CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Zhu, Rong ^a   Zhang, Chun Ge ^a   Liu, Yang ^a   Yuan, Zhi Qiang ^a   Chen, Wei Liang ^a   Yang, Shu Di ^a   Li, Ji Zhao ^a   Zhu, Wen Jing ^a   Zhou, Xiao Feng ^a,b   You, Ben Gang ^a   Zhang, Xue Nong ^a  

^a SOOCHOW UNIVERSITY   (China)

^b Changshu City Chinese Medicine Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA HEDERIN; ANTINEOPLASTIC AGENT; CD147 ANTIGEN; CHITOSAN; LIPOCORTIN 5; MONOCLONAL ANTIBODY; NANOPARTICLE; OLEANOLIC ACID; PROPIDIUM IODIDE; SAPONIN;

ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; CELL FRACTIONATION; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG EFFECTS; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE; HEP-G2 CELL LINE; HUMAN; IMMUNOLOGY; INFRARED SPECTROSCOPY; INTRACELLULAR SPACE; LIVER TUMOR; METABOLISM; NEAR INFRARED SPECTROSCOPY; NUDE MOUSE; PARTICLE SIZE; PATHOLOGY; SYNTHESIS; THREE DIMENSIONAL IMAGING; ULTRASTRUCTURE;

ANIMALS; ANNEXIN A5; ANTIBODIES, MONOCLONAL; ANTIGENS, CD147; ANTINEOPLASTIC AGENTS; APOPTOSIS; CHITOSAN; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE; HEP G2 CELLS; HUMANS; IMAGING, THREE-DIMENSIONAL; INTRACELLULAR SPACE; LIVER NEOPLASMS; MICE, NUDE; MICROSCOPY, CONFOCAL; NANOPARTICLES; OLEANOLIC ACID; PARTICLE SIZE; PROPIDIUM; SAPONINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPECTROSCOPY, NEAR-INFRARED; SUBCELLULAR FRACTIONS;

EID: 84949525249     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep17904     Document Type: Article

References (42)

