepezil; Spatial orientation; Tacrine

Indexed keywords

CHOLINESTERASE INHIBITOR; DONEPEZIL; INDAN DERIVATIVE; MUSCARINIC RECEPTOR BLOCKING AGENT; NOOTROPIC AGENT; PIPERIDINE DERIVATIVE; QUINUCLIDINYL BENZILATE; TACRINE;

EID: 84949679442     PISSN: 12138118     EISSN: 18047521     Source Type: Journal    
DOI: 10.5507/bp.2015.006     Document Type: Article
Times cited : (18)

References (51)
  • 2
    • 84901357991 scopus 로고    scopus 로고
    • KucaK. Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine
    • Zemek F, Drtinova L, Nepovimova E, Sepsova V, Korabecny J, Klimes J, KucaK. Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine. Expert Opin Drug Saf 2014;13(6):759-74.
    • (2014) Expert Opin Drug Saf , vol.13 , Issue.6 , pp. 759-774
    • Zemek, F.1    Drtinova, L.2    Nepovimova, E.3    Sepsova, V.4    Korabecny, J.5    Klimes, J.6
  • 3
    • 79955738773 scopus 로고    scopus 로고
    • The history of the cholinergic hypothesis
    • Contestabile A. The history of the cholinergic hypothesis. Behav Brain Res 2011;221(2):334-40.
    • (2011) Behav Brain Res , vol.221 , Issue.2 , pp. 334-340
    • Contestabile, A.1
  • 5
    • 84885816253 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection
    • Singh M, Kaur M, Kukreja H, Chugh R, Silakari O, Singh D. Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection. Eur J Med Chem 2013;70:165-88.
    • (2013) Eur J Med Chem , vol.70 , pp. 165-188
    • Singh, M.1    Kaur, M.2    Kukreja, H.3    Chugh, R.4    Silakari, O.5    Singh, D.6
  • 6
    • 0032763708 scopus 로고    scopus 로고
    • Effect of rivastigmine on scopolamine-induced memory impairment in rats
    • Bejar C, Wang RH, Weinstock M. Effect of rivastigmine on scopolamine-induced memory impairment in rats. Eur J Pharmacol 1999;383:231-40.
    • (1999) Eur J Pharmacol , vol.383 , pp. 231-240
    • Bejar, C.1    Wang, R.H.2    Weinstock, M.3
  • 7
    • 0032101015 scopus 로고    scopus 로고
    • Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities
    • Cheng DH, Tang XC. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav 1998;60:377-86.
    • (1998) Pharmacol Biochem Behav , vol.60 , pp. 377-386
    • Cheng, D.H.1    Tang, X.C.2
  • 8
    • 0031973559 scopus 로고    scopus 로고
    • Effects of the potassium channel blockers, apamin and 4-aminopyridine, on scopolamine-induced deficits in the delayed matching to position task in rats: A comparison with the cholinesterase inhibitor E2020
    • Poorheidari G, Stanhope KJ, Pratt JA. Effects of the potassium channel blockers, apamin and 4-aminopyridine, on scopolamine-induced deficits in the delayed matching to position task in rats: a comparison with the cholinesterase inhibitor E2020. Psychopharmacology 1998;135:42-255.
    • (1998) Psychopharmacology , vol.135 , pp. 42-255
    • Poorheidari, G.1    Stanhope, K.J.2    Pratt, J.A.3
  • 10
    • 0034304034 scopus 로고    scopus 로고
    • Cholinesterase inhibitors stabilize Alzheimer disease
    • Giacobini E. Cholinesterase inhibitors stabilize Alzheimer disease. Neurochem Res 2000;25:1185-90.
    • (2000) Neurochem Res , vol.25 , pp. 1185-1190
    • Giacobini, E.1
  • 12
  • 13
    • 84864213744 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitors: A patent review (2008 - present)
    • Pohanka M. Acetylcholinesterase inhibitors: a patent review (2008 - present). Expert Opin Ther Pat 2012;22:871-86.
    • (2012) Expert Opin Ther Pat , vol.22 , pp. 871-886
    • Pohanka, M.1
  • 14
    • 56049122716 scopus 로고    scopus 로고
    • From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): A step forward in the treatment of Alzheimer's disease
    • Bolognesi ML, Minarini A, Rosini M, Tumiatti V, Melchiorre C. From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease. Mini Rev Med Chem 2008;8(10):960-7.
