메뉴 건너뛰기




Volumn 1382, Issue , 2016, Pages 367-382

Viral vector-based modeling of neurodegenerative disorders: Parkinson’s disease

Author keywords

Adeno associated virus; Dopamine; Lentivirus; Leucine rich repeat kinase 2; Lewy body; Parkin; Parkinson s disease; PTEN induced putative kinase 1; Striatum; Substantia nigra; Tyrosine hydroxylase; synuclein

Indexed keywords

VIRUS VECTOR;

EID: 84948809260     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-3271-9_26     Document Type: Chapter
Times cited : (17)

References (94)
  • 2
    • 33846604242 scopus 로고    scopus 로고
    • How common are the “common” neurologic disorders?
    • Hirtz D et al (2007) How common are the “common” neurologic disorders? Neurology 68(5):326-337
    • (2007) Neurology , vol.68 , Issue.5 , pp. 326-337
    • Hirtz, D.1
  • 3
    • 41149163183 scopus 로고    scopus 로고
    • Parkinson’s disease: Clinical features and diagnosis
    • Jankovic J (2008) Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 79(4):368-376
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , Issue.4 , pp. 368-376
    • Jankovic, J.1
  • 4
    • 0035008154 scopus 로고    scopus 로고
    • Parkinson’s disease
    • Aminoff MJ (2001) Parkinson’s disease. Neurol Clin 19(1):119-128, vi
    • (2001) Neurol Clin , vol.19 , Issue.1 , pp. 119-128
    • Aminoff, M.J.1
  • 7
    • 84879122389 scopus 로고    scopus 로고
    • The Lewy body in Parkinson’s disease and related neurodegenerative disorders
    • Wakabayashi K et al (2013) The Lewy body in Parkinson’s disease and related neurodegenerative disorders. Mol Neurobiol 47(2):495-508
    • (2013) Mol Neurobiol , vol.47 , Issue.2 , pp. 495-508
    • Wakabayashi, K.1
  • 8
    • 84884250340 scopus 로고    scopus 로고
    • The function of alpha-synuclein
    • Bendor JT, Logan TP, Edwards RH (2013) The function of alpha-synuclein. Neuron 79(6):1044-1066
    • (2013) Neuron , vol.79 , Issue.6 , pp. 1044-1066
    • Bendor, J.T.1    Logan, T.P.2    Edwards, R.H.3
  • 9
    • 77952852437 scopus 로고    scopus 로고
    • Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss
    • Spieles-Engemann AL et al (2010) Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss. Neurobiol Dis 39(1):105-115
    • (2010) Neurobiol Dis , vol.39 , Issue.1 , pp. 105-115
    • Spieles-Engemann, A.L.1
  • 10
    • 84880932230 scopus 로고    scopus 로고
    • Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease
    • Kordower JH et al (2013) Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease. Brain 136 (Pt 8): 2419-2431
    • (2013) Brain , vol.136 , pp. 2419-2431
    • Kordower, J.H.1
  • 11
    • 0028171374 scopus 로고
    • Interleukin-1 beta, inter- leukin-6, epidermal growth factor and trans-forming growth factor-alpha are elevated in the brain from parkinsonian patients
    • Mogi M et al (1994) Interleukin-1 beta, inter- leukin-6, epidermal growth factor and trans-forming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci Lett 180(2):147-150
    • (1994) Neurosci Lett , vol.180 , Issue.2 , pp. 147-150
    • Mogi, M.1
  • 12
    • 0028178281 scopus 로고
    • Tumor necrosis factor- alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinso- nian patients
    • Mogi M et al (1994) Tumor necrosis factor- alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinso- nian patients. Neurosci Lett 165(1-2): 208-210
    • (1994) Neurosci Lett , vol.165 , Issue.1-2 , pp. 208-210
    • Mogi, M.1
  • 13
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson’s and Alzheimer’s disease brains
    • McGeer PL et al (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson’s and Alzheimer’s disease brains. Neurology 38(8):1285-1291
    • (1988) Neurology , vol.38 , Issue.8 , pp. 1285-1291
    • McGeer, P.L.1
