메뉴 건너뛰기




Volumn 195, Issue 11, 2015, Pages 5309-5317

IgM-dependent phagocytosis in microglia is mediated by complement receptor 3, Not Fcα/μ receptor

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD11B ANTIGEN; CD18 ANTIGEN; COMPLEMENT COMPONENT C3 RECEPTOR; COMPLEMENT RECEPTOR; COMPLEMENT RECEPTOR 3; FC ALPHA RECEPTOR; FC MU RECEPTOR; FC RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; UNCLASSIFIED DRUG; BLOCKING ANTIBODY; COMPLEMENT COMPONENT C3; FCALPHA-MU PROTEIN, MOUSE;

EID: 84948784013     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401195     Document Type: Article
Times cited : (32)

References (56)
  • 1
    • 36448961645 scopus 로고    scopus 로고
    • Engulfment of apoptotic cells: Signals for a good meal
    • Ravichandran, K. S., and U. Lorenz. 2007. Engulfment of apoptotic cells: signals for a good meal. Nat. Rev. Immunol. 7: 964-974.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 964-974
    • Ravichandran, K.S.1    Lorenz, U.2
  • 2
    • 0036216769 scopus 로고    scopus 로고
    • Phagocytosis of microbes: Complexity in action
    • Underhill, D. M., and A. Ozinsky. 2002. Phagocytosis of microbes: complexity in action. Annu. Rev. Immunol. 20: 825-852.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 825-852
    • Underhill, D.M.1    Ozinsky, A.2
  • 3
    • 84875410765 scopus 로고    scopus 로고
    • Intravenous immunoglobulin therapy: How does IgG modulate the immune system?
    • Schwab, I., and F. Nimmerjahn. 2013. Intravenous immunoglobulin therapy: how does IgG modulate the immune system? Nat. Rev. Immunol. 13: 176-189.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 176-189
    • Schwab, I.1    Nimmerjahn, F.2
  • 4
    • 0029731813 scopus 로고    scopus 로고
    • Fc receptors and their interactions with immunoglobulins
    • Raghavan, M., and P. J. Bjorkman. 1996. Fc receptors and their interactions with immunoglobulins. Annu. Rev. Cell Dev. Biol. 12: 181-220.
    • (1996) Annu. Rev. Cell Dev. Biol. , vol.12 , pp. 181-220
    • Raghavan, M.1    Bjorkman, P.J.2
  • 5
    • 0038579717 scopus 로고    scopus 로고
    • Opsonization of apoptotic cells and its effect on macrophage and T cell immune responses
    • Kim, S. J., D. Gershov, X. Ma, N. Brot, and K. B. Elkon. 2003. Opsonization of apoptotic cells and its effect on macrophage and T cell immune responses. Ann. N. Y. Acad. Sci. 987: 68-78.
    • (2003) Ann. N. Y. Acad. Sci. , vol.987 , pp. 68-78
    • Kim, S.J.1    Gershov, D.2    Ma, X.3    Brot, N.4    Elkon, K.B.5
  • 6
    • 22144437349 scopus 로고    scopus 로고
    • IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo
    • Ogden, C. A., R. Kowalewski, Y. Peng, V. Montenegro, and K. B. Elkon. 2005. IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo. Autoimmunity 38: 259-264.
    • (2005) Autoimmunity , vol.38 , pp. 259-264
    • Ogden, C.A.1    Kowalewski, R.2    Peng, Y.3    Montenegro, V.4    Elkon, K.B.5
  • 7
    • 0027053111 scopus 로고
    • Receptors for IgA on phagocytic cells
    • Shen, L. 1992. Receptors for IgA on phagocytic cells. Immunol. Res. 11: 273-282.
    • (1992) Immunol. Res. , vol.11 , pp. 273-282
    • Shen, L.1
  • 9
    • 33845437084 scopus 로고    scopus 로고
    • Molecular and functional characteristics of the Fcalpha/muR, a novel Fc receptor for IgM and IgA
    • Shibuya, A., and S. Honda. 2006. Molecular and functional characteristics of the Fcalpha/muR, a novel Fc receptor for IgM and IgA. Springer Semin. Immunopathol. 28: 377-382.
    • (2006) Springer Semin. Immunopathol. , vol.28 , pp. 377-382
    • Shibuya, A.1    Honda, S.2
  • 11
    • 0028672732 scopus 로고
    • Molecular basis of Fc receptor function
    • Hulett, M. D., and P. M. Hogarth. 1994. Molecular basis of Fc receptor function. Adv. Immunol. 57: 1-127.
