Are we really at the dawn of understanding sporadic pediatric thyroid carcinoma?

Endocrine-Related Cancer

Volumn 22, Issue 6, 2015, Pages R311-R324

  Cordioli, Maria Isabel C Vieira ^a   Moraes, Lais ^a   Cury, Adriano Namo ^b   Cerutti, Janete M ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b IRMANDADE DA SANTA CASA DE MISERICÓRDIA DE SÃO PAULO   (Brazil)

Author keywords

BRAF; ETV6 NTRK3; Radiation exposed papillary thyroid carcinomas; RAS; RET PTC; Sporadic pediatric papillary hyroid carcinomas

Indexed keywords

B RAF KINASE; PROTEIN PATCHED; PROTEIN RET; RAS PROTEIN; TRANSCRIPTION FACTOR ETV6; COTRANSPORTER; ONCOPROTEIN; RADIOACTIVE IODINE; SODIUM IODIDE SYMPORTER;

CANCER PATIENT; CANCER PROGNOSIS; CHILDHOOD CANCER; DIFFERENTIATED THYROID CANCER; GENETIC TRANSCRIPTION; HUMAN; POINT MUTATION; PROTEIN METABOLISM; RADIATION EXPOSURE; REVIEW; RISK FACTOR; ADENOCARCINOMA, FOLLICULAR; ADOLESCENT; ADULT; ADVERSE EFFECTS; AGE DISTRIBUTION; CARCINOMA, PAPILLARY; CHILD; DISASTER; FEMALE; FORECASTING; GENETICS; INCIDENCE; MALE; METASTASIS; MIDDLE AGED; NEOPLASMS, RADIATION-INDUCED; NEOPLASMS, SECOND PRIMARY; NUCLEAR ACCIDENT; ONSET AGE; PATHOLOGY; PRESCHOOL CHILD; RADIOTHERAPY; SEX RATIO; SIGNAL TRANSDUCTION; THYROID NEOPLASMS; THYROID NODULE; THYROIDECTOMY; TUMOR GENE; YOUNG ADULT;

ADENOCARCINOMA, FOLLICULAR; ADOLESCENT; ADULT; AGE DISTRIBUTION; AGE OF ONSET; CARCINOMA, PAPILLARY; CHILD; CHILD, PRESCHOOL; DISASTERS; FEMALE; FORECASTING; GENES, NEOPLASM; HUMANS; INCIDENCE; IODINE RADIOISOTOPES; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASMS, RADIATION-INDUCED; NEOPLASMS, SECOND PRIMARY; ONCOGENE PROTEINS, FUSION; POINT MUTATION; RADIOACTIVE HAZARD RELEASE; RADIOTHERAPY; SEX DISTRIBUTION; SIGNAL TRANSDUCTION; SYMPORTERS; THYROID NEOPLASMS; THYROID NODULE; THYROIDECTOMY; YOUNG ADULT;

EID: 84948134250     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-15-0381     Document Type: Review

References (109)

1. Adeniran AJ, Zhu Z, Gandhi M, Steward DL, Fidler JP, Giordano TJ, Biddinger PW & Nikiforov YE 2006 Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas. American Journal of Surgical Pathology 30 216-222. (doi:10.1097/01.pas. 0000176432.73455.1b)
2. Ahn BH, Kim JR, Jeong HC, Lee JS, Chang ES & Kim YH 2015 Predictive factors of central lymph node metastasis in papillary thyroid carcinoma. Annals of Surgical Treatment and Research 88 63-68. (doi:10.4174/astr.2015.88.2.63)
3. Alessandri AJ, Goddard KJ, Blair GK, Fryer CJ & Schultz KR 2000 Age is the major determinant of recurrence in pediatric differentiated thyroid carcinoma. Medical and Pediatric Oncology 35 41-46. (doi:10.1002/ 1096-911X(200007)35:1!41::AID-MPO7O3.0.CO;2-7)
4. Alzahrani AS, Alkhafaji D, Tuli M, Al-Hindi H & Bin Sadiq B 2015 Comparison of differentiated thyroid cancer in children and adolescents (!/Z20 years) with young adults. Clinical Endocrinology [in press]. (doi:10.1111/cen.12845)
5. Ashizawa K, Shibata Y, Yamashita S, Namba H, Hoshi M, Yokoyama N, Izumi M & Nagataki S1997Prevalenceof goiter andurinary iodineexcretion levels in children around Chernobyl. Journal of Clinical Endocrinology and Metabolism 82 3430-3433. (doi:10.1210/jcem.82.10.4285)