  • 14
    • 0023782375 scopus 로고
    • Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
    • McGeer PL, Itagaki S, McGeer EG (1988) Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol 76(6):550-557
    • (1988) Acta Neuropathol , vol.76 , Issue.6 , pp. 550-557
    • McGeer, P.L.1    Itagaki, S.2    McGeer, E.G.3
  • 15
    • 0344444234 scopus 로고    scopus 로고
    • Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson’s disease brains
    • Imamura K et al (2003) Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson’s disease brains. Acta Neuropathol 106(6):518-526
    • (2003) Acta Neuropathol , vol.106 , Issue.6 , pp. 518-526
    • Imamura, K.1
  • 16
    • 27344438938 scopus 로고    scopus 로고
    • Microglial inflamma- tion in the parkinsonian substantia nigra: Relationship to alpha-synuclein deposition
    • Croisier E et al (2005) Microglial inflamma- tion in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition. J Neuroinflammation 2:14
    • (2005) J Neuroinflammation , vol.2 , pp. 14
    • Croisier, E.1
  • 17
    • 30744472146 scopus 로고    scopus 로고
    • In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson’s disease
    • Gerhard A et al (2006) In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson’s disease. Neurobiol Dis 21(2):404-412
    • (2006) Neurobiol Dis , vol.21 , Issue.2 , pp. 404-412
    • Gerhard, A.1
  • 18
    • 84907407571 scopus 로고    scopus 로고
    • Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson inverted question marks disease patients
    • Doorn KJ et al (2014) Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson inverted question marks disease patients. Acta Neuropathol Commun 2(1):90
    • (2014) Acta Neuropathol Commun , vol.2 , Issue.1 , pp. 90
    • Doorn, K.J.1
  • 19
    • 77952926102 scopus 로고    scopus 로고
    • Clinical progression in Parkinson disease and the neurobiology of axons
    • Cheng HC, Ulane CM, Burke RE (2010) Clinical progression in Parkinson disease and the neurobiology of axons. Ann Neurol 67(6):715-725
    • (2010) Ann Neurol , vol.67 , Issue.6 , pp. 715-725
    • Cheng, H.C.1    Ulane, C.M.2    Burke, R.E.3
  • 20
    • 0038015531 scopus 로고    scopus 로고
    • Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors
    • Kirik D, Bjorklund A (2003) Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors. Trends Neurosci 26(7):386-392
    • (2003) Trends Neurosci , vol.26 , Issue.7 , pp. 386-392
    • Kirik, D.1    Bjorklund, A.2
  • 21
    • 37549030985 scopus 로고    scopus 로고
    • In vivo alpha-synuclein overexpression in rodents: A useful model of Parkinson’s disease?
    • Chesselet MF (2008) In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson’s disease? Exp Neurol 209(1):22-27
    • (2008) Exp Neurol , vol.209 , Issue.1 , pp. 22-27
    • Chesselet, M.F.1
  • 22
    • 47049084912 scopus 로고    scopus 로고
    • Viral vectors, animal models and new therapies for Parkinson’s disease
    • Schneider B, Zufferey R, Aebischer P (2008) Viral vectors, animal models and new therapies for Parkinson’s disease. Parkinsonism Relat Disord 14(Suppl 2):S169-S171
    • (2008) Parkinsonism Relat Disord , vol.14 , pp. S169-S171
    • Schneider, B.1    Zufferey, R.2    Aebischer, P.3
  • 23
    • 37549032800 scopus 로고    scopus 로고
    • In vivo gene delivery for development of mammalian models for Parkinson’s disease
    • Ulusoy A et al (2008) In vivo gene delivery for development of mammalian models for Parkinson’s disease. Exp Neurol 209(1):89-100
    • (2008) Exp Neurol , vol.209 , Issue.1 , pp. 89-100
    • Ulusoy, A.1
  • 24
    • 84863701701 scopus 로고    scopus 로고
    • Do alpha-synuclein vector injections provide a better model of Parkinson’s disease than the classic 6-hydroxydopamine model?
