Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6

Biochemical and Biophysical Research Communications

Volumn 468, Issue 4, 2015, Pages 684-690

  Murata, Yasuhiko ^a   Uehara, Yoshihiko ^a   Hosoi, Yoshio ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Liver cancer; mTORC1; Radiosensitivity; Rapamycin; Starvation

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN KINASE B; RAPAMYCIN; SMALL INTERFERING RNA; CULTURE MEDIUM; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CANCER RADIOTHERAPY; CLINICAL ASSESSMENT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; HEPATOBLASTOMA CELL LINE; HEPG2 CELL LINE; HUH6 CELL LINE; HUMAN; HUMAN CELL; LIVER PARENCHYMA; LM217 CELL LINE; NUTRIENT AVAILABILITY; NUTRIENT STARVATION; NUTRIENT UPTAKE; PRIORITY JOURNAL; RADIOSENSITIVITY; SIMIAN VIRUS 40; STARVATION; CELL SURVIVAL; CULTURE MEDIUM; LIVER NEOPLASMS; METABOLISM; PATHOPHYSIOLOGY; RADIATION RESPONSE; RADIATION TOLERANCE; RADIOTHERAPY DOSAGE; UPREGULATION;

CELL SURVIVAL; CULTURE MEDIA; DOSE-RESPONSE RELATIONSHIP, RADIATION; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MULTIPROTEIN COMPLEXES; RADIATION TOLERANCE; RADIOTHERAPY DOSAGE; TOR SERINE-THREONINE KINASES; UP-REGULATION;

EID: 84949549922     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.11.016     Document Type: Article

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