Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease

Nature Communications

Volumn 6, Issue , 2015, Pages

  Leshchyns'Ka, Iryna ^a   Liew, Heng Tai ^a   Shepherd, Claire ^b   Halliday, Glenda M ^b   Stevens, Claire H ^a,b   Ke, Yazi D ^a   Ittner, Lars M ^a,b   Sytnyk, Vladimir ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; NERVE CELL ADHESION MOLECULE; NEURAL CELL ADHESION MOLECULE 2; UNCLASSIFIED DRUG; AMPA RECEPTOR; AMYLOID PRECURSOR PROTEIN; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1; NCAM2 PROTEIN, HUMAN; NCAM2 PROTEIN, MOUSE; NERVE CELL ADHESION MOLECULE L1;

BRAIN; DISEASE; GENE; GENE EXPRESSION; MUTATION; NEUROLOGY;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CONTROLLED STUDY; GLUTAMATERGIC SYNAPSE; HIPPOCAMPAL NEURONAL CULTURE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PROTEIN BINDING; SYNAPSE; AGED; ANIMAL; BRAIN; BRAIN CORTEX; CASE CONTROL STUDY; CELL CULTURE; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE SILENCING; GENETICS; METABOLISM; NERVE CELL; PATHOLOGY; PHOTON CORRELATION SPECTROSCOPY; VERY ELDERLY;

MUS;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CASE-CONTROL STUDIES; CELL ADHESION; CELLS, CULTURED; CEREBRAL CORTEX; DYNAMIC LIGHT SCATTERING; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE KNOCKDOWN TECHNIQUES; HIPPOCAMPUS; HUMANS; MALE; MICE; NEURAL CELL ADHESION MOLECULE L1; NEURAL CELL ADHESION MOLECULES; NEURONS; RECEPTORS, AMPA; SYNAPSES;

EID: 84948689255     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9836     Document Type: Article

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