Rifabutin-loaded solid lipid nanoparticles for inhaled antitubercular therapy: Physicochemical and in vitro studies

International Journal of Pharmaceutics

Volumn 497, Issue 1-2, 2016, Pages 199-209

  Gaspar, Diana P ^a,b   Faria, Vasco ^a   Gonçalves, Lídia M D ^a   Taboada, Pablo ^b   Remuñán López, Carmen ^b   Almeida, António J ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Cell viability and uptake; Pulmonary administration; Rifabutin; Solid lipid nanoparticles; Stability; Tuberculosis

Indexed keywords

GLYCERYL DIBEHENATE; LIPID; RIFABUTIN; SOLID LIPID NANOPARTICLE; TRISTEARIN; UNCLASSIFIED DRUG; DRUG CARRIER; EXCIPIENT; FATTY ACID; GLYCEROL BEHENATE; NANOPARTICLE; TRIACYLGLYCEROL; TUBERCULOSTATIC AGENT;

ANTIBIOTIC THERAPY; ARTICLE; CANCER CELL LINE; CELL VIABILITY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; FREEZE DRYING; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGHT SCATTERING; MACROPHAGE; NANOENCAPSULATION; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; THERMAL ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; INHALATIONAL DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; SOLUBILITY; TEMPERATURE; ULTRASTRUCTURE;

ADMINISTRATION, INHALATION; ANTITUBERCULAR AGENTS; CELL LINE; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG LIBERATION; DRUG STABILITY; EXCIPIENTS; FATTY ACIDS; FREEZE DRYING; HUMANS; NANOPARTICLES; PARTICLE SIZE; RIFABUTIN; SOLUBILITY; TEMPERATURE; TRIGLYCERIDES;

EID: 84949514778     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.11.050     Document Type: Article

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