Obesity and the gastrointestinal microbiota: A review of associations and mechanisms

Nutrition Reviews

Volumn 73, Issue 6, 2015, Pages 376-385

  Graham, Catherine ^a   Mullen, Anne ^a   Whelan, Kevin ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACILLUS; BACTEROIDETES; CLOSTRIDIUM; DIET; DISEASE COURSE; FIRMICUTES; GENE FUNCTION; HOST; HUMAN; INFLAMMATION; INTESTINE FLORA; LACTOBACILLUS; METABOLISM; MYCOPLASMA; NONHUMAN; OBESITY; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT; COMPLICATION; GASTROINTESTINAL TRACT; MICROBIOLOGY;

ADIPOSITY; ANIMALS; BODY WEIGHT; DIET; GASTROINTESTINAL MICROBIOME; GASTROINTESTINAL TRACT; HUMANS; INFLAMMATION; OBESITY;

EID: 84948770305     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1093/nutrit/nuv004     Document Type: Article

References (64)

1. Wang YC, McPherson K, Marsh T, et al. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet. 2011;378:815-825.
2. Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59-65.
3. Bajzer M, Seeley R. Obesity and gut flora. Nature. 2006;444:1009-1010.
4. Esteve E, Ricart W, Fernández-Real J. Gut microbiota interactions with obesity, insulin resistance and type 2 diabetes: did gut microbiota co-evolve with insulin resistance? Curr Opin Clin Nutr Metab Care. 2011;14:483-490.
5. De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Nat Acad Sci USA. 2010;107:14691-14696.
6. Power SE, O'Toole PW, Stanton C, et al. Intestinal microbiota, diet and health. Br J Nutr. 2014;111:387-402.
7. Yatsunenko T, Rey F, Manary M, et al. Human gut microbiome viewed across age and geography. Nature. 2012;486:222-227.
8. Rajilic-Stojanovic M, Heilig H, Molenaar D, et al. Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults. Environ Micro. 2009;11:1736-1751.
9. Claesson M, Jeffery I, Conde S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature. 2012;488:178-184.
10. Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature. 2011;473:174-180.
11. Wu G, Chen J, Hoffman C, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334:105-108.
12. Ding T, Schloss PD. Dynamics and associations of microbial community types across the human body. Nature. 2014;509:357-360.
13. Koren O, Knights D, Gonzalez A, et al. A guide to enterotypes across the human body: meta analysis of microbial community structures in human microbiome datasets. PLoS Comput Biol. 2013;9:e1002863. doi: 10.1371/journal.pcbi.1002863.
14. Ursell L, Haiser H, Van Treuren W, et al. The intestinal metabolome: an intersection between microbiota and host. Gastroenterology. 2014;146:1470-1476.
15. Le Chatelier E, Nielsen T, Qin J, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500:541-546.
16. Cotillard A, Kennedy S, Chun Kong L, et al. Dietary intervention impact on gut microbial gene richness. Nature. 2013;500:585-588.
17. David L, Maurice C, Carmody R, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505:559-563.
18. Faith J, McNulty N, Rey F, et al. Predicting a human gut microbiota's response to diet in gnotobiotic mice. Science. 2011;333:101-104.
19. Jumpertz R, Le D, Turnbaugh P, et al. Energy-balance studies reveal associations between gut microbes, caloric load and nutrient absorption in humans. Am J Clin Nutr. 2011;94:58-65.
20. Walker A, Ince J, Duncan S, et al. Dominant and diet-responsive groups of bacteria within the human colonic microbiota. ISME J. 2011;5:220-230.
21. Cani P, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761-1772.
22. Ley R, Turnbaugh P, Klein S, et al. Human gut microbes associated with obesity. Nature. 2006;444:1022-1023.
23. Turnbaugh PJ, Hamady M, Yatsunenko T, et al. A core gut microbiome in obese and lean twins. Nature. 2009;457:480-484.
24. Schwiertz A, Taras D, Schäfer K, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity. 2009;18:190-195.
25. Duncan S, Lobley G, Holtrop G, et al. Human colonic microbiota associated with diet, obesity and weight loss. Inter J Obesity. 2008;32:1720-1724.
26. Turnbaugh P, Gordon J. The core gut microbiome, energy balance and obesity. J Physiol. 2009;587:4153-4158.
27. Liou A, Paziuk M, Luevano J, et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Science Transl Med. 2013;5:178ra41. doi: 10.1126/scitranslmed.3005687.
28. Zhang H, DiBaise J, Zuccolo A, et al. Human gut microbiota in obesity and after gastric bypass. Proc Nat Acad Sci USA. 2009;106:2365-2370.
29. Kong L, Tap J, Aron-Wisnewsky J, et al. Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes. Am J Clin Nutr. 2013;98:16-24.
30. McNeil N. The contribution of the large intestine to energy supplies in man. Am J Clin Nutr. 1984;39:338-342.
