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Volumn 8, Issue , 2015, Pages 3691-3701

Profile of nintedanib in the treatment of solid tumors: The evidence to date

Author keywords

Angiogenesis; BIBF 1120; Nintedanib; Tyrosine kinase inhibitors; VEGF

Indexed keywords

AFATINIB; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; FIBROBLAST GROWTH FACTOR RECEPTOR; FLUOROURACIL; FOLINIC ACID; GAMMA GLUTAMYLTRANSFERASE; GEMCITABINE; MITOGEN ACTIVATED PROTEIN KINASE; NINTEDANIB; OXALIPLATIN; PACLITAXEL; PEMETREXED; PLATELET DERIVED GROWTH FACTOR; SORAFENIB; SUNITINIB; VASCULOTROPIN RECEPTOR;

EID: 84949658578     PISSN: 11786930     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S78805     Document Type: Review
Times cited : (56)

References (78)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971; 285(21): 1182-1186.
    • (1971) N Engl J Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 3
    • 84938095333 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) inhibition-a critical review
    • Moreira IS, Fernandes PA, Ramos MJ. Vascular endothelial growth factor (VEGF) inhibition-a critical review. Anticancer Agents Med Chem. 2007; 7(2): 223-245.
    • (2007) Anticancer Agents Med Chem , vol.7 , Issue.2 , pp. 223-245
    • Moreira, I.S.1    Fernandes, P.A.2    Ramos, M.J.3
  • 4
    • 2942590261 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a target for anticancer therapy
    • Ferrara N. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist. 2004; 9(Suppl 1): 2-10.
    • (2004) Oncologist , vol.9 , pp. 2-10
    • Ferrara, N.1
  • 5
    • 39749166386 scopus 로고    scopus 로고
    • Antiangiogenic therapy for cancer: An update
    • Shojaei F, Ferrara N. Antiangiogenic therapy for cancer: an update. Cancer J. 2007; 13(6): 345-348.
    • (2007) Cancer J , vol.13 , Issue.6 , pp. 345-348
    • Shojaei, F.1    Ferrara, N.2
  • 6
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007; 25(12): 1539-1544.
    • (2007) J Clin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 7
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 2006; 355(24): 2542-2550.
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 8
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med. 2007; 357(26): 2666-2676.
    • (2007) N Engl J Med , vol.357 , Issue.26 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 9
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, et al. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol. 2010; 28(13): 2137-2143.
    • (2010) J Clin Oncol , vol.28 , Issue.13 , pp. 2137-2143
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 10
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007; 356(2): 115-124.
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 11
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007; 356(2): 125-134.
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 12
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol. 2010; 28(6): 1061-1068.
    • (2010) J Clin Oncol , vol.28 , Issue.6 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 13
    • 84655175698 scopus 로고    scopus 로고
    • Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind phase III trial
    • Wells SA Jr, Robinson BG, Gagel RF, et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J Clin Oncol. 2012; 30(2): 134-141.
    • (2012) J Clin Oncol , vol.30 , Issue.2 , pp. 134-141
    • Wells, S.A.1    Robinson, B.G.2    Gagel, R.F.3
  • 14
    • 84876974877 scopus 로고    scopus 로고
    • Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a randomised phase 3 trial
    • Motzer RJ, Escudier B, Tomczak P, et al. Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol. 2013; 14(6): 552-562.
    • (2013) Lancet Oncol , vol.14 , Issue.6 , pp. 552-562
    • Motzer, R.J.1    Escudier, B.2    Tomczak, P.3
  • 15
    • 84872921660 scopus 로고    scopus 로고
    • Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial
    • Grothey A, Van Cutsem E, Sobrero A, et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013; 381(9863): 303-312.
    • (2013) Lancet , vol.381 , Issue.9863 , pp. 303-312
    • Grothey, A.1    Van Cutsem, E.2    Sobrero, A.3
  • 16
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    • Van Cutsem E, Tabernero J, Lakomy R, et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol. 2012; 30(28): 3499-3506.
    • (2012) J Clin Oncol , vol.30 , Issue.28 , pp. 3499-3506
    • Van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3
  • 17
    • 84890571003 scopus 로고    scopus 로고
    • Cabozantinib in progressive medullary thyroid cancer
    • Elisei R, Schlumberger MJ, Muller SP, et al. Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol. 2013; 31(29): 3639-3646.
