Oxymatrine and cancer therapy

European Journal of Inflammation

Volumn 13, Issue 3, 2015, Pages 148-153

  Lu, W W ^a   Zhang, R ^a   Zhu, Jin Shui ^a   Xia, L Q ^a   Zhang, J ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Apoptosis; Cancer; Metastasis; Oxymatrine; Therapy

Indexed keywords

ALPHA2B INTERFERON; FERULIC ACID; OXYMATRINE;

ANALGESIC ACTIVITY; ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ANTIVIRAL ACTIVITY; APOPTOSIS; CANCER THERAPY; CELL CYCLE ARREST; CHRONIC HEPATITIS B; DIABETES MELLITUS; DNA REPLICATION; DRUG POTENTIATION; HEART PROTECTION; HUMAN; HYPERLIPIDEMIA; LIVER FIBROSIS; MESENCHYMAL STEM CELL TRANSPLANTATION; METASTASIS INHIBITION; PROTEIN EXPRESSION; REPERFUSION INJURY; REVIEW;

EID: 84949204078     PISSN: 1721727X     EISSN: 20587392     Source Type: Journal    
DOI: 10.1177/1721727X15613911     Document Type: Review

References (49)

1. Wen JB, Zhu FQ, Chen WG, et al. (2014) Oxymatrine improves intestinal epithelial barrier function involving NF-?B-mediated signaling pathway in CCl4- induced cirrhotic rats. PLoS One 9: E106082.
2. Yang Z, Yin R, Cong Y, et al. (2014) Oxymatrine lightened the inflammatory response of LPSinduced mastitis in mice through affecting NF-?B and MAPKs signaling pathways. Inflammation 137: 2047-2055.
3. Guzman JR, Koo JS, Goldsmith JR, et al. (2013) Oxymatrine prevents NF-?B nuclear translocation and ameliorates acute intestinal inflammation. Scientific Reports 3: 1629.
4. Yuan X, Sun Y, Miao N, et al. (2011) The synergistic anti-inflammatory effect of the combination of sodium ferulate and oxymatrine and its modulation on inflammation- associated mediators in RAW 264.7 cells. Journal of Ethnopharmacology 137: 1477-1485.
5. Hu YY, He KW, Guo RL, et al. (2012) Six alkaloids inhibit secretion of IL-1a, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells. Immunological Investigations 41: 261-274.
6. Dong XQ, Yu WH, Hu YY, et al. (2011) Oxymatrine reduces neuronal cell apoptosis by inhibiting Tolllike receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury. Inflammation Research 60: 533-539.
7. Zhang Z, Wang Y, Dong M, et al. (2012) Oxymatrine ameliorates L-arginine-induced acute pancreatitis in rats. Inflammation 35: 605-613.
8. Mao YM, Zeng MD and Lu LG (2004) Capsule oxymatrine in treatment of hepatic fibrosis due to chronic viral hepatitis: A randomized, double blind, placebocontrolled, multicenter clinical study. World Journal of Gastroenterology 10: 3269-3273.
9. Chai NL, Xu SP, Wan J, et al. (2013) Oxymatrine could promote mesenchymal stem cell therapy in hepatic fibrosis rats: An experimental research. Zhongguo Zhong Xi Yi Jie He Za Zhi 33: 840-844.
10. Chai NL, Fu Q, Shi H, et al. (2012) Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells. World Journal of Gastroenterology 18: 4199-4206.
11. Deng ZY, Li J, Jin Y, et al. (2009) Effect of oxymatrine on the p38 mitogen-activated protein kinases signalling pathway in rats with CCl4 induced hepatic fibrosis. Chinese Medical Journal 122: 1449-1454.
12. Shen XC, Yang YP, Xiao TT, et al. (2011) Protective effect of oxymatrine on myocardial fibrosis induced by acute myocardial infarction in rats involved in TGF-ß1-Smads signal pathway. Journal of Asian Natural Products Research 13: 215-224.
13. Lu LG, Zeng MD, Mao YM, et al. (2003) Oxymatrine therapy for chronic hepatitis B: A randomized doubleblind and placebo-controlled multi-center trial. World Journal of Gastroenterology 9: 2480-2483.