6. Boas M, Feldt-Rasmussen U, Skakkebaek NE & Main KM 2006 Environmental chemicals and thyroid function. European Journal of Endocrinology 154 599-611. (doi:10.1530/eje.1.02128)
7. Bongarzone I, Fugazzola L, Vigneri P, Mariani L, Mondellini P, Pacini F, Basolo F, Pinchera A, Pilotti S & Pierotti MA 1996 Age-related activation of the tyrosine kinase receptor protooncogenes RET and NTRK1 in papillary thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism 81 2006-2009. (doi:10.1210/jcem.81.5.8626874)
8. Buryk MA, Monaco SE, Witchel SF, Mehta DK, Gurtunca N, Nikiforov YE & Simons JP 2013 Preoperative cytology with molecular analysis to help guide surgery for pediatric thyroidnodules. International Journal of Pediatric Otorhinolaryngology 77 1697-1700. (doi:10.1016/j.ijporl.2013.07.029)
9. Castro P, Rebocho AP, Soares RJ, Magalhaes J, Roque L, Trovisco V, ieiradeCastro I, Cardoso-de-Oliveira M, Fonseca E, Soares P et al. 2006 PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism 91 213-220. (doi:10.1210/jc.2005-1336)
10. Chow SM, Law SC, Mendenhall WM, Au SK, Yau S, Mang O & Lau WH 2004 Differentiated thyroid carcinoma in childhood and adolescenceclinical course and role of radioiodine. Pediatric Blood & Cancer 42 176-183. (doi:10.1002/pbc.10410)
11. Ciampi R, Knauf JA, Kerler R, Gandhi M, Zhu Z, Nikiforova MN, Rabes HM, Fagin JA & Nikiforov YE 2005 Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer. Journal of Clinical Investigation 115 94-101. (doi:10.1172/JCI23237)
12. Dadachova E & Carrasco N 2004 The Na/I symporter (NIS): imaging and therapeutic applications. Seminars in Nuclear Medicine 34 23-31. (doi:10.1053/j.semnuclmed.2003.09.004)
13. Davies L & Welch HG 2006 Increasing incidence of thyroid cancer in the United States, 1973-2002. Journal of the American Medical Association 295 2164-2167. (doi:10.1001/jama.295.18.2164)
14. Demidchik YE, Saenko VA & Yamashita S 2007 Childhood thyroid cancer in Belarus, Russia, and Ukraine after Chernobyl and at present. Arquivos Brasileiros de Endocrinologia e Metabologia 51 748-762. (doi:10.1590/ S0004-27302007000500012)
15. Dinauer CA, Breuer C & Rivkees SA 2008 Differentiated thyroid cancer in children: diagnosis and management. Current Opinion in Oncology 20 59-65. (doi:10.1097/CCO.0b013e3282f30220)
16. Dorffel WV, Reitzig P, Dorffel Y & Possinger K 2000 Secondary malignant neoplasms in patients with breast cancer. Zentralblatt fur Gynakologie 122 419-427. (doi:10.1055/s-2000-10604)
17. Elisei R, Romei C, Vorontsova T, Cosci B, Veremeychik V, Kuchinskaya E, Basolo F, Demidchik EP, Miccoli P, Pinchera A et al. 2001 RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults. Journal of Clinical Endocrinology and Metabolism 86 3211-3216. (doi:10.1210/jcem.86.7.7678)
18. Espadinha C, Santos JR, Sobrinho LG & Bugalho MJ 2009 Expression of iodine metabolism genes in human thyroid tissues: evidence for age and BRAFV600E mutation dependency. Clinical Endocrinology 70 629-635. (doi:10.1111/j.1365-2265.2008.03376.x)
19. Faggiano A, Coulot J, Bellon N, Talbot M, Caillou B, Ricard M, Bidart JM & Schlumberger M 2004 Age-dependent variation of follicular size and expression of iodine transporters in human thyroid tissue Journal of nuclear medicine: official publication. Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine 45 232-237.