    • Lindgren HS, Lelos MJ, Dunnett SB (2012) Do alpha-synuclein vector injections provide a better model of Parkinson’s disease than the classic 6-hydroxydopamine model? Exp Neurol 237(1):36-42
    • (2012) Exp Neurol , vol.237 , Issue.1 , pp. 36-42
    • Lindgren, H.S.1    Lelos, M.J.2    Dunnett, S.B.3
  • 25
    • 84865535547 scopus 로고    scopus 로고
    • Use of viral vectors to create animal models for Parkinson’s disease
    • Low K, Aebischer P (2012) Use of viral vectors to create animal models for Parkinson’s disease. Neurobiol Dis 48(2):189-201
    • (2012) Neurobiol Dis , vol.48 , Issue.2 , pp. 189-201
    • Low, K.1    Aebischer, P.2
  • 27
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease
    • Polymeropoulos MH et al (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease. Science 276(5321):2045-2047
    • (1997) Science , vol.276 , Issue.5321 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 28
    • 4644236043 scopus 로고    scopus 로고
    • Causal relation between alpha-synuclein gene duplication and familial Parkinson’s disease
    • Ibáñez P et al (2004) Causal relation between alpha-synuclein gene duplication and familial Parkinson’s disease. Lancet 364(9440):1169-1171
    • (2004) Lancet , vol.364 , Issue.9440 , pp. 1169-1171
    • Ibáñez, P.1
  • 29
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson’s disease
    • Kruger R et al (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson’s disease. Nat Genet 18(2):106-108
    • (1998) Nat Genet , vol.18 , Issue.2 , pp. 106-108
    • Kruger, R.1
  • 30
    • 0242300619 scopus 로고    scopus 로고
    • -Synuclein locus triplication causes Parkinson’s disease
    • Singleton AB et al (2003) alpha-Synuclein locus triplication causes Parkinson’s disease. Science 302(5646):841
    • (2003) Science , vol.302 , Issue.5646 , pp. 841
    • Singleton, A.B.1
  • 31
    • 79957617156 scopus 로고    scopus 로고
    • Milestones in PD genetics
    • Gasser T, Hardy J, Mizuno Y (2011) Milestones in PD genetics. Mov Disord 26(6):1042-1048
    • (2011) Mov Disord , vol.26 , Issue.6 , pp. 1042-1048
    • Gasser, T.1    Hardy, J.2    Mizuno, Y.3
  • 32
    • 66949152096 scopus 로고    scopus 로고
    • Parkinson’s disease
    • Lees AJ, Hardy J, Revesz T (2009) Parkinson’s disease. Lancet 373(9680):2055-2066
    • (2009) Lancet , vol.373 , Issue.9680 , pp. 2055-2066
    • Lees, A.J.1    Hardy, J.2    Revesz, T.3
  • 33
    • 0030882856 scopus 로고    scopus 로고
    • Alpha-synuclein in Lewy bodies
    • Spillantini MG et al (1997) Alpha-synuclein in Lewy bodies. Nature 388(6645):839-840
    • (1997) Nature , vol.388 , Issue.6645 , pp. 839-840
    • Spillantini, M.G.1
  • 34
    • 0036679197 scopus 로고    scopus 로고
    • Alpha-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson’s diseas
    • Lo Bianco C et al (2002) alpha-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson’s disease. Proc Natl Acad Sci U S A 99(16):10813-10818
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.16 , pp. 10813-10818
    • Lo Bianco, C.1
  • 35
    • 0036550101 scopus 로고    scopus 로고
    • Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system
    • Kirik D et al (2002) Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. J Neurosci 22(7):2780-2791
    • (2002) J Neurosci , vol.22 , Issue.7 , pp. 2780-2791
    • Kirik, D.1
  • 36
    • 0036202813 scopus 로고    scopus 로고
    • Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra
    • Klein RL et al (2002) Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra. Hum Gene Ther 13(5):605-612
    • (2002) Hum Gene Ther , vol.13 , Issue.5 , pp. 605-612
    • Klein, R.L.1
  • 37
    • 38649084032 scopus 로고    scopus 로고
    • The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease
    • Gorbatyuk OS et al (2008) The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proc Natl Acad Sci U S A 105(2):763-768
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.2 , pp. 763-768
    • Gorbatyuk, O.S.1
  • 38
    • 60549109895 scopus 로고    scopus 로고
    • Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson’s disease
