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Volumn 39, Issue 12, 2015, Pages 1750-1756

Leptin-induced mitochondrial fusion mediates hepatic lipid accumulation

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADIPONECTIN; CHOLESTEROL; FATTY ACID; GLUCOSE; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MITOFUSIN 1; MITOFUSIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RNA; STAT3 PROTEIN; TRANSCRIPTION FACTOR NRF1; TRIACYLGLYCEROL;

EID: 84949626079     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2015.120     Document Type: Article
Times cited : (36)

References (30)
  • 1
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
    • Tile H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006; 6: 772-782
    • (2006) Nat Rev Immunol , vol.6 , pp. 772-782
    • Tile, H.1    Moschen, A.R.2
  • 2
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjorbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1998; 1: 619-625
    • (1998) Mol Cell , vol.1 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 3
    • 79952559571 scopus 로고    scopus 로고
    • Chronic central leptin infusion modifies the response to acute central insulin injection by reducing the interaction of the insulin receptor with IRS2 and increasing its association with SOCS3
    • Burgos-Ramos E, Chowen JA, Arilla-Ferreiro E, Canelles S, Argente J, Barrios V. Chronic central leptin infusion modifies the response to acute central insulin injection by reducing the interaction of the insulin receptor with IRS2 and increasing its association with SOCS3. J Neurochem 2011; 117: 175-185
    • (2011) J Neurochem , vol.117 , pp. 175-185
    • Burgos-Ramos, E.1    Chowen, J.A.2    Arilla-Ferreiro, E.3    Canelles, S.4    Argente, J.5    Barrios, V.6
  • 5
    • 84878854783 scopus 로고    scopus 로고
    • The role of leptin in the control of insulin-glucose axis
    • Amitani M, Asakawa A, Amitani H, Inui A. The role of leptin in the control of insulin-glucose axis. Front Neurosci 2013; 7: 51
    • (2013) Front Neurosci , vol.7 , pp. 51
    • Amitani, M.1    Asakawa, A.2    Amitani, H.3    Inui, A.4
  • 6
    • 84857127132 scopus 로고    scopus 로고
    • Glucose enhances leptin signaling through modulation of AMPK activity
    • Su H, Liang L, Carter-Su C, Rui L. Glucose enhances leptin signaling through modulation of AMPK activity. PLoS One 2012; 7: e31636
    • (2012) PLoS One , vol.7 , pp. e31636
    • Su, H.1    Liang, L.2    Carter-Su, C.3    Rui, L.4
  • 7
    • 70350317881 scopus 로고    scopus 로고
    • Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis
    • Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J et al. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology 2009; 150: 4874-4882
    • (2009) Endocrinology , vol.150 , pp. 4874-4882
    • Hill, J.W.1    Xu, Y.2    Preitner, F.3    Fukuda, M.4    Cho, Y.R.5    Luo, J.6
  • 8
    • 79959879208 scopus 로고    scopus 로고
    • Central insulin and leptin-mediated autonomic control of glucose homeostasis
    • Marino JS, Xu Y, Hill JW. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endocrinol Metab 2011; 22: 275-285
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 275-285
    • Marino, J.S.1    Xu, Y.2    Hill, J.W.3
  • 9
    • 11144357516 scopus 로고    scopus 로고
    • Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
    • Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat Med 2004; 10: 168-174
    • (2004) Nat Med , vol.10 , pp. 168-174
    • Inoue, H.1    Ogawa, W.2    Ozaki, M.3    Haga, S.4    Matsumoto, M.5    Furukawa, K.6
  • 10
    • 84859563667 scopus 로고    scopus 로고
    • CITED2 links hormonal signaling to PGC-1alpha acetylation in the regulation of gluconeogenesis
    • Sakai M, Matsumoto M, Tujimura T, Yongheng C, Noguchi T, Inagaki K et al. CITED2 links hormonal signaling to PGC-1alpha acetylation in the regulation of gluconeogenesis. Nat Med 2012; 18: 612-618
    • (2012) Nat Med , vol.18 , pp. 612-618
    • Sakai, M.1    Matsumoto, M.2    Tujimura, T.3    Yongheng, C.4    Noguchi, T.5    Inagaki, K.6
  • 11