20. Fenton CL, Lukes Y, Nicholson D, Dinauer CA, Francis GL & Tuttle RM 2000 The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults. Journal of Clinical Endocrinology and Metabolism 85 1170-1175. (doi:10.1210/jcem.85.3.6472)
21. Francis G, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti J, Dinauer CA, Hamilton JK, Hay ID & Luster M 2015 Management guidelines for children with thyroid nodules and differentiated thyroid cancer. The American Thyroid Association Guidelines Task Force on Pediatric Thyroid Cancer. Thyroid 25 716-759. (doi:10.1089/thy.2014. 0460)
22. Frasca F, Nucera C, Pellegriti G, Gangemi P, Attard M, Stella M, Loda M, Vella V, Giordano C, Trimarchi F et al. 2008 BRAF(V600E) mutation and the biology of papillary thyroid cancer. Endocrine-Related Cancer 15 191-205. (doi:10.1677/ERC-07-0212)
23. Fukahori M, Yoshida A, Hayashi H, Yoshihara M, Matsukuma S, Sakuma Y, Koizume S, Okamoto N, Kondo T, Masuda M et al. 2012 The associations between RAS mutations and clinical characteristics in follicular thyroid tumors: new insights from a single center and a large patient cohort. Thyroid: Official Journal of the American Thyroid Association 22 683-689. (doi:10.1089/thy.2011.0261)
24. Fusco A & Santoro M 2007 20 years of RET/PTC in thyroid cancer: clinicopathological correlations. Arquivos Brasileiros de Endocrinologia e Metabologia 51 731-735. (doi:10.1590/S0004-27302007000500010)
25. Fusco A, Grieco M, Santoro M, Berlingieri MT, Pilotti S, Pierotti MA, Della Porta G & Vecchio G 1987 A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases. Nature 328 170-172. (doi:10.1038/328170a0)
26. Gharib H & Papini E 2007 Thyroid nodules: clinical importance, assessment, and treatment. Endocrinology and Metabolism Clinics of North America 36 707-735, vi. (doi:10.1016/j.ecl.2007.04.009)
27. Givens DJ, Buchmann LO, Agarwal AM, Grimmer JF & Hunt JP 2014 BRAF V600E does not predict aggressive features of pediatric papillary thyroid carcinoma. Laryngoscope 124 E389-E393. (doi:10.1002/lary.24668)
28. Gorman MF, Ji L, Ko RH, Barnette P, Bostrom B, Hutchinson R, Raetz E, Seibel NL, Twist CJ, Eckroth E et al. 2010 Outcome for children treated for relapsed or refractory acute myelogenous leukemia (rAML): a Therapeutic Advances in Childhood Leukemia (TACL) Consortium study. Pediatric Blood & Cancer 55 421-429. (doi:10.1002/pbc.22612)
29. Grigsby PW, Gal-or A, Michalski JM & Doherty GM 2002 Childhood and adolescent thyroid carcinoma. Cancer 95 724-729. (doi:10.1002/cncr. 10725)
30. Handkiewicz-Junak D, Wloch J, Roskosz J, Krajewska J, Kropinska A, Pomorski L, Kukulska A, Prokurat A, Wygoda Z & Jarzab B 2007 Total thyroidectomy and adjuvant radioiodine treatment independently decrease locoregional recurrence risk in childhood and adolescent differentiated thyroid cancer. Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine 48 879-888.