    • (2013) J Clin Oncol , vol.31 , Issue.29 , pp. 3639-3646
    • Elisei, R.1    Schlumberger, M.J.2    Muller, S.P.3
  • 18
    • 84892852372 scopus 로고    scopus 로고
    • Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): An international, randomised, multicentre, placebo-controlled, phase 3 trial
    • Fuchs CS, Tomasek J, Yong CJ, et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 2014; 383(9911): 31-39.
    • (2014) Lancet , vol.383 , Issue.9911 , pp. 31-39
    • Fuchs, C.S.1    Tomasek, J.2    Yong, C.J.3
  • 19
    • 49249087039 scopus 로고    scopus 로고
    • Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
    • Rini BI, Michaelson MD, Rosenberg JE, et al. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol. 2008; 26(22): 3743-3748.
    • (2008) J Clin Oncol , vol.26 , Issue.22 , pp. 3743-3748
    • Rini, B.I.1    Michaelson, M.D.2    Rosenberg, J.E.3
  • 20
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell. 2009; 15(3): 232-239.
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 21
    • 34447253095 scopus 로고    scopus 로고
    • Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies
    • Rusnati M, Presta M. Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies. Curr Pharm Des. 2007; 13(20): 2025-2044.
    • (2007) Curr Pharm Des , vol.13 , Issue.20 , pp. 2025-2044
    • Rusnati, M.1    Presta, M.2
  • 22
    • 57049093954 scopus 로고    scopus 로고
    • Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells
    • Wu E, Palmer N, Tian Z, et al. Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells. PLoS One. 2008; 3(11): e3794.
    • (2008) PLoS One , vol.3 , Issue.11
    • Wu, E.1    Palmer, N.2    Tian, Z.3
  • 23
    • 79953313814 scopus 로고    scopus 로고
    • Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor-resistant human lung adenocarcinoma
    • Cascone T, Herynk MH, Xu L, et al. Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor-resistant human lung adenocarcinoma. J Clin Invest. 2011; 121(4): 1313-1328.
    • (2011) J Clin Invest , vol.121 , Issue.4 , pp. 1313-1328
    • Cascone, T.1    Herynk, M.H.2    Xu, L.3
  • 25
    • 35548982639 scopus 로고    scopus 로고
    • Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    • Fischer C, Jonckx B, Mazzone M, et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell. 2007; 131(3): 46-475.
    • (2007) Cell , vol.131 , Issue.3 , pp. 46-475
    • Fischer, C.1    Jonckx, B.2    Mazzone, M.3
  • 26
    • 58149190795 scopus 로고    scopus 로고
    • Pathways mediating resistance to vascular endothelial growth factor-targeted therapy
    • Ellis LM, Hicklin DJ. Pathways mediating resistance to vascular endothelial growth factor-targeted therapy. Clin Cancer Res. 2008; 14(20): 6371-6375.
    • (2008) Clin Cancer Res , vol.14 , Issue.20 , pp. 6371-6375
    • Ellis, L.M.1    Hicklin, D.J.2
  • 27
    • 84863305116 scopus 로고    scopus 로고
    • Mechanisms of resistance to vascular endothelial growth factor blockade
    • Abdullah SE, Perez-Soler R. Mechanisms of resistance to vascular endothelial growth factor blockade. Cancer. 2012; 118(14): 3455-3467.
    • (2012) Cancer , vol.118 , Issue.14 , pp. 3455-3467
    • Abdullah, S.E.1    Perez-Soler, R.2
  • 28
    • 61649100307 scopus 로고    scopus 로고
    • The FGF family: Biology, pathophysiology and therapy
    • Beenken A, Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov. 2009; 8(3): 235-253.
    • (2009) Nat Rev Drug Discov , vol.8 , Issue.3 , pp. 235-253
    • Beenken, A.1    Mohammadi, M.2
  • 30
    • 0032875460 scopus 로고    scopus 로고
    • Mechanism of action and in vivo role of platelet-derived growth factor
    • Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 1999; 79(4): 1283-1316.
