-
2
-
-
76249089855
-
Annual report to the nation on the status of cancer 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates
-
Edwards BK, Ward E, Kohler BA., et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer. 2010; 116: 544-573.
-
(2010)
Cancer
, vol.116
, pp. 544-573
-
-
Edwards, B.K.1
Ward, E.2
Kohler, B.A.3
-
3
-
-
79955405206
-
Recent trends in colorectal cancer mortality in Europe
-
Bosetti C, Levi F, Rosato V., et al. Recent trends in colorectal cancer mortality in Europe. Int J Cancer. 2011; 129: 180-191.
-
(2011)
Int J Cancer
, vol.129
, pp. 180-191
-
-
Bosetti, C.1
Levi, F.2
Rosato, V.3
-
5
-
-
0027461840
-
Randomised comparison of combination chemotherapy plus supportive care alone in patients with metastatic colorectal cancer
-
Scheithauer W, Rosen H, Kornek GV., et al. Randomised comparison of combination chemotherapy plus supportive care alone in patients with metastatic colorectal cancer. BMJ. 1993; 306: 752-755.
-
(1993)
BMJ
, vol.306
, pp. 752-755
-
-
Scheithauer, W.1
Rosen, H.2
Kornek, G.V.3
-
6
-
-
84901589715
-
Seeing the forest through the trees: A systematic review of the safety and efficacy of combination chemotherapies used in the treatment of colorectal cancer
-
Bekaii-Saab T, Wu C. Seeing the forest through the trees: a systematic review of the safety and efficacy of combination chemotherapies used in the treatment of colorectal cancer. Crit Rev Oncol Hematol. 2014; 91: 9-34.
-
(2014)
Crit Rev Oncol Hematol
, vol.91
, pp. 9-34
-
-
Bekaii-Saab, T.1
Wu, C.2
-
7
-
-
77957077907
-
HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer
-
Jackson AL, Zhou B, Kim WY. HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer. Expert Opin Ther Targets. 2010; 14: 1047-1057.
-
(2010)
Expert Opin Ther Targets
, vol.14
, pp. 1047-1057
-
-
Jackson, A.L.1
Zhou, B.2
Kim, W.Y.3
-
8
-
-
80054910709
-
Serum vascular endothelial growth factor and COX-2/5-LOX inhibition in advanced non-small cell lung cancer. Cancer and Leukemia Group B 150304
-
Edelman MJ, Hodgson L, Wang X., et al. Serum vascular endothelial growth factor and COX-2/5-LOX inhibition in advanced non-small cell lung cancer. Cancer and Leukemia Group B 150304. J Thorac Oncol. 2011; 6: 1902-1906.
-
(2011)
J Thorac Oncol
, vol.6
, pp. 1902-1906
-
-
Edelman, M.J.1
Hodgson, L.2
Wang, X.3
-
9
-
-
84975525035
-
Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis
-
Folkman J. Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med. 1995; 333: 1757-1763.
-
(1995)
N Engl J Med
, vol.333
, pp. 1757-1763
-
-
Folkman, J.1
-
11
-
-
0036240885
-
Clinical experience with angiogenesis signaling inhibitors: Focus on vascular endothelial growth factor (VEGF) blockers
-
Rosen LS. Clinical experience with angiogenesis signaling inhibitors: focus on vascular endothelial growth factor (VEGF) blockers. Cancer Control. 2002; 9: 36-44.
-
(2002)
Cancer Control
, vol.9
, pp. 36-44
-
-
Rosen, L.S.1
-
12
-
-
0025141337
-
What is the evidence that tumors are angiogenesis dependent
-
Folkman J. What is the evidence that tumors are angiogenesis dependent J Natl Cancer Inst. 1990; 82: 4-6.
-
(1990)
J Natl Cancer Inst
, vol.82
, pp. 4-6
-
-
Folkman, J.1
-
13
-
-
0023157363
-
Angiogenic factors
-
Folkman J, Klagsbrun M. Angiogenic factors. Science. 1987; 235: 442-447.
-
(1987)
Science
, vol.235
, pp. 442-447
-
-
Folkman, J.1
Klagsbrun, M.2
-
14
-
-
0034894793
-
Vascular endothelial growth factor in the serum of patients with non-small cell lung cancer: Correlation with platelet and leucocyte counts
-
Choi JH, Kim HC, Hy L., et al. Vascular endothelial growth factor in the serum of patients with non-small cell lung cancer: correlation with platelet and leucocyte counts. Lung Cancer. 2001; 33: 171-179.
-
(2001)
Lung Cancer
, vol.33
, pp. 171-179
-
-
Choi, J.H.1
Kim, H.C.2
Hy, L.3
-
15
-
-
0029004025
-
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
-
Dvorak HF, Brown LF, Detmar M., et al. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol. 1995; 146: 1029-1039.
-
(1995)
Am J Pathol
, vol.146
, pp. 1029-1039
-
-
Dvorak, H.F.1
Brown, L.F.2
Detmar, M.3
-
16
-
-
0029010434
-
Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
-
Roberts WG, Palade GE. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci. 1995; 108: 2369-2379.