31. Hay ID, Gonzalez-Losada T, Reinalda MS, Honetschlager JA, Richards ML & Thompson GB 1940 Long-term outcome in 215 children and adolescents with papillary thyroid cancer treated during 1940 through 2008. World Journal of Surgery 34 1192-1202. (doi:10.1007/s00268-009-0364-0)
32. Hayashida N, Imaizumi M, Shimura H, Okubo N, Asari Y, Nigawara T, Midorikawa S, Kotani K, Nakaji S, Otsuru A et al. 2013 Thyroid ultrasound findings in children from three Japanese prefectures: Aomori. PLo S ONE 8 e83220. (doi:10.1371/journal.pone.0083220)
33. Henke LE, Perkins SM, Pfeifer JD, Ma C, Chen Y, De Wees T & Grigsby PW 2014 BRAF V600E mutational status in pediatric thyroid cancer. Pediatric Blood & Cancer 61 1168-1172. (doi:10.1002/pbc.24935)
34. Hogan AR, Zhuge Y, Perez EA, Koniaris LG, Lew JI & Sola JE 2009 Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients. Journal of Surgical Research 156 167-172. (doi:10.1016/j.jss.2009.03.098)
35. Iwaku K, Noh JY, Sasaki E, Suzuki N, Kameda T, Kobayashi S, Yoshihara A, Ohye H, Watanabe N, Suzuki M et al. 2014 Changes in pediatric thyroid sonograms in or nearby the Kanto region before and after the accident at the Fukushima Daiichi nuclear power plant. Endocrine Journal 61 875-881. (doi:10.1507/endocrj.EJ14-0032)
36. Ito Y, Kihara M, Takamura Y, Kobayashi K, Miya A, Hirokawa M & Miyauchi A 2012 Prognosis and prognostic factors of papillary thyroid carcinoma in patients under 20 years. Endocrine Journal 59 539-545. (doi:10.1507/endocrj.EJ12-0086)
37. Jarzab B & Handkiewicz-Junak D 2007 Differentiated thyroid cancer in children and adults: same or distinct disease? Hormones 6 200-209.
38. Jarzab B, Handkiewicz-Junak D & Wloch J 2005 Juvenile differentiated thyroid carcinoma and the role of radioiodine in its treatment: a qualitative review. Endocrine-Related Cancer 12 773-803. (doi:10.1677/ erc.1.00880)
39. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE & Fagin JA 2003 High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Research 63 1454-1457.
40. Klugbauer S, Lengfelder E, Demidchik EP & Rabes HM 1995 High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident. Oncogene 11 2459-2467.
41. Koo JS, Hong S & Park CS 2009 Diffuse sclerosing variant is a major subtype of papillary thyroid carcinoma in the young. Thyroid: Official Journal of the American Thyroid Association 19 1225-1231. (doi:10.1089/ thy.2009.0073)
42. Kroll TG, Sarraf P, Pecciarini L, Chen CJ, Mueller E, Spiegelman BM & Fletcher JA 2000 PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]. Science 289 1357-1360. (doi:10.1126/ science.289.5483.1357)
43. Kumagai A, Namba H, Saenko VA, Ashizawa K, Ohtsuru A, Ito M, Ishikawa N, Sugino K, Ito K, Jeremiah S et al. 2004 Low frequency of BRAFT1796A mutations in childhood thyroid carcinomas. Journal of Clinical Endocrinology and Metabolism 89 4280-4284. (doi:10.1210/jc. 2004-0172)
44. Lamartina L, Durante C, Filetti S & Cooper DS 2015 Low-risk differentiated thyroid cancer and radioiodine remnant ablation: a systematic review of the literature. Journal of Clinical Endocrinology and Metabolism 100 1748-1761. (doi:10.1210/jc.2014-3882)
45. Landau D, Vini L, A'Hern R & Harmer C 2000 Thyroid cancer in children: the Royal Marsden Hospital experience. European Journal of Cancer 36 214-220. (doi:10.1016/S0959-8049(99)00281-6)
46. La Quaglia MP, Black T, Holcomb GW III, Sklar C, Azizkhan RG, Haase GM & Newman KD 2000 Differentiated thyroid cancer: clinical characteristics, treatment, and outcome in patients under 21 years of age who present with distant metastases. A report from the Surgical Discipline Committee of the Children's Cancer Group. Journal of Pediatric Surgery 35 955-959, discussion 960. (doi:10.1053/jpsu.2000.6935)
47. Lazar L, Lebenthal Y, Steinmetz A, Yackobovitch-Gavan M & Phillip M 2009 Differentiated thyroid carcinoma in pediatric patients: comparison of presentation and course between pre-pubertal children and adolescents. Journal of Pediatrics 154 708-714. (doi:10.1016/j.jpeds. 2008.11.059)
