Aβ-42 lowering agents from the marine-derived fungus Dichotomomyces cejpii

Steroids

Volumn 104, Issue , 2015, Pages 182-188

  Harms, Henrik ^a   Kehraus, Stefan ^a   Nesaei Mosaferan, Damun ^a   Hufendieck, Peter ^a   Meijer, Laurent ^b   König, Gabriele M ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Centre de Perharidy   (France)

Author keywords

Alzheimer's disease; Dichotomomyces cejpii; Ergosterol derivatives

Indexed keywords

16 O DESMETHYLASPORYERGOSTEROL BETA DEXTRO MANNOSIDE; 16 O DESMETHYLASPORYERGOSTERON BETA DEXTRO MANNOSIDE; AMYLOID BETA PROTEIN[1-42]; FUNGAL EXTRACT; NOOTROPIC AGENT; UNCLASSIFIED DRUG; XANTHOCILLIN X DIMETHYL ETHER; 1,3 BUTADIENE DERIVATIVE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT; STEROL;

ALZHEIMER DISEASE; ARTICLE; ASCOMYCETES; CALLYSPONGIA; CARBON NUCLEAR MAGNETIC RESONANCE; DICHOTOMOMYCES CEJPII; FUNGAL BIOMASS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; OPTICAL ROTATION; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ASCOMYCOTA; BUTADIENES; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; PEPTIDE FRAGMENTS; PORIFERA; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84947930107     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2015.09.012     Document Type: Article

References (23)

1. M.F. Elsebai, S. Kehraus, and G.M. König Caught between triterpene- and steroid-metabolism: 4 alpha-carboxylic pregnane-derivative from the marine alga-derived fungus Phaeosphaeria spartinae Steroids 78 2013 880 883
2. C. Almeida, Y. Hemberger, S.M. Schmitt, S. Bouhired, L. Natesan, S. Kehraus, K. Dimas, M. Gütschow, G. Bringmann, and G.M. König Marilines A-C: novel phthalimidines from the sponge-derived fungus Stachylidium sp. Chem. Eur. J. 18 2012 8827 8834
3. S. Felder, S. Dreisigacker, S. Kehraus, E. Neu, G. Bierbaum, P.R. Wright, D. Menche, T.F. Schäberle, and G.M. König Salimabromide: unexpected chemistry from the obligate marine myxobacterium Enhygromxya salina Chem. Eur. J. 19 2013 9319 9324
4. J. Hardy A hundred years of Alzheimer's disease research Neuron 52 2006 3 13
5. K. Bettayeb, N. Oumata, Y. Zhang, W. Luo, V. Bustos, H. Galons, P. Greengard, L. Meijer, and M. Flajolet Small-molecule inducers of A beta-42 peptide production share a common mechanism of action FASEB J. 26 2012 5115 5123
6. D.J. Selkoe The therapeutics of Alzheimer's disease: where we stand and where we are heading Ann. Neurol. 74 2013 328 336
7. T.E. Golde, E.H. Koo, K.M. Felsenstein, B.A. Osborne, and L. Miele Gamma-secretase inhibitors and modulators Biochim. Biophys. Acta Biomembr. 1828 2013 2898 2907
8. A.K. Ghosh, M. Brindisi, and J.J. Tang Developing ss-secretase inhibitors for treatment of Alzheimer's disease J. Neurochem. 120 2012 71 83
9. A. Hochard, N. Oumata, K. Bettayeb, O. Gloulou, X. Fant, E. Durieu, N. Buron, M. Porceddu, A. Borgne-Sanchez, H. Galons, M. Flajolet, and L.J. Meijer Aftins increase amyloid-beta(42), lower amyloid-beta(38), and do not alter amyloid-beta(40) extracellular production in vitro: toward a chemical model of Alzheimer's disease? J. Alzheimers Dis. 35 2013 107 120
10. M. Ogata, J. Ueda, M. Hoshi, J. Hashimoto, T. Nakashima, K. Anzai, M. Takagi, and K. Shin-ya A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559 J. Antibiot. (Tokyo) 60 2007 645 648
11. H. Harms, V. Rempel, S. Kehraus, M. Kaiser, P. Hufendiek, C.E. Müller, and G.M. König Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors J. Nat. Prod. 77 2014 673 677
12. I. Hagedorn, U. Eholzer, and H. Etling Isonitrile, V. Darstellung von α.β-ungesaettigten Isonitrilen, β-Keto- und β-Chlorisonitrilen. Synthese des Xanthocillin-dimethylaethers Chem. Berichte 98 1965 193 201
13. P.D. Mehta, and T. Pirttila Increased cerebrospinal fluid A beta 38/A beta 42 ratio in Alzheimer disease Neurodegener. Dis. 2 2005 242 245
14. M.-F. Qiao, N.-Y. Ji, X.-H. Liu, F. Li, and Q.-Z. Xue Asporyergosterol, a new steroid from an algicolous isolate of Aspergillus oryzae Nat. Prod. Commun. 5 2010 1575 1578
15. H.L. Holland, P.C. Chenchaiah, E.M. Thomas, B. Mader, and M.J. Dennis Microbial hydroxylation of steroids. 9. Epoxidation of delta-6-3-ketosteroids by Rhizopus arrhizus ATCC11145, and the mechanism of the 6-beta-hydroxylase enzyme Can. J. Chem. 62 1984 2740 2747
16. C. Altona, and C.A.G. Haasnoot Prediction of anti and gauche vicinal proton-proton coupling-constants in carbohydrates - a simple additively rule for pyranose rings Org. Magn. Reson. 13 1980 417 429
17. K. Bock, and C. Pedersen Study of C-13H coupling-constants in hexopyranoses J. Chem. Soc. Perkin Trans. 2 1974 293 297
18. K.-H. Gan, S.-H. Kuo, and C.-N. Lin Steroidal constituents of Ganoderma applanatum and Ganoderma neo-japonicum J. Nat. Prod. 61 1998 1421 1422
19. A. Takatsuki, S. Suzuki, K. Ando, G. Tamura, and K. Arima New antiviral antibiotics - xanthocillin X mono- and dimethylether and methoxy-xanthocillin X dimethylether. I. isolation and characterization - studies on antiviral and antitumor antibiotics J. Antibiot. 21 1968 671 675
20. T. Morino, M. Nishimoto, N. Itou, and T. Nishikiori NK372135S, novel antifungal agents produced by Neosartoria fischeri J. Antibiot. 47 1994 1546 1548
21. K. Tatsuta, and T. Yamaguchi The first stereoselective total synthesis of antiviral antibiotic, xanthocillin X dimethylether and its stereoisomer Tetrahedron Lett. 46 2005 5017 5020
22. J.L. Hubbs, N.O. Fuller, W.F. Austin, R. Shen, S.P. Creaser, T.D. McKee, R.M.B. Loureiro, B. Tate, W. Xia, J. Ives, and B.S. Bronk Optimization of a natural product-based class of gamma-secretase modulators J. Med. Chem. 55 2012 9270 9282
23. M.A. Findeis, F. Schroeder, T.D. McKee, D. Yager, P.C. Fraering, S.P. Creaser, W.F. Austin, J. Clardy, R. Wang, D. Selkoe, and C.B. Eckman Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa ACS Chem. Neurosci. 3 2012 941 951