Exaggerated arsenic nephrotoxicity in female mice through estrogen-dependent impairments in the autophagic flux

Toxicology

Volumn 339, Issue , 2016, Pages 9-18

  Kimura, Akihiko ^a   Ishida, Yuko ^a   Nosaka, Mizuho ^a   Kuninaka, Yumi ^a   Hama, Mizuki ^a   Kawaguchi, Takashi ^a   Sakamoto, Shoichi ^a   Shinozaki, Kohei ^a   Iwahashi, Yumi ^a   Takayasu, Tatsunori ^b   Kondo, Toshikazu ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Arsenite; Autophagy; Estrogen; Gender; Renal injury

Indexed keywords

ARSENIC; ARSENITE SODIUM; BIOLOGICAL MARKER; ESTROGEN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P62; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; ARSENOUS ACID DERIVATIVE; HEAT SHOCK PROTEIN; HEAVY METAL; INTERLEUKIN-6, MOUSE; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SOCS3 PROTEIN, MOUSE; SODIUM DERIVATIVE; SQSTM1 PROTEIN, MOUSE; STAT3 PROTEIN, MOUSE; SUPPRESSOR OF CYTOKINE SIGNALING;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BIOACCUMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ESTROGEN THERAPY; FEMALE; GENE; HISTOPATHOLOGY; IN VITRO STUDY; KIDNEY TUBULE CELL; KIDNEY TUBULE DAMAGE; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; ORCHIECTOMY; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SOCS3 GENE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; KIDNEY; KIDNEY DISEASE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SEXUAL DEVELOPMENT; SUBCUTANEOUS DRUG ADMINISTRATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ARSENITES; AUTOPHAGY; ESTROGENS; FEMALE; HEAT-SHOCK PROTEINS; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-6; KIDNEY; KIDNEY DISEASES; MAP KINASE SIGNALING SYSTEM; METALS, HEAVY; MICE; MICE, INBRED BALB C; MICROTUBULE-ASSOCIATED PROTEINS; OVARIECTOMY; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION; SODIUM COMPOUNDS; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 84949057516     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2015.11.005     Document Type: Article

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