Future research directions in asthma: An NHLBI working group report

American Journal of Respiratory and Critical Care Medicine

Volumn 192, Issue 11, 2015, Pages 1366-1372

  Levy, Bruce D ^a   Noel, Patricia J ^b   Freemer, Michelle M ^b   Cloutier, Michelle M ^c   Georas, Steve N ^d   Jarjour, Nizar N ^e   Ober, Carole ^f   Woodruff, Prescott G ^g   Barnes, Kathleen C ^h,t   Bender, Bruce G ⁱ   Camargo, Carlos A ^j   Chupp, Geoff L ^k   Denlinger, Loren C ^e   Fahy, John V ^g   Fitzpatrick, Anne M ^l   Fuhlbrigge, Anne ^a   Gaston, Ben M ^m   Hartert, Tina V ⁿ   Kolls, Jay K ^o   Lynch, Susan V ^g   Moore, Wendy C ^p   Morgan, Wayne J ^q   Nadeau, Kari C ^r   Ownby, Dennis R ^s   Solway, Julian ^f   Szefler, Stanley J ^t   Wenzel, Sally E ^o   Wright, Rosalind J ^u   Smith, Robert A ^b   Erzurum, Serpil C ^v   more..

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^d UNIVERSITY OF ROCHESTER   (United States)

^e University of Wisconsin Health   (United States)

^f UNIVERSITY OF CHICAGO   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h JOHNS HOPKINS UNIVERSITY   (United States)

ⁱ DEPARTMENT OF MEDICINE   (United States)

^j MASSACHUSETTS GENERAL HOSPITAL   (United States)

^k YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m CASE WESTERN RESERVE UNIVERSITY   (United States)

ⁿ VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^o UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^p WAKE FOREST SCHOOL OF MEDICINE   (United States)

^q UNIVERSITY OF ARIZONA   (United States)

^r STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^s AUGUSTA UNIVERSITY   (United States)

^t UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^u MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^v CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

more..

Author keywords

Asthma; Disease modification; Implementation; Phenotype; Prevention

Indexed keywords

ARTICLE; ASTHMA; CELL DISRUPTION; COHORT ANALYSIS; ENVIRONMENTAL EXPOSURE; HUMAN; NONHUMAN; PATHOLOGY; PHENOTYPE; PRIMARY PREVENTION; PRIORITY JOURNAL; TRANSLATIONAL RESEARCH; EDUCATION; NATIONAL HEALTH ORGANIZATION; PATHOPHYSIOLOGY; RESEARCH; UNITED STATES;

ASTHMA; EDUCATION; HUMANS; NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (U.S.); RESEARCH; UNITED STATES;

EID: 84948585279     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201505-0963WS     Document Type: Article

References (42)

