A PPARγ agonist enhances bacterial clearance through neutrophil extracellular trap formation and improves survival in sepsis

Shock

Volumn 45, Issue 4, 2016, Pages 393-403

  Araú Jo, Cláudia V ^a,b   Campbell, Clarissa ^a   Gonçalves De Albuquerque, Cassiano F ^a   Molinaro, Raphael ^a   Cody, Mark J ^b   Yost, Christian C ^b   Bozza, Patricia T ^a   Zimmerman, Guy A ^b   Weyrich, Andrew S ^b   Castro Faria Neto, Hugo C ^a   Silva, Adriana R ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Bacterial clearance; Bacterial elimination; Infection; Inflammation; Neutrophil extracellular trap; PPAR; Sepsis

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; ANTIINFLAMMATORY AGENT; HISTONE H3; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MICROORGANISM PROTEIN; REACTIVE OXYGEN METABOLITE; ROSIGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 2-CHLORO-5-NITROBENZANILIDE; ANILIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL CLEARANCE; BACTERICIDAL ACTIVITY; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG ACTIVATION; ESCHERICHIA COLI; EXTRACELLULAR TRAP; HUMAN; HUMAN CELL; MALE; MORTALITY; MOUSE; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; OXIDATIVE STRESS; SCANNING ELECTRON MICROSCOPY; SURVIVAL RATE; WESTERN BLOTTING; AGONISTS; ANIMAL; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; MICROBIOLOGY; PATHOLOGY; SEPSIS; SIGNAL TRANSDUCTION;

ANILIDES; ANIMALS; DISEASE MODELS, ANIMAL; ESCHERICHIA COLI; EXTRACELLULAR TRAPS; MALE; MICE; NEUTROPHILS; PPAR GAMMA; SEPSIS; SIGNAL TRANSDUCTION; THIAZOLIDINEDIONES;

EID: 84949036088     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000520     Document Type: Article

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