-
(1995)
J Cell Sci
, vol.108
, pp. 2369-2379
-
-
Roberts, W.G.1
Palade, G.E.2
-
17
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005; 23: 1011-1027.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
18
-
-
0037011070
-
Vascular permeability factor/vascular endothelial growth factor induces lymphangiogensis as well as angiogenesis
-
Nagy JA, Vasile E, Feng D., et al. Vascular permeability factor/vascular endothelial growth factor induces lymphangiogensis as well as angiogenesis. J Exp Med. 2002; 196: 1497-1506.
-
(2002)
J Exp Med
, vol.196
, pp. 1497-1506
-
-
Nagy, J.A.1
Vasile, E.2
Feng, D.3
-
19
-
-
77956497621
-
Current use and potential role of bevacizumab in the treatment of gastrointestinal cancers
-
Li J, Saif MW. Current use and potential role of bevacizumab in the treatment of gastrointestinal cancers. Biologics. 2009;3: 429-441.
-
(2009)
Biologics
, vol.3
, pp. 429-441
-
-
Li, J.1
Saif, M.W.2
-
20
-
-
0032710319
-
Clinical applications of angiogenic growth factors and their inhibitors
-
Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors. Nat Med. 1999; 5: 1359-1364.
-
(1999)
Nat Med
, vol.5
, pp. 1359-1364
-
-
Ferrara, N.1
Alitalo, K.2
-
21
-
-
16644377775
-
Overview of bevacizumab: A new cancer therapeutic strategy targeting vascular endothelial growth factor
-
Ignoffo RJ. Overview of bevacizumab: a new cancer therapeutic strategy targeting vascular endothelial growth factor. Am J Health Syst Pharm. 2004; 61: S21-26.
-
(2004)
Am J Health Syst Pharm
, vol.61
, pp. S21-26
-
-
Ignoffo, R.J.1
-
22
-
-
55549102649
-
Clinical use of anti-vascular endothelial growth factor monoclonal antibodies in metastatic colorectal cancer
-
Chase JL. Clinical use of anti-vascular endothelial growth factor monoclonal antibodies in metastatic colorectal cancer. Pharmacotherapy. 2008; 23S-30S.
-
(2008)
Pharmacotherapy
, pp. 23S-30S
-
-
Chase, J.L.1
-
23
-
-
0026708632
-
The vascular endothelial growth factor proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies
-
Kim KJ, Li B, Houck K., et al. The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors. 1992; 7: 53-64.
-
(1992)
Growth Factors
, vol.7
, pp. 53-64
-
-
Kim, K.J.1
Li, B.2
Houck, K.3
-
24
-
-
84872921660
-
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial
-
Grothey A, Van Cutsem E, Sobrero A., et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013; 381: 303-312.
-
(2013)
Lancet
, vol.381
, pp. 303-312
-
-
Grothey, A.1
Van Cutsem, E.2
Sobrero, A.3
-
25
-
-
33750373924
-
Mechanisms of action of bevacizumab as a component of therapy for metastatic colorectal cancer
-
Ellis LM. Mechanisms of action of bevacizumab as a component of therapy for metastatic colorectal cancer. Semin Oncol. 2006; 33: S1-7.
-
(2006)
Semin Oncol
, vol.33
, pp. S1-7
-
-
Ellis, L.M.1
-
26
-
-
8744262693
-
Integration of novel agents in the treatment of colorectal cancer
-
Iqbal S, Lenz HJ. Integration of novel agents in the treatment of colorectal cancer. Cancer Chemother Pharmacol. 2004; 54: S32-39.
-
(2004)
Cancer Chemother Pharmacol
, vol.54
, pp. S32-39
-
-
Iqbal, S.1
Lenz, H.J.2
-
27
-
-
80053474763
-
Bevacizumab has differential and dose-dependent effects on glioma blood vessels and tumor cells
-
Von Baumgarten L, Brucker D, Tirniceru A., et al. Bevacizumab has differential and dose-dependent effects on glioma blood vessels and tumor cells. Clin Cancer Res. 2011; 17: 6192-6205.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6192-6205
-
-
Von Baumgarten, L.1
Brucker, D.2
Tirniceru, A.3
-
28
-
-
77954008527
-
Bevacizumab combined with chemotherapy for patients with advanced colorectal cancer: A systematic review
-
Welch S, Spithoff K, Rumble RB., et al. Bevacizumab combined with chemotherapy for patients with advanced colorectal cancer: a systematic review. Ann Oncol. 2010; 21: 1152-1162.
-
(2010)
Ann Oncol
, vol.21
, pp. 1152-1162
-
-
Welch, S.1
Spithoff, K.2
Rumble, R.B.3
-
29
-
-
84877047276
-
Toxicity of bevacizumab in combination with chemotherapy in older patients
-
Mohile SG, Hardt M, Tew W., et al. Toxicity of bevacizumab in combination with chemotherapy in older patients. Oncologist. 2013; 18: 408-414.
-
(2013)
Oncologist
, vol.18
, pp. 408-414
-
-
Mohile, S.G.1
Hardt, M.2
Tew, W.3
-
30
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004; 350: 2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
31
-
-
36048960109
-
Randomized, controlled trial of irinotecan plus infusional bolus or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C study
-
Fuchs CS, Marshall J, Mitchell E., et al. Randomized, controlled trial of irinotecan plus infusional bolus or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C study. J Clin Oncol. 2007; 25: 4779-4786.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4779-4786
-
-
Fuchs, C.S.1
Marshall, J.2
Mitchell, E.3
-
32
-
-
39149108869
-
Randomized, controlled trial of irinotecan plus infusional bolus or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Updated results from the BICC-C study
-
Fuchs CS, Marschall J, Barrueco J. Randomized, controlled trial of irinotecan plus infusional bolus or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: updated results from the BICC-C study. J Clin Oncol. 2008; 26: 689-690.