    • (1999) Physiol Rev , vol.79 , Issue.4 , pp. 1283-1316
    • Heldin, C.H.1    Westermark, B.2
  • 31
    • 0035979147 scopus 로고    scopus 로고
    • A role of PDGFRalpha in basal cell carcinoma proliferation
    • Xie J, Aszterbaum M, Zhang X, et al. A role of PDGFRalpha in basal cell carcinoma proliferation. Proc Natl Acad Sci U S A. 2001; 98(16): 9255-9259.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.16 , pp. 9255-9259
    • Xie, J.1    Aszterbaum, M.2    Zhang, X.3
  • 32
    • 0025019999 scopus 로고
    • Expression of platelet-derived growth factor beta-receptors on stromal tissue cells in human carcinoid tumors
    • Funa K, Papanicolaou V, Juhlin C, et al. Expression of platelet-derived growth factor beta-receptors on stromal tissue cells in human carcinoid tumors. Cancer Res. 1990; 50(3): 748-753.
    • (1990) Cancer Res , vol.50 , Issue.3 , pp. 748-753
    • Funa, K.1    Papanicolaou, V.2    Juhlin, C.3
  • 33
    • 0028330152 scopus 로고
    • Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation
    • Bornfeldt KE, Raines EW, Nakano T, Graves LM, Krebs EG, Ross R. Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation. J Clin Invest. 1994; 93(3): 1266-1274.
    • (1994) J Clin Invest , vol.93 , Issue.3 , pp. 1266-1274
    • Bornfeldt, K.E.1    Raines, E.W.2    Nakano, T.3    Graves, L.M.4    Krebs, E.G.5    Ross, R.6
  • 34
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS. Tumor angiogenesis. N Engl J Med. 2008; 358(19): 2039-2049.
    • (2008) N Engl J Med , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.S.1
  • 35
    • 0032768156 scopus 로고    scopus 로고
    • Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    • Hellstrom M, Kalen M, Lindahl P, Abramsson A, Betsholtz C. Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development. 1999; 126(14): 3047-3055.
    • (1999) Development , vol.126 , Issue.14 , pp. 3047-3055
    • Hellstrom, M.1    Kalen, M.2    Lindahl, P.3    Abramsson, A.4    Betsholtz, C.5
  • 37
    • 84890467312 scopus 로고    scopus 로고
    • Targeting the PDGF signaling pathway in tumor treatment
    • Heldin CH. Targeting the PDGF signaling pathway in tumor treatment. Cell Commun Signal. 2013; 11: 97.
    • (2013) Cell Commun Signal , vol.11 , pp. 97
    • Heldin, C.H.1
  • 38
    • 81055124256 scopus 로고    scopus 로고
    • Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer
    • Taeger J, Moser C, Hellerbrand C, et al. Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer. Mol Cancer Ther. 2011; 10(11): 2157-2167.
    • (2011) Mol Cancer Ther , vol.10 , Issue.11 , pp. 2157-2167
    • Taeger, J.1    Moser, C.2    Hellerbrand, C.3
  • 39
    • 77956543006 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the proliferation-stimulating effect of human lung cancer-associated stromal fibroblasts on lung cancer cells
    • Kinoshita K, Nakagawa K, Hamada J, et al. Imatinib mesylate inhibits the proliferation-stimulating effect of human lung cancer-associated stromal fibroblasts on lung cancer cells. Int J Oncol. 2010; 37(4): 869-877.
    • (2010) Int J Oncol , vol.37 , Issue.4 , pp. 869-877
    • Kinoshita, K.1    Nakagawa, K.2    Hamada, J.3
  • 40
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R, Thurnher A, Katsen AD, et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J. 2004; 18(2): 338-340.
    • (2004) FASEB J , vol.18 , Issue.2 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3
  • 41
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest. 2003; 111(9): 1287-1295.
    • (2003) J Clin Invest , vol.111 , Issue.9 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 42
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell. 2005; 8(4): 299-309.
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 43
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov. 2004; 3(5): 391-400.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.5 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 44
    • 84920400299 scopus 로고    scopus 로고
    • The toxicity of anti-VEGF agents when coupled with standard chemotherapeutics
    • Afranie-Sakyi JA, Klement GL. The toxicity of anti-VEGF agents when coupled with standard chemotherapeutics. Cancer Lett. 2015; 357(1): 1-7.
