Expression, modulation, and clinical correlates of the autophagy protein Beclin-1 in esophageal adenocarcinoma

Molecular Carcinogenesis

Volumn 55, Issue 11, 2016, Pages 1876-1885

  Weh, Katherine M ^a   Howell, Amy B ^b   Kresty, Laura A ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

autophagy; esophagus; natural product; rapamycin

Indexed keywords

BECLIN 1; CRANBERRY EXTRACT; PROANTHOCYANIDIN; RAPAMYCIN; SERINE; SMALL INTERFERING RNA; ANTHOCYANIN; BECN1 PROTEIN, HUMAN; PLANT EXTRACT;

ARTICLE; AUTOPHAGY; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CARCINOGENESIS; CELL SURVIVAL; CONTROLLED STUDY; ESOPHAGEAL ADENOCARCINOMA; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; MODULATION; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TISSUE MICROARRAY; ADENOCARCINOMA; CANCER GRADING; CHEMISTRY; CRANBERRY; DRUG EFFECTS; ESOPHAGUS TUMOR; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR CELL LINE;

ADENOCARCINOMA; ANTHOCYANINS; AUTOPHAGY; BECLIN-1; CELL LINE, TUMOR; ESOPHAGEAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM GRADING; NEOPLASM STAGING; PHOSPHORYLATION; PLANT EXTRACTS; PROGNOSIS; SIROLIMUS; SURVIVAL ANALYSIS; VACCINIUM MACROCARPON;

EID: 84947998677     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22432     Document Type: Article

References (40)

1. Brown LM, Devesa SS, Chow WH. Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age. J Natl Cancer Inst 2008; 100:1184–1187.
2. Spechler SJ, Souza RF. Barrett's esophagus. N Engl J Med 2014; 371:836–845.
3. Howlader N, Noone AM, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.
4. American Cancer Society. Cancer Facts & Figures 2015. Atlanta: American Cancer Society; 2015.
5. Napier KJ, Scheerer M, Misra S. Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities. World J Gastrointest Oncol 2014; 6:112–120.
6. Spechler SJ. Barrett esophagus and risk of esophageal cancer: A clinical review. JAMA 2013; 310:627–636.
7. Dawsey SM, Fagundes RB, Jacobson BC, et al. Diet and esophageal disease. Ann N Y Acad Sci 2014; 1325:127–137.
8. Peng S, Huo X, Rezaei D, et al. In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids. Am J Physiol Gastrointest Liver Physiol 2014; 307:G129–G139.
9. Roesly HB, Khan MR, Chen HD, et al. The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: The role of deoxycholic acid. Am J Physiol Gastrointest Liver Physiol 2012; 302:G864–G872.
10. Green DR, Levine B. To be or not to be? How selective autophagy and cell death govern cell fate. Cell 2014; 157:65–75.
11. Kim YC, Guan KL. MTOR: A pharmacologic target for autophagy regulation. J Clin Invest 2015; 125:25–32.
12. Kroemer G. Autophagy: A druggable process that is deregulated in aging and human disease. J Clin Invest 2015; 125:1–4.
13. Levine B, Packer M, Codogno P. Development of autophagy inducers in clinical medicine. J Clin Invest 2015; 125:14–24.
14. Dalby KN, Tekedereli I, Lopez-Berestein G, Ozpolat B. Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy 2010; 6:322–329.
15. Foo LY, Lu Y, Howell AB, Vorsa N. The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro. Phytochemistry 2000; 54:173–181.
16. Foo LY, Lu Y, Howell AB, Vorsa N. A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli. J Nat Prod 2000; 63:1225–1228.
17. Howell AB, Reed JD, Krueger CG, Winterbottom R, Cunningham DG, Leahy M. A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry 2005; 66:2281–2291.
18. Krueger CG, Reed JD, Feliciano RP, Howell AB. Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health. Anal Bioanal Chem 2013; 405:4385–4395.
19. Blumberg JB, Camesano TA, Cassidy A, et al. Cranberries and their bioactive constituents in human health. Adv Nutr 2013; 4:618–632.
20. Kresty LA, Clarke J, Ezell K, Exum A, Howell AB, Guettouche T. MicroRNA alterations in Barrett's esophagus, esophageal adenocarcinoma, and esophageal adenocarcinoma cell lines following cranberry extract treatment: Insights for chemoprevention. J Carcinog 2011; 10:34.
21. Kresty LA, Howell AB, Baird M. Cranberry proanthocyanidins induce apoptosis and inhibit acid-induced proliferation of human esophageal adenocarcinoma cells. J Agric Food Chem 2008; 56:676–680.
22. Kresty LA, Howell AB, Baird M. Cranberry proanthocyanidins mediate growth arrest of lung cancer cells through modulation of gene expression and rapid induction of apoptosis. Molecules 2011; 16:2375–2390.
23. Kresty LA, Weh KM, Zeyzus-Johns B, Perez LN, Howell AB. Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation. Oncotarget 2015; 6:33438–33455.
24. Kaspar KL, Howell AB, Khoo C. A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages. Food Funct 2015; 6:1212–1217.
25. Stoner GD, Kaighn ME, Reddel RR, et al. Establishment and characterization of SV40 T-antigen immortalized human esophageal epithelial cells. Cancer Res 1991; 51:365–371.
26. Botti J, Djavaheri-Mergny M, Pilatte Y, Codogno P. Autophagy signaling and the cogwheels of cancer. Autophagy 2006; 2:67–73.
27. Xu Y, Xia X, Pan H. Active autophagy in the tumor microenvironment: A novel mechanism for cancer metastasis. Oncol Lett 2013; 5:411–416.
28. Cai N, Zhao X, Jing Y, et al. Autophagy protects against palmitate-induced apoptosis in hepatocytes. Cell Biosci 2014; 4:28.
29. Farkas T, Hoyer-Hansen M, Jaattela M. Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux. Autophagy 2009; 5:1018–1025.
30. Nyfeler B, Bergman P, Triantafellow E, et al. Relieving autophagy and 4EBP1 from rapamycin resistance. Mol Cell Biol 2011; 31:2867–2876.
31. Song H, Pan B, Yi J, Chen L. Autophagic activation with nimotuzumab enhanced chemosensitivity and radiosensitivity of esophageal squamous cell carcinoma. Exp Biol Med (Maywood) 2014; 239:529–541.
32. Klionsky DJ, Abdalla FC, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445–544.
33. Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007; 3:542–545.
34. Codogno P, Mehrpour M, Proikas-Cezanne T. Canonical and non-canonical autophagy: Variations on a common theme of self-eating? Nat Rev Mol Cell Biol 2012; 13:7–12.
35. Fogel AI, Dlouhy BJ, Wang C, et al. Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Mol Cell Biol 2013; 33:3675–3688.
36. Kim J, Kim YC, Fang C, et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 2013; 152:290–303.
37. Russell RC, Tian Y, Yuan H, et al. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol 2013; 15:741–750.
38. Wang RC, Wei Y, An Z, et al. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 2012; 338:956–959.
39. Alers S, Loffler AS, Wesselborg S, Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks. Mol Cell Biol 2012; 32:2–11.
40. Gao W, Shen Z, Shang L, Wang X. Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death. Cell Death Differ 2011; 18:1598–1607.