48. Leeman-Neill RJ, Kelly LM, Liu P, Brenner AV, Little MP, Bogdanova TI, Evdokimova VN, Hatch M, Zurnadzy LY, Nikiforova MN et al. 2014 ETV6-NTRK3 is a common chromosomal rearrangement in radiationassociated thyroid cancer. Cancer 120 799-807. (doi:10.1002/cncr. 28484)
49. Levy GH, Marti JL, Cai G, Kayne RD, Udelsman R, Hammers LW, Kowalski DP & Prasad ML 2012 Pleomorphic adenoma arising in an incidental midline isthmic thyroid nodule: a case report and review of the literature. Human Pathology 43 134-137. (doi:10.1016/j.humpath. 2011.02.025)
50. Lima J, Trovisco V, Soares P, Maximo V, Magalhaes J, Salvatore G, Santoro M, Bogdanova T, Tronko M, Abrosimov A et al. 2004 BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas. Journal of Clinical Endocrinology and Metabolism 89 4267-4271. (doi:10.1210/jc.2003-032224)
51. Lise M, Franceschi S, Buzzoni C, Zambon P, Falcini F, Crocetti E, Serraino D, Iachetta F, Zanetti R, Vercelli M et al. 2012 Changes in the incidence of thyroid cancer between 1991 and 2005 in Italy: a geographical analysis. Thyroid: Official Journal of the American Thyroid Association 22 27-34. (doi:10.1089/thy.2011.0038)
52. Liu YY, Zhang X, Ringel MD & Jhiang SM 2012 Modulation of sodium iodide symporter expression and function by LY294002. Akti-1/2 and Rapamycin in thyroid cells. Endocrine-Related Cancer 19 291-304. (doi:10.1530/ERC-11-0288)
53. Lui WO, Zeng L, Rehrmann V, Deshpande S, Tretiakova M, Kaplan EL, Leibiger I, Leibiger B, Enberg U, Hoog A et al. 2008 CREB3L2- PPARgamma fusion mutation identifies a thyroid signaling pathway regulated by intramembrane proteolysis. Cancer Research 68 7156-7164. (doi:10.1158/0008-5472.CAN-08-1085)
54. Marti JL, Clark VE, Harper H, Chhieng DC, Sosa JA & Roman SA 2012 Optimal surgical management of well-differentiated thyroid cancer arising in struma ovarii: a series of 4 patients and a review of 53 reported cases. Thyroid: Official Journal of the American Thyroid Association 22 400-406. (doi:10.1089/thy.2011.0162)
55. Marti JL, Jain KS & Morris LG 2015 Increased risk of second primary malignancy in pediatric and young adult patients treated with radioactive iodine for differentiated thyroid cancer. Thyroid: Official Journal of the American Thyroid Association 25 681-687. (doi:10.1089/ thy.2015.0067)
56. Mazonakis M, Tzedakis A, Damilakis J & Gourtsoyiannis N 2007 Thyroid dose from common head and neck CT examinations in children: is there an excess risk for thyroid cancer induction? European Radiology 17 1352-1357. (doi:10.1007/s00330-006-0417-9)
57. Mazzaferri EL 1993 Management of a solitary thyroid nodule. New England Journal of Medicine 328 553-559. (doi:10.1056/ NEJM199302253280807)
58. Memon A, Godward S, Williams D, Siddique I & Al-Saleh K 2010 Dental x-rays and the risk of thyroid cancer: a case-control study. Acta Oncologica 49 447-453. (doi:10.3109/02841861003705778)
59. Monaco SE, Pantanowitz L, Khalbuss WE, Benkovich VA, Ozolek J, Nikiforova MN, Simons JP & Nikiforov YE 2012 Cytomorphological and molecular genetic findings in pediatric thyroid fine-needle aspiration. Cancer Cytopathology 120 342-350. (doi:10.1002/cncy.21199)
60. Neiva F, Mesquita J, Paco Lima S, Matos MJ, Costa C, Castro-Correia C, Fontoura M & Martins S 2012 Thyroid carcinoma in children and adolescents: a retrospective review. Endocrinologia y Nutricion: Organo de la Sociedad Espanola de Endocrinologia y Nutricion 59 105-108. (doi:10.1016/j.endonu.2011.11.003)
61. Newman KD, Black T, Heller G, Azizkhan RG, Holcomb GW III, Sklar C, Vlamis V, Haase GM & La Quaglia MP 1998 Differentiated thyroid cancer: determinants of disease progression in patients !21 years of age at diagnosis: a report from the Surgical Discipline Committee of the Children's Cancer Group. Annals of Surgery 227 533-541. (doi:10.1097/ 00000658-199804000-00014)
62. Niedziela M 2006 Pathogenesis, diagnosis and management of thyroid nodules in children. Endocrine-Related Cancer 13 427-453. (doi:10.1677/erc.1.00882)
63. Nikiforov YE & Nikiforova MN 2011 Molecular genetics and diagnosis of thyroid cancer Nature reviews. Endocrinology 7 569-580. (doi:10.1038/ nrendo.2011.142)
64. Nikiforov YE, Rowland JM, Bove KE, Monforte-Munoz H & Fagin JA 1997 Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Research 57 1690-1694.
