Celastrol induces autophagy by targeting AR/miR-101 in prostate cancer cells

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Guo, Jianquan ^a   Huang, Xuemei ^a   Wang, Hui ^a   Yang, Huanjie ^a  

^a HARBIN INSTITUTE OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; AUTOPHAGY PROTEIN 5; CELASTROL; MICRORNA 101; PROTEIN P62; AR PROTEIN, HUMAN; MICRORNA; MIRN101 MICRORNA, HUMAN; RNA; TRIPTERINE; TRITERPENE; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; ATG5 GENE; ATG7 GENE; AUTOPHAGY; BINDING SITE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG TARGETING; GAIN OF FUNCTION MUTATION; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; LNCAP CELL LINE; MALE; MIR 101 GENE; MUTAGENESIS; PROSTATE CANCER CELL LINE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSACTIVATION; BIOSYNTHESIS; DRUG DELIVERY SYSTEM; DRUG EFFECTS; METABOLISM; PATHOLOGY; PROSTATIC NEOPLASMS; TUMOR CELL LINE;

AUTOPHAGY; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; NEOPLASM PROTEINS; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RNA, NEOPLASM; TRITERPENES;

EID: 84948977272     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0140745     Document Type: Article

References (27)

1. Mehrpour M, Esclatine A, Beau I, Codogno P. Overview of macroautophagy regulation in mammalian cells. Cell Res. 2010; 20(7): 748-62. doi: 10.1038/cr.2010.82 PMID: 20548331
2. Yang Z, Klionsky DJ. An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol. 2009; 335:1-32. doi: 10.1007/978-3-642-00302-8 1 PMID: 19802558
3. Shao L, Zhou Z, Cai Y, Castro P, Dakhov O, Shi P, et al. Celastrol suppresses tumor cell growth through targeting an AR-ERG-NF-kappaB pathway in TMPRSS2/ERG fusion gene expressing prostate cancer. PLoS ONE. 2013; 8(3): e58391. doi: 10.1371/journal.pone.0058391 PMID: 23554889
4. Yang H, Chen D, Cui QC, Yuan X, Dou QP. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine, " is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006; 66(9): 4758-65. PMID: 16651429
5. Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, et al. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell. 2006; 10(4): 321-30. PMID: 17010675
6. Yang H, Murthy S, Sarkar FH, Sheng S, Reddy GP, Dou QP. Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells. J Cell Physiol. 2008; 217(3): 569-76. doi: 10.1002/jcp. 21565 PMID: 18726991
7. Reddy GP, Barrack ER, Dou QP, Menon M, Pelley R, Sarkar FH, et al. Regulatory processes affecting androgen receptor expression, stability, and function: potential targets to treat hormone-refractory prostate cancer. J Cell Biochem. 2006; 98(6): 1408-23. PMID: 16619263
8. Bennett HL, Fleming JT, O'Prey J, Ryan KM, Leung HY. Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death Dis. 2010; 1: e72. doi: 10.1038/cddis.2010.50 PMID: 21364676
9. Chhipa RR, Wu Y, Ip C. AMPK-mediatedautophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia. Cell Signal. 2011; 23(9): 1466-72. doi: 10.1016/j.cellsig.2011.04.008 PMID: 21554950
10. Jiang Q, Yeh S, Wang X, Xu D, Zhang Q, Wen X, et al. Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy. J Urol. 2012; 188(4): 1361-8. doi: 10.1016/j.juro. 2012.06.004 PMID: 22906664
11. Li M, Jiang X, Liu D, Na Y, Gao GF, Xi Z. Autophagy protects LNCaP cells under androgen deprivation conditions. Autophagy. 2008; 4(1): 54-60. PMID: 17993778
12. Frankel LB, Wen J, Lees M, Hoyer-Hansen M, Farkas T, Krogh A, et al. microRNA-101 is a potent inhibitor of autophagy. EMBO J. 2011; 30(22): 4628-41. doi: 10.1038/emboj.2011.331 PMID: 21915098
13. Cao P, Deng Z, Wan M, Huang W, Cramer SD, Xu J, et al. MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta. Mol Cancer. 2010; 9: 108. doi: 10.1186/1476-4598-9-108 PMID: 20478051
14. Shi R, Chiang VL. Facile means for quantifying microRNA expression by real-time PCR. Biotechniques. 2005; 39(4): 519-25. PMID: 16235564
15. Frezza M, Yang H, Dou QP. Modulation of the tumor cell death pathway by androgen receptor in response to cytotoxic stimuli. J Cell Physiol. 2011; 226(11): 2731-9. doi: 10.1002/jcp.22758 PMID: 21448923
16. Yang H, Wu GS. p53 Transactivates the phosphatase MKP1 through both intronicandexonicp53 responsive elements. Cancer Biol Ther. 2004; 3(12): 1277-82. PMID: 15611668
17. Lippai M, Low P. The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy. Biomed Res Int. 2014; 2014: 832704. doi: 10.1155/2014/832704 PMID: 25013806
18. Huang W, He T, Chai C, Yang Y, Zheng Y, Zhou P, et al. Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression. PLoS ONE. 2012; 7(5): e37693. doi: 10.1371/journal.pone.0037693 PMID: 22666381
19. Castoria G, Giovannelli P, Di Donato M, Ciociola A, Hayashi R, Bernal F, et al. Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells. Cell Death Dis. 2014; 5: e1548. doi: 10.1038/cddis.2014.497 PMID: 25476896
20. Kung HJ. Targeting tyrosine kinases and autophagy in prostate cancer. Horm Cancer. 2011; 2(1): 38-46. doi: 10.1007/s12672-010-0053-3 PMID: 21350583
21. Zhao X, Gao S, Ren H, Huang H, Ji W, Hao J. Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models. Curr Mol Med. 2014; 14(4):555-63. PMID: 24730520
22. Han X, Sun S, Zhao M, Cheng X, Chen G, Lin S, et al. Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1 a protein synthesis. PLoS One. 2014; 9(11):e112470. doi: 10.1371/journal.pone. 0112470 PMID: 25383959
23. Beer TM, Armstrong AJ, Rathkopf DE, Loriot Y, Sternberg CN, Higano CS, et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N Engl J Med. 2014; 371(5): 424-33. doi: 10.1056/NEJMoa1405095 PMID: 24881730
24. Hoy SM. Abiraterone acetate: a review of its use in patients with metastatic castration-resistant prostate cancer. Drugs. 2013; 73(18): 2077-91. doi: 10.1007/s40265-013-0150-z PMID: 24271422
25. Tombal B, Borre M, Rathenborg P, Werbrouck P, Van Poppel H, Heidenreich A, et al. Enzalutamide monotherapy in hormone-naive prostate cancer: primary analysis of an open-label, single-arm, phase 2 study. Lancet Oncol. 2014; 15(6): 592-600. doi: 10.1016/S1470-2045(14)70129-9 PMID: 24739897
26. Boutin B, Tajeddine N, Vandersmissen P, Zanou N, Van Schoor M, Mondin L, et al. Androgen deprivation and androgen receptor competition by bicalutamide induce autophagy of hormone-resistant prostate cancer cells and confer resistance to apoptosis. Prostate. 2013; 73(10): 1090-102. doi: 10.1002/pros.22658 PMID: 23532738
27. Nguyen HG, Yang JC, Kung HJ, Shi XB, Tilki D, Lara PN, et al. Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model. Oncogene. 2014; 33(36): 4521-30. doi: 10.1038/onc.2014.25 PMID: 24662833