Procalcitonin to guide antibiotic therapy in the ICU

International Journal of Antimicrobial Agents

Volumn 46, Issue , 2015, Pages S19-S24

  Bréchot, Nicolas ^a,b   Hékimian, Guillaume ^a,c   Chastre, Jean ^a,c   Luyt, Charles Edouard ^a,c  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b PSL RESEARCH UNIVERSITY   (France)

^c INSERM   (France)

Author keywords

Antibiotic stewardship; Nosocomial infection; Procalcitonin; Sepsis

Indexed keywords

ANTIBIOTIC AGENT; PROCALCITONIN; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; CALCA PROTEIN, HUMAN; CALCITONIN; CALCITONIN GENE RELATED PEPTIDE; PROTEIN PRECURSOR;

ALGORITHM; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; COMMUNITY ACQUIRED INFECTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; DRUG SAFETY; HUMAN; INTENSIVE CARE UNIT; KINETICS; LOWER RESPIRATORY TRACT INFECTION; MEASUREMENT ACCURACY; NONHUMAN; PATIENT MONITORING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; TREATMENT DURATION; TREATMENT INDICATION; TREATMENT RESPONSE; BLOOD; CROSS INFECTION; DRUG MONITORING; PROCEDURES; SEPSIS; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; BIOMARKERS; CALCITONIN; CALCITONIN GENE-RELATED PEPTIDE; CROSS INFECTION; DRUG MONITORING; HUMANS; INTENSIVE CARE UNITS; PROTEIN PRECURSORS; SEPSIS; TREATMENT OUTCOME;

EID: 84949531742     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2015.10.012     Document Type: Review

References (56)

