Yokukansan Increases 5-HTReceptors in the Prefrontal Cortex and Enhances 5-HTReceptor Agonist-Induced Behavioral Responses in Socially Isolated Mice

Evidence-based Complementary and Alternative Medicine

Volumn 2015, Issue , 2015, Pages

  Ueki, Toshiyuki ^a   Mizoguchi, Kazushige ^a   Yamaguchi, Takuji ^a   Nishi, Akinori ^a   Ikarashi, Yasushi ^a   Hattori, Tomohisa ^a   Kase, Yoshio ^a  

^a TSUMURA AND CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXY 2 (DIPROPYLAMINO)TETRALIN HYDROBROMIDE; ANXIOLYTIC AGENT; MESSENGER RNA; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ALTERNATIVE MEDICINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EVIDENCE BASED PRACTICE; IMMUNOBLOTTING; MALE; MOTOR ACTIVITY; MOUSE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BINDING ASSAY; RECEPTOR DENSITY; REPEATED DRUG DOSE; SOCIAL ISOLATION;

EID: 84949254718     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2015/726471     Document Type: Article

References (44)

1. H. G. Baumgarten and Z. Grozdanovic, "Anatomy of central serotoninergic projection systems, " in Serotoninergic Neurons and 5-HT Receptors in the CNS, H. G. Baumgarten and M. Göthert, Eds., pp. 41-89, Springer, Berlin, Germany, 1997.
2. K. A. George and S. B. Elaine, "Serotonin, " in Neuropsychopharmacology: The Fifth Generation of Progress, K. L. Davis, D. Charney, J. T. Coyle, C. Nemeroff, and Lippincott Williams & Wilkins, Eds., pp. 15-34, Raven Press, Philadelphia, Pa, USA, 2002.
3. D. Hoyer, J. P. Hannon, and G. R. Martin, "Molecular, pharmacological and functional diversity of 5-HT receptors, " Pharmacology Biochemistry and Behavior, vol. 71, no. 4, pp. 533-554, 2002.
4. C. Sánchez and J. Hyttel, "Isolation-induced aggression in mice: effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT1A receptors, " European Journal of Pharmacology, vol. 264, no. 3, pp. 241-247, 1994.
5. Y. Ago, K. Takuma, and T. Matsuda, "Potential role of serotonin1A receptors in post-weaning social isolation-induced abnormal behaviors in rodents, " Journal of Pharmacological Sciences, vol. 125, no. 3, pp. 237-241, 2014.
6. A. Pazos and J. M. Palacios, "Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors, " Brain Research, vol. 346, no. 2, pp. 205-230, 1985.
7. D. Verge, G. Daval, M. Marcinkiewicz et al., "Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5, 7-dihydroxytryptamine-treated rats, " The Journal of Neuroscience, vol. 6, no. 12, pp. 3474-3482, 1986.
8. T. Yamamoto and A. Hirano, "Nucleus raphe dorsalis in Alzheimer's disease: neurofibrillary tangles and loss of large neurons, " Annals of Neurology, vol. 17, no. 6, pp. 573-577, 1985.
9. M. A. Aletrino, O. J. M. Vogels, P. H. M. F. Van Domburg, and H. J. Ten Donkelaar, "Cell loss in the nucleus raphes dorsalis in Alzheimer's disease, " Neurobiology of Aging, vol. 13, no. 4, pp. 461-468, 1992.
10. G. M. Halliday, H. L. McCann, R. Pamphlett et al., "Brain stem serotonin-synthesizing neurons in Alzheimer's disease: A clinicopathological correlation, " Acta Neuropathologica, vol. 84, no. 6, pp. 638-650, 1992.
11. V. Kepe, J. R. Barrio, S. C. Huang et al., "Serotonin 1A receptors in the living brain of Alzheimer's disease patients, " Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 3, pp. 702-707, 2009.
12. M. K. P. Lai, S. W. Y. Tsang, P. T. Francis et al., "Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease, " Brain Research, vol. 974, no. 1-2, pp. 82-87, 2003.