    • (2015) Cancer Lett , vol.357 , Issue.1 , pp. 1-7
    • Afranie-Sakyi, J.A.1    Klement, G.L.2
  • 45
    • 34249686689 scopus 로고    scopus 로고
    • Toxicities of antiangiogenic therapy in non-small-cell lung cancer
    • Herbst RS. Toxicities of antiangiogenic therapy in non-small-cell lung cancer. Clin Lung Cancer. 2006; 8(Suppl 1): S23-S30.
    • (2006) Clin Lung Cancer , vol.8 , pp. S23-S30
    • Herbst, R.S.1
  • 46
    • 84901353075 scopus 로고    scopus 로고
    • Incidence and relative risk of hepatic toxicity in patients treated with anti-angiogenic tyrosine kinase inhibitors for malignancy
    • Iacovelli R, Palazzo A, Procopio G, et al. Incidence and relative risk of hepatic toxicity in patients treated with anti-angiogenic tyrosine kinase inhibitors for malignancy. Br J Clin Pharmacol. 2014; 77(6): 929-938.
    • (2014) Br J Clin Pharmacol , vol.77 , Issue.6 , pp. 929-938
    • Iacovelli, R.1    Palazzo, A.2    Procopio, G.3
  • 47
    • 34147145539 scopus 로고    scopus 로고
    • Clinical trials of VEGF receptor tyrosine kinase inhibitors in pancreatic cancer
    • Cabebe E, Fisher GA. Clinical trials of VEGF receptor tyrosine kinase inhibitors in pancreatic cancer. Expert Opin Investig Drugs. 2007; 16(4): 467-476.
    • (2007) Expert Opin Investig Drugs , vol.16 , Issue.4 , pp. 467-476
    • Cabebe, E.1    Fisher, G.A.2
  • 48
    • 27544479318 scopus 로고    scopus 로고
    • Role of tyrosine kinase inhibitors in cancer therapy
    • Arora A, Scholar EM. Role of tyrosine kinase inhibitors in cancer therapy. J Pharmacol Exp Ther. 2005; 315(3): 971-979.
    • (2005) J Pharmacol Exp Ther , vol.315 , Issue.3 , pp. 971-979
    • Arora, A.1    Scholar, E.M.2
  • 49
    • 84908349004 scopus 로고    scopus 로고
    • What could Nintedanib (BIBF 1120), a triple inhibitor of VEGFR, PDGFR, and FGFR, add to the current treatment options for patients with metastatic colorectal cancer?
    • Capdevila J, Carrato A, Tabernero J, Grande E. What could Nintedanib (BIBF 1120), a triple inhibitor of VEGFR, PDGFR, and FGFR, add to the current treatment options for patients with metastatic colorectal cancer? Crit Rev Oncol Hematol. 2014; 92: 83-106.
    • (2014) Crit Rev Oncol Hematol , vol.92 , pp. 83-106
    • Capdevila, J.1    Carrato, A.2    Tabernero, J.3    Grande, E.4
  • 50
    • 84862103506 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: Multi-targeted or single-targeted?
    • Broekman F, Giovannetti E, Peters GJ. Tyrosine kinase inhibitors: multi-targeted or single-targeted? World J Clin Oncol. 2011; 2(2): 80-93.
    • (2011) World J Clin Oncol , vol.2 , Issue.2 , pp. 80-93
    • Broekman, F.1    Giovannetti, E.2    Peters, G.J.3
  • 51
    • 67650714103 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120)
    • Roth GJ, Heckel A, Colbatzky F, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem. 2009; 52(14): 4466-4480.
    • (2009) J Med Chem , vol.52 , Issue.14 , pp. 4466-4480
    • Roth, G.J.1    Heckel, A.2    Colbatzky, F.3
  • 52
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F, Roth GJ, Krssak M, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 2008; 68(12): 4774-4782.
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 53
    • 84901810710 scopus 로고    scopus 로고
    • Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis
    • Richeldi L, du Bois RM, Raghu G, et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014; 370(22): 2071-2082.