    • (1994) Adv. Immunol. , vol.57 , pp. 1-127
    • Hulett, M.D.1    Hogarth, P.M.2
  • 12
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch, U. K., and H. Kettenmann. 2007. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 10: 1387-1394.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 13
    • 33747463996 scopus 로고    scopus 로고
    • Microglia biology in health and disease
    • Garden, G. A., and T. Möller. 2006. Microglia biology in health and disease. J. Neuroimmune Pharmacol. 1: 127-137.
    • (2006) J. Neuroimmune Pharmacol. , vol.1 , pp. 127-137
    • Garden, G.A.1    Möller, T.2
  • 14
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: Unique stimuli, specialized responses
    • Ransohoff, R. M., and V. H. Perry. 2009. Microglial physiology: unique stimuli, specialized responses. Annu. Rev. Immunol. 27: 119-145.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 16
    • 33748696772 scopus 로고    scopus 로고
    • The role of Toll-like receptors in CNS response to microbial challenge
    • Konat, G. W., T. Kielian, and I. Marriott. 2006. The role of Toll-like receptors in CNS response to microbial challenge. J. Neurochem. 99: 1-12.
    • (2006) J. Neurochem. , vol.99 , pp. 1-12
    • Konat, G.W.1    Kielian, T.2    Marriott, I.3
  • 17
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard, F., C. Cannon, R. Barbour, R. L. Burke, D. Games, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, et al. 2000. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6: 916-919.
    • (2000) Nat. Med. , vol.6 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3    Burke, R.L.4    Games, D.5    Grajeda, H.6    Guido, T.7    Hu, K.8    Huang, J.9    Johnson-Wood, K.10
  • 20
    • 33845434966 scopus 로고    scopus 로고
    • Parkinson disease IgG and C5a-induced synergistic dopaminergic neurotoxicity: Role of microglia
    • Wang, X. J., Z. Q. Yan, G. Q. Lu, S. Stuart, and S. D. Chen. 2007. Parkinson disease IgG and C5a-induced synergistic dopaminergic neurotoxicity: role of microglia. Neurochem. Int. 50: 39-50.
    • (2007) Neurochem. Int. , vol.50 , pp. 39-50
    • Wang, X.J.1    Yan, Z.Q.2    Lu, G.Q.3    Stuart, S.4    Chen, S.D.5
  • 21
    • 0028981215 scopus 로고
    • Myc-immortalized microglial cells express a functional platelet-activating factor receptor
    • Righi, M., O. Letari, P. Sacerdote, F. Marangoni, A. Miozzo, and S. Nicosia. 1995. myc-immortalized microglial cells express a functional platelet-activating factor receptor. J. Neurochem. 64: 121-129.
    • (1995) J. Neurochem. , vol.64 , pp. 121-129
    • Righi, M.1    Letari, O.2    Sacerdote, P.3    Marangoni, F.4    Miozzo, A.5    Nicosia, S.6
  • 23
    • 0029558338 scopus 로고
    • Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity
    • Wessels, M. R., P. Butko, M. Ma, H. B. Warren, A. L. Lage, and M. C. Carroll. 1995. Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Proc. Natl. Acad. Sci. USA 92: 11490-11494.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11490-11494
    • Wessels, M.R.1    Butko, P.2    Ma, M.3    Warren, H.B.4    Lage, A.L.5    Carroll, M.C.6
  • 24
    • 0022922108 scopus 로고
    • Characterization of ameboid microglia isolated from developing mammalian brain
    • Giulian, D., and T. J. Baker. 1986. Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6: 2163-2178.
    • (1986) J. Neurosci. , vol.6 , pp. 2163-2178
    • Giulian, D.1    Baker, T.J.2
  • 25
    • 0033822556 scopus 로고    scopus 로고
    • Thrombin-induced activation of cultured rodent microglia
    • Möller, T., U. K. Hanisch, and B. R. Ransom. 2000. Thrombin-induced activation of cultured rodent microglia. J. Neurochem. 75: 1539-1547.
    • (2000) J. Neurochem. , vol.75 , pp. 1539-1547
    • Möller, T.1    Hanisch, U.K.2    Ransom, B.R.3
  • 26
    • 69249218888 scopus 로고    scopus 로고
    • Regulation of Fcgamma receptors and immunoglobulin G-mediated phagocytosis in mouse microglia
    • Quan, Y., T. Möller, and J. R. Weinstein. 2009. Regulation of Fcgamma receptors and immunoglobulin G-mediated phagocytosis in mouse microglia. Neurosci. Lett. 464: 29-33.