1. K.L. Becker, E.S. Nylen, J.C. White, B. Muller, and R.H. Snider Jr. Clinical review 167: Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors J Clin Endocrinol Metab 89 2004 1512 1525
2. B. Müller, J.C. White, E.S. Nylén, R.H. Snider, K.L. Becker, and J.F. Habener Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis J Clin Endocrinol Metab 86 2001 396 404
3. P. Linscheid, D. Seboek, E.S. Nylen, I. Langer, M. Schlatter, K.L. Becker, and et al. In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue Endocrinology 144 2003 5578 5584
4. P. Linscheid, D. Seboek, D.J. Schaer, H. Zulewski, U. Keller, and B. Muller Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes Crit Care Med 32 2004 1715 1721
5. M. Meisner, F.M. Brunkhorst, H.B. Reith, J. Schmidt, H.G. Lestin, and K. Reinhart Clinical experiences with a new semi-quantitative solid phase immunoassay for rapid measurement of procalcitonin Clin Chem Lab Med 38 2000 989 995
6. K.E. Wagner, J.M. Martinez, S.D. Vath, R.H. Snider, E.S. Nylen, K.L. Becker, and et al. Early immunoneutralization of calcitonin precursors attenuates the adverse physiologic response to sepsis in pigs Crit Care Med 30 2002 2313 2321
7. M. Meisner, J. Schmidt, H. Huttner, and K. Tschaikowsky The natural elimination rate of procalcitonin in patients with normal and impaired renal function Intensive Care Med 26 Suppl. 2 2000 S212 S216
8. M. Meisner, E. Huttemann, T. Lohs, L. Kasakov, and K. Reinhart Plasma concentrations and clearance of procalcitonin during continuous veno-venous hemofiltration in septic patients Shock 15 2001 171 175
9. M. Meisner, T. Lohs, E. Huettemann, J. Schmidt, M. Hueller, and K. Reinhart The plasma elimination rate and urinary secretion of procalcitonin in patients with normal and impaired renal function Eur J Anaesthesiol 18 2001 79 87
10. O. Mimoz, J.F. Benoist, A.R. Edouard, M. Assicot, C. Bohuon, and K. Samii Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome Intensive Care Med 24 1998 185 188
11. H. Carsin, M. Assicot, F. Feger, O. Roy, I. Pennacino, H. Le Bever, and et al. Evolution and significance of circulating procalcitonin levels compared with IL-6, TNF alpha and endotoxin levels early after thermal injury Burns 23 1997 218 224
12. M. Meisner, K. Tschaikowsky, A. Hutzler, C. Schick, and J. Schuttler Postoperative plasma concentrations of procalcitonin after different types of surgery Intensive Care Med 24 1998 680 684
13. A. Aouifi, V. Piriou, O. Bastien, P. Blanc, H. Bouvier, R. Evans, and et al. Usefulness of procalcitonin for diagnosis of infection in cardiac surgical patients Crit Care Med 28 2000 3171 3176
14. M. Hensel, T. Volk, W.D. Docke, F. Kern, D. Tschirna, K. Egerer, and et al. Hyperprocalcitonemia in patients with noninfectious SIRS and pulmonary dysfunction associated with cardiopulmonary bypass Anesthesiology 89 1998 93 104
15. J. Bro-Jeppesen, J. Kjaergaard, M. Wanscher, N. Nielsen, H. Friberg, M. Bjerre, and et al. Systemic inflammatory response and potential prognostic implications after out-of-hospital cardiac arrest: a substudy of the Target Temperature Management Trial Crit Care Med 43 2015 1223 1232
16. M. Annborn, J. Dankiewicz, D. Erlinge, S. Hertel, M. Rundgren, J.G. Smith, and et al. Procalcitonin after cardiac arrest - an indicator of severity of illness, ischemia-reperfusion injury and outcome Resuscitation 84 2013 782 787
17. M.L. Kylanpaa-Back, A. Takala, E.A. Kemppainen, P.A. Puolakkainen, A.K. Leppaniemi, S.L. Karonen, and et al. Procalcitonin, soluble interleukin-2 receptor, and soluble E-selectin in predicting the severity of acute pancreatitis Crit Care Med 29 2001 63 69
18. S. Hammer, F. Meisner, P. Dirschedl, P. Fraunberger, B. Meiser, B. Reichart, and et al. Procalcitonin for differential diagnosis of graft rejection and infection in patients with heart and/or lung grafts Intensive Care Med 26 Suppl. 2 2000 S182 S186
19. C. Muroi, J.B. Lemb, M. Hugelshofer, M. Seule, D. Bellut, and E. Keller Early systemic procalcitonin levels in patients with aneurysmal subarachnoid hemorrhage Neurocrit Care 21 2014 73 77
20. S. Harbarth, K. Holeckova, C. Froidevaux, D. Pittet, B. Ricou, G.E. Grau, and et al. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis Am J Respir Crit Care Med 164 2001 396 402
21. B. Muller, K.L. Becker, H. Schachinger, P.R. Rickenbacher, P.R. Huber, W. Zimmerli, and et al. Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit Crit Care Med 28 2000 977 983
22. R. Mofidi, S.A. Suttie, P.V. Patil, S. Ogston, and R.W. Parks The value of procalcitonin at predicting the severity of acute pancreatitis and development of infected pancreatic necrosis: systematic review Surgery 146 2009 72 81
23. C.E. Luyt, A. Combes, C. Reynaud, G. Hekimian, A. Nieszkowska, M. Tonnellier, and et al. Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumonia Intensive Care Med 34 2008 1434 1440
24. F. Duflo, R. Debon, G. Monneret, J. Bienvenu, D. Chassard, and B. Allaouchiche Alveolar and serum procalcitonin: diagnostic and prognostic value in ventilator-associated pneumonia Anesthesiology 96 2002 74 79
25. E.S. Nylen, K.T. Whang, R.H. Snider Jr., P.M. Steinwald, J.C. White, and K.L. Becker Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis Crit Care Med 26 1998 1001 1006
26. A. Kumar, D. Roberts, K.E. Wood, B. Light, J.E. Parrillo, S. Sharma, and et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock Crit Care Med 34 2006 1589 1596
27. B. Müller, S. Harbarth, D. Stolz, R. Bingisser, C. Mueller, J. Leuppi, and et al. Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia BMC Infect Dis 7 2007 10
28. P. Hausfater, G. Juillien, B. Madonna-Py, J. Haroche, M. Bernard, and B. Riou Serum procalcitonin measurement as diagnostic and prognostic marker in febrile adult patients presenting to the emergency department Crit Care 11 2007 R60