    • (2008) Mini Rev Med Chem , vol.8 , Issue.10 , pp. 960-967
    • Bolognesi, M.L.1    Minarini, A.2    Rosini, M.3    Tumiatti, V.4    Melchiorre, C.5
  • 15
    • 84890894521 scopus 로고    scopus 로고
    • Pharmacophore mapping-based virtual screening followed by molecular docking studies in search of potential acetylcholinesterase inhibitors as anti-Alzheimer's agents
    • Ambure P, Kar S, Roy K. Pharmacophore mapping-based virtual screening followed by molecular docking studies in search of potential acetylcholinesterase inhibitors as anti-Alzheimer's agents. Biosystems 2014;116:10-20.
    • (2014) Biosystems , vol.116 , pp. 10-20
    • Ambure, P.1    Kar, S.2    Roy, K.3
  • 16
    • 84889650250 scopus 로고    scopus 로고
    • Tacrine- Flurbiprofen Hybrids as Multifunctional Drug Candidates for the Treatment of Alzheimer's Disease
    • Chen Y, Sun JF, Peng SX, Liao H, Zhang YH, Lehmann J. Tacrine- Flurbiprofen Hybrids as Multifunctional Drug Candidates for the Treatment of Alzheimer's Disease. Arch Pharm (Weinheim) 2013;346:865-71.
    • (2013) Arch Pharm (Weinheim) , vol.346 , pp. 865-871
    • Chen, Y.1    Sun, J.F.2    Peng, S.X.3    Liao, H.4    Zhang, Y.H.5    Lehmann, J.6
  • 18
  • 19
    • 84874613897 scopus 로고    scopus 로고
    • 7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment-synthesis, biological evaluation and molecular modelling studies
    • 201
    • Spilovska K, Korabecny J, Kral J, Horova A, Musilek K, Soukup O, Drtinova L, Gazova Z, Siposova K, Kuca K. 7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment-synthesis, biological evaluation and molecular modelling studies. Molecules 201;18(2):2397-418.
    • Molecules , vol.18 , Issue.2 , pp. 2397-2418
    • Spilovska, K.1    Korabecny, J.2    Kral, J.3    Horova, A.4    Musilek, K.5    Soukup, O.6    Drtinova, L.7    Gazova, Z.8    Siposova, K.9    Kuca, K.10
  • 20
    • 84891877160 scopus 로고    scopus 로고
    • Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease
    • Li SY, Jiang N, Xie SS, Wang KD, Wang XB, Kong LY. Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease. Org Biomol Chem 2014;12(5):801-14.
    • (2014) Org Biomol Chem , vol.12 , Issue.5 , pp. 801-814
    • Li, S.Y.1    Jiang, N.2    Xie, S.S.3    Wang, K.D.4    Wang, X.B.5    Kong, L.Y.6
  • 22
    • 84855519788 scopus 로고    scopus 로고
    • New acetylcholinesterase inhibitors for Alzheimer's disease
    • [Epub ahead of print]
    • Mehta M, Adem A, Sabbagh M. New acetylcholinesterase inhibitors for Alzheimer's disease. Int J Alzheimers Dis 2012. [Epub ahead of print] doi:10.1155/2012/728983
    • (2012) Int J Alzheimers Dis
    • Mehta, M.1    Adem, A.2    Sabbagh, M.3
  • 25
    • 78650664701 scopus 로고    scopus 로고
    • KucaK. Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment
    • Korabecny J, Musilek K, Holas O, Nepovimova E, Jun D, Zemek F, Opletalova V, Patocka J, Dohnal V, Nachon F, Hroudova J, Fisar Z, Kuca K. Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment. Molecules 2010;15(12):8804-12.
    • (2010) Molecules , vol.15 , Issue.12 , pp. 8804-8812
    • Korabecny, J.1    Musilek, K.2    Holas, O.3    Nepovimova, E.4    Jun, D.5    Zemek, F.6    Opletalova, V.7    Patocka, J.8    Dohnal, V.9    Nachon, F.10    Hroudova, J.11    Fisar, Z.12    Kuca, K.13
  • 27
    • 84897877777 scopus 로고    scopus 로고
    • Cholinergic antagonist 3-quinuclidinyl benzilate - Impact on learning and memory in Wistar rats
    • Misik J, Vanek J, Musilek K, Kassa J. Cholinergic antagonist 3-quinuclidinyl benzilate - Impact on learning and memory in Wistar rats. Behav Brain Res 2014;266:193-200.
    • (2014) Behav Brain Res , vol.266 , pp. 193-200
    • Misik, J.1    Vanek, J.2    Musilek, K.3    Kassa, J.4
  • 28
    • 84877873373 scopus 로고    scopus 로고
    • A review on cholinesterase inhibitors for Alzheimer's disease
    • Anand P, Singh B. A review on cholinesterase inhibitors for Alzheimer's disease. Arch Pharm Res 2013;36(4):375-99.
