Nonsense mutations in the rhodopsin gene that give rise to mild phenotypes trigger mRNA degradation in human cells by nonsense-mediated decay

Experimental Eye Research

Volumn 145, Issue , 2016, Pages 444-449

  Roman Sanchez, Ramon ^a   Wensel, Theodore G ^a   Wilson, John H ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Nonsense mutations; Nonsense mediated decay; Patterns of inheritance; Retinitis pigmentosa; Rhodopsin

Indexed keywords

GLOBIN MESSENGER RNA; HEMOGLOBIN BETA CHAIN; MESSENGER RNA; RHODOPSIN; TRIOSEPHOSPHATE ISOMERASE; WORTMANNIN; ANDROSTANE DERIVATIVE; STOP CODON;

ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EXON; GENETIC TRANSFECTION; HEK293 CELL LINE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; INTRON; NONSENSE MEDIATED MRNA DECAY; NONSENSE MUTATION; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; RETINAL ROD OUTER SEGMENT; RETINITIS PIGMENTOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA DEGRADATION; RNA SPLICING; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; STOP CODON;

ANDROSTADIENES; CODON, NONSENSE; HEK293 CELLS; HUMANS; NONSENSE MEDIATED MRNA DECAY; PHENOTYPE; RETINITIS PIGMENTOSA; RHODOPSIN; RNA, MESSENGER;

EID: 84948822796     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2015.09.013     Document Type: Article

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