    • 84924732269 scopus 로고    scopus 로고
    • Leptin administration activates irisin-induced myogenesis via nitric oxidedependent mechanisms, but reduces its effect on subcutaneous fat browning in mice
    • Rodriguez A, Becerril S, Mendez-Gimenez L, Ramirez B, Sainz B, Catalan V et al. Leptin administration activates irisin-induced myogenesis via nitric oxidedependent mechanisms, but reduces its effect on subcutaneous fat browning in mice. Int J Obes (Lond) 2015; 39: 397-407
    • (2015) Int J Obes (Lond , vol.39 , pp. 397-407
    • Rodriguez, A.1    Becerril, S.2    Mendez-Gimenez, L.3    Ramirez, B.4    Sainz, B.5    Catalan, V.6
  • 12
    • 84902294427 scopus 로고    scopus 로고
    • RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1alpha-mediated mitochondrial oxidative phosphorylation and glycolysis
    • Chen W, Wang Q, Bai L, Chen W, Wang X, Tellez CS et al. RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1alpha-mediated mitochondrial oxidative phosphorylation and glycolysis. Cell Death Differ 2014; 21: 1061-1070
    • (2014) Cell Death Differ , vol.21 , pp. 1061-1070
    • Chen, W.1    Wang, Q.2    Bai, L.3    Chen, W.4    Wang, X.5    Tellez, C.S.6
  • 13
    • 84884823792 scopus 로고    scopus 로고
    • Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance
    • Schneeberger M, Dietrich MO, Sebastian D, Imbernon M, Castano C, Garcia A et al. Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell 2013; 155: 172-187
    • (2013) Cell , vol.155 , pp. 172-187
    • Schneeberger, M.1    Dietrich, M.O.2    Sebastian, D.3    Imbernon, M.4    Castano, C.5    Garcia, A.6
  • 14
    • 84864341714 scopus 로고    scopus 로고
    • The obesityrelated peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis
    • Martinez-Abundis E, Rajapurohitam V, Haist JV, Gan XT, Karmazyn M. The obesityrelated peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis. PLoS One 2012; 7: e41612
    • (2012) PLoS One , vol.7 , pp. e41612
    • Martinez-Abundis, E.1    Rajapurohitam, V.2    Haist, J.V.3    Gan, X.T.4    Karmazyn, M.5
  • 16
    • 33748312093 scopus 로고    scopus 로고
    • Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
    • Matsumoto M, Han S, Kitamura T, Accili D. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest 2006; 116: 2464-2472
    • (2006) J Clin Invest , vol.116 , pp. 2464-2472
    • Matsumoto, M.1    Han, S.2    Kitamura, T.3    Accili, D.4
  • 17
    • 84858376953 scopus 로고    scopus 로고
    • Mitochondria: In sickness and in health
    • Nunnari J, Suomalainen A. Mitochondria: in sickness and in health. Cell 2012; 148: 1145-1159
    • (2012) Cell , vol.148 , pp. 1145-1159
    • Nunnari, J.1    Suomalainen, A.2
  • 19
    • 77649244994 scopus 로고    scopus 로고
    • Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1(alpha)/Mitofusin-2 regulatory pathway in response to physical activity
    • Hernandez-Alvarez MI, Thabit H, Burns N, Shah S, Brema I, Hatunic M et al. Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1(alpha)/Mitofusin-2 regulatory pathway in response to physical activity. Diabetes Care 2010; 33: 645-651
    • (2010) Diabetes Care , vol.33 , pp. 645-651
    • Hernandez-Alvarez, M.I.1    Thabit, H.2    Burns, N.3    Shah, S.4    Brema, I.5    Hatunic, M.6
  • 20
    • 77953807425 scopus 로고    scopus 로고
    • Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes
    • Zorzano A, Hernandez-Alvarez MI, Palacin M, Mingrone G. Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes. Biochim Biophys Acta 2010; 1797: 1028-1033
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 1028-1033
    • Zorzano, A.1    Hernandez-Alvarez, M.I.2    Palacin, M.3    Mingrone, G.4
  • 21
    • 84859448265 scopus 로고    scopus 로고
    • Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
    • Sebastian D, Hernandez-Alvarez MI, Segales J, Sorianello E, Munoz JP, Sala D et al. Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proc Natl Acad Sci USA 2012; 109: 5523-5528
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 5523-5528
    • Sebastian, D.1    Hernandez-Alvarez, M.I.2    Segales, J.3    Sorianello, E.4    Munoz, J.P.5    Sala, D.6