    • (2014) N Engl J Med , vol.370 , Issue.22 , pp. 2071-2082
    • Richeldi, L.1    du Bois, R.M.2    Raghu, G.3
  • 54
    • 79953244361 scopus 로고    scopus 로고
    • Antiangiogenic therapy: Impact on invasion, disease progression, and metastasis
    • Ebos JM, Kerbel RS. Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol. 2011; 8(4): 210-221.
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.4 , pp. 210-221
    • Ebos, J.M.1    Kerbel, R.S.2
  • 55
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009; 15(3): 220-231.
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 56
    • 84863704553 scopus 로고    scopus 로고
    • Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors
    • Sennino B, Ishiguro-Oonuma T, Wei Y, et al. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov. 2012; 2(3): 270-287.
    • (2012) Cancer Discov , vol.2 , Issue.3 , pp. 270-287
    • Sennino, B.1    Ishiguro-Oonuma, T.2    Wei, Y.3
  • 57
    • 84879292510 scopus 로고    scopus 로고
    • BIBF 1120 (nintedanib), a triple angiokinase inhibitor, induces hypoxia but not EMT and blocks progression of preclinical models of lung and pancreatic cancer
    • Kutluk Cenik B, Ostapoff KT, Gerber DE, Brekken RA. BIBF 1120 (nintedanib), a triple angiokinase inhibitor, induces hypoxia but not EMT and blocks progression of preclinical models of lung and pancreatic cancer. Mol Cancer Ther. 2013; 12(6): 992-1001.
    • (2013) Mol Cancer Ther , vol.12 , Issue.6 , pp. 992-1001
    • Kutluk Cenik, B.1    Ostapoff, K.T.2    Gerber, D.E.3    Brekken, R.A.4
  • 58
    • 84902662529 scopus 로고    scopus 로고
    • Nintedanib (BIBF-1120) inhibits hepatocellular carcinoma growth independent of angiokinase activity
    • Tai WT, Shiau CW, Li YS, et al. Nintedanib (BIBF-1120) inhibits hepatocellular carcinoma growth independent of angiokinase activity. J Hepatol. 2014; 61(1): 89-97.
    • (2014) J Hepatol , vol.61 , Issue.1 , pp. 89-97
    • Tai, W.T.1    Shiau, C.W.2    Li, Y.S.3
  • 59
    • 84921274316 scopus 로고    scopus 로고
    • Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer
    • Awasthi N, Hinz S, Brekken RA, Schwarz MA, Schwarz RE. Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer. Cancer Lett. 2015; 358(1): 59-66.
    • (2015) Cancer Lett , vol.358 , Issue.1 , pp. 59-66
    • Awasthi, N.1    Hinz, S.2    Brekken, R.A.3    Schwarz, M.A.4    Schwarz, R.E.5
  • 60
    • 77953206902 scopus 로고    scopus 로고
    • Efficacy of BIBF 1120, a potent triple angiokinase inhibitor, in models of human non-small cell lung cancer is augmented by chemotherapy
    • Hilberg F, Brandstetter I. Efficacy of BIBF 1120, a potent triple angiokinase inhibitor, in models of human non-small cell lung cancer is augmented by chemotherapy. Eur J Cancer. 2007; 2: S380.
    • (2007) Eur J Cancer , vol.2
    • Hilberg, F.1    Brandstetter, I.2
  • 61
    • 79952943038 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers
    • Stopfer P, Rathgen K, Bischoff D, et al. Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers. Xenobiotica. 2011; 41(4): 297-311.
    • (2011) Xenobiotica , vol.41 , Issue.4 , pp. 297-311
    • Stopfer, P.1    Rathgen, K.2    Bischoff, D.3
  • 62
    • 74949090791 scopus 로고    scopus 로고
    • Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors
    • Mross K, Stefanic M, Gmehling D, et al. Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors. Clin Cancer Res. 2010; 16(1): 311-319.
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 311-319
    • Mross, K.1    Stefanic, M.2    Gmehling, D.3
  • 63
    • 77958038695 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors
    • Okamoto I, Kaneda H, Satoh T, et al. Phase I safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors. Mol Cancer Ther. 2010; 9(10): 2825-2833.