-
(2008)
J Clin Oncol
, vol.26
, pp. 689-690
-
-
Fuchs, C.S.1
Marschall, J.2
Barrueco, J.3
-
33
-
-
67650996205
-
Phase IV study of bevacizumab in combination with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) in first-line metastatic colorectal cancer
-
Sobrero A, Ackland S, Clarke S., et al. Phase IV study of bevacizumab in combination with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) in first-line metastatic colorectal cancer. Oncology. 2009; 77: 113-119.
-
(2009)
Oncology
, vol.77
, pp. 113-119
-
-
Sobrero, A.1
Ackland, S.2
Clarke, S.3
-
34
-
-
84908573757
-
FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): A randomized, open-label, phase 3 trial
-
Heinemann V, Von Weikersthal LF, Decker T., et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomized, open-label, phase 3 trial. Lancet Oncol. 2014; 15: 1067-1075.
-
(2014)
Lancet Oncol
, vol.15
, pp. 1067-1075
-
-
Heinemann, V.1
Von Weikersthal, L.F.2
Decker, T.3
-
35
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
-
Saltz LB, Clarke S, Diaz-Rubio E., et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008; 26: 2013-2019.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
-
36
-
-
49049105525
-
Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE study
-
Hochster HS, Hart LL, Ramanathan RK., et al. Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE study. J Clin Oncol. 2008; 26: 3523-3529.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3523-3529
-
-
Hochster, H.S.1
Hart, L.L.2
Ramanathan, R.K.3
-
37
-
-
84867115561
-
Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: A double-blind, randomized phase III study (HORIZON III)
-
Schmoll HJ, Cunningham D, Sobrero A., et al. Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: a double-blind, randomized phase III study (HORIZON III). J Clin Oncol. 2012; 30: 3588-3595.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3588-3595
-
-
Schmoll, H.J.1
Cunningham, D.2
Sobrero, A.3
-
38
-
-
70349181476
-
Effect of intravenous (IV) calcium and magnesium (Ca/Mg) versus placebo on response to FOLFOX+bevacizumab (BEV) in the CONcePT trial
-
Hochster HS, Grothey A, Shpilsky A. et al. Effect of intravenous (IV) calcium and magnesium (Ca/Mg) versus placebo on response to FOLFOX+bevacizumab (BEV) in the CONcePT trial. Gastrointestinal Cancers Symp. 2008;23: Abstract 280.
-
(2008)
Gastrointestinal Cancers Symp
, vol.23
-
-
Hochster, H.S.1
Grothey, A.2
Shpilsky, A.3
-
39
-
-
84861318872
-
FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer-subgroup analysis of patients with KRAS mutated tumours in the randomized German AIO study KRK-0306
-
Stintzing S, Fischer Von Weikersthal F, Decker T., et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer-subgroup analysis of patients with KRAS mutated tumours in the randomized German AIO study KRK-0306. Ann Oncol. 2012; 23: 1693-1699.
-
(2012)
Ann Oncol
, vol.23
, pp. 1693-1699
-
-
Stintzing, S.1
Fischer Von Weikersthal, F.2
Decker, T.3
-
40
-
-
84905870196
-
PEAK: A randomized multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer
-
Schwartzberg LS, Rivera F, Karthaus M., et al. PEAK: a randomized multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer. J Clin Oncol. 2014; 32: 2240-2247.
-
(2014)
J Clin Oncol
, vol.32
, pp. 2240-2247
-
-
Schwartzberg, L.S.1
Rivera, F.2
Karthaus, M.3
-
41
-
-
84907027361
-
CALGB/SWOG 80405: Phase III trial of irinotecan/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetixumab (CET) for patients with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the colon or rectum (MCRC)
-
Venook AP, Niedzwiecki D, Lenz HJ., et al. CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetixumab (CET) for patients with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the colon or rectum (MCRC). Proc Am Soc Clin Oncol. 2014; 32: LBA3 (abstr).
-
(2014)
Proc Am Soc Clin Oncol
, vol.32
, pp. LBA3
-
-
Venook, A.P.1
Niedzwiecki, D.2
Lenz, H.J.3
-
42
-
-
77956189945
-
Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil and folinate) as first-line treatment for metastatic colorectal cancer: A phase 2 trial
-
Masi G, Loupakis F, Salvatore L., et al. Bevacizumab with FOLFOXIRI (irinotecan, oxaliplatin, fluorouracil and folinate) as first-line treatment for metastatic colorectal cancer: a phase 2 trial. Lancet Oncol. 2010; 11: 845-852.
-
(2010)
Lancet Oncol
, vol.11
, pp. 845-852
-
-
Masi, G.1
Loupakis, F.2
Salvatore, L.3
-
43
-
-
84908139591
-
Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer
-
Loupakis F, Cremolinr C, Masi G., et al. Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer. N Engl J Med. 2014; 371: 1609-1618.
