Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin)

Molecular Cancer

Volumn 13, Issue 1, 2014, Pages

  Singh, Kamini ^a,d   Sharma, Arishya ^a,c   Mir, Maria C ^b   Drazba, Judith A ^a   Heston, Warren D ^a   Magi Galluzzi, Cristina ^a,b   Hansel, Donna ^b,e   Rubin, Brian P ^a,b   Klein, Eric A ^a   Almasan, Alexandru ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b TAUSSIG CANCER INSTITUTE   (United States)

^c CLEVELAND STATE UNIVERSITY   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apo2L TRAIL; Autophagy; Caspase 8; Dulanermin; p62 SQSTM1; Prostate cancer

Indexed keywords

3 METHYLADENINE; BECLIN 1; CASPASE 8; CHLOROQUINE; DULANERMIN; LIPOCORTIN 5; PROTEIN; PROTEIN P62; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL CULTURE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DNA CONTENT; DRUG RESPONSE; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; PROSTATE CANCER; PROTEIN AGGREGATION; TISSUE MICROARRAY; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT RESPONSE;

ANTINEOPLASTIC AGENTS; AUTOPHAGY; CASPASE 8; CELL LINE, TUMOR; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; PROSTATIC NEOPLASMS; RNA-BINDING PROTEINS; TISSUE ARRAY ANALYSIS; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84899132317     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-70     Document Type: Article

References (30)

1. Kroemer G, Marino G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010, 40:280-293. 10.1016/j.molcel.2010.09.023, 3127250, 20965422.
2. Kourtis N, Tavernarakis N. Autophagy and cell death in model organisms. Cell Death Differ 2009, 16:21-30. 10.1038/cdd.2008.120, 19079286.
3. Kroemer G, Jaattela M. Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005, 5:886-897. 10.1038/nrc1738, 16239905.
4. Nakatogawa H, Ichimura Y, Ohsumi Y. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 2007, 130:165-178. 10.1016/j.cell.2007.05.021, 17632063.
5. Xie Z, Nair U, Klionsky DJ. Atg8 controls phagophore expansion during autophagosome formation. Mol Biol Cell 2008, 19:3290-3298. 10.1091/mbc.E07-12-1292, 2488302, 18508918.
6. Itakura E, Mizushima N. p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol 2011, 192:17-27. 10.1083/jcb.201009067, 3019556, 21220506.
7. Almasan A, Ashkenazi A. Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. Cytokine Growth Factor Rev 2003, 14:337-348. 10.1016/S1359-6101(03)00029-7, 12787570.
8. Gonzalvez F, Ashkenazi A. New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 2010, 29:4752-4765. 10.1038/onc.2010.221, 20531300.
9. Mora R, Abschuetz A, Kees T, Dokic I, Joschko N, Kleber S, Geibig R, Mosconi E, Zentgraf H, Martin-Villalba A, Regnier-Vigouroux A. TNF-alpha- and TRAIL-resistant glioma cells undergo autophagy-dependent cell death induced by activated microglia. Glia 2009, 57:561-581. 10.1002/glia.20785, 18942750.
10. Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M. TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J 2009, 28:677-685. 10.1038/emboj.2009.8, 2666037, 19197243.
11. Chhipa RR, Wu Y, Ip C. AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia. Cell Signal 2011, 23:1466-1472. 10.1016/j.cellsig.2011.04.008, 3115439, 21554950.
12. Wu Z, Chang PC, Yang JC, Chu CY, Wang LY, Chen NT, Ma AH, Desai SJ, Lo SH, Evans CP, Lam KS, Kung HJ. Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors. Genes Cancer 2010, 1:40-49. 10.1177/1947601909358324, 2930266,2930266, 20811583.
13. Jin Z, Li Y, Pitti R, Lawrence D, Pham VC, Lill JR, Ashkenazi A. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 2009, 137:721-735. 10.1016/j.cell.2009.03.015, 19427028.
14. Wagner KW, Punnoose EA, Januario T, Lawrence DA, Pitti RM, Lancaster K, Lee D, von Goetz M, Yee SF, Totpal K, Huw L, Katta V, Cavet G, Hymowitz SG, Amler L, Ashkenazi A. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med 2007, 13:1070-1077. 10.1038/nm1627, 17767167.
15. Hughes MA, Harper N, Butterworth M, Cain K, Cohen GM, MacFarlane M. Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival. Mol Cell 2009, 35:265-279. 10.1016/j.molcel.2009.06.012, 19683492.
16. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 2009, 459:428-432. 10.1038/nature08012, 2858974, 19363473.
17. Pankiv S, Lamark T, Bruun JA, Overvatn A, Bjorkoy G, Johansen T. Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies. J Biol Chem 2010, 285:5941-5953. 10.1074/jbc.M109.039925, 2820819, 20018885.
18. Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell 2009, 34:259-269. 10.1016/j.molcel.2009.04.026, 19450525.
19. Ray S, Shyam S, Fraizer GC, Almasan A. S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells. Mol Cancer Ther 2007, 6:1368-1378.
20. Ray S, Almasan A. Apoptosis induction in prostate cancer cells and xenografts by combined treatment with Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand and CPT-11. Cancer Res 2003, 63:4713-4723.
21. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000, 19:5720-5728. 10.1093/emboj/19.21.5720, 305793, 11060023.
22. Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005, 171:603-614. 10.1083/jcb.200507002, 2171557, 16286508.
23. Jaakkola PM, Pursiheimo JP. p62 degradation by autophagy: another way for cancer cells to survive under hypoxia. Autophagy 2009, 5:410-412. 10.4161/auto.5.3.7823, 19197142.
24. Cheong H, Lu C, Lindsten T, Thompson CB. Therapeutic targets in cancer cell metabolism and autophagy. Nat Biotechnol 2012, 30:671-678. 10.1038/nbt.2285, 3876738, 22781696.
25. Rubinsztein DC, Codogno P, Levine B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov 2012, 11:709-730. 10.1038/nrd3802, 3518431, 22935804.
26. Han J, Hou W, Goldstein LA, Lu C, Stolz DB, Yin XM, Rabinowich H. Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. J Biol Chem 2008, 283:19665-19677. 10.1074/jbc.M710169200, 2443661, 18375389.
27. Yang ZJ, Chee CE, Huang S, Sinicrope FA. The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther 2011, 10:1533-1541. 10.1158/1535-7163.MCT-11-0047, 3170456, 21878654.
28. Ziparo E, Petrungaro S, Marini ES, Starace D, Conti S, Facchiano A, Filippini A, Giampietri C. Autophagy in prostate cancer and androgen suppression therapy. Int J Mol Sci 2013, 14:12090-12106. 10.3390/ijms140612090, 3709775, 23743823.
29. Gupta A, Roy S, Lazar AJ, Wang WL, McAuliffe JC, Reynoso D, McMahon J, Taguchi T, Floris G, Debiec-Rychter M, Schoffski P, Trent JA, Debnath J, Rubin BP. Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc Natl Acad Sci U S A 2010, 107:14333-14338. 10.1073/pnas.1000248107, 2922542, 20660757.
30. Singh K, Matsuyama S, Drazba JA, Almasan A. Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress. Autophagy 2012, 8:236-257. 10.4161/auto.8.2.18600, 3336077, 22240589.