    • (2010) Mol Cancer Ther , vol.9 , Issue.10 , pp. 2825-2833
    • Okamoto, I.1    Kaneda, H.2    Satoh, T.3
  • 64
    • 77952325749 scopus 로고    scopus 로고
    • Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients
    • Ellis PM, Kaiser R, Zhao Y, Stopfer P, Gyorffy S, Hanna N. Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients. Clin Cancer Res. 2010; 16(10): 2881-2889.
    • (2010) Clin Cancer Res , vol.16 , Issue.10 , pp. 2881-2889
    • Ellis, P.M.1    Kaiser, R.2    Zhao, Y.3    Stopfer, P.4    Gyorffy, S.5    Hanna, N.6
  • 65
    • 84864955678 scopus 로고    scopus 로고
    • A phase I, open-label dose-escalation study of continuous treatment with BIBF 1120 in combination with paclitaxel and carboplatin as first-line treatment in patients with advanced non-small-cell lung cancer
    • Doebele RC, Conkling P, Traynor AM, et al. A phase I, open-label dose-escalation study of continuous treatment with BIBF 1120 in combination with paclitaxel and carboplatin as first-line treatment in patients with advanced non-small-cell lung cancer. Ann Oncol. 2012; 23(8): 2094-2102.
    • (2012) Ann Oncol , vol.23 , Issue.8 , pp. 2094-2102
    • Doebele, R.C.1    Conkling, P.2    Traynor, A.M.3
  • 66
    • 79957452054 scopus 로고    scopus 로고
    • A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer
    • Reck M, Kaiser R, Eschbach C, et al. A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer. Ann Oncol. 2011; 22(6): 1374-1381.
    • (2011) Ann Oncol , vol.22 , Issue.6 , pp. 1374-1381
    • Reck, M.1    Kaiser, R.2    Eschbach, C.3
  • 67
    • 84892967581 scopus 로고    scopus 로고
    • Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): A phase 3, double-blind, randomised controlled trial
    • Reck M, Kaiser R, Mellemgaard A, et al. Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial. Lancet Oncol. 2014; 15(2): 143-155.
    • (2014) Lancet Oncol , vol.15 , Issue.2 , pp. 143-155
    • Reck, M.1    Kaiser, R.2    Mellemgaard, A.3
  • 68
    • 84886393615 scopus 로고    scopus 로고
    • Lume-lung 2: A multicenter, randomized, double-blind, phase III study of nintedanib plus pem-etrexed versus placebo plus pemetrexed in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) after failure of first-line chemotherapy
    • Hanna NK, Kaiser R, Sullivan, RN, et al. Lume-lung 2: a multicenter, randomized, double-blind, phase III study of nintedanib plus pem-etrexed versus placebo plus pemetrexed in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) after failure of first-line chemotherapy. J Clin Oncol. 2013; 31(Suppl: 8034).
    • (2013) J Clin Oncol , vol.31
    • Hanna, N.K.1    Kaiser, R.2    Sullivan, R.N.3
  • 69
    • 80053561888 scopus 로고    scopus 로고
    • Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer
    • Ledermann JA, Hackshaw A, Kaye S, et al. Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer. J Clin Oncol. 2011; 29(28): 3798-3804.
    • (2011) J Clin Oncol , vol.29 , Issue.28 , pp. 3798-3804
    • Ledermann, J.A.1    Hackshaw, A.2    Kaye, S.3
  • 70
    • 84894046261 scopus 로고    scopus 로고
    • AGO-Ovar 12: A randomized placebo-controlled GCIG/ENGOT-intergroup phase III trial of standard frontline chemotherapy ± nintedanib for advanced ovarian cancer
    • du Bois A, Kristensen G, Ray-Coquard I, et al. AGO-Ovar 12: a randomized placebo-controlled GCIG/ENGOT-intergroup phase III trial of standard frontline chemotherapy ± nintedanib for advanced ovarian cancer. Int J Gynecol Cancer. 2013; 23: PL01.
    • (2013) Int J Gynecol Cancer , vol.23
    • du Bois, A.1    Kristensen, G.2    Ray-Coquard, I.3
  • 71
    • 84885599759 scopus 로고    scopus 로고
    • Phase II efficacy and safety study of nintedanib versus sunitinib in previously untreated renal cell carcinoma (RCC) patients
    • (abstract 4506)
    • Eisen T, Shparyk Y, Jones R, et al. Phase II efficacy and safety study of nintedanib versus sunitinib in previously untreated renal cell carcinoma (RCC) patients. J Clin Oncol. 2013; 31(abstract 4506).