-
(2014)
N Engl J Med
, vol.371
, pp. 1609-1618
-
-
Loupakis, F.1
Cremolinr, C.2
Masi, G.3
-
44
-
-
84926460438
-
Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer: The OLIVIA multinational randomized phase II trial
-
Gruenberger T, Bridgewater J, Chau I., et al. Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer: the OLIVIA multinational randomized phase II trial. Ann Oncol. 2015; 26: 702-708.
-
(2015)
Ann Oncol
, vol.26
, pp. 702-708
-
-
Gruenberger, T.1
Bridgewater, J.2
Chau, I.3
-
45
-
-
84856304557
-
First-line XELOX plus bevacizumab followed by XELOX plus bevacizumab or single-agent bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: The phase III MACRO TTD study
-
Diaz-Rubio E, Gomez-Espana A, Massuti B., et al. First-line XELOX plus bevacizumab followed by XELOX plus bevacizumab or single-agent bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: the phase III MACRO TTD study. Oncologist. 2012; 17: 25-35.
-
(2012)
Oncologist
, vol.17
, pp. 25-35
-
-
Diaz-Rubio, E.1
Gomez-Espana, A.2
Massuti, B.3
-
46
-
-
84872316412
-
XELOX and bevacizumab followed by single-agent bevacizumab as maintenance therapy as first-line treatment in elderly patients with advanced colorectal cancer: The boxe study
-
Rosati G, Avallone A, Aprile G., et al. XELOX and bevacizumab followed by single-agent bevacizumab as maintenance therapy as first-line treatment in elderly patients with advanced colorectal cancer: the boxe study. Cancer Chemother Pharmacol. 2013; 71: 257-264.
-
(2013)
Cancer Chemother Pharmacol
, vol.71
, pp. 257-264
-
-
Rosati, G.1
Avallone, A.2
Aprile, G.3
-
47
-
-
84883339111
-
A randomized phase III trial on maintenance treatment with bevacizumab alone or in combination with erlotinib after chemotherapy and bevacizumab in metastatic colorectal cancer: The Nordic ACT trial
-
Johnsson A, Hagman H, Frodin JE., et al. A randomized phase III trial on maintenance treatment with bevacizumab alone or in combination with erlotinib after chemotherapy and bevacizumab in metastatic colorectal cancer: the Nordic ACT trial. Ann Oncol. 2013; 24: 2335-2341.
-
(2013)
Ann Oncol
, vol.24
, pp. 2335-2341
-
-
Johnsson, A.1
Hagman, H.2
Frodin, J.E.3
-
48
-
-
84926475781
-
Bevacizumab continuation versus no continuation after first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer: A randomized phase III non-inferiority trial (SAKK 41/06)
-
Koeberle D, Betticher DC, Von Moos R., et al. Bevacizumab continuation versus no continuation after first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer: a randomized phase III non-inferiority trial (SAKK 41/06). Ann Oncol. 2015; 26: 709-714.
-
(2015)
Ann Oncol
, vol.26
, pp. 709-714
-
-
Koeberle, D.1
Betticher, D.C.2
Von Moos, R.3
-
49
-
-
84929514070
-
Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): A phase 3 randomized controlled trial of the Dutch Colorectal Cancer Group
-
Simkens LH, Van Tinteren H, May A., et al. Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): a phase 3 randomized controlled trial of the Dutch Colorectal Cancer Group. Lancet. 2015; 385: 1843-1852.
-
(2015)
Lancet
, vol.385
, pp. 1843-1852
-
-
Simkens, L.H.1
Van Tinteren, H.2
May, A.3
-
50
-
-
84954026956
-
Maintenance strategies after first-line oxaliplatin plus fluoropyrimidine plus bevacizumab for patients with metastatic colorectal cancer (AIO 0207): A randomized, non-inferiority, open-label, phase 3 trial
-
[Epub ahead of print]
-
Hegewisch-Becker S, Graeven U, Lerchenmuller CA., et al. Maintenance strategies after first-line oxaliplatin plus fluoropyrimidine plus bevacizumab for patients with metastatic colorectal cancer (AIO 0207): a randomized, non-inferiority, open-label, phase 3 trial. Lancet Oncol. 2015. DOI: 10.1016/S1470-2045(15)00042-X. [Epub ahead of print].
-
(2015)
Lancet Oncol
-
-
Hegewisch-Becker, S.1
Graeven, U.2
Lerchenmuller, C.A.3
-
51
-
-
33745464490
-
Fluorinated pyrimidines, a new class of tumor-inhibitory compounds
-
Heidelberger C, Chaudhuri NK, Danneberg P., et al. Fluorinated pyrimidines, a new class of tumor-inhibitory compounds. Nature. 1957; 179: 663-666.
-
(1957)
Nature
, vol.179
, pp. 663-666
-
-
Heidelberger, C.1
Chaudhuri, N.K.2
Danneberg, P.3
-
52
-
-
0005086073
-
Cytotoxicity of 5-fluoro-2-deoxyuridine: Requirement for reduced folate cofactors and antagonism by methotrexate
-
Ullman B, Lee M, Martin DW Jr., et al., Cytotoxicity of 5-fluoro-2-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate. Proc Natl Acad Sci USA. 1978; 75: 980-983.