65. Nikiforova MN, Stringer JR, Blough R, Medvedovic M, Fagin JA & Nikiforov YE 2000 Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells. Science 290 138-141. (doi:10.1126/science.290.5489.138)
66. Nikiforova MN, Ciampi R, Salvatore G, Santoro M, Gandhi M, Knauf JA, Thomas GA, Jeremiah S, Bogdanova TI, Tronko MD et al. 2004 Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. Cancer Letters 209 1-6. (doi:10.1016/j.canlet.2003.12.004)
67. O'Gorman CS, Hamilton J, Rachmiel M, Gupta A, Ngan BY & Daneman D 2010 Thyroid cancer in childhood: a retrospective review of childhood course. Thyroid: Official Journal of the American Thyroid Association 20 375-380. (doi:10.1089/thy.2009.0386)
68. Oler G & Cerutti JM 2009 High prevalence of BRAF mutation in a Brazilian cohort of patients with sporadic papillary thyroid carcinomas: correlation with more aggressive phenotype and decreased expression of iodide-metabolizing genes. Cancer 115 972-980. (doi:10.1002/cncr. 24118)
69. Park JY, Kim WY, Hwang TS, Lee SS, Kim H, Han HS, Lim SD, Kim WS, Yoo YB & Park KS 2013 BRAF and RAS mutations in follicular variants of papillary thyroid carcinoma. Endocrine Pathology 24 69-76. (doi:10.1007/s12022-013-9244-0)
70. Patel A, Jhiang S, Dogra S, Terrell R, Powers PA, Fenton C, Dinauer CA, Tuttle RM & Francis GL 2002 Differentiated thyroid carcinoma that express sodium-iodide symporter have a lower risk of recurrence for children and adolescents. Pediatric Research 52 737-744. (doi:10.1203/ 00006450-200211000-00021)
71. Pellegriti G, Frasca F, Regalbuto C, Squatrito S & Vigneri R 2013 Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. Journal of Cancer Epidemiology 2013 965212. (doi:10.1155/ 2013/965212)
72. Penko K, Livezey J, Fenton C, Patel A, Nicholson D, Flora M, Oakley K, Tuttle RM & Francis G 2005 BRAF mutations are uncommon in papillary thyroid cancer of young patients. Thyroid: Official Journal of the American Thyroid Association 15 320-325. (doi:10.1089/ thy.2005.15.320)
73. Pisarchik AV, Ermak G, Fomicheva V, Kartel NA & Figge J 1998 The ret/PTC1 rearrangement is a common feature of Chernobyl-associated papillary thyroid carcinomas from Belarus. Thyroid: Official Journal of the American Thyroid Association 8 133-139. (doi:10.1089/thy.1998.8.133)
74. Pita JM, Figueiredo IF, Moura MM, Leite V & Cavaco BM 2014 Cell cycle deregulation and TP53 and RAS mutations are major events in poorly differentiated and undifferentiated thyroid carcinomas. Journal of Clinical Endocrinology and Metabolism 99 E497-E507. (doi:10.1210/ jc.2013-1512)
75. Placzkowski KA, Reddi HV, Grebe SK, Eberhardt NL & Mc Iver B 2008 The role of the PAX8/PPARgamma fusion oncogene in thyroid cancer. PPAR Research 2008 672829. (doi:10.1155/2008/672829)
76. Rabes HM, Demidchik EP, Sidorow JD, Lengfelder E, Beimfohr C, Hoelzel D & Klugbauer S 2000 Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications. Clinical Cancer Research 6 1093-1103.