    • da Azeredo Silveira S et al (2009) Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson’s disease. Hum Mol Genet 18(5):872-887
    • (2009) Hum Mol Genet , vol.18 , Issue.5 , pp. 872-887
    • Da Azeredo Silveira, S.1
  • 39
    • 70149118325 scopus 로고    scopus 로고
    • Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease
    • McFarland NR et al (2009) Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. J Neuropathol Exp Neurol 68(5):515-524
    • (2009) J Neuropathol Exp Neurol , vol.68 , Issue.5 , pp. 515-524
    • McFarland, N.R.1
  • 40
    • 79952742454 scopus 로고    scopus 로고
    • In vivo demonstration that alpha-synuclein oligomers are toxic
    • Winner B et al (2011) In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A 108(10):4194-4199
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.10 , pp. 4194-4199
    • Winner, B.1
  • 41
    • 5444249974 scopus 로고    scopus 로고
    • Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: Resemblance to pathogenetic changes in Parkinson’s disease
    • Yamada M et al (2004) Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson’s disease. J Neurochem 91(2):451-461
    • (2004) J Neurochem , vol.91 , Issue.2 , pp. 451-461
    • Yamada, M.1
  • 42
    • 14844303486 scopus 로고    scopus 로고
    • Parkin gene therapy for alpha-synucleinopathy: A rat model of Parkinson’s disease
    • Yamada M, Mizuno Y, Mochizuki H (2005) Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson’s disease. Hum Gene Ther 16(2):262-270
    • (2005) Hum Gene Ther , vol.16 , Issue.2 , pp. 262-270
    • Yamada, M.1    Mizuno, Y.2    Mochizuki, H.3
  • 43
    • 77955141273 scopus 로고    scopus 로고
    • Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology
    • Ulusoy A et al (2010) Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology. Eur J Neurosci 32(3):409-422
    • (2010) Eur J Neurosci , vol.32 , Issue.3 , pp. 409-422
    • Ulusoy, A.1
  • 44
    • 77649294300 scopus 로고    scopus 로고
    • Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathol- ogy in a rAAV based model of Parkinson’s disease
    • Sanchez-Guajardo V et al (2010) Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathol- ogy in a rAAV based model of Parkinson’s disease. PLoS One 5(1):e8784
    • (2010) Plos One , vol.5 , Issue.1
    • Sanchez-Guajardo, V.1
  • 45
    • 80051985178 scopus 로고    scopus 로고
    • GDNF fails to exert neuroprotection in a rat alpha-synuclein model of Parkinson’s disease
    • Decressac M et al (2011) GDNF fails to exert neuroprotection in a rat alpha-synuclein model of Parkinson’s disease. Brain 134(Pt 8):2302-2311
    • (2011) Brain , vol.134 , pp. 2302-2311
    • Decressac, M.1
  • 46
    • 84856570373 scopus 로고    scopus 로고
    • Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of alpha- synuclein in midbrain dopamine neurons
    • Decressac M et al (2012) Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of alpha- synuclein in midbrain dopamine neurons. Neurobiol Dis 45(3):939-953
    • (2012) Neurobiol Dis , vol.45 , Issue.3 , pp. 939-953
    • Decressac, M.1
  • 47
    • 84859889965 scopus 로고    scopus 로고
    • Comparison of the behavioural and histological characteristics of the 6-OHDA and alpha- synuclein rat models of Parkinson’s disease
    • Decressac M, Mattsson B, Bjorklund A (2012) Comparison of the behavioural and histological characteristics of the 6-OHDA and alpha- synuclein rat models of Parkinson’s disease. Exp Neurol 235(1):306-315
    • (2012) Exp Neurol , vol.235 , Issue.1 , pp. 306-315
    • Decressac, M.1    Mattsson, B.2    Bjorklund, A.3
  • 48
    • 84856440571 scopus 로고    scopus 로고
    • Development and char- acterisation of a novel rat model of Parkinson’s disease induced by sequential intranigral administration of AAV-alpha-synuclein and the pesticide, rotenone
    • Mulcahy P et al (2012) Development and char- acterisation of a novel rat model of Parkinson’s disease induced by sequential intranigral administration of AAV-alpha-synuclein and the pesticide, rotenone. Neuroscience 203:170-179
