Circadian disruption and diet-induced obesity synergize to promote development of β-cell failure and diabetes in male rats

Endocrinology

Volumn 156, Issue 12, 2015, Pages 4426-4436

  Qian, Jingyi ^b   Yeh, Bonnie ^b   Rakshit, Kuntol ^a   Colwell, Christopher S ^b   Matveyenko, Aleksey V ^a,b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LUCIFERASE; PER1 PROTEIN; TRIACYLGLYCEROL; CIRCADIAN RHYTHM SIGNALING PROTEIN; PER1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOLUMINESCENCE; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CELL EXPANSION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELLULAR SECRETION; CIRCADIAN RHYTHM; CONTROLLED STUDY; DIET INDUCED OBESITY; EPIDIDYMIS FAT; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULINEMIA; LIGHT DARK CYCLE; LIGHT EXPOSURE; LIPID DIET; LIPID STORAGE; LOCOMOTION; MALE; METABOLIC REGULATION; MOLECULAR CLOCK; MOLECULAR WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET CELL HYPERPLASIA; PATHOGENESIS; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; ANIMAL; BIOLOGICAL RHYTHM; DISEASE MODEL; GENETICS; METABOLISM; OBESITY; PHOTOPERIODICITY; REPORTER GENE; SECRETION (PROCESS); SLEEP DISORDER; SPRAGUE DAWLEY RAT; TRANSGENIC RAT;

ADIPOSITY; ANIMALS; APOPTOSIS; BIOLOGICAL CLOCKS; BODY WEIGHT; CHRONOBIOLOGY DISORDERS; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; GENES, REPORTER; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; LUCIFERASES; MALE; OBESITY; PERIOD CIRCADIAN PROTEINS; PHOTOPERIOD; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC;

EID: 84948144133     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2015-1516     Document Type: Article

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