Investigating the dissolution performance of amorphous solid dispersions using magnetic resonance imaging and proton NMR

Molecules

Volumn 20, Issue 9, 2015, Pages 16404-16418

  Tres, Francesco ^a   Coombes, Steven R ^b   Phillips, Andrew R ^b   Hughes, Leslie P ^b   Wren, Stephen A C ^b   Aylott, Jonathan W ^a   Burley, Jonathan C ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Amorphous solid dispersions; Bicalutamide; Hot melt extrusion; Magnetic resonance imaging; Poorly soluble drugs; Solid state transformations; Suppressed water 1H NMR

Indexed keywords

ANILIDE; BICALUTAMIDE; NITRILE; TOLUENESULFONIC ACID DERIVATIVE;

CHEMISTRY; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; MEDICINAL CHEMISTRY; NUCLEAR MAGNETIC RESONANCE IMAGING; PROCEDURES; PROTON NUCLEAR MAGNETIC RESONANCE;

ANILIDES; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG LIBERATION; DRUG STABILITY; MAGNETIC RESONANCE IMAGING; NITRILES; PROTON MAGNETIC RESONANCE SPECTROSCOPY; TOSYL COMPOUNDS;

EID: 84947998254     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules200916404     Document Type: Article

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