13. J. J. Sramek, V. Zarotsky, and N. R. Cutler, "Generalised anxiety disorder: Treatment options, " Drugs, vol. 62, no. 11, pp. 1635-1648, 2002.
14. Y. Hayashi, Y. Ishida, T. Inoue et al., "Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with Yokukansan in clinical practice, " Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 34, no. 3, pp. 541-545, 2010.
15. K. Iwasaki, M. Maruyama, N. Tomita et al., "Effects of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies, " The Journal of Clinical Psychiatry, vol. 66, no. 12, pp. 1612-1613, 2005.
16. A. Monji, M. Takita, T. Samejima et al., "Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease, " Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 33, no. 2, pp. 308-311, 2009.
17. Y. Matsuda, T. Kishi, H. Shibayama, and N. Iwata, "Yokukansan in the treatment of behavioral and psychological symptoms of dementia: A systematic review andmeta-analysis of randomized controlled trials, "Human Psychopharmacology, vol. 28, no. 1, pp. 80-86, 2013.
18. H. Kanno, K. Sekiguchi, T. Yamaguchi et al., "Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats, " Journal of Pharmacy and Pharmacology, vol. 61, no. 9, pp. 1249-1256, 2009.
19. A. Nishi, T. Yamaguchi, K. Sekiguchi et al., "Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin1 receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan, " Neuroscience, vol. 207, pp. 124-136, 2012.
20. T. Yamaguchi, A. Tsujimatsu, H. Kumamoto et al., "Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress, " Journal of Ethnopharmacology, vol. 143, no. 2, pp. 533-539, 2012.
21. H. Shoji and K. Mizoguchi, "Brain region-specific reduction in c-Fos expression associated with an anxiolytic effect of yokukansan in rats, " Journal of Ethnopharmacology, vol. 149, no. 1, pp. 93-102, 2013.
22. B. Bert, H. Fink, H. Hörtnagl et al., "Mice over-expressing the 5-HT1A receptor in cortex and dentate gyrus display exaggerated locomotor and hypothermic response to 8-OHDPAT, " Behavioural Brain Research, vol. 167, no. 2, pp. 328-341, 2006.
23. R. Zhou, S. Niwa, L. Guillaud, Y. Tong, and N. Hirokawa, "A molecular motor, KIF13A, controls anxiety by transporting the serotonin type 1A receptor, " Cell Reports, vol. 3, no. 2, pp. 509-519, 2013.
24. U. Renner, K. Glebov, T. Lang et al., "Localization of the mouse 5-hydroxytryptamine1A receptor in lipid microdomains depends on its palmitoylation and is involved in receptormediated signaling, "Molecular Pharmacology, vol. 72, no. 3, pp. 502-513, 2007.
25. Q. Li and N. A. Muma, "Estradiol potentiates 8-OH-DPATinduced sumoylation of 5-HT1A receptor: characterization and subcellular distribution of sumoylated 5-HT1A receptors, " Psychoneuroendocrinology, vol. 38, no. 11, pp. 2542-2553, 2013.
26. S. Barrondo and J. Sallés, "Allosteric modulation of 5-HT1A receptors by zinc: binding studies, " Neuropharmacology, vol. 56, no. 2, pp. 455-462, 2009.
27. S. ?ukasiewicz, E. B?asiak, A. Faron-Górecka et al., "Fluorescence studies of homooligomerization of adenosine A2A and serotonin 5-HT1A receptors reveal the specificity of receptor interactions in the plasma membrane, " Pharmacological Reports, vol. 59, no. 4, pp. 379-392, 2007.
28. D. Cussac, I. Rauly-Lestienne, P. Heusler et al., "-opioid and 5-HT1A receptors heterodimerize and show signalling crosstalk via G protein and MAP-kinase pathways, " Cellular Signalling, vol. 24, no. 8, pp. 1648-1657, 2012.