    • (2009) Neurosci. Lett. , vol.464 , pp. 29-33
    • Quan, Y.1    Möller, T.2    Weinstein, J.R.3
  • 27
    • 0037421507 scopus 로고    scopus 로고
    • Expression of Fc receptor for immunoglobulin M in oligodendrocytes and myelin of mouse central nervous system
    • Nakahara, J., C. Seiwa, A. Shibuya, S. Aiso, and H. Asou. 2003. Expression of Fc receptor for immunoglobulin M in oligodendrocytes and myelin of mouse central nervous system. Neurosci. Lett. 337: 73-76.
    • (2003) Neurosci. Lett. , vol.337 , pp. 73-76
    • Nakahara, J.1    Seiwa, C.2    Shibuya, A.3    Aiso, S.4    Asou, H.5
  • 28
    • 59849125611 scopus 로고    scopus 로고
    • Thrombin-induced regulation of CD95(Fas) expression in the N9 microglial cell line: Evidence for involvement of proteinaseactivated receptor(1) and extracellular signal-regulated kinase 1/2
    • Weinstein, J. R., M. Zhang, M. Kutlubaev, R. Lee, C. Bishop, H. Andersen, U. K. Hanisch, and T. Möller. 2009. Thrombin-induced regulation of CD95(Fas) expression in the N9 microglial cell line: evidence for involvement of proteinaseactivated receptor(1) and extracellular signal-regulated kinase 1/2. Neurochem. Res. 34: 445-452.
    • (2009) Neurochem. Res. , vol.34 , pp. 445-452
    • Weinstein, J.R.1    Zhang, M.2    Kutlubaev, M.3    Lee, R.4    Bishop, C.5    Andersen, H.6    Hanisch, U.K.7    Möller, T.8
  • 29
    • 0034936968 scopus 로고    scopus 로고
    • Role of natural and immune IgM antibodies in immune responses
    • Boes, M. 2000. Role of natural and immune IgM antibodies in immune responses. Mol. Immunol. 37: 1141-1149.
    • (2000) Mol. Immunol. , vol.37 , pp. 1141-1149
    • Boes, M.1
  • 30
    • 0141450468 scopus 로고    scopus 로고
    • Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease
    • Rotshenker, S. 2003. Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease. J. Mol. Neurosci. 21: 65-72.
    • (2003) J. Mol. Neurosci. , vol.21 , pp. 65-72
    • Rotshenker, S.1
  • 31
    • 5144222255 scopus 로고    scopus 로고
    • Complement: A unique innate immune sensor for danger signals
    • Gasque, P. 2004. Complement: a unique innate immune sensor for danger signals. Mol. Immunol. 41: 1089-1098.
    • (2004) Mol. Immunol. , vol.41 , pp. 1089-1098
    • Gasque, P.1
  • 32
    • 0037791771 scopus 로고    scopus 로고
    • Activation of complement in the central nervous system: Roles in neurodegeneration and neuroprotection
    • van Beek, J., K. Elward, and P. Gasque. 2003. Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection. Ann. N. Y. Acad. Sci. 992: 56-71.
    • (2003) Ann. N. Y. Acad. Sci. , vol.992 , pp. 56-71
    • Van Beek, J.1    Elward, K.2    Gasque, P.3
  • 33
    • 0034332074 scopus 로고    scopus 로고
    • Fc alpha/microR: Single member or first born in the family?
    • Kinet, J. P., and P. Launay. 2000. Fc alpha/microR: single member or first born in the family? Nat. Immunol. 1: 371-372.
    • (2000) Nat. Immunol. , vol.1 , pp. 371-372
    • Kinet, J.P.1    Launay, P.2
  • 34
    • 74749102329 scopus 로고    scopus 로고
    • Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages
    • Feng, X., Y. Zhang, R. Xu, X. Xie, L. Tao, H. Gao, Y. Gao, Z. He, and H. Wang. 2010. Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages. Atherosclerosis 208: 396-405.
    • (2010) Atherosclerosis , vol.208 , pp. 396-405
    • Feng, X.1    Zhang, Y.2    Xu, R.3    Xie, X.4    Tao, L.5    Gao, H.6    Gao, Y.7    He, Z.8    Wang, H.9
  • 35
    • 0031985336 scopus 로고    scopus 로고
    • Mature microglia resemble immature antigen-presenting cells
    • Carson, M. J., C. R. Reilly, J. G. Sutcliffe, and D. Lo. 1998. Mature microglia resemble immature antigen-presenting cells. Glia 22: 72-85.