29. M.D. de Kruif, M. Limper, H. Gerritsen, C.A. Spek, D.P. Brandjes, H. ten Cate, and et al. Additional value of procalcitonin for diagnosis of infection in patients with fever at the emergency department Crit Care Med 38 2010 457 463
30. B. Uzzan, R. Cohen, P. Nicolas, M. Cucherat, and G.Y. Perret Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis Crit Care Med 34 2006 1996 2003
31. B.M. Tang, G.D. Eslick, J.C. Craig, and A.S. McLean Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis Lancet Infect Dis 7 2007 210 217
32. C. Wacker, A. Prkno, F.M. Brunkhorst, and P. Schlattmann Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis Lancet Infect Dis 13 2013 426 435
33. C. Sponholz, Y. Sakr, K. Reinhart, and F. Brunkhorst Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature Crit Care 10 2006 R145
34. J. Chastre, and J.Y. Fagon Ventilator-associated pneumonia Am J Respir Crit Care Med 165 2002 867 903
35. S. Gibot, A. Cravoisy, B. Levy, M.C. Bene, G. Faure, and P.E. Bollaert Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia N Engl J Med 350 2004 451 458
36. B. Jung, N. Embriaco, F. Roux, J.M. Forel, D. Demory, J. Allardet-Servent, and et al. Microbiogical data, but not procalcitonin improve the accuracy of the Clinical Pulmonary Infection Score Intensive Care Med 36 2010 790 798
37. P. Ramirez, M.A. Garcia, M. Ferrer, J. Aznar, M. Valencia, J.M. Sahuquillo, and et al. Sequential measurements of procalcitonin levels in diagnosing ventilator-associated pneumonia Eur Respir J 31 2008 356 362
38. P.E. Charles, E. Kus, S. Aho, S. Prin, J.M. Doise, N.O. Olsson, and et al. Serum procalcitonin for the early recognition of nosocomial infection in the critically ill patients: a preliminary report BMC Infect Dis 9 2009 49
39. R. Pfister, M. Kochanek, T. Leygeber, C. Brun-Buisson, E. Cuquemelle, M.B. Machado, and et al. Procalcitonin for diagnosis of bacterial pneumonia in critically ill patients during 2009 H1N1 influenza pandemic: a prospective cohort study, systematic review and individual patient data meta-analysis Crit Care 18 2014 R44
40. D. Stolz, A. Stulz, B. Muller, A. Gratwohl, and M. Tamm BAL neutrophils, serum procalcitonin, and C-reactive protein to predict bacterial infection in the immunocompromised host Chest 132 2007 504 514
41. N. Bele, M. Darmon, I. Coquet, J.P. Feugeas, S. Legriel, N. Adaoui, and et al. Diagnostic accuracy of procalcitonin in critically ill immunocompromised patients BMC Infect Dis 11 2011 224
42. J.U. Jensen, L. Heslet, T.H. Jensen, K. Espersen, P. Steffensen, and M. Tvede Procalcitonin increase in early identification of critically ill patients at high risk of mortality Crit Care Med 34 2006 2596 2602
43. C.E. Luyt, V. Guerin, A. Combes, J.L. Trouillet, S.B. Ayed, M. Bernard, and et al. Procalcitonin kinetics as a prognostic marker of ventilator-associated pneumonia Am J Respir Crit Care Med 171 2005 48 53
44. P. Schuetz, B. Muller, M. Christ-Crain, D. Stolz, M. Tamm, L. Bouadma, and et al. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections Cochrane Database Syst Rev 9 2012 CD007498
45. M. Christ-Crain, D. Jaccard-Stolz, R. Bingisser, M.M. Gencay, P.R. Huber, M. Tamm, and et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial Lancet 363 2004 600 607
46. L. Bouadma, C.E. Luyt, F. Tubach, C. Cracco, A. Alvarez, C. Schwebel, and et al. Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial Lancet 375 2010 463 474
47. N. Layios, B. Lambermont, J.L. Canivet, P. Morimont, J.C. Preiser, C. Garweg, and et al. Procalcitonin usefulness for the initiation of antibiotic treatment in intensive care unit patients Crit Care Med 40 2012 2304 2309
48. J. Chastre, M. Wolff, J.Y. Fagon, S. Chevret, F. Thomas, D. Wermert, and et al. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial JAMA 290 2003 2588 2598
49. D. Stolz, N. Smyrnios, P. Eggimann, H. Pargger, N. Thakkar, M. Siegemund, and et al. Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study Eur Respir J 34 2009 1364 1375
50. V. Nobre, S. Harbarth, J.D. Graf, P. Rohner, and J. Pugin Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial Am J Respir Crit Care Med 177 2008 498 505
51. M. Hochreiter, T. Kohler, A.M. Schweiger, F.S. Keck, B. Bein, T. von Spiegel, and et al. Procalcitonin to guide duration of antibiotic therapy in intensive care patients: a randomized prospective controlled trial Crit Care 13 2009 R83
52. S. Schroeder, M. Hochreiter, T. Koehler, A.M. Schweiger, B. Bein, F.S. Keck, and et al. Procalcitonin (PCT)-guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study Langenbecks Arch Surg 394 2009 221 226
53. P. Kopterides, I.I. Siempos, I. Tsangaris, A. Tsantes, and A. Armaganidis Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials Crit Care Med 38 2010 2229 2241
54. D.K. Heyland, A.P. Johnson, S.C. Reynolds, and J. Muscedere Procalcitonin for reduced antibiotic exposure in the critical care setting: a systematic review and an economic evaluation Crit Care Med 39 2011 1792 1799
55. E. Assink-de Jong, D.W. de Lange, J.A. van Oers, M.W. Nijsten, J.W. Twisk, and A. Beishuizen Stop Antibiotics on guidance of Procalcitonin Study (SAPS): a randomised prospective multicenter investigator-initiated trial to analyse whether daily measurements of procalcitonin versus a standard-of-care approach can safely shorten antibiotic duration in intensive care unit patients - calculated sample size: 1816 patients BMC Infect Dis 13 2013 178
56. J.U. Jensen, L. Hein, B. Lundgren, M.H. Bestle, T.T. Mohr, M.H. Andersen, and et al. Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial Crit Care Med 39 2011 2048 2058