The melatonin agonist ramelteon induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Nishiyama, Keiji ^a   Hirai, Keisuke ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; LUZINDOLE; MELATONIN RECEPTOR; MESSENGER RNA; RAMELTEON; TRANSCRIPTION FACTOR CLOCK; ARNTL PROTEIN, HUMAN; CREB1 PROTEIN, HUMAN; CYCLIC AMP; INDENE DERIVATIVE; NUCLEAR RECEPTOR NR1D1; TRANSCRIPTION FACTOR ARNTL; TRYPTAMINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BMAL1 GENE; CIRCADIAN RHYTHM; CLOCK GENE; CONTROLLED STUDY; DRUG ACTIVITY; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; IMMUNOREACTIVITY; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REV ERB ALPHA GENE; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; CELL LINE; DRUG EFFECTS; HUMAN; METABOLISM; PHOSPHORYLATION;

ANIMALS; ARNTL TRANSCRIPTION FACTORS; CELL LINE; COLFORSIN; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; HUMANS; INDENES; INSULIN-SECRETING CELLS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 1; PHOSPHORYLATION; RATS; RECEPTORS, MELATONIN; TRYPTAMINES;

EID: 84904262173     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102073     Document Type: Article

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