    • (1998) Glia , vol.22 , pp. 72-85
    • Carson, M.J.1    Reilly, C.R.2    Sutcliffe, J.G.3    Lo, D.4
  • 36
    • 65349101724 scopus 로고    scopus 로고
    • The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain
    • Griffiths, M. R., P. Gasque, and J. W. Neal. 2009. The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain. J. Neuropathol. Exp. Neurol. 68: 217-226.
    • (2009) J. Neuropathol. Exp. Neurol. , vol.68 , pp. 217-226
    • Griffiths, M.R.1    Gasque, P.2    Neal, J.W.3
  • 37
    • 0036065586 scopus 로고    scopus 로고
    • CR3 (CD11b/CD18) and CR4 (CD11c/CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans
    • Taborda, C. P., and A. Casadevall. 2002. CR3 (CD11b/CD18) and CR4 (CD11c/CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans. Immunity 16: 791-802.
    • (2002) Immunity , vol.16 , pp. 791-802
    • Taborda, C.P.1    Casadevall, A.2
  • 38
    • 33744796798 scopus 로고    scopus 로고
    • CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: Diverse effect on subsequent synthesis of tumor necrosis factor alpha and nitric oxide
    • Pan, W., O. Ogunremi, G. Wei, M. Shi, and H. Tabel. 2006. CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent synthesis of tumor necrosis factor alpha and nitric oxide. Microbes Infect. 8: 1209-1218.
    • (2006) Microbes Infect. , vol.8 , pp. 1209-1218
    • Pan, W.1    Ogunremi, O.2    Wei, G.3    Shi, M.4    Tabel, H.5
  • 39
    • 0025732287 scopus 로고
    • The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: A systematic study using chimaeric anti-NIP antibodies with human Fc regions
    • Lucisano Valim, Y. M., and P. J. Lachmann. 1991. The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions. Clin. Exp. Immunol. 84: 1-8.
    • (1991) Clin. Exp. Immunol. , vol.84 , pp. 1-8
    • Lucisano Valim, Y.M.1    Lachmann, P.J.2
  • 40
    • 0017356973 scopus 로고
    • The role of membrane receptors for C3b and C3d in phagocytosis
    • Ehlenberger, A. G., and V. Nussenzweig. 1977. The role of membrane receptors for C3b and C3d in phagocytosis. J. Exp. Med. 145: 357-371.
    • (1977) J. Exp. Med. , vol.145 , pp. 357-371
    • Ehlenberger, A.G.1    Nussenzweig, V.2
  • 41
    • 0014413221 scopus 로고
    • Human monocytes: Distinct receptor sites for the third component of complement and for immunoglobulin G
    • Huber, H., M. J. Polley, W. D. Linscott, H. H. Fudenberg, and H. J. Muller-Eberhard. 1968. Human monocytes: distinct receptor sites for the third component of complement and for immunoglobulin G. Science 162: 1281-1283.
    • (1968) Science , vol.162 , pp. 1281-1283
    • Huber, H.1    Polley, M.J.2    Linscott, W.D.3    Fudenberg, H.H.4    Muller-Eberhard, H.J.5
  • 43
    • 22244439504 scopus 로고    scopus 로고
    • Recognition of Staphylococcus aureus by the innate immune system
    • Fournier, B., and D. J. Philpott. 2005. Recognition of Staphylococcus aureus by the innate immune system. Clin. Microbiol. Rev. 18: 521-540.
    • (2005) Clin. Microbiol. Rev. , vol.18 , pp. 521-540
    • Fournier, B.1    Philpott, D.J.2
  • 44
    • 60349127531 scopus 로고    scopus 로고
    • Complement activation and inhibition: A delicate balance
    • Sjöberg, A. P., L. A. Trouw, and A. M. Blom. 2009. Complement activation and inhibition: a delicate balance. Trends Immunol. 30: 83-90.
    • (2009) Trends Immunol. , vol.30 , pp. 83-90
    • Sjöberg, A.P.1    Trouw, L.A.2    Blom, A.M.3
  • 45
    • 0027530684 scopus 로고
    • The i domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands
    • Diamond, M. S., J. Garcia-Aguilar, J. K. Bickford, A. L. Corbi, and T. A. Springer. 1993. The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands. J. Cell Biol. 120: 1031-1043.
    • (1993) J. Cell Biol. , vol.120 , pp. 1031-1043
    • Diamond, M.S.1    Garcia-Aguilar, J.2    Bickford, J.K.3    Corbi, A.L.4    Springer, T.A.5
  • 46
    • 0034122721 scopus 로고    scopus 로고
    • CR3: A general purpose adhesion-recognition receptor essential for innate immunity
    • Ehlers, M. R. 2000. CR3: a general purpose adhesion-recognition receptor essential for innate immunity. Microbes Infect. 2: 289-294.