-
(1978)
Proc Natl Acad Sci USA
, vol.75
, pp. 980-983
-
-
Ullman, B.1
Lee, M.2
Martin, Jr.D.W.3
-
53
-
-
0022479537
-
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells
-
Keyomarsi K, Moran RG. Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. Cancer Res. 1986; 46: 5229-5235.
-
(1986)
Cancer Res
, vol.46
, pp. 5229-5235
-
-
Keyomarsi, K.1
Moran, R.G.2
-
54
-
-
0024578676
-
Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft
-
Radparvar S, Houghton PJ, Houghton JA. Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft. Biochem Pharmacol. 1989; 38: 335-342.
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 335-342
-
-
Radparvar, S.1
Houghton, P.J.2
Houghton, J.A.3
-
55
-
-
0024227210
-
Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines
-
Park JG, Collins JM, Gazdar AF., et al. Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines. J Natl Cancer Inst. 1988; 80: 1560-1564.
-
(1988)
J Natl Cancer Inst
, vol.80
, pp. 1560-1564
-
-
Park, J.G.1
Collins, J.M.2
Gazdar, A.F.3
-
56
-
-
0019906743
-
Treatment of advanced colorectal and gastric adenocarcinomas with 5-FU combined with high-dose folinic acid: A pilot study
-
Machover D, Schwarzenberg L, Goldschmidt E., et al. Treatment of advanced colorectal and gastric adenocarcinomas with 5-FU combined with high-dose folinic acid: a pilot study. Cancer Treat Rep. 1982; 66: 1803-1807.
-
(1982)
Cancer Treat Rep
, vol.66
, pp. 1803-1807
-
-
MacHover, D.1
Schwarzenberg, L.2
Goldschmidt, E.3
-
57
-
-
0021130547
-
Phase I-II trial of high-dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer
-
Madajewicz S, Petrelli N, Rustum YM., et al. Phase I-II trial of high-dose calcium leucovorin and 5-fluorouracil in advanced colorectal cancer. Cancer Res. 1984; 44: 4667-4669.
-
(1984)
Cancer Res
, vol.44
, pp. 4667-4669
-
-
Madajewicz, S.1
Petrelli, N.2
Rustum, Y.M.3
-
58
-
-
0024385167
-
The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: A prospective randomized phase III trial. Gastrointestinal Tumor Study Group
-
Petrelli N, Douglass HO Jr, Herrera L., et al. The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group. J Clin Oncol. 1989; 7: 1419-1426.
-
(1989)
J Clin Oncol
, vol.7
, pp. 1419-1426
-
-
Petrelli, N.1
Douglass, Jr.H.O.2
Herrera, L.3
-
59
-
-
0023520170
-
A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma
-
Petrelli N, Herrera L, Rustum Y., et al. A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol. 1987; 5: 1559-1565.
-
(1987)
J Clin Oncol
, vol.5
, pp. 1559-1565
-
-
Petrelli, N.1
Herrera, L.2
Rustum, Y.3
-
60
-
-
4644252335
-
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: An updated meta-analysis
-
Thirion P, Michiels S, Pignon JP., et al. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis. J Clin Oncol. 2004; 22: 3766-3775.
-
(2004)
J Clin Oncol
, vol.22
, pp. 3766-3775
-
-
Thirion, P.1
Michiels, S.2
Pignon, J.P.3
-
61
-
-
84922754254
-
A review of the evolution of systemic chemotherapy in the management of colorectal cancer
-
Gustavvson B, Carlsson G, Machover D., et al. A review of the evolution of systemic chemotherapy in the management of colorectal cancer. Clin Colorectal Cancer. 2015; 14: 1-10.
-
(2015)
Clin Colorectal Cancer
, vol.14
, pp. 1-10
-
-
Gustavvson, B.1
Carlsson, G.2
MacHover, D.3
-
62
-
-
31444450593
-
Advances in the treatment of metastatic colorectal cancer
-
Goldberg RM. Advances in the treatment of metastatic colorectal cancer. Oncologist. 2005; 10 (Suppl 3): 40-48.
-
(2005)
Oncologist
, vol.10
, pp. 40-48
-
-
Goldberg, R.M.1
-
63
-
-
0036176033
-
Capecitabine as first-line treatment in colorectal cancer. Pooled data from two large, phase III trials
-
Xeloda Colorectal Cancer Group
-
Twelves C, Xeloda Colorectal Cancer Group. Capecitabine as first-line treatment in colorectal cancer. Pooled data from two large, phase III trials. Eur J Cancer. 2002; 38 (Suppl 2): 15-20.
-
(2002)
Eur J Cancer
, vol.38
, pp. 15-20
-
-
Twelves, C.1
-
64
-
-
0036235128
-
First-line oral capecitabine therapy in metastatic colorectal cancer: A favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
-
Cassidy J, Twelves C, Van Cutsem E., et al. First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol. 2002; 13; 566-575.
-
(2002)
Ann Oncol
, vol.13
, pp. 566-575
-
-
Cassidy, J.1
Twelves, C.2
Van Cutsem, E.3
-
65
-
-
0004700371
-
Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: A phase II multicentric study
-
Diaz-Rubio E, Sastre J, Zaniboni A., et al. Oxaliplatin as single agent in previously untreated colorectal carcinoma patients: a phase II multicentric study. Ann Oncol. 1998; 9: 105-108.
