Microsecond thermal ablation of skin for transdermal drug delivery

Journal of Controlled Release

Volumn 154, Issue 1, 2011, Pages 58-68

  Lee, Jeong Woo ^a   Gadiraju, Priya ^b   Park, Jung Hwan ^c   Allen, Mark G ^b   Prausnitz, Mark R ^a  

^a Georgia Institute of Technology   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c Gachon University College of Medicine   (South Korea)

Author keywords

Electrical discharge; Finite element model; Jet; Skin permeability; Thermal ablation; Transdermal drug delivery

Indexed keywords

ELECTRICAL DISCHARGES; FINITE ELEMENT MODELS; SKIN PERMEABILITY; THERMAL ABLATION; TRANSDERMAL DRUG DELIVERY;

BODY FLUIDS; CONTROLLED DRUG DELIVERY; ELECTRIC DISCHARGES; FINITE ELEMENT METHOD; TISSUE;

ABLATION;

BOVINE SERUM ALBUMIN; SULFORHODAMINE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FINITE ELEMENT ANALYSIS; HEATING; HUMAN; HUMAN CELL; METHODOLOGY; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; SKIN PENETRATION; SKIN PERMEABILITY; SKIN SURFACE; STRATUM CORNEUM; TEMPERATURE RELATED PHENOMENA; THERMAL ABLATION METHOD;

ABLATION TECHNIQUES; ADMINISTRATION, CUTANEOUS; ANIMALS; CATTLE; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HOT TEMPERATURE; HUMANS; MODELS, BIOLOGICAL; RHODAMINES; SERUM ALBUMIN, BOVINE; SKIN; SKIN ABSORPTION; TIME FACTORS;

EID: 79960913671     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.05.003     Document Type: Article

References (27)

1. M.R. Prausnitz, R. Langer, Transdermal drug delivery, Nat. Biotech. 26 (11) (2008) 1261-1268.
2. R.L. Bronaugh, H.I. Maibach, Percutaneous absorption : drugs, cosmetics, mechanisms, methodology, Taylor & Francis, Boca Raton, 2005.
3. A.C. Williams, B.W. Barry, Penetration enhancers, Adv. Drug Deliver Rev. 56 (5) (2004) 603-618.
4. J.A. Subramony, A. Sharma, J.B. Phipps, Microprocessor controlled transdermal drug delivery, Int. J. Pharma 317 (1) (2006) 1-6. (Pubitemid 43866349)
5. M. Ogura, S. Pahwal, S. Mitragotri, Low-frequency sonophoresis: current status and future prospects, Adv. Drug Deliver Rev. 60 (10) (2008) 1218-1223.
6. A. Arora, M.R. Prausnitz, S. Mitragotri, Micro-scale devices for transdermal drug delivery, Int. J. Pharma 364 (2) (2008) 227-236.
7. M.R. Prausnitz, J.A. Mikszta, M. Cormier, A.K. Andrianov, Microneedle-based vaccines, Curr. Top. Microbiol. Immunol. 333 (2009) 369-393.
8. J. Bramson, K. Dayball, C. Evelegh, Y.H. Wan, D. Page, A. Smith, Enabling topical immunization via microporation: a novel method for pain-free and needle-free delivery of adenovirus-based vaccines, Gene Ther. 10 (3) (2003) 251-260. (Pubitemid 36204414)
9. V. Yuzhakov, Skin microporation with PassPort(TM) system for continuous transdermal delivery of proteins, AAPS 7 (S1) (2005).
10. A.C. Sintov, I. Krymberk, D. Daniel, T. Hannan, Z. Sohn, G. Levin, Radiofrequency-driven skin microchanneling as a new way for electrically assisted transdermal delivery of hydrophilic drugs, J. Control. Release 89 (2) (2003) 311-320. (Pubitemid 36507024)
11. G. Levin, A. Gershonowitz, H. Sacks, M. Stern, A. Sherman, S. Rudaev, I. Zivin, M. Phillip, Transdermal delivery of human growth hormone through RF-microchannels, Pharm. Res. 22 (4) (2005) 550-555.
12. H. Shapiro, L. Harris, F.W. Hetzel, D. Bar-Or, Laser assisted delivery of topical anesthesia for intramuscular needle insertion in adults, Laser Surg Med 31 (4) (2002) 252-256. (Pubitemid 35193029)
13. Y.G. Bachhav, S. Summer, A. Heinrich, T. Bragagna, C. Bohler, Y.N. Kalia, Effect of controlled laser microporation on drug transport kinetics into and across the skin, J. Control. Release 146 (1) (2010) 31-36.
14. J.H. Park, J.W. Lee, Y.C. Kim, M.R. Prausnitz, The effect of heat on skin permeability, Int. J. Pharma 359 (1-2) (2008) 94-103.
15. M.L. Cohen, Measurement of thermal-properties of human-skin, A review, J. Invest. Derm. 69 (3) (1977) 333-338.
16. F.P. Incropera, D.P. Dewitt, T.L. Bergman, A.S. Lavine, Fundamentals of heat and mass transfer, John Wiley & Sons, Inc., Hoboken NJ, 2007.
17. J.A. Eppstein, M.R. Hatch, D. Yang, Microporation of human skin for drug delivery and monitoring applicaions, USA Patent 2000.
18. B.A. English, P. Gadiraju, C.S. Rinehart, A. Glezer, M.G. Allen, Gas generator actuator arrays for flight control of spinning body projectiles, 19th IEEE International Conference on MicroElectro Mechanical Systems (MEMS), Istanbul, Turkey, 2006.
19. R.M. Felder, R.W. Rousseau, Elementary principles of chemical processes, John Wiley, New York, 2000, p. 637.
20. R.C. Lee, D.J. Zhang, J. Hannig, Biophysical injury mechanisms in electrical shock trauma, Annu. Rev. Biomed. Eng. 2 (2000) 477-509.
21. R. Defrin, A. Ohry, N. Blumen, G. Urca, Sensory determinants of thermal pain, Brain 125 (2002) 501-510. (Pubitemid 34194406)
22. J. Fore, The epidermal skin barrier: implications for the wound care practitioner, Part I, Adv. Skin Wound Care 17 (8) (2004) 417-425.
23. J. Carlson, The Kodak one-time-use flash camera, Phys. Teach. 42 (6) (2004) 375-376.
24. Y.N. Kalia, Y.G. Bachhav, T. Bragagna, C. Böhler, P.L.E.A.S.E.® (Painless Laser Epidermal System). A new laser microporation technology, Drug Deliv. Technol. 8 (2008) 26-31.
25. Abbey Norwood, Executive Informational Overview, Crystal Research Associates, New York, 2004 http://www.crystalra.com/pdf/Norwood-Abbey-EIO-12-15- 04. pdf accessed on 26 Jan 2011.
26. A.V. Badkar, A.M. Smith, J.A. Eppstein, A.K. Banga, Transdermal delivery of interferon alpha-2B using microporation and iontophoresis in hairless rats, Pharma Res. 24 (7) (2007) 1389-1395. (Pubitemid 46876496)
27. B.E. Poling, J.M. Prausnitz, J.P. O'Connell, The properties of gases and liquids, McGraw-Hill, New York, 2001.