    • (2013) Arch Pharm Res , vol.36 , Issue.4 , pp. 375-399
    • Anand, P.1    Singh, B.2
  • 29
    • 84925934689 scopus 로고    scopus 로고
    • The Evaluation of Prophylactic Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase in Soman-Poisoned Mice - A Comparison with Commonly Used Pyridostigmine
    • Kassa J, Korabecny J, Sepsova V, Tumova M. The Evaluation of Prophylactic Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase in Soman-Poisoned Mice - A Comparison with Commonly Used Pyridostigmine. Basic Clin Pharmacol Toxicol 2014;115(6):571-6.
    • (2014) Basic Clin Pharmacol Toxicol , vol.115 , Issue.6 , pp. 571-576
    • Kassa, J.1    Korabecny, J.2    Sepsova, V.3    Tumova, M.4
  • 32
    • 0036240048 scopus 로고    scopus 로고
    • Elevated T-maze as an animal model of memory: Effects of scopolamine
    • De-Mello N, Carobrez AP. Elevated T-maze as an animal model of memory: effects of scopolamine. Behav Pharmacol 2002;13:139-48.
    • (2002) Behav Pharmacol , vol.13 , pp. 139-148
    • De-Mello, N.1    Carobrez, A.P.2
  • 33
    • 0034888287 scopus 로고    scopus 로고
    • Applications of the Morris water maze in the study of learning and memory
    • D'Hooge R, De Deyn PP. Applications of the Morris water maze in the study of learning and memory. Brain Res Rev 2001;36:60-90.
    • (2001) Brain Res Rev , vol.36 , pp. 60-90
    • D'hooge, R.1    De Deyn, P.P.2
  • 34
    • 84857572969 scopus 로고    scopus 로고
    • Scopolamine administration modulates muscarinic, nicotinic and NMDA receptor systems
    • 2012 Feb 27. [Epub ahead of print] doi
    • Falsafi SK, Deli A, Höger H, Pollak A, Lubec G. Scopolamine administration modulates muscarinic, nicotinic and NMDA receptor systems. PLoS ONE 2012 Feb 27. [Epub ahead of print] doi: 10.1371/journal.pone.0032082
    • Plos ONE
    • Falsafi, S.K.1    Deli, A.2    Höger, H.3    Pollak, A.4    Lubec, G.5
  • 35
    • 79959841848 scopus 로고    scopus 로고
    • Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats
    • Gacar N, Mutlu O, Utkan T, Komsuoglu Celikyurt I, Gocmez SS, Ulak G. Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats. Pharmacol Biochem Behav 2011;99:316-23.
    • (2011) Pharmacol Biochem Behav , vol.99 , pp. 316-323
    • Gacar, N.1    Mutlu, O.2    Utkan, T.3    Komsuoglu Celikyurt, I.4    Gocmez, S.S.5    Ulak, G.6
  • 36
    • 84897830285 scopus 로고    scopus 로고
    • A comparison of cholinesterase inhibitors in the treatment of quinuclidinyl benzilate-induced behavioural deficit in rats performing the multiple T-maze
    • Misik J, Kassa J. A comparison of cholinesterase inhibitors in the treatment of quinuclidinyl benzilate-induced behavioural deficit in rats performing the multiple T-maze. J Appl Biomed 2014;12:211-7.
    • (2014) J Appl Biomed , vol.12 , pp. 211-217
    • Misik, J.1    Kassa, J.2
  • 37
    • 85027927198 scopus 로고    scopus 로고
    • Modafinil improves performance in the multiple T-Maze and modifies GluR1, GluR2, D2 and NR1 receptor complex levels in the C57BL/6J mouse
    • Sase S, Khan D, Sialana F, Höger H, Russo-Schlaff N, Lubec G. Modafinil improves performance in the multiple T-Maze and modifies GluR1, GluR2, D2 and NR1 receptor complex levels in the C57BL/6J mouse. Amino Acids 2012;43:2285-92.
    • (2012) Amino Acids , vol.43 , pp. 2285-2292
    • Sase, S.1    Khan, D.2    Sialana, F.3    Höger, H.4    Russo-Schlaff, N.5    Lubec, G.6
  • 38
    • 77957885945 scopus 로고    scopus 로고
    • Assessment of spatial memory in mice
    • Sharma S, Rakoczy S, Brown-Borg H. Assessment of spatial memory in mice. Life Sci 2010;87:521-36.
    • (2010) Life Sci , vol.87 , pp. 521-536
    • Sharma, S.1    Rakoczy, S.2    Brown-Borg, H.3
  • 40
    • 79955745304 scopus 로고    scopus 로고
    • The cholinergic system and spatial learning
    • Deiana S, Platt B, Riedel G. The cholinergic system and spatial learning. Behav Brain Res 2011;221:389-411.