14. Wang BE (2000) Treatment of chronic liver diseases with traditional Chinese medicine. Journal of Gastroenterology and Hepatology 15 (Suppl.): E67-70.
15. Gu XB, Yang XJ, Hua Z, et al. (2012) Effect of oxymatrine on specific cytotoxic T lymphocyte surface programmed death receptor-1 expression in patients with chronic hepatitis B. Chinese Medical Journal 125: 1434-1438.
16. Wang YP, Liu F, He HW, et al. (2010) Heat stress cognate 70 host protein as a potential drug target against drug resistance in hepatitis B virus. Antimicrobial Agents and Chemotherapy 54: 2070-2077.
17. Wang YP, Zhao W, Xue R, et al. (2011) Oxymatrine inhibits hepatitis B infection with an advantage of overcoming drug-resistance. Antiviral Research 89: 227-231.
18. Xu WS, Zhao KK, Miao XH, et al. (2010) Effect of oxymatrine on the replication cycle of hepatitis B virus in vitro. World Journal of Gastroenterology 16: 2028-2037.
19. Dong Y, Xi H, Yu Y, et al. (2002) Effects of oxymatrine on the serum levels of T helper cell 1 and 2 cytokines and the expression of the S gene in hepatitis B virus S gene transgenic mice: A study on the antihepatitis B virus mechanism of oxymatrine. Journal of Gastroenterology and Hepatology 17: 1299-1306.
20. Ma ZJ, Li Q, Wang JB, et al. (2013) Combining oxymatrine or matrine with lamivudine increased its antireplication effect against the Hepatitis B virus in vitro. Evidence-based Complementary and Alternative Medicine 2013: 186573.
21. Wang Y, Xu YH, Xiong AQ, et al. (2014) Protective effect of oxymatrine on chronic heart failure and ADMA metabolism pathway in isoproterenol-induced chronic heart failure in rats. Zhongguo Zhong Yao Za Zhi 39: 471-477.
22. Huang XY and Chen CX (2013) Effect of oxymatrine, the active component from Radix Sophorae flavescentis (Kushen), on ventricular remodeling in spontaneously hypertensive rats. Phytomedicine 20: 202-212.
23. Xiao TT, Wang YY, Zhang Y, et al. (2014) Similar to spironolactone, oxymatrine is protective in aldosterone- induced cardiomyocyte injury via inhibition of calpain and apoptosis-inducing factor signaling. PLoS One 9: E88856.
24. Hu ST, Tang Y, Shen YF, et al. (2011) Protective effect of oxymatrine on chronic rat heart failure. Journal of Physiological Sciences 61: 363-372.
25. Runtao G, Guo D, Jiangbo Y, et al. (2011) Oxymatrine, the main alkaloid component of Sophora roots, protects heart against arrhythmias in rats. Planta Medica 77: 226-230.
26. Cao YG, Jing S, Li L, et al. (2010) Antiarrhythmic effects and ionic mechanisms of oxymatrine from Sophora flavescens. Phytotherapy Research 24: 1844-1849.
27. Guo C, Zhang C, Li L, et al. (2014) Hypoglycemic and hypolipidemic effects of oxymatrine in highfat diet and streptozotocin-induced diabetic rats. Phytomedicine 21: 807-814.
28. Shi LJ, Shi L, Song GY, et al. (2013) Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1) and activation of peroxisome proliferator activated receptor alpha (Ppara). European Journal of Pharmacology 714: 89-95.
29. Guo C, Han F, Zhang C, et al. (2014) Protective effects of oxymatrine on experimental diabetic nephropathy. Planta Medica 80: 269-276.
30. Fan H, Li L, Zhang X, et al. (2009) Oxymatrine downregulates TLR4, TLR2, MyD88, and NF-kappaB and protects rat brains against focal ischemia. Mediators of Inflammation 2009: 704706.