    • (2012) Neuroscience , vol.203 , pp. 170-179
    • Mulcahy, P.1
  • 49
    • 84896694412 scopus 로고    scopus 로고
    • Morphological and behavioral impact of AAV2/5-mediated over-expression of human wildtype alpha-synuclein in the rat nigrostriatal system
    • Gombash SE et al (2013) Morphological and behavioral impact of AAV2/5-mediated over-expression of human wildtype alpha-synuclein in the rat nigrostriatal system. PLoS One 8(11):e81426
    • (2013) Plos One , vol.8 , Issue.11
    • Gombash, S.E.1
  • 50
    • 33847699408 scopus 로고    scopus 로고
    • Dopaminergic neu- ron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra
    • St. Martin JL et al (2007) Dopaminergic neu- ron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra. J Neurochem 100(6):1449-1457
    • (2007) J Neurochem , vol.100 , Issue.6 , pp. 1449-1457
    • Martin, S.T.1
  • 51
    • 58149380755 scopus 로고    scopus 로고
    • Targeted overexpres- sion of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease
    • Theodore S et al (2008) Targeted overexpres- sion of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease. J Neuropathol Exp Neurol 67(12):1149-1158
    • (2008) J Neuropathol Exp Neurol , vol.67 , Issue.12 , pp. 1149-1158
    • Theodore, S.1
  • 52
    • 84888119924 scopus 로고    scopus 로고
    • RAAV2/7 vector- mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
    • Oliveras-Salva M et al (2013) rAAV2/7 vector- mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration. Mol Neurodegener 8:44
    • (2013) Mol Neurodegener , vol.8 , pp. 44
    • Oliveras-Salva, M.1
  • 53
    • 84918820798 scopus 로고    scopus 로고
    • Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice
    • Oliveras-Salva M et al (2014) Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice. Neurobiol Aging 35(11):2625-2636
    • (2014) Neurobiol Aging , vol.35 , Issue.11 , pp. 2625-2636
    • Oliveras-Salva, M.1
  • 54
    • 0345269757 scopus 로고    scopus 로고
    • Nigrostriatal alpha-synucleinopathy induced by viral vector- mediated overexpression of human Viral Vectors to Model PD 381 alpha-synuclein: A new primate model of Parkinson's disease
    • Kirik D et al (2003) Nigrostriatal alpha-synucleinopathy induced by viral vector- mediated overexpression of human Viral Vectors to Model PD 381 alpha-synuclein: a new primate model of Parkinson's disease. Proc Natl Acad Sci U S A 100(5):2884-2889
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.5 , pp. 2884-2889
    • Kirik, D.1
  • 55
    • 33947127695 scopus 로고    scopus 로고
    • Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
    • Eslamboli A et al (2007) Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain. Brain 130(Pt 3):799-815
    • (2007) Brain , vol.130 , pp. 799-815
    • Eslamboli, A.1
  • 56
    • 33845196246 scopus 로고    scopus 로고
    • Neuronal specificity of alpha-synuclein toxicity and effect of Parkin coexpression in primates
    • Yasuda T et al (2007) Neuronal specificity of alpha-synuclein toxicity and effect of Parkin coexpression in primates. Neuroscience 144(2):743-753
    • (2007) Neuroscience , vol.144 , Issue.2 , pp. 743-753
    • Yasuda, T.1
  • 57
    • 5144225578 scopus 로고    scopus 로고
    • Lentiviral nigral delivery of GDNF does not prevent neurode-generation in a genetic rat model of Parkinson’s disease
    • Lo Bianco C et al (2004) Lentiviral nigral delivery of GDNF does not prevent neurode-generation in a genetic rat model of Parkinson’s disease. Neurobiol Dis 17(2):283-289
    • (2004) Neurobiol Dis , vol.17 , Issue.2 , pp. 283-289
    • Lo Bianco, C.1
  • 58
    • 10644281090 scopus 로고    scopus 로고
    • Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson’s disease
    • Lo Bianco C et al (2004) Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson’s disease. Proc Natl Acad Sci U S A 101(50):17510-17515
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.50 , pp. 17510-17515
    • Lo Bianco, C.1
  • 59
    • 33845482072 scopus 로고    scopus 로고
    • Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression
    • Lauwers E et al (2007) Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiol Aging 28(2):248-257
    • (2007) Neurobiol Aging , vol.28 , Issue.2 , pp. 248-257
    • Lauwers, E.1
  • 60
    • 0041625923 scopus 로고    scopus 로고
    • Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein
    • Lauwers E et al (2003) Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein. Brain Pathol 13(3): 364-372
    • (2003) Brain Pathol , vol.13 , Issue.3 , pp. 364-372
    • Lauwers, E.1
  • 61
    • 33747441863 scopus 로고    scopus 로고
    • Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression
    • Maingay M et al (2006) Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression. Neurobiol Dis 23(3):522-532
    • (2006) Neurobiol Dis , vol.23 , Issue.3 , pp. 522-532
    • Maingay, M.1
  • 62
    • 63849332293 scopus 로고    scopus 로고
    • Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy
    • Chung CY et al (2009) Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. J Neurosci 29(11):3365-3373
    • (2009) J Neurosci , vol.29 , Issue.11 , pp. 3365-3373
    • Chung, C.Y.1
  • 63
    • 79952321038 scopus 로고    scopus 로고
    • Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson’s disease produced by decreasing doses of alpha-synuclein
    • Koprich JB et al (2011) Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson’s disease produced by decreasing doses of alpha-synuclein. PLoS One 6(3):e17698
    • (2011) Plos One , vol.6 , Issue.3
    • Koprich, J.B.1
  • 64
    • 84858621036 scopus 로고    scopus 로고
    • Long-term polarization of microglia upon alpha-synuclein overexpression in nonhuman primates
    • Barkholt P et al (2012) Long-term polarization of microglia upon alpha-synuclein overexpression in nonhuman primates. Neuroscience 208:85-96
    • (2012) Neuroscience , vol.208 , pp. 85-96
    • Barkholt, P.1
  • 65
    • 84877352565 scopus 로고    scopus 로고
    • Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson’s disease
    • Febbraro F et al (2013) Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson’s disease. Neurobiol Dis 56:47-58
    • (2013) Neurobiol Dis , vol.56 , pp. 47-58
    • Febbraro, F.1
  • 66
    • 84857716290 scopus 로고    scopus 로고
    • Impaired neurotransmission caused by overexpression of alpha-synuclein in nigral dopamine neurons
    • Lundblad M et al (2012) Impaired neurotransmission caused by overexpression of alpha-synuclein in nigral dopamine neurons. Proc Natl Acad Sci U S A 109(9):3213-3219
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.9 , pp. 3213-3219
    • Lundblad, M.1
  • 67
    • 77957224859 scopus 로고    scopus 로고
    • Viral vector-mediated overexpression of alpha-synuclein as a progressive model of Parkinson’s disease
    • Ulusoy A et al (2010) Viral vector-mediated overexpression of alpha-synuclein as a progressive model of Parkinson’s disease. Prog Brain Res 184:89-111
    • (2010) Prog Brain Res , vol.184 , pp. 89-111
    • Ulusoy, A.1
  • 68
    • 84877965817 scopus 로고    scopus 로고
    • Neuroimmunological processes in Parkinson’s disease and their relation to alpha-synuclein: Microglia as the referee between neuronal processes and peripheral immunity
    • Sanchez-Guajardo V et al (2013) Neuroimmunological processes in Parkinson’s disease and their relation to alpha-synuclein: microglia as the referee between neuronal processes and peripheral immunity. ASN Neuro 5(2):113-139
    • (2013) ASN Neuro , vol.5 , Issue.2 , pp. 113-139
    • Sanchez-Guajardo, V.1
  • 69
    • 33646151866 scopus 로고    scopus 로고
    • LRRK2 in Parkinson’s disease: Protein domains and functional insights
    • Mata IF et al (2006) LRRK2 in Parkinson’s disease: protein domains and functional insights. Trends Neurosci 29(5):286-293
    • (2006) Trends Neurosci , vol.29 , Issue.5 , pp. 286-293
    • Mata, I.F.1
  • 70
    • 32044432395 scopus 로고    scopus 로고
    • Biochemical and pathological characterization of Lrrk2
    • Giasson BI et al (2006) Biochemical and pathological characterization of Lrrk2. Ann Neurol 59(2):315-322
