Muscle weakness in TPM3-myopathy is due to reduced Ca2+-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres

Human Molecular Genetics

Volumn 24, Issue 22, 2015, Pages 6278-6292

  Yuen, Michaela ^a,b   Cooper, Sandra T ^a,b   Marston, Steve B ^c   Nowak, Kristen J ^d   Mcnamara, Elyshia ^d   Mokbe, Nancy ^a,e   Ilkovski, Biljana ^a   Ravenscroft, Gianina ^d   Rendu, John ^f   Dewinter, Josine M ^g   Klinge, Lars ^h   Beggs, Alan H ⁱ   North, Kathryn N ^a,b,j,k   Ottenheijm, Coen A C ^g   Clarke, Nigel F ^b  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e UNIVERSITY OF BALAMAND   (Lebanon)

^f GRENOBLE UNIVERSITY HOSPITAL   (France)

^g VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^h UNIVERSITY OF GÖTTINGEN   (Germany)

ⁱ HARVARD MEDICAL SCHOOL   (United States)

^j ROYAL CHILDREN'S HOSPITAL   (Australia)

^k UNIVERSITY OF MELBOURNE   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CALCIUM; MUTANT PROTEIN; MYOSIN; TPM3 PROTEIN; TROPOMYOSIN; TROPONIN; UNCLASSIFIED DRUG; ISOPROTEIN; TPM3 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHILD; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS LINKING; CROSS-SECTIONAL STUDY; ENZYME MECHANISM; FEMALE; FORCE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INFANT; KINETICS; MALE; MIDDLE AGED; MOLECULAR MODEL; MOUSE; MUSCLE CONTRACTION; MUSCLE WEAKNESS; MYOPATHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; SEDIMENTATION; SLOW MUSCLE FIBER; TWO DIMENSIONAL GEL ELECTROPHORESIS; YOUNG ADULT; GENETICS; METABOLISM; MUSCLE ATROPHY; MUSCLE DISEASE; MUTATION; PHYSIOLOGY; PRESCHOOL CHILD;

ACTINS; ADOLESCENT; ADULT; CALCIUM; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE FIBERS, SLOW-TWITCH; MUSCLE WEAKNESS; MUSCULAR ATROPHY; MUSCULAR DISEASES; MUTATION; MYOSINS; PROTEIN ISOFORMS; TROPOMYOSIN;

EID: 84949057883     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv334     Document Type: Article

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