1. Busse W, Banks-Schlegel S, Noel P, Ortega H, Taggart V, Elias J; NHLBI Working Group. Future research directions in asthma: an NHLBI Working Group report. Am J Respir Crit Care Med 2004;170: 683-690.
2. National Asthma Education and Prevention Program. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Bethesda, MD: National Heart, Lung, and Blood Institute; 2007 Aug [accessed 2015 Oct 29]. Report No.: 07-4051. Available from: http://www.nhlbi.nih.gov/files/docs/guidelines/asthgdln.pdf
3. Busse WW, Morgan WJ, Taggart V, Togias A. Asthma outcomes workshop: overview. J Allergy Clin Immunol 2012;129(3 Suppl): S1-S8.
4. Jackson DJ, Hartert TV, Martinez FD, Weiss ST, Fahy JV. Asthma: NHLBI workshop on the primary prevention of chronic lung diseases. Ann Am Thorac Soc 2014;11: S139-S145.
5. Walker ML, Holt KE, Anderson GP, Teo SM, Sly PD, Holt PG, Inouye M. Elucidation of pathways driving asthma pathogenesis: development of a systems-level analytic strategy. Front Immunol 2014;5:447.
6. Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P, Thomsen C, Wright J, Athersuch TJ, Avellana N, et al. The human early-life exposome (HELIX): project rationale and design. Environ Health Perspect 2014;122:535-544.
7. Wild CP. Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomarkers Prev 2005;14: 1847-1850.
8. Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 2012;18:716-725.
9. Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, Wardlaw AJ, Green RH. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008;178:218-224.
10. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro M, Curran-Everett D, Fitzpatrick AM, et al.; National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010;181:315-323.
11. Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Castro M, Bacharier LB, et al.; National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol 2011;127:382-389.e1-e13.
12. Boudier A, Curjuric I, Basagaña X, Hazgui H, Anto JM, Bousquet J, Bridevaux PO, Dupuis-Lozeron E, Garcia-Aymerich J, Heinrich J, et al. Ten-year follow-up of cluster-based asthma phenotypes in adults: a pooled analysis of three cohorts. Am J Respir Crit Care Med 2013;188:550-560.
13. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009;180:388-395.
14. Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, Wenzel SE, Peters SP, Meyers DA, Bleecker ER; National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. J Allergy Clin Immunol 2014; 133:1557-1563.e5.
15. Ortega H, Li H, Suruki R, Albers F, Gordon D, Yancey S. Cluster analysis and characterization of response to mepolizumab. A step closer to personalized medicine for patients with severe asthma. Ann Am Thorac Soc 2014;11:1011-1017.
16. Belkaid Y, Artis D. Immunity at the barriers. Eur J Immunol 2013;43: 3096-3097.
17. Holtzman MJ, Byers DE, Alexander-Brett J, Wang X. The role of airway epithelial cells and innate immune cells in chronic respiratory disease. Nat Rev Immunol 2014;14:686-698.
18. Walker JA, Barlow JL, McKenzie AN. Innate lymphoid cells-how did we miss them? Nat Rev Immunol 2013;13:75-87.
19. Halim TY, Steer CA, Mathä L, Gold MJ, Martinez-Gonzalez I, McNagny KM, McKenzie AN, Takei F. Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity 2014;40:425-435.
20. Monticelli LA, Sonnenberg GF, Abt MC, Alenghat T, Ziegler CG, Doering TA, Angelosanto JM, Laidlaw BJ, Yang CY, Sathaliyawala T, et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol 2011;12: 1045-1054.
21. Barnig C, Cernadas M, Dutile S, Liu X, Perrella MA, Kazani S, Wechsler ME, Israel E, Levy BD. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med 2013;5:174ra26.
22. Georas SN, Rezaee F. Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation. J Allergy Clin Immunol 2014;134:509-520.
23. Bossley CJ, Fleming L, Gupta A, Regamey N, Frith J, Oates T, Tsartsali L, Lloyd CM, Bush A, Saglani S. Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines. J Allergy Clin Immunol 2012;129: 974-982.e13.
24. James AL, Elliot JG, Jones RL, Carroll ML, Mauad T, Bai TR, Abramson MJ, McKay KO, Green FH. Airway smooth muscle hypertrophy and hyperplasia in asthma. Am J Respir Crit Care Med 2012;185: 1058-1064.
25. Szefler SJ, Chmiel JF, Fitzpatrick AM, Giacoia G, Green TP, Jackson DJ, Nielsen HC, Phipatanakul W, Raissy HH. Asthma across the ages: knowledge gaps in childhood asthma. J Allergy Clin Immunol 2014;133:3-13, quiz 14.
26. Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, et al.; NHLBI Severe Asthma Research Program (SARP). Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med 2012;185: 356-362.
27. Holgate ST. Stratified approaches to the treatment of asthma. Br J Clin Pharmacol 2013;76:277-291.
28. Sahiner UM, Yavuz ST, Buyuktiryaki B, Cavkaytar O, Arik Yilmaz E, Tuncer A, Sackesen C. Serum basal tryptase levels in healthy children: correlation between age and gender. Allergy Asthma Proc 2014;35:404-408.
29. Agache I, Akdis C, Jutel M, Virchow JC. Untangling asthma phenotypes and endotypes. Allergy 2012;67:835-846.
30. Wagener AH, Yick CY, Brinkman P, van der Schee MP, Fens N, Sterk PJ. Toward composite molecular signatures in the phenotyping of asthma. Ann Am Thorac Soc 2013;10: S197-S205.
31. Castro M, Fain SB, Hoffman EA, Gierada DS, Erzurum SC, Wenzel S; National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Lung imaging in asthmatic patients: the picture is clearer. J Allergy Clin Immunol 2011;128:467-478.
32. Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest 2010;137:1410-1416.
33. Bunyavanich S, Schadt EE. Systems biology of asthma and allergic diseases: a multiscale approach. J Allergy Clin Immunol 2015;135:31-42.
34. Peters DH, Adam T, Alonge O, Agyepong IA, Tran N. Implementation research: what it is and how to do it. BMJ 2013;347: f6753.
35. Cloutier MM, Wakefield DB. Translation of a pediatric asthmamanagement program into a community in Connecticut. Pediatrics 2011;127:11-18.
36. Gerald LB, McClure LA, Mangan JM, Harrington KF, Gibson L, Erwin S, Atchison J, Grad R. Increasing adherence to inhaled steroid therapy among schoolchildren: randomized, controlled trial of school-based supervised asthma therapy. Pediatrics 2009;123:466-474.
37. Cicutto L, Gleason M, Szefler SJ. Establishing school-centered asthma programs. J Allergy Clin Immunol 2014;134:1223-1230, quiz 1231.
38. Apter AJ, Wan F, Reisine S, Bender B, Rand C, Bogen DK, Bennett IM, Bryant-Stephens T, Roy J, Gonzalez R, et al. The association of health literacy with adherence and outcomes in moderate-severe asthma. J Allergy Clin Immunol 2013;132:321-327.
39. Akinbami LJ, Moorman JE, Bailey C, Zahran HS, King M, Johnson CA, Liu X. Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010. NCHS Data Brief, no 94. Hyattsville, MD: National Center for Health Statistics; 2012.
40. Okelo SO, Butz AM, Sharma R, Diette GB, Pitts SI, King TM, Linn ST, Reuben M, Chelladurai Y, Robinson KA. Interventions to modify adherence to asthma guidelines. Comparative Effectiveness Review No. 95 (Prepared by Johns Hopkins University Evidence-based Practice Center under Contract No. 290-2007-10061-I). AHRQ Publication No. 13-EHC022-EF. Rockville, MD: Agency for Healthcare Research and Quality; 2013 May [accessed 2015 Oct 29]. Available from: www. effectivehealthcare.ahrq.gov/reports/final.cfm
41. Busse WW, Morgan WJ, Taggart V, Togias A, Akinbami LJ, Brown R, Cabana MD, Clark N, Camargo CA Jr, Campbell JD, et al. Standardizing asthma outcomes in clinical research: report of the Asthma Outcomes Workshop. J Allergy Clin Immunol 2012;129:(3 Suppl): S1-S142.
42. Fung V, Graetz I, Galbraith A, Hamity C, Huang J, Vollmer WM, Hsu J, Wu AC. Financial barriers to care among low-income children with asthma: health care reform implications. JAMA Pediatr 2014;168: 649-656.