Nebulin alters cross-bridge cycling kinetics and increases thin filament activation. A novel mechanism for increasing tension and reducing tension cost

Journal of Biological Chemistry

Volumn 284, Issue 45, 2009, Pages 30889-30896

  Chandra, Murali ^a   Manidi, Ranganath ^a   Ford, Steven ^a   Hidalgo, Carlos ^b   Witt, Christian ^c   Ottenheijm, Coen ^b   Labeit, Siegfried ^c   Granzier, Henk ^b  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COOPERATIVITY; CROSS-BRIDGE; F-ACTIN; FIBER BUNDLES; ISOFORMS; KNOCK OUTS; MECHANICAL STUDY; MOUSE MODELS; MUSCLE CONTRACTIONS; MUSCLE FIBER; MUSCLE PROTEINS; MUSCLE WEAKNESS; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAINS; SKELETAL MUSCLE; STRUCTURAL PROTEINS; THIN FILAMENTS; TROPONIN; WILD TYPES;

CALCIUM; COST REDUCTION; FIBERS; FILAMENTS (LAMP); PHOSPHORYLATION; PROTEINS; SHRINKAGE;

MUSCLE;

ADENOSINE TRIPHOSPHATASE; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAIN 2; NEBULIN; RECOMBINANT TROPONIN; TROPONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; KNOCKOUT MOUSE; MOUSE; MUSCLE CONTRACTION; MUSCLE FIBER MEMBRANE; MUSCLE FORCE; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; THIN FILAMENT; TIBIALIS CRANIALIS; WILD TYPE;

ANIMALS; CALCIUM; KINETICS; MICE; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCLE TONUS; SARCOMERES;

EID: 71449111552     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.049718     Document Type: Article

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