    • (2000) Microbes Infect. , vol.2 , pp. 289-294
    • Ehlers, M.R.1
  • 47
    • 0031569082 scopus 로고    scopus 로고
    • A MAC-1 attack: Integrin functions directly challenged in knockout mice
    • Plow, E. F., and L. Zhang. 1997. A MAC-1 attack: integrin functions directly challenged in knockout mice. J. Clin. Invest. 99: 1145-1146.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1145-1146
    • Plow, E.F.1    Zhang, L.2
  • 48
    • 0027160034 scopus 로고
    • CR3 (CD11b, CD18): A phagocyte and NK cell membrane receptor with multiple ligand specificities and functions
    • Ross, G. D., and V. Vetvicka. 1993. CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions. Clin. Exp. Immunol. 92: 181-184.
    • (1993) Clin. Exp. Immunol. , vol.92 , pp. 181-184
    • Ross, G.D.1    Vetvicka, V.2
  • 49
    • 0034934083 scopus 로고    scopus 로고
    • IgM and stromal cell-associated heparan sulfate/heparin as complement-independent ligands for CD19
    • de Fougerolles, A. R., F. Batista, E. Johnsson, and D. T. Fearon. 2001. IgM and stromal cell-associated heparan sulfate/heparin as complement-independent ligands for CD19. Eur. J. Immunol. 31: 2189-2199.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2189-2199
    • De Fougerolles, A.R.1    Batista, F.2    Johnsson, E.3    Fearon, D.T.4
  • 50
    • 0036709090 scopus 로고    scopus 로고
    • Characterization of microglial responses to Staphylococcus aureus: Effects on cytokine, costimulatory molecule, and Toll-like receptor expression
    • Kielian, T., P. Mayes, and M. Kielian. 2002. Characterization of microglial responses to Staphylococcus aureus: effects on cytokine, costimulatory molecule, and Toll-like receptor expression. J. Neuroimmunol. 130: 86-99.
    • (2002) J. Neuroimmunol. , vol.130 , pp. 86-99
    • Kielian, T.1    Mayes, P.2    Kielian, M.3
  • 51
    • 2442566717 scopus 로고    scopus 로고
    • Persistent immune activation associated with a mouse model of Staphylococcus aureus-induced experimental brain abscess
    • Baldwin, A. C., and T. Kielian. 2004. Persistent immune activation associated with a mouse model of Staphylococcus aureus-induced experimental brain abscess. J. Neuroimmunol. 151: 24-32.
    • (2004) J. Neuroimmunol. , vol.151 , pp. 24-32
    • Baldwin, A.C.1    Kielian, T.2
  • 52
    • 84885102672 scopus 로고    scopus 로고
    • Pathways mediating resolution of inflammation: When enough is too much
    • Fullerton, J. N., A. J. O'Brien, and D. W. Gilroy. 2013. Pathways mediating resolution of inflammation: when enough is too much. J. Pathol. 231: 8-20.
    • (2013) J. Pathol. , vol.231 , pp. 8-20
    • Fullerton, J.N.1    O'Brien, A.J.2    Gilroy, D.W.3
  • 53
    • 73949103664 scopus 로고    scopus 로고
    • C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production
    • Fraser, D. A., K. Pisalyaput, and A. J. Tenner. 2010. C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production. J. Neurochem. 112: 733-743.
    • (2010) J. Neurochem. , vol.112 , pp. 733-743
    • Fraser, D.A.1    Pisalyaput, K.2    Tenner, A.J.3
  • 54
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon, S. 2003. Alternative activation of macrophages. Nat. Rev. Immunol. 3: 23-35.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 23-35
    • Gordon, S.1
  • 55
    • 65649098369 scopus 로고    scopus 로고
    • The role of microglia in antibody-mediated clearance of amyloid-beta from the brain
    • Morgan, D. 2009. The role of microglia in antibody-mediated clearance of amyloid-beta from the brain. CNS Neurol. Disord. Drug Targets 8: 7-15.
    • (2009) CNS Neurol. Disord. Drug Targets , vol.8 , pp. 7-15
    • Morgan, D.1
  • 56
    • 77956393132 scopus 로고    scopus 로고
    • Involvement of Fc receptors in disorders of the central nervous system
    • Okun, E., M. P. Mattson, and T. V. Arumugam. 2010. Involvement of Fc receptors in disorders of the central nervous system. Neuromolecular Med. 12: 164-178.
    • (2010) Neuromolecular Med. , vol.12 , pp. 164-178
    • Okun, E.1    Mattson, M.P.2    Arumugam, T.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.