-
(1998)
Ann Oncol
, vol.9
, pp. 105-108
-
-
Diaz-Rubio, E.1
Sastre, J.2
Zaniboni, A.3
-
66
-
-
0344783805
-
Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers
-
Becouarn Y, Ychou M, Ducreux M., et al. Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers. J Clin Oncol. 1998; 16: 2739-2744.
-
(1998)
J Clin Oncol
, vol.16
, pp. 2739-2744
-
-
Becouarn, Y.1
Ychou, M.2
Ducreux, M.3
-
67
-
-
0031014627
-
Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naïve patients and patients pretreated with fluorouracil-based chemotherapy
-
Rougier P, Bugat R, Douillard JY., et al. Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naïve patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol. 1997; 1: 251-260.
-
(1997)
J Clin Oncol
, vol.1
, pp. 251-260
-
-
Rougier, P.1
Bugat, R.2
Douillard, J.Y.3
-
68
-
-
0035864844
-
Phase II study of irinotecan as first-line chemotherapy for patients with advanced colorectal carcinoma
-
Firvida JL, Irigoyen A, Vazquez-Estevez S., et al. Phase II study of irinotecan as first-line chemotherapy for patients with advanced colorectal carcinoma. Cancer. 2001; 91: 704-711.
-
(2001)
Cancer
, vol.91
, pp. 704-711
-
-
Firvida, J.L.1
Irigoyen, A.2
Vazquez-Estevez, S.3
-
69
-
-
0035038493
-
A randomized phase II study of oxaliplatin alone versus oxaliplatin combined with 5-fluorouracil and folinic acid (Mayo Clinic regimen) in previously untreated metastatic colorectal cancer patients
-
Zori Comba A, Blajman C, Richardet E., et al. A randomized phase II study of oxaliplatin alone versus oxaliplatin combined with 5-fluorouracil and folinic acid (Mayo Clinic regimen) in previously untreated metastatic colorectal cancer patients. Eur J Cancer. 2001; 37: 1006-1013.
-
(2001)
Eur J Cancer
, vol.37
, pp. 1006-1013
-
-
Zori Comba, A.1
Blajman, C.2
Richardet, E.3
-
70
-
-
0037093207
-
Bolus fluorouracil and leucovorin with oxaliplatin as first-line treatment in metastatic colorectal cancer
-
Ravaioli A, Marangolo M, Pasquini E., et al. Bolus fluorouracil and leucovorin with oxaliplatin as first-line treatment in metastatic colorectal cancer. J Clin Oncol. 2002; 20: 2545-2550.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2545-2550
-
-
Ravaioli, A.1
Marangolo, M.2
Pasquini, E.3
-
71
-
-
0039276846
-
A multicenter evaluation of intensified, ambulatory, chronomodulated chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin as initial treatment of patients with metastatic colorectal carcinoma
-
International Organization for Cancer Chronotherapy
-
Levi F, Zidani R, Brienza S., et al. A multicenter evaluation of intensified, ambulatory, chronomodulated chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin as initial treatment of patients with metastatic colorectal carcinoma. International Organization for Cancer Chronotherapy. Cancer. 1999; 85: 2532-2540.
-
(1999)
Cancer
, vol.85
, pp. 2532-2540
-
-
Levi, F.1
Zidani, R.2
Brienza, S.3
-
72
-
-
10344253782
-
Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil, and leucovorin in patients with metastatic colorectal cancer
-
Bertheault-Cvitkovic F, Jami A, Ithzaki M., et al. Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil, and leucovorin in patients with metastatic colorectal cancer. J Clin Oncol. 1996; 14: 2950-2958.
-
(1996)
J Clin Oncol
, vol.14
, pp. 2950-2958
-
-
Bertheault-Cvitkovic, F.1
Jami, A.2
Ithzaki, M.3
-
73
-
-
0033798125
-
5-Fluorouracil and folinic acid with or without CPT-11 in advanced colorectal cancer patients: A multicenter randomized phase II study of the Southern Italy Oncology Group
-
Maiello E, Gebbia V, Guiliani F., et al. 5-Fluorouracil and folinic acid with or without CPT-11 in advanced colorectal cancer patients: a multicenter randomized phase II study of the Southern Italy Oncology Group. Ann Oncol. 2000; 11: 1045-1051.
-
(2000)
Ann Oncol
, vol.11
, pp. 1045-1051
-
-
Maiello, E.1
Gebbia, V.2
Guiliani, F.3
-
74
-
-
0034712536
-
Irinotecan combined with fluorouracil compared with fluorouracil alone as fist-line treatment for metastatic colorectal cancer: A multicenter randomized trial
-
Douillard JY, Cunningham D, Roth AD., et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as fist-line treatment for metastatic colorectal cancer: a multicenter randomized trial. Lancet. 2000; 355: 1041-1047.
-
(2000)
Lancet
, vol.355
, pp. 1041-1047
-
-
Douillard, J.Y.1
Cunningham, D.2
Roth, A.D.3
-
75
-
-
0034727063
-
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
-
Irinotecan Study Group
-
Saltz B, Cox JV, Blanke C., et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med. 2000; 343: 905-914.