77. Ricarte-Filho JC, Li S, Garcia-Rendueles ME, Montero-Conde C, Voza F, Knauf JA, Heguy A, Viale A, Bogdanova T, Thomas GA et al. 2013 Identification of kinase fusion oncogenes in post-Chernobyl radiationinduced thyroid cancers. Journal of Clinical Investigation 123 4935-4944. (doi:10.1172/JCI69766)
78. Rivera M, Ricarte-Filho J, Knauf J, Shaha A, Tuttle M, Fagin JA & Ghossein RA 2010 Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. Modern Pathology 23 1191-1200. (doi:10.1038/modpathol.2010.112)
79. Rivkees SA, Mazzaferri EL, Verburg FA, Reiners C, Luster M, Breuer CK, Dinauer CA & Udelsman R 2011 The treatment of differentiated thyroid cancer in children: emphasis on surgical approach and radioactive iodine therapy. Endocrine Review 32 798-826. (doi:10.1210/ er.2011-0011)
80. Romei C & Elisei R 2012 RET/PTC translocations and clinico-pathological features in human papillary thyroid carcinoma. Frontiers in Endocrinology 3 54. (doi:10.3389/fendo.2012.00054)
81. Romei C, Ciampi R, Faviana P, Agate L, Molinaro E, Bottici V, Basolo F, Miccoli P, Pacini F, Pinchera A et al. 2008 BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer. Endocrine-Related Cancer 15 511-520. (doi:10.1677/ ERC-07-0130)
82. Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, Schneider AB, Tucker MA & Boice JD Jr 1995 Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiation Research 141 259-277. (doi:10.2307/3579003)
83. Sahin M, Allard BL, Yates M, Powell JG, Wang XL, Hay ID, Zhao Y, Goellner JR, Sebo TJ, Grebe SK et al. 2005 PPARgamma staining as a surrogate for PAX8/PPARgamma fusion oncogene expression in follicular neoplasms: clinicopathological correlation and histopathological diagnostic value. Journal of Clinical Endocrinology and Metabolism 90 463-468. (doi:10.1210/jc.2004-1203)
84. Sassolas G, Hafdi-Nejjari Z, Ferraro A, Decaussin-Petrucci M, Rousset B, Borson-Chazot F, Borbone E, Berger N & Fusco A 2012 Oncogenic alterations in papillary thyroid cancers of young patients. Thyroid: Official Journal of the American Thyroid Association 22 17-26. (doi:10.1089/thy.2011.0215)
85. Siegel R, Ma J, Zou Z & Jemal A 2014a Cancer statistics, 2014. CA: A Cancer Journal for Clinicians 64 9-29. (doi:10.3322/caac.21208)
86. Siegel DA, King J, Tai E, Buchanan N, Ajani UA & Li J 2014b Cancer incidence rates and trends among children and adolescents in the United States, 2001-2009. Pediatrics 134 e945-e955. (doi:10.1542/peds. 2013-3926)
87. Sigurdson AJ, Ronckers CM, Mertens AC, Stovall M, Smith SA, Liu Y, Berkow RL, Hammond S, Neglia JP, Meadows AT et al. 2005 Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study. Lancet 365 2014-2023. (doi:10.1016/S0140-6736(05)66695-0)
88. Smida J, Salassidis K, Hieber L, Zitzelsberger H, Kellerer AM, Demidchik EP, Negele T, Spelsberg F, Lengfelder E, Werner M et al. 1999 Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus International journal of cancer. International Journal of Cancer. Journal International du Cancer 80 32-38. (doi:10.1002/(SICI)1097-0215(19990105)80:1!32::AID-IJC7O3.0. CO;2-L)
89. Suchy B, Waldmann V, Klugbauer S & Rabes HM 1998 Absence of RAS and p53 mutations in thyroid carcinomas of children after Chernobyl in contrast to adult thyroid tumours. British Journal of Cancer 77 952-955. (doi:10.1038/bjc.1998.157)
90. The Cancer Genome Atlas Research Network 2014 Integrated genomic characterization of papillary thyroid carcinoma. Cell 159 676-690. (doi:10.1016/j.cell.2014.09.050)
91. Thomas GA, Bunnell H, Cook HA, Williams ED, Nerovnya A, Cherstvoy ED, Tronko ND, Bogdanova TI, Chiappetta G, Viglietto G et al. 1999 High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant. Journal of Clinical Endocrinology and Metabolism 84 4232-4238. (doi:10.1210/jcem.84.11. 6129)
