Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment

Acta Crystallographica Section D: Biological Crystallography

Volumn 71, Issue , 2015, Pages 2412-2421

  Skar Gislinge, Nicholas ^a,c   Kynde, Søren A R ^a   Denisov, Ilia G ^b   Ye, Xin ^b   Lenov, Ivan ^b   Sligar, Stephen G ^b   Arleth, Lise ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Cytochrome P450 3A4; Membrane proteins; Nanodiscs; Small angle scattering

Indexed keywords

1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; LIPID BILAYER; NANOMATERIAL; PHOSPHATIDYLCHOLINE; RECOMBINANT PROTEIN;

CHEMISTRY; DRUG FORMULATION; ENZYME ACTIVE SITE; GENE EXPRESSION; GENETICS; HUMAN; LIPID BILAYER; METABOLISM; MOLECULAR GENETICS; MOLECULAR MODEL; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; SMALL ANGLE SCATTERING; ULTRASTRUCTURE; X RAY DIFFRACTION;

AMINO ACID MOTIFS; CATALYTIC DOMAIN; CYTOCHROME P-450 CYP3A; DRUG COMPOUNDING; GENE EXPRESSION; HUMANS; LIPID BILAYERS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NANOSTRUCTURES; PHOSPHATIDYLCHOLINES; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SCATTERING, SMALL ANGLE; X-RAY DIFFRACTION;

EID: 84948808384     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004715018702     Document Type: Article

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