-
(2000)
N Engl J Med
, vol.343
, pp. 905-914
-
-
Saltz, B.1
Cox, J.V.2
Blanke, C.3
-
76
-
-
0033874892
-
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
-
De Gramont A, Figer A, Seymour M., et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol. 2000; 18: 2938-2947.
-
(2000)
J Clin Oncol
, vol.18
, pp. 2938-2947
-
-
De Gramont, A.1
Figer, A.2
Seymour, M.3
-
77
-
-
1842569206
-
A randomized controlled trial of fluorouracil plus leucovorin, irinotecan and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
-
Goldberg RM, Sargent DJ, Morton RF., et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2004; 22: 23-30.
-
(2004)
J Clin Oncol
, vol.22
, pp. 23-30
-
-
Goldberg, R.M.1
Sargent, D.J.2
Morton, R.F.3
-
78
-
-
7344243730
-
Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with weekly high-dose 48-hour continuous-infusion fluorouracil for advanced colorectal cancer: A Spanish Cooperative Group for Gastrointestinal Tumor Therapy (TTD) study
-
Aranda E, Diaz-Rubio E, Cervantes A., et al. Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with weekly high-dose 48-hour continuous-infusion fluorouracil for advanced colorectal cancer: a Spanish Cooperative Group for Gastrointestinal Tumor Therapy (TTD) study. Ann Oncol. 1998; 9: 727-731.
-
(1998)
Ann Oncol
, vol.9
, pp. 727-731
-
-
Aranda, E.1
Diaz-Rubio, E.2
Cervantes, A.3
-
79
-
-
0031019918
-
Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: A French intergroup study
-
De Gramont A, Bosset JF, Milan C., et al. Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study. J Clin Oncol. 1997; 15: 808-815.
-
(1997)
J Clin Oncol
, vol.15
, pp. 808-815
-
-
De Gramont, A.1
Bosset, J.F.2
Milan, C.3
-
80
-
-
0036787717
-
Biweekly chemotherapy with oxaliplatin, irinotecan, infusional fluorouracil, and leucovorin: A pilot study in patients with metastatic colorectal cancer
-
Falcone A, Masi G, Allegrini G., et al. Biweekly chemotherapy with oxaliplatin, irinotecan, infusional fluorouracil, and leucovorin: a pilot study in patients with metastatic colorectal cancer. J Clin Oncol. 2002; 20: 4006-4014.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4006-4014
-
-
Falcone, A.1
Masi, G.2
Allegrini, G.3
-
81
-
-
19944425122
-
First-line treatment of metastatic colorectal cancer with irinotecan, oxaliplatin and 5-fluorouracil/leucovorin (FOLFOXIRI): Results of a phase II study with a simplified biweekly schedule
-
Masi G, Allegrini G, Cupini S., et al. First-line treatment of metastatic colorectal cancer with irinotecan, oxaliplatin and 5-fluorouracil/leucovorin (FOLFOXIRI): results of a phase II study with a simplified biweekly schedule. Ann Oncol. 2004; 15: 1766-1772.
-
(2004)
Ann Oncol
, vol.15
, pp. 1766-1772
-
-
Masi, G.1
Allegrini, G.2
Cupini, S.3
-
82
-
-
33645309877
-
FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): A mutlicentre randomized phase III trial from the Hellenic Oncology Research Group (HORG)
-
Souglakos J, Androulakis N, Syrigos K., et al. FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): a mutlicentre randomized phase III trial from the Hellenic Oncology Research Group (HORG). Br J Cancer. 2006; 94: 798-805.
-
(2006)
Br J Cancer
, vol.94
, pp. 798-805
-
-
Souglakos, J.1
Androulakis, N.2
Syrigos, K.3
-
83
-
-
34249000361
-
Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: The Gruppo Oncologico Nord Ovest
-
Falcone A, Ricci S, Brunetti I., et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol. 2007; 25: 1670-1676.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1670-1676
-
-
Falcone, A.1
Ricci, S.2
Brunetti, I.3
-
84
-
-
84883138328
-
FOLFIRI-bevacizumab as first-line chemotherapy in 3500 patients with advanced colorectal cancer: A pooled analysis of 29 published trials
-
Petrelli F, Borgonovo K, Cabiddu M., et al. FOLFIRI-bevacizumab as first-line chemotherapy in 3500 patients with advanced colorectal cancer: a pooled analysis of 29 published trials. Clin Colorectal Cancer. 2013; 12: 145-151.
-
(2013)
Clin Colorectal Cancer
, vol.12
, pp. 145-151
-
-
Petrelli, F.1
Borgonovo, K.2
Cabiddu, M.3
-
85
-
-
84871536208
-
Treatment patterns and clinical outcomes in patients with metastatic colorectal cancer initially treated with FOLFOX-bevacizumab or FOLFIRI-bevacizumab: Results from ARIES, a bevacizumab observational cohort study
-
Bendell JC, Bekaii-Saab TS, Cohn AL., et al. Treatment patterns and clinical outcomes in patients with metastatic colorectal cancer initially treated with FOLFOX-bevacizumab or FOLFIRI-bevacizumab: results from ARIES, a bevacizumab observational cohort study. Oncologist. 2012; 17: 1486-1495.