  • 22
    • 84908556712 scopus 로고    scopus 로고
    • Decreasing mitochondrial fission alleviates hepatic steatosis in a muring model of nonalcoholic fatty liver disease
    • Galloway CA, Lee H, Brookes PS, Yoon Y. Decreasing mitochondrial fission alleviates hepatic steatosis in a muring model of nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol 2014; 307: G632-G641
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.307 , pp. G632-G641
    • Galloway, C.A.1    Lee, H.2    Brookes, P.S.3    Yoon, Y.4
  • 23
    • 84873284664 scopus 로고    scopus 로고
    • A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice
    • Huynh FK, Neumann UH, Wang Y, Rodrigues B, Kieffer TJ, Covey SD. A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice. Hepatology 2013; 57: 543-554
    • (2013) Hepatology , vol.57 , pp. 543-554
    • Huynh, F.K.1    Neumann, U.H.2    Wang, Y.3    Rodrigues, B.4    Kieffer, T.J.5    Covey, S.D.6
  • 24
    • 84890423248 scopus 로고    scopus 로고
    • Monascin and ankaflavin act as natural AMPK activators with PPARalpha agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice
    • Hsu WH, Chen TH, Lee BH, Hsu YW, Pan TM. Monascin and ankaflavin act as natural AMPK activators with PPARalpha agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. Food Chem Toxicol 2014; 64: 94-103
    • (2014) Food Chem Toxicol , vol.64 , pp. 94-103
    • Hsu, W.H.1    Chen, T.H.2    Lee, B.H.3    Hsu, Y.W.4    Pan, T.M.5
  • 25
    • 84901826624 scopus 로고    scopus 로고
    • Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats
    • Zhao L, Zou X, Feng Z, Luo C, Liu J, Li H et al. Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Exp Gerontol 2014; 56: 3-12
    • (2014) Exp Gerontol , vol.56 , pp. 3-12
    • Zhao, L.1    Zou, X.2    Feng, Z.3    Luo, C.4    Liu, J.5    Li, H.6
  • 26
    • 71949083755 scopus 로고    scopus 로고
    • Possible role of mitochondrial remodelling on cellular triacylglycerol accumulation
    • Kita T, Nishida H, Shibata H, Niimi S, Higuti T, Arakaki N. Possible role of mitochondrial remodelling on cellular triacylglycerol accumulation. J Biochem 2009; 146: 787-796
    • (2009) J Biochem , vol.146 , pp. 787-796
    • Kita, T.1    Nishida, H.2    Shibata, H.3    Niimi, S.4    Higuti, T.5    Arakaki, N.6
  • 27
    • 84883139636 scopus 로고    scopus 로고
    • Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice
    • Holmstrom MH, Tom RZ, Bjornholm M, Garcia-Roves PM, Zierath JR. Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice. Metabolism 2013; 62: 1258-1267
    • (2013) Metabolism , vol.62 , pp. 1258-1267
    • Holmstrom, M.H.1    Tom, R.Z.2    Bjornholm, M.3    Garcia-Roves, P.M.4    Zierath, J.R.5
  • 28
    • 84917705467 scopus 로고    scopus 로고
    • Decreasing mitochondrial fission prevents cholestatic liver injury
    • Yu T, Wang L, Lee H, O'Brien DK, Bronk SF, Gores GJ et al. Decreasing mitochondrial fission prevents cholestatic liver injury. J Biol Chem 2014; 289: 34074-34088
    • (2014) J Biol Chem , vol.289 , pp. 34074-34088
    • Yu, T.1    Wang, L.2    Lee, H.3    O'Brien, D.K.4    Bronk, S.F.5    Gores, G.J.6
  • 29
    • 34247554887 scopus 로고    scopus 로고
    • Genomewide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma
    • Dufour CR, Wilson BJ, Huss JM, Kelly DP, Alaynick WA, Downes M et al. Genomewide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab 2007; 5: 345-356
    • (2007) Cell Metab , vol.5 , pp. 345-356
    • Dufour, C.R.1    Wilson, B.J.2    Huss, J.M.3    Kelly, D.P.4    Alaynick, W.A.5    Downes, M.6
  • 30
    • 84858007745 scopus 로고    scopus 로고
    • Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3
    • Szczepanek K, Chen Q, Larner AC, Lesnefsky EJ. Cytoprotection by the modulation of mitochondrial electron transport chain: the emerging role of mitochondrial STAT3. Mitochondrion 2012; 12: 180-189
    • (2012) Mitochondrion , vol.12 , pp. 180-189
    • Szczepanek, K.1    Chen, Q.2    Larner, A.C.3    Lesnefsky, E.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.