Treatment during a vulnerable developmental period rescues a genetic epilepsy

Nature Medicine

Volumn 21, Issue 12, 2015, Pages 1436-1444

  Marguet, Stephan Lawrence ^a,b,c   Le Schulte, Vu Thao Quyen ^c   Merseburg, Andrea ^a,b,c   Neu, Axel ^c   Eichler, Ronny ^c   Jakovcevski, Igor ^a,b   Ivanov, Anton ^d   Hanganu Opatz, Ileana Livia ^c   Bernard, Christophe ^d   Morellini, Fabio ^c   Isbrandt, Dirk ^a,b,c  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BUMETANIDE; VOLTAGE GATED POTASSIUM CHANNEL; MESSENGER RNA; POTASSIUM CHANNEL KCNQ; PROTEIN C FOS; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG SAFETY; EPILEPSY; EXPERIMENTAL MODEL; HIPPOCAMPUS; HUMAN; HYPERACTIVITY; IN VIVO STUDY; MOUSE; NERVE CELL; NEWBORN; NEWBORN PERIOD; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEREOTYPY; WILD TYPE; ANIMAL; ANIMAL BEHAVIOR; BODY WEIGHT; C57BL MOUSE; COGNITION; DRUG EFFECTS; ELECTROENCEPHALOGRAPHY; FEMALE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HIPPOCAMPAL CA1 REGION; INFLAMMATION; MALE; MAMMALIAN EMBRYO; METABOLISM; MUTATION; NERVE CELL NETWORK; PATHOLOGY; TIME FACTOR;

ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; BODY WEIGHT; BUMETANIDE; CA1 REGION, HIPPOCAMPAL; COGNITION; ELECTROENCEPHALOGRAPHY; EMBRYO, MAMMALIAN; EPILEPSY; FEMALE; GROWTH AND DEVELOPMENT; INFLAMMATION; KCNQ POTASSIUM CHANNELS; MALE; MICE, INBRED C57BL; MUTATION; NERVE NET; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; RNA, MESSENGER; SOLUTE CARRIER FAMILY 12, MEMBER 2; TIME FACTORS;

EID: 84949625141     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3987     Document Type: Article

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