29. U. Renner, A. Zeug, A. Woehler et al., "Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking, " Journal of Cell Science, vol. 125, no. 10, pp. 2486-2499, 2012.
30. V. S. Naumenko, N. K. Popova, E. Lacivita, M. Leopoldo, and E. G. Ponimaskin, "Interplay between serotonin 5-HT1 and 5-HT7 receptors in depressive disorders, " CNS Neuroscience and Therapeutics, vol. 20, no. 7, pp. 582-590, 2014.
31. D. O. Borroto-Escuela, F. Corrales, M. Narvaez et al., "Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of beta-arrestin2, " Biochemical and Biophysical Research Communications, vol. 441, no. 2, pp. 387-392, 2013.
32. C. M. T. Queiroz, F. B. Alcântara, A. M. L. Yagüe, T. Bibancos, and R. Frussa-Filho, "Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice, " Brazilian Journal ofMedicalandBiological Research, vol. 35, no. 2, pp. 237-242, 2002.
33. J. C. Cole andR. J. Rodgers, "Ethological evaluationof the effects of acute and chronic buspirone treatment in themurine elevated plus-maze test: comparison with haloperidol, " Psychopharmacology, vol. 114, no. 2, pp. 288-296, 1994.
34. L. E. Arvidsson, U. Hacksell, J. L. G. Nilsson et al., "8-Hydroxy-2-(dipropylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist, " Journal of Medicinal Chemistry, vol. 24, no. 8, pp. 921-923, 1981.
35. R. J. Blanchard, J. K. Shepherd, J. Armstrong, S. F. Tsuda, and D. C. Blanchard, "An ethopharmacological analysis of the behavioral effects of 8-OH-DPAT, " Psychopharmacology, vol. 112, no. 1, pp. 55-65, 1993.
36. J. L. Evenden and K. Angeby-Moller, "Effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on locomotor activity and rearing of mice and rats, " Psychopharmacology, vol. 102, no. 4, pp. 485-491, 1990.
37. J. Yamada, Y. Sugimoto, and K. Horisaka, "The behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT) in mice, " European Journal of Pharmacology, vol. 154, no. 3, pp. 299-304, 1988.
38. G. M. Goodwin, R. J. De Souza, and A. R. Green, "The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(din-propylamino)tetralin (8-OH-DPAT). Amodel of presynaptic 5-HT1 function, " Neuropharmacology, vol. 24, no. 12, pp. 1187-1194, 1985.
39. K. F. Martin, I. Phillips, M. Hearson, M. R. Prow, and D. J. Heal, "Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants, " British Journal of Pharmacology, vol. 107, no. 1, pp. 15-21, 1992.
40. P. R. Albert, Q.-Y. Zhou, H. H. M. Van Tol, J. R. Bunzow, and O. Civelli, "Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene, " The Journal of Biological Chemistry, vol. 265, no. 10, pp. 5825-5832, 1990.
41. P. Blier and C. deMontigny, "Electrophysiological investigation of the adaptive response of the 5-HT system to the administration of 5-HT1A receptor agonists, " Journal of Cardiovascular Pharmacology, vol. 15, supplement 7, pp. S42-S48, 1990.
42. Y. Ago, Y. Koyama, A. Baba, and T. Matsuda, "Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex, " Neuropharmacology, vol. 45, no. 8, pp. 1050-1056, 2003.
43. S. Imamura, M. Tabuchi, H. Kushida et al., "The bloodbrain barrier permeability of geissoschizine methyl ether in Uncaria hook, a galenical constituent of the traditional Japanese medicine yokukansan, " Cellular and Molecular Neurobiology, vol. 31, no. 5, pp. 787-793, 2011.
44. K. Mizoguchi, H. Kushida, H. Kanno et al., "Specific binding and characteristics of geissoschizine methyl ether, an indole alkaloid of Uncaria Hook, in the rat brain, " Journal of Ethnopharmacology, vol. 158, pp. 264-270, 2014.