    • (2006) Ann Neurol , vol.59 , Issue.2 , pp. 315-322
    • Giasson, B.I.1
  • 71
    • 8844266996 scopus 로고    scopus 로고
    • Cloning of the gene containing mutations that cause PARK8-linked Parkinson’s disease
    • Paisan-Ruiz C et al (2004) Cloning of the gene containing mutations that cause PARK8-linked Parkinson’s disease. Neuron 44(4):595-600
    • (2004) Neuron , vol.44 , Issue.4 , pp. 595-600
    • Paisan-Ruiz, C.1
  • 72
    • 32044466285 scopus 로고    scopus 로고
    • Lrrk2 and Lewy body disease
    • Ross OA et al (2006) Lrrk2 and Lewy body disease. Ann Neurol 59(2):388-393
    • (2006) Ann Neurol , vol.59 , Issue.2 , pp. 388-393
    • Ross, O.A.1
  • 73
    • 9144261126 scopus 로고    scopus 로고
    • The PARK8 locus in autosomal dominant parkinsonism: Confirmation of linkage and further delineation of the disease-containing interval
    • Zimprich A et al (2004) The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval. Am J Hum Genet 74(1):11-19
    • (2004) Am J Hum Genet , vol.74 , Issue.1 , pp. 11-19
    • Zimprich, A.1
  • 74
    • 67249165702 scopus 로고    scopus 로고
    • Genetic neuropathology of Parkinson’s disease
    • Cookson MR, Hardy J, Lewis PA (2008) Genetic neuropathology of Parkinson’s disease. Int J Clin Exp Pathol 1(3):217-231
    • (2008) Int J Clin Exp Pathol , vol.1 , Issue.3 , pp. 217-231
    • Cookson, M.R.1    Hardy, J.2    Lewis, P.A.3
  • 75
    • 78751522558 scopus 로고    scopus 로고
    • A rat model of progressive nigral neurodegeneration induced by the Parkinson’s disease-associated G2019S mutation in LRRK2
    • Dusonchet J et al (2011) A rat model of progressive nigral neurodegeneration induced by the Parkinson’s disease-associated G2019S mutation in LRRK2. J Neurosci 31(3):907-912
    • (2011) J Neurosci , vol.31 , Issue.3 , pp. 907-912
    • Dusonchet, J.1
  • 76
    • 77956441086 scopus 로고    scopus 로고
    • Inhibitors of leucinerich repeat kinase-2 protect against models of Parkinson’s disease
    • Lee BD et al (2010) Inhibitors of leucinerich repeat kinase-2 protect against models of Parkinson’s disease. Nat Med 16(9):998-1000
    • (2010) Nat Med , vol.16 , Issue.9 , pp. 998-1000
    • Lee, B.D.1
  • 77
    • 0032499264 scopus 로고    scopus 로고
    • Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
    • Kitada T et al (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392(6676):605-608
    • (1998) Nature , vol.392 , Issue.6676 , pp. 605-608
    • Kitada, T.1
  • 78
    • 0342368772 scopus 로고    scopus 로고
    • Association between early-onset Parkinson’s disease and mutations in the parkin gene
    • Lucking CB et al (2000) Association between early-onset Parkinson’s disease and mutations in the parkin gene. N Engl J Med 342(21):1560-1567
    • (2000) N Engl J Med , vol.342 , Issue.21 , pp. 1560-1567
    • Lucking, C.B.1
  • 79
    • 0033933048 scopus 로고    scopus 로고
    • Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
    • Shimura H et al (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 25(3):302-305
    • (2000) Nat Genet , vol.25 , Issue.3 , pp. 302-305
    • Shimura, H.1
  • 80
    • 0028198309 scopus 로고
    • Familial juvenile parkinsonism: Clinical and pathologic study in a family
    • Takahashi H et al (1994) Familial juvenile parkinsonism: clinical and pathologic study in a family. Neurology 44(3 Pt 1):437-441
    • (1994) Neurology , vol.44 , Issue.3 , pp. 437-441
    • Takahashi, H.1
  • 81
    • 0142059791 scopus 로고    scopus 로고
    • Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1
    • Dong Z et al (2003) Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1. Proc Natl Acad Sci U S A 100(21):12438-12443
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.21 , pp. 12438-12443
    • Dong, Z.1
  • 82
    • 33846511271 scopus 로고    scopus 로고
    • Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation
    • Kitao Y et al (2007) Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum Mol Genet 16(1):50-60
    • (2007) Hum Mol Genet , vol.16 , Issue.1 , pp. 50-60
    • Kitao, Y.1
  • 83
    • 67349270248 scopus 로고    scopus 로고
    • Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson’s disease
    • Dusonchet J et al (2009) Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson’s disease. Neurobiol Dis 35(1):32-41
    • (2009) Neurobiol Dis , vol.35 , Issue.1 , pp. 32-41
    • Dusonchet, J.1
  • 84
    • 24144497601 scopus 로고    scopus 로고
    • Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death
    • Ko HS et al (2005) Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J Neurosci 25(35):7968-7978
    • (2005) J Neurosci , vol.25 , Issue.35 , pp. 7968-7978
    • Ko, H.S.1
  • 85
    • 57249086431 scopus 로고    scopus 로고
    • Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors
    • Krenz A et al (2009) Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors. J Neurochem 108(1):139-146
    • (2009) J Neurochem , vol.108 , Issue.1 , pp. 139-146
    • Krenz, A.1
  • 86
    • 0346216853 scopus 로고    scopus 로고
    • Local gene knock-down in the brain using viral-mediated RNA interference
    • Hommel JD et al (2003) Local gene knock-down in the brain using viral-mediated RNA interference. Nat Med 9(12):1539-1544
    • (2003) Nat Med , vol.9 , Issue.12 , pp. 1539-1544
    • Hommel, J.D.1
  • 87
    • 69949144286 scopus 로고    scopus 로고
    • Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons
    • Ulusoy A et al (2009) Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons. Mol Ther 17(9):1574-1584
    • (2009) Mol Ther , vol.17 , Issue.9 , pp. 1574-1584
    • Ulusoy, A.1
  • 88
    • 84865864065 scopus 로고    scopus 로고
    • The genet- ics and neuropathology of Parkinson’s disease
    • Houlden H, Singleton AB (2012) The genet- ics and neuropathology of Parkinson’s disease. Acta Neuropathol 124(3):325-338
    • (2012) Acta Neuropathol , vol.124 , Issue.3 , pp. 325-338
    • Houlden, H.1    Singleton, A.B.2
  • 89
    • 84878775802 scopus 로고    scopus 로고
    • Structure and function of Parkin, PINK1, and DJ-1, the three musketeers of neuroprotection
    • Trempe JF, Fon EA (2013) Structure and function of Parkin, PINK1, and DJ-1, the three musketeers of neuroprotection. Front Neurol 4:38
    • (2013) Front Neurol , vol.4 , pp. 38
    • Trempe, J.F.1    Fon, E.A.2
  • 90
    • 84863305249 scopus 로고    scopus 로고
    • Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahy- dropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1
    • Haque ME et al (2012) Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahy- dropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. J Biol Chem 287(27): 23162-23170
    • (2012) J Biol Chem , vol.287 , Issue.27 , pp. 23162-23170
    • Haque, M.E.1
  • 91
    • 79957467314 scopus 로고    scopus 로고
    • Ageing as a primary risk factor for Parkinson’s disease: Evidence from studies of non-human primates
    • Collier TJ, Kanaan NM, Kordower JH (2011) Ageing as a primary risk factor for Parkinson’s disease: evidence from studies of non-human primates. Nat Rev Neurosci 12(6):359-366
    • (2011) Nat Rev Neurosci , vol.12 , Issue.6 , pp. 359-366
    • Collier, T.J.1    Kanaan, N.M.2    Kordower, J.H.3
  • 92
    • 84922805939 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain
    • Polinski NK et al (2015) Recombinant adeno-associated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain. Neurobiol Aging 36(2):1110-1120
    • (2015) Neurobiol Aging , vol.36 , Issue.2 , pp. 1110-1120
    • Polinski, N.K.1
  • 93
    • 1342290210 scopus 로고    scopus 로고
    • The effects of rAAV2- mediated NGF gene delivery in adult and aged rats
    • Wu K et al (2004) The effects of rAAV2- mediated NGF gene delivery in adult and aged rats. Mol Ther 9(2):262-269
    • (2004) Mol Ther , vol.9 , Issue.2 , pp. 262-269
    • Wu, K.1
  • 94
    • 78650177451 scopus 로고    scopus 로고
    • Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer
    • Klein RL et al (2010) Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer. Neurobiol Aging 31(12): 2091-2102
    • (2010) Neurobiol Aging , vol.31 , Issue.12 , pp. 2091-2102
    • Klein, R.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.