    • (2013) J Clin Oncol , vol.31
    • Eisen, T.1    Shparyk, Y.2    Jones, R.3
  • 72
    • 84949675031 scopus 로고    scopus 로고
    • Efficacy and safety study of nintedanib (N) versus sorafenib (S) in Caucasian and Asian patients with advanced hepatocellular carcinoma (HCC): Pooled analysis of two randomized phase II trials
    • (abstract 4074)
    • Meyer T, Palmer DH, Chao Y, et al. Efficacy and safety study of nintedanib (N) versus sorafenib (S) in Caucasian and Asian patients with advanced hepatocellular carcinoma (HCC): pooled analysis of two randomized phase II trials. J Clin Oncol. 2015; 33(abstract 4074).
    • (2015) J Clin Oncol , vol.33
    • Meyer, T.1    Palmer, D.H.2    Chao, Y.3
  • 73
    • 85027944730 scopus 로고    scopus 로고
    • Randomized phase II study of nintedanib in metastatic castration-resistant prostate cancer postdocetaxel
    • Droz JP, Medioni J, Chevreau C, et al. Randomized phase II study of nintedanib in metastatic castration-resistant prostate cancer postdocetaxel. Anticancer Drugs. 2014; 25(9): 1081-1088.
    • (2014) Anticancer Drugs , vol.25 , Issue.9 , pp. 1081-1088
    • Droz, J.P.1    Medioni, J.2    Chevreau, C.3
  • 74
    • 84893819316 scopus 로고    scopus 로고
    • Randomized Phase II trial of nintedanib, afatinib and sequential combination in castration-resistant prostate cancer
    • Molife LR, Omlin A, Jones RJ, et al. Randomized Phase II trial of nintedanib, afatinib and sequential combination in castration-resistant prostate cancer. Future Oncol. 2014; 10(2): 219-231.
    • (2014) Future Oncol , vol.10 , Issue.2 , pp. 219-231
    • Molife, L.R.1    Omlin, A.2    Jones, R.J.3
  • 75
    • 79960443101 scopus 로고    scopus 로고
    • Phase II trial of weekly alternating sequential BIBF 1120 and afatinib for advanced colorectal cancer
    • Bouche O, Maindrault-Goebel F, Ducreux M, et al. Phase II trial of weekly alternating sequential BIBF 1120 and afatinib for advanced colorectal cancer. Anticancer Res. 2011; 31(6): 2271-2281.
    • (2011) Anticancer Res , vol.31 , Issue.6 , pp. 2271-2281
    • Bouche, O.1    Maindrault-Goebel, F.2    Ducreux, M.3
  • 76
    • 84872600553 scopus 로고    scopus 로고
    • A phase I/II, open-label, randomised study of BIBF 1120* plus mFOLFOX6 compared to bevacizumab plus mFOLFOX6 in patients with metastatic colorectal cancer
    • Van Cutsem E, Prenen H, Guillen-Ponce C, et al. A phase I/II, open-label, randomised study of BIBF 1120* plus mFOLFOX6 compared to bevacizumab plus mFOLFOX6 in patients with metastatic colorectal cancer. Eur J Cancer. 2011; 47: 8-9.
    • (2011) Eur J Cancer , vol.47 , pp. 8-9
    • Van Cutsem, E.1    Prenen, H.2    Guillen-Ponce, C.3
  • 78
    • 84908360684 scopus 로고    scopus 로고
    • Phase I clinical trial of nintedanib plus paclitaxel in early HER-2-negative breast cancer (CNIO-BR-01-2010/GEICAM-2010-10 study)
    • Quintela-Fandino M, Urruticoechea A, Guerra J, et al. Phase I clinical trial of nintedanib plus paclitaxel in early HER-2-negative breast cancer (CNIO-BR-01-2010/GEICAM-2010-10 study). Br J Cancer. 2014; 111(6): 1060-1064.
    • (2014) Br J Cancer , vol.111 , Issue.6 , pp. 1060-1064
    • Quintela-Fandino, M.1    Urruticoechea, A.2    Guerra, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.