31. Den Besten G, van Eunen K, Groen AK, et al. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res. 2013;54:2325-2340.
32. Cummings J, Pomare E, Branch W, et al. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut. 1987;28:1221-1227.
33. Fava F, Gitau R, Griffin BA, et al. The type and quantity of dietary fat and carbohydrate alter fecal microbiome and short-chain fatty acid excretion in a metabolic syndrome "at-risk" population. Inter J Obesity. 2013;37:216-223.
34. Bäckhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004;101:15718-15723.
35. Xiong Y, Miyamoto N, Shibata K, et al. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Nat Acad Sci U S A. 2004;101:1045-1050.
36. Brown A, Goldsworthy S, Barnes A, et al. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem. 2003;278:11312-11319.
37. Karaki S, Tazoe H, Hayashi H, et al. Expression of the short-chain fatty acid receptor, GPR43,in the human colon. J Mol Hist. 2008;39:135-142.
38. Samuel B, Shaito A, Motoike T, et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A. 2008;105:16767-16772.
39. Tilg H, Kaser A. Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest. 2011;121:2126-2132.
40. Frost G, Sleeth M, Sahuri-Arisoylu M, et al. The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nature Comm. 2014;5:3611. doi: 10.1038/ncomms4611.
41. Cani P, Rodrigo B, Knauf C, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008;57:1470-1481.
42. Kim H, Youn B, Shin M, et al. Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight. Diabetes. 2010;59:2772-2780.
43. Bäckhed F, Manchester J, Semenkovich C, et al. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Nat Acad Sci USA. 2007;104:979-984.
44. Sanz Y, Santacruz A, De Palma G. Insights into the roles of gut microbes in obesity. Interdisc Perspect Infect Dis. 2008;2008:829101. doi: 10.1155/2008/829101.
45. Delzenne NM, Neyrinck AM, Cani PD. Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microbial Cell Factories. 2011;10(Suppl 1):S10. doi: 10.1186/1475-2859-10-S1-S10.
46. Fleissner C, Huebel N, El-Bary M, et al. Absence of intestinal microbiota does not protect mice from diet-induced obesity. Brit J Nutr. 2010;104:919-929.
47. de La Serre C, Ellis C, Lee J, Hartman A, et al. Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am J Physiol Gastrointest Liver Physiol. 2010;299:440-448.
48. Harris K, Kassis A, Geneviève M, et al. Is the gut microbiota a new factor contributing to obesity and its metabolic disorders? J Obesity. 2012;2012:879151. doi: 10.1155/2012/879151.
49. Shi H, Kokoeva M, Inouye K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116:3015-3025.
50. Ghoshal S, Witta J, Zhong J, et al. Chylomicrons promote intestinal absorption of lipopolysaccharides. J Lipid Res. 2009;50:90-97.
51. Laugerette F, Vorsa C, Géloën A, et al. Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation. J Nutr Biochem. 2011;22:53-59.
52. Membrez M, Blancher F, Jaquet M, et al. Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice. FASEB J. 2008;22:2416-2426.
53. Cavaglieri C, Nishiyamab A, Fernandes L, et al. Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes. Life Sciences. 2003;73:1683-1690.
54. Louis P, Flint HJ. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS Microbiol Lett. 2009;294:1-8.
55. Benus RF, van der Werf TS, Welling GW, et al. Association between Faecalibacterium prausnitzii and dietary fibre in colonic fermentation in healthy human subjects. Br J Nutr. 2010;104:693-700.
56. Lartigue G, de la Serre C, Espero E, et al. Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons. Am J Physiol Endocrinol Metab. 2011;301:E187-E195.
57. Raybould HE. Gut microbiota, epithelial function and derangements in obesity. J Physiol. 2012;590:441-446.
58. Macia L, Thorburn A, Binge L, et al. Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunol Rev. 2012;245:164-176.
59. Amar J, Chabo C, Waget A, et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med. 2011;3:559-572.
60. Gaudier E, Jarry A, Blottière H, et al. Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. Am J Physiol Gastrointest Liver Physiol. 2004;287:G1168-G1174.
61. Sanchez M, Darimont C, Drapeau V, et al. Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women. Br J Nutr. 2014;111:1507-1519.
62. Cani PD, Lecourt E, Dewulf EM, et al. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am J Clin Nutr. 2009;90:1236-1243.
63. Kellow NJ, Coughlan MT, Reid CM. Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials. Br J Nutr. 2014;111:1147-1161.
64. Vrieze A, Van Nood E, Holleman F, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012;143:913-916.