31. Li M, Zhang X, Cui L, et al. (2011) The neuroprotection of oxymatrine in cerebral ischemia/reperfusion is related to nuclear factor erythroid 2-related factor 2 (nrf2)-mediated antioxidant response: Role of nrf2 and hemeoxygenase-1 expression. Biological & Pharmaceutical Bulletin 34: 595-601.
32. Huang M, Hu YY, Dong XQ, et al. (2012) The protective role of oxymatrine on neuronal cell apoptosis in the hemorrhagic rat brain. Journal of Ethnopharmacology 143: 228-235.
33. Zhu B, Yang JR, Chen SF, et al. (2014) The attenuation of lung ischemia reperfusion injury by oxymatrine. Cell Biochemistry and Biophysics 70: 333-336.
34. Zhang B, Niu W, Xu D, et al. (2014) Oxymatrine prevents hypoxia- and monocrotaline-induced pulmonary hypertension in rats. Free Radical Biology & Medicine 69: 198-207.
35. Kim C, Kasuya J, Jeon J, et al. (2015) A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs. Lab on a Chip 15: 301-310.
36. Chen H, Zhang J, Luo J, et al. (2013) Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-?B-mediated VEGF signaling pathway. Oncology Reports 30: 589-595.
37. Song MQ, Zhu JS, Chen JL, et al. (2007) Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells. World Journal of Gastroenterology 13: 1788-1793.
38. Wei J, Zhu Y, Xu G, et al. (2014) Oxymatrine extracted from Sophora flavescens inhibited cell growth and induced apoptosis in human osteosarcoma MG-63 cells in vitro. Cell Biochemistry and Biophysics 70: 1439-1444.
39. Zhang Y, Piao B, Zhang Y, et al. (2011) Oxymatrine diminishes the side population and inhibits the expression of ß-catenin in MCF-7 breast cancer cells. Medical Oncology 28: S99-107.
40. Song G, Luo Q, Qin J, et al. (2006) Effects of oxymatrine on proliferation and apoptosis in human hepatoma cells. Colloids and Surfaces B - Biointerfaces 48: 1-5.
41. Ling Q, Xu X, Wei X, et al. (2011) Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. Journal of Experimental & Clinical Cancer Research 30: 66.
42. Song G, Luo Q and Qin J (2006) Effects of oxymatrine on proliferation and apoptosis in human hepatoma cells. Colloids and Surfaces B - Biointerfaces 48: 1-5.
43. Saleem M, Qadir MI, Perveen N, et al. (2013) Inhibitors of apoptotic proteins: New targets for anticancer therapy. Chemical Biology & Drug Design 82: 243-251.
44. Augello C, Caruso L, Maggioni M, et al. (2009) Inhibitors of apoptosis proteins (iaps) expression and their prognostic significance in hepatocellular carcinoma. BMC Cancer 9: 125.
45. Li Y, Yue H, Xing Y, et al. (2010) Oxymatrine inhibits development of morphine-induced tolerance associated with decreased expression of Pglycoprotein in rats. Integrative Cancer Therapy 9: 213-218.
46. Wang H, Li Y, Dun L, et al. (2013) Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a mice model of neuropathic pain. Phytomedicine 20: 1039-1045.
47. Wang Y, Yuan J, Yuan X, et al. (2012) Observation of antinociceptive effects of oxymatrine and its effect on delayed rectifier K+ currents (Ik) in PC12 cells. Neurochemical Research 37: 2143-2149.
48. Liu H, Sun Y, Gao Y, et al. (2010) The analgesic effect and mechanism of the combination of sodium ferulate and oxymatrine. Neurochemical Research 35: 1368-1375.
49. Narayana Moorthy NS, Ramos MJ and Fernandes PA (2013) Human ether-a-go-go-related gene channel blockers and its structural analysis for drug design. Current Drug Targets 14: 102-113.