-
(2012)
Oncologist
, vol.17
, pp. 1486-1495
-
-
Bendell, J.C.1
Bekaii-Saab, T.S.2
Cohn, A.L.3
-
86
-
-
70349413045
-
Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: The BRITE observational cohort study
-
Kozloff M, Ulcickas M, Berlin J., et al. Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: the BRITE observational cohort study. Oncologist. 2009; 14: 862-870.
-
(2009)
Oncologist
, vol.14
, pp. 862-870
-
-
Kozloff, M.1
Ulcickas, M.2
Berlin, J.3
-
87
-
-
66149120036
-
Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: The BEAT study
-
Van Cutsem E, Rivera F, Berry S., et al. Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann Oncol. 2009; 20: 1842-1847.
-
(2009)
Ann Oncol
, vol.20
, pp. 1842-1847
-
-
Van Cutsem, E.1
Rivera, F.2
Berry, S.3
-
88
-
-
84864912888
-
Treatment with bevacizumab and FOLFOXIRI in patients with advanced colorectal cancer: Presentation of two novel trials (CHARTA and PERIMAX) and review of the literature
-
Stein A, Glockzin G, Wienke A., et al. Treatment with bevacizumab and FOLFOXIRI in patients with advanced colorectal cancer: presentation of two novel trials (CHARTA and PERIMAX) and review of the literature. BMC Cancer. 2012; 12: 356.
-
(2012)
BMC Cancer
, vol.12
, pp. 356
-
-
Stein, A.1
Glockzin, G.2
Wienke, A.3
-
89
-
-
84940728715
-
Similar but different: Distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance
-
Morkel M, Riemer P, Blaker H., et al. Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance. Oncotarget. 2015; 6: 20785-20800.
-
(2015)
Oncotarget
, vol.6
, pp. 20785-20800
-
-
Morkel, M.1
Riemer, P.2
Blaker, H.3
-
90
-
-
84903301924
-
The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis
-
Therkildsen C, Bergmann TK, Hennrichsen-Schnack T., et al. The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: a systematic review and meta-analysis. Acta Oncol. 2014; 53: 852-864.
-
(2014)
Acta Oncol
, vol.53
, pp. 852-864
-
-
Therkildsen, C.1
Bergmann, T.K.2
Hennrichsen-Schnack, T.3
-
91
-
-
84879240684
-
KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy
-
Valtorta E, Misale S, Sartore-Bianchi A., et al. KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy. Int J Cancer. 2013; 133: 1259-1265.
-
(2013)
Int J Cancer
, vol.133
, pp. 1259-1265
-
-
Valtorta, E.1
Misale, S.2
Sartore-Bianchi, A.3
-
92
-
-
84921946952
-
RAS testing of colorectal carcinoma: A guidance document from the association of clinical pathologists molecular pathology and diagnostics group
-
Wong NA, Gonzalez D, Salto-Tellez M., et al. RAS testing of colorectal carcinoma: a guidance document from the association of clinical pathologists molecular pathology and diagnostics group. J Clin Pathol. 2014; 67: 751-757.
-
(2014)
J Clin Pathol
, vol.67
, pp. 751-757
-
-
Wong, N.A.1
Gonzalez, D.2
Salto-Tellez, M.3
-
93
-
-
21244450758
-
Association of k-ras, b-raf and p53 status with the treatment effect of bevacizumab
-
Ince WL, Jubb AM, Holden SN., et al. Association of k-ras, b-raf and p53 status with the treatment effect of bevacizumab. J Natl Cancer Inst. 2005; 97: 981-989.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 981-989
-
-
Ince, W.L.1
Jubb, A.M.2
Holden, S.N.3
-
94
-
-
61449202998
-
The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of becacizumab with chemotherapy in previously untreated metastatic colorectal cancer
-
Hurwitz HI, Yi J, Ince W., et al. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of becacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist. 2009; 14: 22-28.
-
(2009)
Oncologist
, vol.14
, pp. 22-28
-
-
Hurwitz, H.I.1
Yi, J.2
Ince, W.3
-
95
-
-
84920559168
-
Subgroup analyses in RAS mutant, BRAF mutant and all-wt mCRC pts treated with FOLFOXIRI plus bevacizumab (bev) or FOLFIRI plus bev in the TRIBE study
-
Loupakis F, Cremolini C, Lonardi S., et al. Subgroup analyses in RAS mutant, BRAF mutant and all-wt mCRC pts treated with FOLFOXIRI plus bevacizumab (bev) or FOLFIRI plus bev in the TRIBE study. J Clin Oncol. 2014; 32: abstr 3519.
-
(2014)
J Clin Oncol
, vol.32
-
-
Loupakis, F.1
Cremolini, C.2
Lonardi, S.3
-
96
-
-
84880918721
-
Maintenance single-agent bevacizumab or observation after first-line chemotherapy in patients with metastatic colorectal cancer: A multicenter retrospective study
-
Moscetti L, Nelli F, Fabbri MA., et al. Maintenance single-agent bevacizumab or observation after first-line chemotherapy in patients with metastatic colorectal cancer: a multicenter retrospective study. Invest New Drugs. 2013; 31: 1035-1043.
-
(2013)
Invest New Drugs
, vol.31
, pp. 1035-1043
-
-
Moscetti, L.1
Nelli, F.2
Fabbri, M.A.3
|