Abnormal actin binding of aberrant β-tropomyosins is a molecular cause of muscle weakness in TPM2-related nemaline and cap myopathy

Biochemical Journal

Volumn 442, Issue 1, 2012, Pages 231-239

  Marttila, Minttu ^a,b   Lemola, Elina ^a,b   Wallefeld, William ^c   Memo, Massimiliano ^d   Donner, Kati ^e   Laing, Nigel G ^c   Marston, Steven ^d   Grönholm, Mikaela ^e   Wallgren Pettersson, Carina ^a,b  

^a FOLKHÄLSAN INSTITUTE OF GENETICS   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

tropomyosin ( Tm); Actin binding; Calcium sensitivity; Cap myopathy; Circular dichroism (CD); Nemaline myopathy (NM)

Indexed keywords

ACTIN; CALCIUM ION; COMPLEMENTARY DNA; RECOMBINANT PROTEIN; TROPOMYOSIN;

ACETYLATION; AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; BINDING AFFINITY; CELL MIGRATION; CELL MOTILITY; CIRCULAR DICHROISM; CONTROLLED STUDY; GENE; GENE MAPPING; GENE MUTATION; GENETIC ASSOCIATION; IN VITRO STUDY; MOLECULAR MECHANICS; MUSCLE CONTRACTILITY; MUSCLE WEAKNESS; NEMALINE MYOPATHY; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MODIFICATION; ROOM TEMPERATURE; THERMODYNAMICS; THIN FILAMENT;

ACTINS; ANIMALS; HUMANS; MYOPATHIES, NEMALINE; MYOPATHIES, STRUCTURAL, CONGENITAL; RECOMBINANT PROTEINS; SPODOPTERA; TROPOMYOSIN;

EID: 84856249208     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111030     Document Type: Article

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