    • (2011) Behav Brain Res , vol.221 , pp. 389-411
    • Deiana, S.1    Platt, B.2    Riedel, G.3
  • 41
    • 0030462894 scopus 로고    scopus 로고
    • Effects of anticholinesterase drugs tacrine and E2020, the 5-HT(3) antagonist ondansetron, and the H(3) antagonist thioperamide, in models of cognition and cholinergic function
    • Kirkby DL, Jones DN, Barnes JC, Higgins GA. Effects of anticholinesterase drugs tacrine and E2020, the 5-HT(3) antagonist ondansetron, and the H(3) antagonist thioperamide, in models of cognition and cholinergic function. Behav Pharmacol 1996;7:513-25.
    • (1996) Behav Pharmacol , vol.7 , pp. 513-525
    • Kirkby, D.L.1    Jones, D.N.2    Barnes, J.C.3    Higgins, G.A.4
  • 42
    • 16544392226 scopus 로고    scopus 로고
    • The T-maze continuous alternation task for assessing the effects of putative cognition enhancers in the mouse
    • Spowart-Manning L, van der Staay FJ. The T-maze continuous alternation task for assessing the effects of putative cognition enhancers in the mouse. Behav Brain Res 2004;151:37-46.
    • (2004) Behav Brain Res , vol.151 , pp. 37-46
    • Spowart-Manning, L.1    Van Der Staay, F.J.2
  • 43
    • 0032837398 scopus 로고    scopus 로고
    • Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats
    • Kosasa T, Kuriya Y, Matsui K, Yamanishi Y. Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats. Eur J Pharmacol 1999;380:101-7.
    • (1999) Eur J Pharmacol , vol.380 , pp. 101-107
    • Kosasa, T.1    Kuriya, Y.2    Matsui, K.3    Yamanishi, Y.4
  • 44
    • 0034103787 scopus 로고    scopus 로고
    • Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats
    • Ogura H, Kosasa T, Kuriya Y, Yamanishi Y. Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats. Methods Find Exp Clin Pharmacol 2000;22:89-95.
    • (2000) Methods Find Exp Clin Pharmacol , vol.22 , pp. 89-95
    • Ogura, H.1    Kosasa, T.2    Kuriya, Y.3    Yamanishi, Y.4
  • 47
    • 0033746887 scopus 로고    scopus 로고
    • Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat
    • Dronfield S, Egan K, Marsden CA, Green AR. Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat. J Psychopharmacol 2000;14:275-9.
    • (2000) J Psychopharmacol , vol.14 , pp. 275-279
    • Dronfield, S.1    Egan, K.2    Marsden, C.A.3    Green, A.R.4
  • 48
    • 0024589925 scopus 로고
    • Physostigmine, tacrine and metrifonate: The effect of multiple doses on acetylcholine metabolism in rat brain
    • Hallak M, Giacobini E. Physostigmine, tacrine and metrifonate: the effect of multiple doses on acetylcholine metabolism in rat brain. Neuropharmacology 1989;28:199-206.
    • (1989) Neuropharmacology , vol.28 , pp. 199-206
    • Hallak, M.1    Giacobini, E.2
  • 50
    • 77954618477 scopus 로고    scopus 로고
    • Investigation into the in vivo effects of five novel tacrine/ferulic acid and beta-carboline derivatives on scopolamine-induced cognitive impairment in rats using radial maze paradigm
    • Fleck C, Appenroth D, Fang L, Schott Y, Lehmann J, Decker M. Investigation into the in vivo effects of five novel tacrine/ferulic acid and beta-carboline derivatives on scopolamine-induced cognitive impairment in rats using radial maze paradigm. Arzneimittelforschung 2010;60(6):299-306.
    • (2010) Arzneimittelforschung , vol.60 , Issue.6 , pp. 299-306
    • Fleck, C.1    Appenroth, D.2    Fang, L.3    Schott, Y.4    Lehmann, J.5    Decker, M.6
  • 51
    • 84863144997 scopus 로고    scopus 로고
    • Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo
    • 2012 Feb 23 [Epub ahead of print] doi
    • Pi R, Mao X, Chao X, Cheng Z, Liu M, Duan X, Ye M, Chen X, Mei Z, Liu P, Li W, Han Y. Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo. PLoS ONE 2012 Feb 23 [Epub ahead of print] doi: 10.1371/journal.pone.0031921
    • Plos ONE
    • Pi, R.1    Mao, X.2    Chao, X.3    Cheng, Z.4    Liu, M.5    Duan, X.6    Ye, M.7    Chen, X.8    Mei, Z.9    Liu, P.10    Li, W.11    Han, Y.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.