1. Vogelzang, E. H., et al. Adalimumab trough concentrations in patients with rheumatoid arthritis and psoriatic arthritis treated with concomitant disease-modifying antirheumatic drugs. Ann Rheum Dis. 74, 474-475 (2015
2. Buch, M. H., et al. Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis. Ann Rheum Dis. 70, 909-920 (2011
3. Strickler, J. H., & Hurwitz, H. I. Bevacizumab-based therapies in the First-Line Treatment of Metastatic Colorectal Cancer. Oncologist. 17, 513-524 (2012
4. Martin-Castillo, B., et al. Basal/HER2 breast carcinomas-Integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin). Cell Cycle. 12, 225-245 (2013
5. Yu, M., et al. Determination of Saponins and Flavonoids in Ivy Leaf Extracts Using HPLC-DAD. J Chromatogr Sci. 53, 478-483 (2015
6. Rooney, S., & Ryan, M. F. Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer Res. 25, 2199-2204 (2005
7. Rooney, S., & Ryan, M. F. Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells. Anticancer Res. 25, 4255-4259 (2005
8. Cheng, L., et al. The anticancer effect and mechanism of α-hederin on breast cancer cells. Int J Oncol. 45, 757-763 (2014
9. Mendel, M., et al. Participation of extracellular calcium in α-hederin-induced contractions of rat isolated stomach strips. J Ethnopharmacol. 146, 423-426 (2013
10. Ganguly, K., et al. Polysaccharide-based micro/nanohydrogels for delivering macromolecular therapeutics. J Control Release. 193, 162-173 (2014
11. Dash, M., Chiellini, F., Ottenbrite, R. M., & Chiellini, E. Chitosan-A versatile semi-synthetic polymer in biomedical applications. Progress in Polymer Science 26, 981-1014 (2011
12. Agnihotri, S. A., Mallikarjuna, N. N., & Aminabhavi, T. M. Recent advances on chitosan-based micro-And nanoparticles in drug delivery. J Control Release. 100, 5-28 (2004
13. Agnihotri, S. A., et al. Recent advances on chitosan-based micro-And nanoparticles in drug delivery. J Control Release. 100, 5-28 (2004
14. Aminabhavi, T. M., et al. Controlled release of therapeutics using interpenetrating polymeric networks. Expert Opin Drug Deliv. 12, 669-688 (2015
15. Aminabhavi, T. M., et al. Guar gum as platform for the oral controlled release of therapeutics. Expert Opin Drug Deliv. 11, 753-766 (2014
16. Gupta, S., Singh, S. K., & Girotraa, P. Targeting silymarin for improved hepatoprotective activity through chitosan nanoparticles. Int J Pharm Investig. 4, 156-163 (2014
17. Sun, Y., et al. Newcastle disease virus vaccine encapsulated in biodegradable nanoparticles for mucosal delivery of a human vaccine. Hum Vaccin Immumother. 10, 2503-2506 (2014
18. Aral, C., & Akbuga, J. Preparation and in vitro transfection efficiency of chitosan microspheres containing plasmid DNA: poly(L-lysine) complexes. J Pharm Pharm Sci. 6, 321-326 (2003
19. Carrillo, C., et al. Chitosan nanoparticles as non-viral gene delivery systems: determination of loading efficiency. Biomed Pharmacother. 68, 775-783 (2014
20. Liu, L., et al. TAT-LHRH conjugated low molecular weight chitosan as a gene carrier specific for hepatocellular carcinoma cells. Int J Nanomedicine. 10, 2879-2889 (2014
21. Chaturvedi, K., et al. Cyclodextrin-based siRNA delivery nanocarrier: a state-of-The-Art review. Expert Opin Drug Deliv. 8, 1455-1468 (2011
22. Rudzinski, W. E., et al. Chitosan as a carrier for targeted delivery of small interfering RNA. Int J Pharm. 399, 1-11 (2010
23. Chaturvedi, K., et al. Polymeric hydrogels for oral insulin delivery. J. Controlled Release. 165, 129-138 (2013
24. Hu, Z. H., et al. Preparation of a novel liver-Targeting nanoparticle of norcantharidin derivative and evaluation of its anti-Tumour activity. J Exp Nanosc. 6, 183-199 (2011
25. Wang, Q., et al. Norcantharidin-Associated galactosylated chitosan nanoparticles for hepatocyte-Targeted delivery. Nanomedicine. 6, 371-381 (2010
26. Kim, T. H., et al. Galactosylated chitosan/DNA nanoparticles prepared using water-soluble chitosan as a gene carrier. Biomaterials. 25, 3783-3792 (2004
27. Park, I. K., et al. Galactosylated chitosan-graft-dextran as hepatocyte-Targeting DNA carrier. J Control Release. 69, 97-108 (2000
28. Park, I. K., et al. Galactosylated chitosan-graft-poly (ethylene glycol) as hepatocyte-Targeting DNA carrier. J Control Release. 76, 349-362 (2001
29. Gao, S. Y., et al. Galactosylated low molecular weight chitosan as DNA carrier for hepatocyte-Targeting. Int J Pharm. 255, 57-68 (2003
30. Zhu, H. Y., et al. Folate-modified chitosan micelles with enhanced tumor targeting evaluated by near infrared imaging system. Carbohydrate Polymers. 86, 1118-1129 (2011
31. Guan, M., et al. N-Trimethyl Chitosan Nanoparticle-encapsulated Lactosyl-Norcantharidin for Liver Cancer Therapy with High Targeting Efficacy. Nanomedicine. 8, 1172-1181 (2012
32. El-Shabouri, M. H., et al. Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A. Int J Pharm. 249, 101-108 (2002
33. Zhang, X., et al. Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro. Oncol Rep. 27, 1128-1134 (2012
34. Arya, G., Vandana, M., Acharya, S., & Sahoo, S. K. Enhanced antiproliferative activity of Herceptin (HER2)-conjugated gemcitabineloaded chitosan nanoparticle in pancreatic cancer therapy. Nanomedicine. 7, 859-870 (2011
35. Niu, H., et al. Treatment of (131)I-labeled anti-CD147 monoclonal antibody in VX2 carcinoma-induced liver tumors. Oncol Rep. 30, 246-252 (2013
36. Zhu, Q. L., et al. Low-density lipoprotein-coupled N-succinyl chitosan nanoparticles co-delivering siRNA and doxorubicin for hepatocyte-Targeted therapy. Biomaterials. 35, 5965-5976 (2014
37. Zhu, R., et al. Preparation and in vitro study of α-Hederin-Loaded Chitosan nanoparticles. Chinese Traditional Patent Medicine. 35, 1906-1911 (2013
38. Zhang, Y. T., et al. Evaluation of transdermal salidroside delivery using niosomes via in vitro cellular uptake. Int J Pharm. 478, 138-146 (2014
39. Warburton, M. J., & Wynn, C. H. The hyperactivity of hamster fibroblast lysosomal enzymes after endocytosis of sucrose. Biochem Biophys Res Commun. 70, 94-100 (1976
40. Ohara, K., Kohno, M., Hamada, T., & Kawakami, K. Entry of a cationic lytic-Type peptide into the cytoplasm via endocytosis-dependent and-independent pathways in human glioma U251 cells. Peptides. 50, 28-35 (2013
41. Plazzo, A. P., et al. Uptake of a fluorescent methyl-β-cyclodextrin via clathrin-dependent endocytosis. Chem Phys Lipids. 16, 505-511 (2012
42. Chiu, Y. L., et al. The characteristics, cellular uptake and intracellular trafficking of nanoparticles made of hydrophobically-modified chitosan. J Control Release. 146, 152-159 (2010