92. Tuttle RM, Vaisman F & Tronko MD 2011 Clinical presentation and clinical outcomes in Chernobyl-related paediatric thyroid cancers: what do we know now? What can we expect in the future? Clinical Oncology 23 268-275. (doi:10.1016/j.clon.2011.01.178)
93. Vaisman F, Corbo R & Vaisman M 2011 Thyroid carcinoma in children and adolescents - systematic review of the literature. Journal of Thyroid Research 2011 845362. (doi:10.4061/2011/845362)
94. Veiga LH, Neta G, Aschebrook-Kilfoy B, Ron E & Devesa SS 2013 Thyroid cancer incidence patterns in Sao Paulo, Brazil, and the U.S. SEER program, 1997-2008. Thyroid: Official Journal of the American Thyroid Association 23 748-757. (doi:10.1089/thy.2012.0532)
95. Vergamini LB, Frazier AL, Abrantes FL, Ribeiro KB & Rodriguez-Galindo C 2014 Increase in the incidence of differentiated thyroid carcinoma in children, adolescents, and young adults: a population-based study. Journal of Pediatrics 164 1481-1485. (doi:10.1016/j.jpeds.2014.01.059)
96. Ward E, De Santis C, Robbins A, Kohler B & Jemal A 2014 Childhood and adolescent cancer statistics, 2014. CA: A Cancer Journal for Clinicians 64 83-103. (doi:10.3322/caac.21219)
97. Welch Dinauer CA, Tuttle RM, Robie DK, Mc Clellan DR, Svec RL, Adair C & Francis GL 1998 Clinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults. Clinical Endocrinology 49 619-628. (doi:10.1046/j.1365-2265.1998.00584.x)
98. Williams D 2008 Radiation carcinogenesis: lessons from Chernobyl. Oncogene 27 (Suppl 2) S9-18. (doi:10.1038/onc.2009.349)
99. Wu XC, Chen VW, Steele B, Roffers S, Klotz JB, Correa CN & Carozza SE 2003 Cancer incidence in adolescents and young adults in the United States, 1992-1997. Journal of Adolescent Health 32 405-415. (doi:10.1016/S1054-139X(03)00057-0)
100. Xing M 2005 BRAF mutation in thyroid cancer. Endocrine-Related Cancer 12 245-262. (doi:10.1677/erc.1.0978)
101. Xing M 2013 Molecular pathogenesis and mechanisms of thyroid cancer. Nature Reviews. Cancer 13 184-199. (doi:10.1038/nrc3431)
102. Yamashita S & Suzuki S 2013 Risk of thyroid cancer after the Fukushima nuclear power plant accident. Respiratory Investigation 51 128-133. (doi:10.1016/j.resinv.2013.05.007)
103. Yamashita S & Takamura N 2012 Post-crisis efforts towards recovery and resilience after the Fukushima Daiichi Nuclear Power Plant accident. Japanese Journal of Clinical Oncology 45 700-707. (doi:10.1093/jjco/ hyv076)
104. Yasumura S, Hosoya M, Yamashita S, Kamiya K, Abe M, Akashi M, Kodama K & Ozasa K 2012 Study protocol for the Fukushima Health Management Survey. Journal of Epidemiology 22 375-383. (doi:10.2188/ jea.JE20120105)
105. Zaydfudim V, Feurer ID, Griffin MR & Phay JE 2008 The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma. Surgery 144 1070-1077; discussion 1077-1078. (doi:10.1016/j.surg.2008.08.034)
106. Zhang Z, Liu D, Murugan AK, Liu Z & Xing M 2014 Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer. Endocrine-Related Cancer 21 161-173. (doi:10.1530/ ERC-13-0399)
107. Zhu Z, Gandhi M, Nikiforova MN, Fischer AH & Nikiforov YE 2003 Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations. American Journal of Clinical Pathology 120 71-77. (doi:10.1309/ND8D9LAJTRCTG6QD)
108. Zhu Z, Ciampi R, Nikiforova MN, Gandhi M & Nikiforov YE 2006 Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity. Journal of Clinical Endocrinology and Metabolism 91 3603-3610. (doi:10.1210/jc.2006-1006)
109. Zimmerman D, Hay ID, Gough IR, Goellner JR, Ryan JJ, Grant CS & Mc Conahey WM 1988 Papillary thyroid carcinoma in children and adults: long-term follow-up of 1039 patients conservatively treated at one institution during three decades. Surgery 104 1157-1166.